LOCUS       NP_032538               4545 aa            linear   ROD 03-JUN-2025
DEFINITION  prolow-density lipoprotein receptor-related protein 1 precursor
            [Mus musculus].
ACCESSION   NP_032538
VERSION     NP_032538.2
DBSOURCE    REFSEQ: accession NM_008512.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 4545)
  AUTHORS   Ito,S., Graf,D.B., Katsumata,Y., Moorleghen,J.J., Zhang,C., Li,Y.,
            LeMaire,S.A., Shen,Y.H., Lu,H.S., Daugherty,A. and Sawada,H.
  TITLE     Smooth muscle cells and fibroblasts in the ascending aorta exhibit
            minor differences between embryonic origins in angiotensin
            II-driven transcriptional alterations
  JOURNAL   Sci Rep 15 (1), 16617 (2025)
   PUBMED   40360730
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 4545)
  AUTHORS   Chandrashekar,D.V., Roules,G.C., Jagadeesan,N., Panchal,U.R.,
            Oyegbesan,A., Imiruaye,O.E., Zhang,H., Garcia,J., Kaur,K., Win,S.,
            Than,T.A., Kaplowitz,N., Roosan,M.R., Han,D. and Sumbria,R.K.
  TITLE     Hepatic LRP-1 plays an important role in amyloidosis in Alzheimer's
            disease mice: Potential role in chronic heavy alcohol feeding
  JOURNAL   Neurobiol Dis 199, 106570 (2024)
   PUBMED   38885850
  REMARK    GeneRIF: Hepatic LRP-1 plays an important role in amyloidosis in
            Alzheimer's disease mice: Potential role in chronic heavy alcohol
            feeding.
REFERENCE   3  (residues 1 to 4545)
  AUTHORS   Yamamoto,K., Scilabra,S.D., Bonelli,S., Jensen,A., Scavenius,C.,
            Enghild,J.J. and Strickland,D.K.
  TITLE     Novel insights into the multifaceted and tissue-specific roles of
            the endocytic receptor LRP1
  JOURNAL   J Biol Chem 300 (8), 107521 (2024)
   PUBMED   38950861
  REMARK    GeneRIF: Novel insights into the multifaceted and tissue-specific
            roles of the endocytic receptor LRP1.
            Review article
REFERENCE   4  (residues 1 to 4545)
  AUTHORS   Lin,H., Fu,L., Zhou,X., Yu,A., Chen,Y., Liao,W., Shu,G., Zhang,L.,
            Tan,L., Liang,H., Wang,Z., Deng,Q., Wang,J., Jin,M., Chen,Z.,
            Wei,J., Cao,J., Chen,W., Li,X., Li,P., Lu,J. and Luo,J.
  TITLE     LRP1 induces anti-PD-1 resistance by modulating the
            DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage
            polarisation in bladder cancer
  JOURNAL   Cancer Lett 593, 216807 (2024)
   PUBMED   38462037
  REMARK    GeneRIF: LRP1 induces anti-PD-1 resistance by modulating the
            DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage
            polarisation in bladder cancer.
REFERENCE   5  (residues 1 to 4545)
  AUTHORS   da Cruz Rodrigues,K.C., Kim,S.C., Uner,A.A., Hou,Z.S., Young,J.,
            Campolim,C., Aydogan,A., Chung,B., Choi,A., Yang,W.M., Kim,W.S.,
            Prevot,V., Caldarone,B.J., Lee,H. and Kim,Y.B.
  TITLE     LRP1 in GABAergic neurons is a key link between obesity and memory
            function
  JOURNAL   Mol Metab 84, 101941 (2024)
   PUBMED   38636794
  REMARK    GeneRIF: LRP1 in GABAergic neurons is a key link between obesity
            and memory function.
REFERENCE   6  (residues 1 to 4545)
  AUTHORS   Herz,J., Clouthier,D.E. and Hammer,R.E.
  TITLE     LDL receptor-related protein internalizes and degrades uPA-PAI-1
            complexes and is essential for embryo implantation
  JOURNAL   Cell 71 (3), 411-421 (1992)
   PUBMED   1423604
  REMARK    Erratum:[Cell. 1993 May 7;73(3):428. doi:
            10.1016/0092-8674(93)90130-i. PMID: 8490961]
REFERENCE   7  (residues 1 to 4545)
  AUTHORS   Hilliker,C., Van Leuven,F. and Van den Berghe,H.
