LOCUS       NM_001287224            6502 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus leucine-rich repeat, immunoglobulin-like and
            transmembrane domains 3 (Lrit3), mRNA.
ACCESSION   NM_001287224
VERSION     NM_001287224.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6502)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6502)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   3  (bases 1 to 6502)
  AUTHORS   Cao,Y., Wang,Y., Dunn,H.A., Orlandi,C., Shultz,N., Kamasawa,N.,
            Fitzpatrick,D., Li,W., Zeitz,C., Hauswirth,W. and Martemyanov,K.A.
  TITLE     Interplay between cell-adhesion molecules governs synaptic wiring
            of cone photoreceptors
  JOURNAL   Proc Natl Acad Sci U S A 117 (38), 23914-23924 (2020)
   PUBMED   32879010
REFERENCE   4  (bases 1 to 6502)
  AUTHORS   Hasan,N., Pangeni,G., Ray,T.A., Fransen,K.M., Noel,J.,
            Borghuis,B.G., McCall,M.A. and Gregg,R.G.
  TITLE     LRIT3 is Required for Nyctalopin Expression and Normal ON and OFF
            Pathway Signaling in the Retina
  JOURNAL   eNeuro 7 (1) (2020)
   PUBMED   31959619
  REMARK    GeneRIF: LRIT3 is Required for Nyctalopin Expression and Normal ON
            and OFF Pathway Signaling in the Retina.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6502)
  AUTHORS   Hasan,N., Pangeni,G., Cobb,C.A., Ray,T.A., Nettesheim,E.R.,
            Ertel,K.J., Lipinski,D.M., McCall,M.A. and Gregg,R.G.
  TITLE     Presynaptic Expression of LRIT3 Transsynaptically Organizes the
            Postsynaptic Glutamate Signaling Complex Containing TRPM1
  JOURNAL   Cell Rep 27 (11), 3107-3116 (2019)
   PUBMED   31189098
  REMARK    GeneRIF: LRIT3 is expressed in rod photoreceptors and acts
            transsynaptically to localize the TRPM1 channel in the postsynaptic
            membrane.
REFERENCE   6  (bases 1 to 6502)
  AUTHORS   Neuille,M., Morgans,C.W., Cao,Y., Orhan,E., Michiels,C.,
            Sahel,J.A., Audo,I., Duvoisin,R.M., Martemyanov,K.A. and Zeitz,C.
  TITLE     LRIT3 is essential to localize TRPM1 to the dendritic tips of
            depolarizing bipolar cells and may play a role in cone synapse
            formation
  JOURNAL   Eur J Neurosci 42 (3), 1966-1975 (2015)
   PUBMED   25997951
  REMARK    GeneRIF: This study confirmed the localization of LRIT3 at the
            dendritic tips of depolarizing bipolar cells in mouse retina and
            demonstrated the dependence of TRPM1 localization on the presence
            of LRIT3.
REFERENCE   7  (bases 1 to 6502)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6502)
  AUTHORS   Neuille,M., El Shamieh,S., Orhan,E., Michiels,C., Antonio,A.,
            Lancelot,M.E., Condroyer,C., Bujakowska,K., Poch,O., Sahel,J.A.,
            Audo,I. and Zeitz,C.
  TITLE     Lrit3 deficient mouse (nob6): a novel model of complete congenital
            stationary night blindness (cCSNB)
  JOURNAL   PLoS One 9 (3), e90342 (2014)
   PUBMED   24598786
  REMARK    GeneRIF: The stationary no b-wave phenotype of mice lacking Lrit3,
            which we named nob6, confirms the findings previously reported in
            patients carrying LRIT3 mutations.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6502)
  AUTHORS   Kim,S.D., Liu,J.L., Roscioli,T., Buckley,M.F., Yagnik,G.,
            Boyadjiev,S.A. and Kim,J.
  TITLE     Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3
            (LRIT3) is a modulator of FGFR1
  JOURNAL   FEBS Lett 586 (10), 1516-1521 (2012)
   PUBMED   22673519
REFERENCE   10 (bases 1 to 6502)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC111097.10.
            
            On Jun 19, 2019 this sequence version replaced NM_001287224.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: KF954709.1, SRR17784644.1065866.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               AC111097.10        90288-90509
            223-695             AC111097.10        93614-94086
            696-1001            AC111097.10        102906-103211
            1002-6502           AC111097.10        104983-110483
FEATURES             Location/Qualifiers
     source          1..6502
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 58.99 cM"
     gene            1..6502
                     /gene="Lrit3"
                     /gene_synonym="Gm421"
                     /note="leucine-rich repeat, immunoglobulin-like and
                     transmembrane domains 3"
                     /db_xref="GeneID:242235"
                     /db_xref="MGI:MGI:2685267"
     exon            1..222
                     /gene="Lrit3"
                     /gene_synonym="Gm421"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2152
                     /gene="Lrit3"
                     /gene_synonym="Gm421"
                     /note="leucine-rich repeat, immunoglobulin-like domain and
                     transmembrane domain-containing protein 3"
                     /codon_start=1
                     /product="leucine-rich repeat, immunoglobulin-like domain
                     and transmembrane domain-containing protein 3 precursor"
                     /protein_id="NP_001274153.1"
                     /db_xref="CCDS:CCDS57256.2"
                     /db_xref="GeneID:242235"
                     /db_xref="MGI:MGI:2685267"
                     /translation="MWLSACLCLVLSFLGGVNGTCPSQCSCEYHGRHDGSGSRLVLCN
                     DLDMNEVPANFPVDTSKLRIEKTVVRRLPAEAFYYLVELQYLWLAYNSVASIETSSFY
                     NLRQLHELRLDGNSLTAFPWVSLLDMPHLRTLDLHNNRIASVPNEAVRYLRNLTCLDL
                     SSNRLTTLPPDFLDSWSHLAVTPSRSPDFPPRRIILGLQDNPWFCDCHISKVIELSKV
                     TDHAVVLLDPLMVCSEPERFQGILFQRVELEKCLKPSVMMSATKITSALGSNVLLRCD
                     AKGHPTPQLTWTRSDGSTVNYTVIQESPGEGIRWSIISLTSISHKDAGDYRCKAKNLA
                     GISEAVVTVTVVGGVTTTLSPDSSERSPGEPPEQHPQPGLGGSTPPSKSWLSPGLTSA
                     PSYPTPSAALYTSTWSPPPSSLPPIFSAASATTSVQTSISGRTARTSHQPPLLHPGGK
                     SNAKIEKNGRKFPPLSASKKEELALLDQAAPMETNVTIKDLRVARETGVSVTLMWNSS
                     SSTQESSVTVLYSKYGEKDLLLVNADDYGKNQATINGLEPGSQYVACVCPKGVGPRED
                     LCITFSTNRVEGRGSQWSLLLVVTSTACVIVVPLICFLLYKVCKLQCTSDPFWEEDLS
                     KETYIQFETLSPRSQSIGELWTRRHRDDGERLLLCSQSSVDSQMNLKSDGCRTEYYG"
     exon            223..695
                     /gene="Lrit3"
                     /gene_synonym="Gm421"
                     /inference="alignment:Splign:2.1.0"
     exon            696..1001
                     /gene="Lrit3"