  TITLE     Assignment of the gene coding for the alpha 2-macroglobulin
            receptor to mouse chromosome 15 and to human chromosome 12q13-q14
            by isotopic and nonisotopic in situ hybridization
  JOURNAL   Genomics 13 (2), 472-474 (1992)
   PUBMED   1377168
REFERENCE   8  (residues 1 to 4545)
  AUTHORS   Kristensen,T., Moestrup,S.K., Gliemann,J., Bendtsen,L., Sand,O. and
            Sottrup-Jensen,L.
  TITLE     Evidence that the newly cloned low-density-lipoprotein receptor
            related protein (LRP) is the alpha 2-macroglobulin receptor
  JOURNAL   FEBS Lett 276 (1-2), 151-155 (1990)
   PUBMED   1702392
REFERENCE   9  (residues 1 to 4545)
  AUTHORS   Strickland,D.K., Ashcom,J.D., Williams,S., Burgess,W.H.,
            Migliorini,M. and Argraves,W.S.
  TITLE     Sequence identity between the alpha 2-macroglobulin receptor and
            low density lipoprotein receptor-related protein suggests that this
            molecule is a multifunctional receptor
  JOURNAL   J Biol Chem 265 (29), 17401-17404 (1990)
   PUBMED   1698775
REFERENCE   10 (residues 1 to 4545)
  AUTHORS   Herz,J., Hamann,U., Rogne,S., Myklebost,O., Gausepohl,H. and
            Stanley,K.K.
  TITLE     Surface location and high affinity for calcium of a 500-kd liver
            membrane protein closely related to the LDL-receptor suggest a
            physiological role as lipoprotein receptor
  JOURNAL   EMBO J 7 (13), 4119-4127 (1988)
   PUBMED   3266596
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK078273.1, AF367720.1, AK154429.1, X67469.1, AC167719.2,
            CA888999.1, CF535491.1, BU615020.1 and CB527265.1.
            
            On Feb 6, 2007 this sequence version replaced NP_032538.1.
            
            Sequence Note: Although this RefSeq record was created from
            transcript sequence data from multiple strains, its existence in a
            single strain is supported by transcript data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF367720.1, X67469.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4545
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.52 cM"
     Protein         1..4545
                     /product="prolow-density lipoprotein receptor-related
                     protein 1 precursor"
                     /note="prolow-density lipoprotein receptor-related protein
                     1; alpha 2-macroglobulin receptor; LRP-1"
                     /calculated_mol_wt=502832
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1962
     mat_peptide     20..4545
                     /product="Prolow-density lipoprotein receptor-related
                     protein 1. /id=PRO_0000273273"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
                     /calculated_mol_wt=502832
     Region          27..60
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(33,42,53..54)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(46,49,53,59..60)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            56..60
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          72..105
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(78,87,98..99)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(91,94,98,104..105)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            101..105
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          120..149
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            137
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          159..189
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            186
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            240
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            275
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          276..315
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          293..335
                     /region_name="LDL-receptor class B 1.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          317..359
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          336..379
                     /region_name="LDL-receptor class B 2.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            358
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          362..402
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          380..423
                     /region_name="LDL-receptor class B 3.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            447
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19349973; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          487..520
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          552..594
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          572..614
                     /region_name="LDL-receptor class B 4.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          595..634
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          615..660
                     /region_name="LDL-receptor class B 5.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          641..690
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          661..711
                     /region_name="LDL-receptor class B 6.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          <701..734
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          712..755
                     /region_name="LDL-receptor class B 7.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            730
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          808..843
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          854..886
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(860,868,879..880)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(872,875,879,885..886)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            882..886
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          896..929
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(901,909,920..921)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(913,916,920,926..927)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            923..927
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            929