                     /gene_synonym="Gm421"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..6502
                     /gene="Lrit3"
                     /gene_synonym="Gm421"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6479..6484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrit3"
                     /gene_synonym="Gm421"
                     /note="hexamer: AATAAA"
     polyA_site      6502
                     /gene="Lrit3"
                     /gene_synonym="Gm421"
                     /note="major polyA site"
ORIGIN      
        1 aagctgctga tgctaactgc ctgtggctgg cggcgggcat tcgtggtagc ttccccatgt
       61 tcttgtttag gccctcacct tttgttcaga gagccactct ggagctatgt ggctctcggc
      121 ctgcctgtgc cttgtgctta gcttcctggg aggagtgaac ggtacctgcc cttctcagtg
      181 ctcctgtgag tatcacggca gacatgacgg ctcaggatca aggttagtgt tgtgtaacga
      241 cctggatatg aacgaagtcc cagcaaactt ccccgtggac acctcgaagc ttcgcataga
      301 gaagactgtg gtccgcaggc tccccgccga ggccttctac tacctggtgg agctgcagta
      361 cctctggctg gcttacaact cagtggccag catagaaacc agtagcttct ataacctgag
      421 gcagctgcac gagttgcgtt tggatgggaa ttctctgacc gctttccctt gggtgtctct
      481 gctggacatg ccccacctga ggacgctgga cttacacaat aacagaatag ccagtgtgcc
      541 aaacgaggcg gtcagatatc tgaggaacct cacctgcttg gacttgtcga gcaaccgact
      601 gaccacgctg ccaccagatt tcctagacag ctggtctcat ttagccgtga caccgtctag
      661 aagcccggac tttccaccga gaagaattat tcttggtttg caggacaacc cctggttctg
      721 tgactgtcac atttccaagg tgatcgagct gtcgaaagtc accgaccacg ctgttgttct
      781 tcttgatcct ctgatggtct gcagtgaacc cgagcgcttc caaggaatct tgttccagag
      841 ggtagagttg gaaaagtgtc tgaagccgtc cgtgatgatg tcagctacca aaatcacatc
      901 tgctctgggt agtaatgttc tgctgagatg tgatgccaag ggtcacccca ccccacagct
      961 gacgtggacc agatccgacg gctccacagt taactataca gtaattcagg agtctccagg
     1021 agaaggcatc agatggtcca tcataagctt gaccagcatc tctcacaagg atgctgggga
     1081 ttacaggtgt aaagccaaaa atctggcagg gatttcggaa gctgtggtta ctgtgacagt
     1141 tgttggtggt gttacgacca ccctatcacc agacagttca gaaagaagtc ctggagagcc
     1201 ccctgagcag catccccagc caggattagg aggatcaaca cctccatcta aatcctggtt
     1261 atcacccggg ctcacttccg ctccttccta ccccaccccc tcagcagctc tctatacatc
     1321 tacgtggtcc cctcctccct cctccttgcc tcccatcttc tcagctgctt ctgcaaccac
     1381 cagtgtacaa accagcatct caggacgcac cgccaggact agccaccagc cacccctgct
     1441 ccaccccggt gggaaaagca atgcgaagat agagaagaac ggaaggaagt ttcctccgct
     1501 cagcgcaagt aagaaagaag agttggcgtt gttggatcag gcagcgccaa tggaaacaaa
     1561 cgtcactatc aaagacctca gggtggcccg tgaaaccggc gtgagtgtga ctctgatgtg
     1621 gaacagcagc agcagcacac aagagtcctc tgtgactgtg ctgtattcta agtacggtga
     1681 gaaggacctg ctgttagtga atgcagacga ctatggcaag aaccaggcaa ccataaatgg
     1741 cctagagccc ggaagtcagt atgtggcatg tgtctgtcca aaaggagtgg gtccccggga
     1801 ggatctgtgt atcacctttt ctaccaacag agttgagggg cgtggctcac agtggtcatt
     1861 gctcctcgtg gtgaccagta ctgcctgtgt tatagtcgtg cccctaattt gtttcttatt