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          936..968
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(942,950,961..962)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(954,957,961,967..968)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            964..968
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          979..1012
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(983,991,1002..1003)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(995,998,1002,1008..1009)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1005..1009
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1016..1049
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1021,1029,1040..1041)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1033,1036,1040,1046..1047)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1043..1047
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            1051
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1063..1098
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1068,1077,1088..1089)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1081,1084,1088,1094..1095)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1091..1095
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1105..1141
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1111,1120,1131..1132)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(1124,1127,1131,1137..1138)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1134..1138
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1146..1179
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(1151,1161,1172..1173)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            1155
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1156
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            order(1165,1168,1172,1178..1179)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            1175..1179
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          1186..1222
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            1196
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1219
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1310..1356
                     /region_name="LDL-receptor class B 8.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1311..>1504
                     /region_name="Vgb"
                     /note="Streptogramin lyase [Defense mechanisms]; COG4257"
                     /db_xref="CDD:443399"
     Region          1337..1377
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1357..1399
                     /region_name="LDL-receptor class B 9.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1381..1424
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1400..1446
                     /region_name="LDL-receptor class B 10.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1447..1491
                     /region_name="LDL-receptor class B 11.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1492..1532
                     /region_name="LDL-receptor class B 12.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1512
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1559
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1576
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1614..1650
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Site            1617
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1628..1670
                     /region_name="LDL-receptor class B 13.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1646
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1651..1694
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1671..1714
                     /region_name="LDL-receptor class B 14.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1698..1735
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1715..1754
                     /region_name="LDL-receptor class B 15.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1724
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1734
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1735..1776
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1755..1799
                     /region_name="LDL-receptor class B 16.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1764
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1826
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1851..1887
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          1917..1957
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Site            1934
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1935..1977
                     /region_name="LDL-receptor class B 17.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          1960..2000
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          1978..2020
                     /region_name="LDL-receptor class B 18.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            1996
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2001..2044
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Site            2010
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2021..2064
                     /region_name="LDL-receptor class B 19.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2046..2088
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Site            2049
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2065..2108
                     /region_name="LDL-receptor class B 20.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            2118
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            2128
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2160..2195
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          2254..2295
                     /region_name="LDL-receptor class B 21.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2276..2316
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          2296..2344
                     /region_name="LDL-receptor class B 22.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2345..2389
                     /region_name="LDL-receptor class B 23.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2345..2387