     1921 atataaagtc tgcaaattgc aatgcacatc ggaccctttc tgggaagagg atttgtcaaa
     1981 agagacatat atccaatttg agaccctgtc acccaggtca cagagtatag gggagctctg
     2041 gacccggagg cacagagacg atggcgagag gttgctgcta tgctcccagt caagtgtgga
     2101 ctcccagatg aatcttaaga gcgatggctg taggacggag tattatggct gaggttttgc
     2161 aggcgagatg aacgtgaaga aaaaagcgcg ggagccaccg tagagcctct gttgggtgac
     2221 ttttggagag acttccatgt gctctgtgag gatcaccaat ggggtatttt ttgacgtgtt
     2281 taaaattttt ttagttggga aacatctcaa ctaaaacaac aaatggtccc gatttgtatt
     2341 aactgcatgg cgtctgtata aagaattttc cagtgaagct tgccacagtt ttagggacat
     2401 ccagttccta aaataaattg acaagaaaat attcacaaca ggtaaagtct gcatttaaga
     2461 agagagacta ttttgaacat tgaaagaaca ttagcataac cagccagggc tgacggccct
     2521 gaacgttcaa agtgctttcg aaggtttgct gtggacattt gctgctgttg cctggtgtgt
     2581 ccatgtgaga ttctaatgaa ttttgtgtct agaaatagtt tttctctcct catttactgt
     2641 tagatatcat tcaaaattag tacaaaaaga tcatagcaaa caaaatgtct atagagttag
     2701 tggttatatt taacacagtt gacagactgt atgggtctca tgatgtgtta gtttaagaac
     2761 aacctcttta ctttctttca ttttcttctc ttaatctcat tgccattttc tttcttcatc
     2821 ctttaaaatg tctcccttaa aggccagaag atgcacagca gccaaaggac tctctaagct
     2881 cagctgtctt cagtgtatta tttattctct ggtagagcaa aggcctttga ggtttctttg
     2941 ctggtgttgt tgttgaggta tagtggtttc ctccttaatt tttatttttt catttttata
     3001 tggatcggtg ttttgcctga atatatattt ggggaccaca tgtgtgccca atgccctcag
     3061 aggatagacg tgggcatctg gttccctggg actagagatt agacacctca ttcattactg
     3121 tatgatgaat gggtcaaagg aaagcaagaa acaaacaaac aaacaaaaaa tacacaaaca
     3181 ggaggaacac tctccaggtc cttttgtaca gccagtttca tgctgatacc aaaccaggga
     3241 aagatacagc cacaaaagaa atgatgttgt aaaacaggaa agctagcaag ctagcaagca
     3301 agccacaaag agaaagagga caatagccct ggcaaacata gattcaaaaa tactcagtaa
     3361 aatgcttgca aaccaagtgt agacatacat caaaaagatc actcaccatg gctgcgttgg
     3421 ctttatccct gtgacgcagg ggtagttcaa ggcatgcaag tcaataacaa ttttcttagc
     3481 cggggtttta ttgctgtgat ggagcatcgc aagtaaacca actcagggag gaaagggttt
     3541 atttggtgca agcttccaca tcacagttaa ttaccaaagg aagtccggac aggaacacac
     3601 acaggtcagt aacctggagg caggagctga tgcagagacc aaggagggat gctgcttact
     3661 agtttgctcc tagtggcttc ttcagcctgc tttcttatag caccactggt ccaggcatgg
     3721 tacatgggcc ctccctcaac aatcgctagt taaggaaata caacatgctt ccccatagcc
     3781 tgattttact gaggcacttt ctaggttgag gcttctttct ctctgatgac tcctgtttct
     3841 atcaagttga cataaaacta gccagcacag taacgaacca cagaagtgga ctgaaaggct
     3901 atgtcataaa acagtgtttt aagattttga aagggaattg ttggtggatc catttgatat
     3961 ttaattttat tttttggtta aaaaaaaaac agggaaattg aaggaggccc acaaacacac
     4021 agaagaaaga cttcataata ctatttagtt tttaaaaaga cttttcacaa gtattgtact
     4081 cattccaaga ggtagtgtgg ctacaaagat tcatgaaggg cacagcgtag cctgcagcca
     4141 agttttttgg aggcctgaca cccttactta gcagtgtgcg gcaacccagg ctggagctat