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          2371..2412
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          2390..2432
                     /region_name="LDL-receptor class B 24.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2433..2474
                     /region_name="LDL-receptor class B 25.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            2473
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2483..2515
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            2503
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            2522
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2528..2558
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2531,2539,2550..2551)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2543,2546,2550,2556..2557)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2553..2557
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2567..2601
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2572,2580,2591..2592)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2584,2587,2591,2597..2598)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2594..2598
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            2602
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2606..2640
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2611,2619,2630..2631)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            2621
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            order(2623,2626,2630,2636..2637)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2633..2637
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            2639
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          <2667..2689
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2672,2675,2679,2685..2686)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2682..2686
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2697..2731
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2702,2710,2721..2722)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2714,2717,2721,2727..2728)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2724..2728
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2735..2766
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(2740,2748,2759..2760)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2752,2755,2759,2765..2766)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2762..2766
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2774..2807
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(2780,2789,2800..2801)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2793,2796,2800,2806..2807)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2803..2807
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            2816
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2818..2850
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(2824,2832,2843..2844)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2836,2839,2843,2849..2850)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2846..2850
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2858..2891
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(2864,2872,2884..2885)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2877,2880,2884,2890..2891)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2887..2891
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            2906
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          2908..2940
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(2911,2919,2930..2931)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(2923,2926,2930,2936..2937)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            2933..2937
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          2952..2981
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Region          2983..>3012
                     /region_name="EGF_CA"
                     /note="Calcium-binding EGF-like domain; smart00179"
                     /db_xref="CDD:214542"
     Site            order(2983,2986,2999)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:238011"
     Site            3049
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19656770; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3050..3094
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3070..3114
                     /region_name="LDL-receptor class B 26.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            3090
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3095..3137
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3115..3157
                     /region_name="LDL-receptor class B 27.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3139..3181
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3158..3201
                     /region_name="LDL-receptor class B 28.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3183..3224
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3202..3244
                     /region_name="LDL-receptor class B 29.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3225..3265
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3245..3285
                     /region_name="LDL-receptor class B 30.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            3265
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3295..3331
                     /region_name="FXa_inhibition"
                     /note="Coagulation Factor Xa inhibitory site; pfam14670"
                     /db_xref="CDD:464251"
     Site            3334
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3335..3366
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3340,3348,3359..3360)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3352,3355,3359,3365..3366)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3362..3366
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3375..3409
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3380,3388,3399..3400)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3392,3395,3399,3405..3406)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3402..3406
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3414..3449
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3419,3428,3439..3440)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3432,3435,3439,3445..3446)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3442..3446
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3453..3486
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(3459,3468,3479..3480)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3472,3475,3479,3485..3486)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3482..3486
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            3489
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3494..3527
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(3500,3509,3520..3521)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3513,3516,3520,3526..3527)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3523..3527
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3537..3571
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3542,3550,3561..3562)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3554,3557,3561,3567..3568)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3564..3568
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3576..3610
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3581,3589,3600..3601)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3593,3596,3600,3606..3607)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3603..3607
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3614..3648
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3619,3627,3638..3639)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3631,3634,3638,3644..3645)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3641..3645
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3654..3686
                     /region_name="LDLa"
                     /note="Low-density lipoprotein receptor domain class A;
                     smart00192"
                     /db_xref="CDD:197566"
     Site            order(3660,3668,3679..3680)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            3663
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            order(3672,3675,3679,3685..3686)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3682..3686
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3696..3732
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3702,3711,3722..3723)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3715,3718,3722,3728..3729)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3725..3729
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Region          3747..3777
                     /region_name="LDLa"
                     /note="Low Density Lipoprotein Receptor Class A domain, a
                     cysteine-rich repeat that plays a central role in
                     mammalian cholesterol metabolism; the receptor protein
                     binds LDL and transports it into cells by endocytosis; 7
                     successive cysteine-rich repeats of about...; cd00112"
                     /db_xref="CDD:238060"
     Site            order(3748,3756,3767..3768)
                     /site_type="active"
                     /note="putative binding surface [active]"
                     /db_xref="CDD:238060"
     Site            order(3760,3763,3767,3773..3774)
                     /site_type="other"
                     /note="calcium-binding site [ion binding]"
                     /db_xref="CDD:238060"
     Site            3770..3774
                     /site_type="other"
                     /note="D-X-S-D-E motif"
                     /db_xref="CDD:238060"
     Site            3789
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            3840
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3863..4065
                     /region_name="YncE"
                     /note="DNA-binding beta-propeller fold protein YncE
                     [General function prediction only]; COG3391"
                     /db_xref="CDD:442618"
     Region          3913..3955
                     /region_name="LDL-receptor class B 31.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3941..3944
                     /region_name="Recognition site for proteolytical
                     processing. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            3954
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          3956..3993
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          3971..4013
                     /region_name="LDL-receptor class B 32.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          4014..4057
                     /region_name="LDL-receptor class B 33.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          4014..4055
                     /region_name="Ldl_recept_b"
                     /note="Low-density lipoprotein receptor repeat class B;
                     pfam00058"
                     /db_xref="CDD:459654"
     Region          4038..4079
                     /region_name="LY"
                     /note="Low-density lipoprotein-receptor YWTD domain;
                     smart00135"
                     /db_xref="CDD:214531"
     Region          4058..4102
                     /region_name="LDL-receptor class B 34.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4076
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4126
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4180
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4279
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4280
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4365
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4425..4445
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          4446..4545
                     /region_name="Interaction with MAFB.
                     /evidence=ECO:0000269|PubMed:15135046"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4461
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Region          4503..4508
                     /region_name="NPXY motif"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4508
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4518
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4521
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q07954; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     Site            4524