     4201 tccagagaca aggctaccta cctcagcaca ggcgtggtca taaactgtga gaaagagcta
     4261 gcctgtacaa gcagttcagt tctgtttatg aaagaaacac ctggtcatgg tgtggctgaa
     4321 tacagatgtg aggggagaag cgtccaccaa actctgagaa tgctctcgga ctgagatgcc
     4381 cttgtccatg tcatcagact ctgatgggat gtggccacgg caccagcatc agtccctggc
     4441 catcttatac agcacttccg gaatgaactg ctaaccaaga ctggtcctgg acgattggtc
     4501 cgaaggagag aagctggttc ctagcaggct ggcctgagct taaacctgaa cactggcaag
     4561 aagataggat tcggcactta aatgagtcat gacggccatt ttccagggag gactgagtgt
     4621 ggccggtggc cggatgtgat gacgaacttc aagtgctgtt ccgtgaactg ctccacaggg
     4681 gtcctggagg gctttgttct gctcgctgcc cttattgact tccgcaagca cttttgtgtg
     4741 tgttatggag gcttccacca ggataaacct gccaaaaatt attcctgagt ttgtccagcc
     4801 tcttgggaag atggacagag gaagaaaggt caggagacat cctggctggg agcagtgaat
     4861 gctacatggt gtgtctccag ttccagatgt gtggaggagc gtctcgcctg gagtttcctt
     4921 ggcaccgtga tgccaggcag ccaaagacga ccaaggagca gcttctcttc agggcgctct
     4981 attgctatcc atcaattgag gaattctcca cggactcctg attaaacaca ccagcagagt
     5041 cacagtctca cccaaaagga cgtgacggca gtcctctgcc catcggtgta ctatctcagt
     5101 gaggcagcac gcctctcaca gggcgtgtgg attcctgtga cgtgtgctgg agtccaatgg
     5161 cagcagtcca caaacagcat gatcaagtcc ttctgccaag tagactgagg gctttaaaat
     5221 aatctgaagt ttgttcagtc actacaggca ggacagtcac tgcctgtcac agtctagccc
     5281 aagctaaaaa agcagctgcc tccgccacac tgttctacag gatacctggc ccggctggct
     5341 gggtatctct catgtggccg cccctggaga atcgtgactg ctctgtccta gtcactgtct
     5401 tttactctta tctacatata ctctcatcca ccctttaggt tcccctaaca tccctggtgt
     5461 ggcgggaaat cttgccaatg ttctgaatca cagatgcaca gtgggctcat tgtagaagaa
     5521 tccattacac cgaactccat tttacctgtc ctgtgaagat tttgaggcat aggatagata
     5581 tctgaagttg tgtcaggagt tctgaaatgt tctgagaagc atattttgtg taagacgcat
     5641 gttggctttt atttaatgta ctacatcaca gaaattataa gtagttgggg aattaaaagt
     5701 cattctaaac accttgttaa aaattaaaaa agaatgttag tttagacatg atgtgcatgc
     5761 tggaagaaca gctgtggatg gatagcttgt ttagattcta aatcttccct atgcccataa
     5821 cttcctggtt tccttttcct cctctttgcc tttctctttc tctttgcctt tccacttcct
     5881 tttctgtttc cttttccctc cccttccctt ctctcccctt cccttctctc cccttccctc
     5941 tccttccttc ccttcccctc tccctcccct cccctctccc tcccctccct tctccctccc
     6001 ctcccctctc cctcccctcc cctctccctc cctacccttc ccttcccttt ctctccctaa
     6061 cctctccctt ctctctccct tcccttccct tcccttcttt ttccattccc cccttccttc
     6121 tctcttcccc ccttccctct ccttccttct ccaactcctc ccttctcttc ccctttccct
     6181 cccctttctt tgtcctcccc tccccttccc ctcccctcca gtttctttct cctcttcttc
     6241 cctgtccctc ttcttccctc ctctcctttc ccttcccttc ccttctcatc cccttccccc
     6301 tttcttttcc ctcccatcca ggtatccctg gtgctctcac cactgagtgc attgtctaac
     6361 gatctaaagc ttttagttta ctaagcattg ctaaggatct tccaaacact ttttataaat
     6421 gactttgttt aactccagtt gacgttagat taacctgttt taaactaaaa ggtcaataaa
     6481 taaaactttt atttatgtac ta
//