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (Q91ZX7.1)"
     CDS             1..4545
                     /gene="Lrp1"
                     /gene_synonym="A2mr; b2b1554Clo; CD91; Lrp"
                     /coded_by="NM_008512.2:462..14099"
                     /db_xref="CCDS:CCDS24245.1"
                     /db_xref="GeneID:16971"
                     /db_xref="MGI:MGI:96828"
ORIGIN      
        1 mltpplllll pllsalvsga tmdapktcsp kqfacrdqit ciskgwrcdg erdcpdgsde
       61 apeicpqska qrcppnehsc lgtelcvpms rlcngiqdcm dgsdegahcr elrancsrmg
      121 cqhhcvptps gptcycnssf qlqadgktck dfdecsvygt csqlctntdg sftcgcvegy
      181 llqpdnrsck aknepvdrpp vlliansqni latylsgaqv stitptstrq ttamdfsyan
      241 etvcwvhvgd saaqtqlkca rmpglkgfvd ehtinislsl hhveqmaidw ltgnfyfvdd
      301 iddrifvcnr ngdtcvtlld lelynpkgia ldpamgkvff tdygqipkve rcdmdgqnrt
      361 klvdskivfp hgitldlvsr lvywadayld yievvdyegk grqtiiqgil iehlygltvf
      421 enylyatnsd nantqqktsv irvnrfnste yqvvtrvdkg galhiyhqrr qprvrshace
      481 ndqygkpggc sdicllansh kartcrcrsg fslgsdgksc kkpehelflv ygkgrpgiir
      541 gmdmgakvpd ehmipienlm npraldfhae tgfiyfadtt syligrqkid gteretilkd
      601 gihnvegvav dwmgdnlywt ddgpkktisv arlekaaqtr ktliegkmth praivvdpln
      661 gwmywtdwee dpkdsrrgrl erawmdgshr difvtsktvl wpnglsldip agrlywvdaf
      721 ydrietilln gtdrkivyeg pelnhafglc hhgnylfwte yrsgsvyrle rgvagapptv
      781 tllrserppi feirmydaqq qqvgtnkcrv nnggcsslcl atpgsrqcac aedqvldtdg
      841 vtclanpsyv pppqcqpgef acannrciqe rwkcdgdndc ldnsdeapal chqhtcpsdr
      901 fkcennrcip nrwlcdgdnd cgnsedesna tcsartcppn qfscasgrci piswtcdldd
      961 dcgdrsdesa scayptcfpl tqftcnngrc ininwrcdnd ndcgdnsdea gcshscsstq
     1021 fkcnsgrcip ehwtcdgdnd cgdysdetha nctnqatrpp ggchsdefqc rldglciplr
     1081 wrcdgdtdcm dssdeksceg vthvcdpnvk fgckdsarci skawvcdgds dcednsdeen
     1141 cealacrpps hpcanntsvc lppdklcdgk ddcgdgsdeg elcdqcslnn ggcshncsva
     1201 pgegivcscp lgmelgsdnh tcqiqsycak hlkcsqkcdq nkfsvkcscy egwvlepdge
     1261 scrsldpfkp fiifsnrhei rridlhkgdy svlvpglrnt ialdfhlsqs alywtdvved
     1321 kiyrgklldn galtsfevvi qyglatpegl avdwiagniy wvesnldqie vakldgtlrt
     1381 tllagdiehp raialdprdg ilfwtdwdas lprieaasms gagrrtihre tgsggwpngl
     1441 tvdylekril widarsdaiy sarydgsghm evlrghefls hpfavtlygg evywtdwrtn
     1501 tlakankwtg hnvtvvqrtn tqpfdlqvyh psrqpmapnp ceanggrgpc shlclinynr
     1561 tvscacphlm klhkdnttcy efkkfllyar qmeirgvdld apyynyiisf tvpdidnvtv
     1621 ldydareqrv ywsdvrtqai krafingtgv etvvsadlpn ahglavdwvs rnlfwtsydt
     1681 nkkqinvarl dgsfknavvq gleqphglvv hplrgklywt dgdnismanm dgsnhtllfs
     1741 gqkgpvglai dfpesklywi ssgnhtinrc nldgselevi dtmrsqlgka talaimgdkl
     1801 wwadqvsekm gtcnkadgsg svvlrnsttl vmhmkvydes iqlehegtnp csvnngdcsq
     1861 lclptsettr scmctagysl rsgqqacegv gsfllysvhe girgipldpn dksdalvpvs
     1921 gtslavgidf haendtiywv dmglstisra krdqtwredv vtngigrveg iavdwiagni
     1981 ywtdqgfdvi evarlngsfr yvvisqgldk praitvhpek gylfwtewgh ypriersrld
     2041 gtervvlvnv siswpngisv dyqggklywc darmdkieri dletgenrev vlssnnmdmf
     2101 svsvfedfiy wsdrthangs ikrgckdnat dsvplrtgig vqlkdikvfn rdrqkgtnvc
     2161 avanggcqql clyrgggqra cacahgmlae dgascreyag yllysertil ksihlsdern
     2221 lnapvqpfed pehmknvial afdyragtsp gtpnriffsd ihfgniqqin ddgsgrttiv
     2281 envgsvegla yhrgwdtlyw tsyttstitr htvdqtrpga feretvitms gddhprafvl
     2341 decqnlmfwt nwnelhpsim raalsganvl tliekdirtp nglaidhrae klyfsdatld
     2401 kierceydgs hryvilksep vhpfglavyg ehifwtdwvr ravqrankyv gsdmkllrvd
     2461 ipqqpmgiia vandtnscel spcrinnggc qdlcllthqg hvncscrggr ilqedftcra
     2521 vnsscraqde fecangecis fsltcdgvsh ckdksdekps ycnsrrckkt frqcnngrcv
     2581 snmlwcngvd dcgdgsdeip cnktacgvge frcrdgscig nssrcnqfvd cedasdemnc
     2641 sttdcssyfr lgvkgvlfqp certslcyap swvcdgandc gdysderdcp gvkrprcpln
     2701 yfacpsgrci pmswtcdked dcengedeth cnkfcseaqf ecqnhrcisk qwlcdgsddc
     2761 gdgsdeaahc egktcgpssf scpgthvcvp erwlcdgdkd ctdgadesvt agclynstcd
     2821 drefmcqnrl cipkhfvcdh drdcadgsde speceyptcg pnefrcangr clssrqwecd
     2881 gendchdhsd eapknphcts pehkcnassq flcssgrcva eallcngqdd cgdgsdergc
     2941 hvneclsrkl sgcsqdcedl kigfkcrcrp gfrlkddgrt cadldecstt fpcsqlcint
     3001 hgsykclcve gyaprggdph sckavtdeep flifanryyl rklnldgsny tllkqglnna
     3061 valdfdyreq miywtdvttq gsmirrmhln gsnvqvlhrt glsnpdglav dwvggnlywc
     3121 dkgrdtievs klngayrtvl vssglrepra lvvdvqngyl ywtdwgdhsl igrigmdgsg
     3181 rsiivdtkit wpngltvdyv teriywadar edyiefasld gsnrhvvlsq diphifaltl
     3241 fedyvywtdw etksinrahk ttganktlli stlhrpmdlh vfhalrqpdv pnhpckvnng
     3301 gcsnlcllsp ggghkcacpt nfylggdgrt cvsnctasqf vckndkcipf wwkcdteddc
     3361 gdhsdeppdc pefkcrpgqf qcstgictnp aficdgdndc qdnsdeancd ihvclpsqfk
     3421 ctntnrcipg ifrcngqdnc gdgederdcp evtcapnqfq csitkrcipr vwvcdrdndc
     3481 vdgsdepanc tqmtcgvdef rckdsgrcip arwkcdgedd cgdgsdepke ecdertcepy
     3541 qfrcknnrcv pgrwqcdydn dcgdnsdees ctprpcsese fscangrcia grwkcdgdhd
     3601 cadgsdekdc tprcdmdqfq cksghciplr wrcdadadcm dgsdeeacgt gvrtcpldef
     3661 qcnntlckpl awkcdgeddc gdnsdenpee carficppnr pfrckndrvc lwigrqcdgv
     3721 dncgdgtdee dcepptaqnp hckdkkeflc rnqrclsssl rcnmfddcgd gsdeedcsid
     3781 pkltscatna smcgdearcv rtekaaycac rsgfhtvpgq pgcqdinecl rfgtcsqlcn
     3841 ntkgghlcsc arnfmkthnt ckaegseyqv lyiaddneir slfpghphsa yeqtfqgdes
     3901 vridamdvhv kagrvywtnw htgtisyrsl ppaappttsn rhrrqidrgv thlnisglkm
     3961 prgiaidwva gnvywtdsgr dvievaqmkg enrktlisgm idephaivvd plrgtmywsd
     4021 wgnhpkieta amdgtlretl vqdniqwptg lavdyhnerl ywadaklsvi gsirlngtdp
     4081 ivaadskrgl shpfsidvfe dyiygvtyin nrvfkihkfg hsplinltgg lshasdvvly
     4141 hqhkqpevtn pcdrkkcewl cllspsgpvc tcpngkrldn gtcvpvpspt pppdaprpgt
     4201 ctlqcfnggs cflnarrqpk crcqprytgd kceldqcwey chnggtcaas psgmptcrcp
     4261 tgftgpkcta qvcagycsnn stctvnqgnq pqcrclpgfl gdrcqyrqcs gfcenfgtcq
     4321 maadgsrqcr ctvyfegprc evnkcsrclq gacvvnkqtg dvtcnctdgr vapscltcid
     4381 hcsnggsctm nskmmpecqc pphmtgprce eqvvsqqqpg hmasilipll lllllllvag
     4441 vvfwykrrvr gakgfqhqrm tngamnveig nptykmyegg epddvgglld adfaldpdkp
     4501 tnftnpvyat lymgghgsrh slastdekre llgrgpedei gdpla
//
