LOCUS       NM_146245               4337 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus leucine-rich repeat, immunoglobulin-like and
            transmembrane domains 1 (Lrit1), mRNA.
ACCESSION   NM_146245
VERSION     NM_146245.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4337)
  AUTHORS   Sarria,I., Cao,Y., Wang,Y., Ingram,N.T., Orlandi,C., Kamasawa,N.,
            Kolesnikov,A.V., Pahlberg,J., Kefalov,V.J., Sampath,A.P. and
            Martemyanov,K.A.
  TITLE     LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone
            Photoreceptors
  JOURNAL   Cell Rep 22 (13), 3562-3573 (2018)
   PUBMED   29590623
REFERENCE   2  (bases 1 to 4337)
  AUTHORS   Ueno,A., Omori,Y., Sugita,Y., Watanabe,S., Chaya,T., Kozuka,T.,
            Kon,T., Yoshida,S., Matsushita,K., Kuwahara,R., Kajimura,N.,
            Okada,Y. and Furukawa,T.
  TITLE     Lrit1, a Retinal Transmembrane Protein, Regulates Selective Synapse
            Formation in Cone Photoreceptor Cells and Visual Acuity
  JOURNAL   Cell Rep 22 (13), 3548-3561 (2018)
   PUBMED   29590622
  REMARK    GeneRIF: Lrit1-deficient retinas exhibit an aberrant morphology of
            cone photoreceptor pedicles, as well as an impairment of signal
            transmission from cone photoreceptors to cone ON-bipolar cells.
            Authors demonstrated that Lrit1 interacts with Frmpd2, a
            photoreceptor scaffold protein, and with mGluR6, an ON-bipolar
            cell-specific glutamate receptor.
            GeneRIF: Lrit1 regulates the synaptic connection between cone
            photoreceptors and cone ON-bipolar cells. Lrit1-deficient retinas
            exhibit an aberrant morphology of cone photoreceptor pedicles, as
            well as an impairment of signal transmission from cone
            photoreceptors to cone ON-bipolar cells.
REFERENCE   3  (bases 1 to 4337)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4337)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   5  (bases 1 to 4337)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044631.1 and BC032270.1.
            
            On Oct 20, 2007 this sequence version replaced NM_146245.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032270.1, AK044631.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AK044631.1         2-288
            288-4337            BC032270.1         294-4343
FEATURES             Location/Qualifiers
     source          1..4337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 21.29 cM"
     gene            1..4337
                     /gene="Lrit1"
                     /gene_synonym="Lrrc21"
                     /note="leucine-rich repeat, immunoglobulin-like and
                     transmembrane domains 1"
                     /db_xref="GeneID:239037"
                     /db_xref="MGI:MGI:2385320"
     exon            1..217
                     /gene="Lrit1"
                     /gene_synonym="Lrrc21"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1970
                     /gene="Lrit1"
                     /gene_synonym="Lrrc21"
                     /note="leucine rich repeat containing 21; leucine-rich
                     repeat, immunoglobulin-like domain and transmembrane
                     domain-containing protein 1; retina-specific protein PAL;
                     leucine-rich repeat-containing protein 21;
                     photoreceptor-associated LRR superfamily protein"
                     /codon_start=1
                     /product="leucine-rich repeat, immunoglobulin-like domain
                     and transmembrane domain-containing protein 1 precursor"
                     /protein_id="NP_666357.2"
                     /db_xref="CCDS:CCDS26950.2"
                     /db_xref="GeneID:239037"
                     /db_xref="MGI:MGI:2385320"
                     /translation="MWVALGMLWLLALGGPHQAWGFCPSECSCSLRILSDGSKARTVV
                     CSDPDLTLPPASIPPDTCKLRLERTAIRRVPGETFRPLSRLEQLWLPYNALSELSALM
                     LRGLRRLRELRLPGNRLVTFPWAALRDTPQLQLLDLQANRLSTLPPEAAHFLENLTFL
                     DLSNNQLMRLPEELLDVWAHLKTGPFLSGHHARLILGLQDNPWVCDCRLYDLVHLLDG
                     WVSSNLIFIEARLRCASPRSLAGVAFSQLELRKCQSPELRPGVTSIISPLGSTVLLRC
                     GATGIPGPEMSWRRANGRPLNGTVHQEVSSDGSSWTLLDLPVVSLFDSGDYICQAKNF
                     LGASETLISLIVTEPQTSTGYSGIPGVLWARTGEGAEAAAYNNKLVARHVPHMPEHVA
                     LATKPSMPSIKEELALQNFQMDVPGEFSREPSEHQEAQMVRSLKVVGDTYHSVSLVWK
                     APQAGNTTAFSVLYAVFGHRDMRRMTVEPGKTSVTIEGLAPKTKYVACVCVRGLVPTK
                     EQCVIFSTDEVVDAEGTQRLINMVVISVAAIIALPPTLLVCCGALRRRCHKCRTGGSA
                     EASGAYVNLERLGHSEDSSEVLSRSSLSEGDRLLSARSSLDSQVLGVRGGRRINEYFC
                     "
     exon            218..684
                     /gene="Lrit1"
                     /gene_synonym="Lrrc21"
                     /inference="alignment:Splign:2.1.0"
     exon            685..993
                     /gene="Lrit1"
                     /gene_synonym="Lrrc21"
                     /inference="alignment:Splign:2.1.0"
     exon            994..4317
                     /gene="Lrit1"
                     /gene_synonym="Lrrc21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3896..3901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrit1"
                     /gene_synonym="Lrrc21"
                     /note="hexamer: AATAAA"
     polyA_site      3916
                     /gene="Lrit1"
                     /gene_synonym="Lrrc21"
                     /note="major polyA site"
ORIGIN      
        1 gatgagcaag tgggtagccg ttggacttac tggacaagca ggacagagca cctctgggac
       61 aggcccctgc ctgggcccaa gaggagccag aagtcatgtg ggtggccctg ggcatgctct
      121 ggctcctcgc acttggggga cctcaccagg cctggggctt ctgtccttct gaatgcagct
      181 gcagtctgcg catcctgagt gacggcagca aggccaggac agtggtgtgc agcgaccctg
      241 acttgactct gcctccagct tcgattcctc cagacacctg caagctgcgc ttagagagaa
      301 ccgccattcg cagggtgccg ggagagacct tcaggcctct cagccgcctg gagcagctgt
      361 ggctacctta caatgctctc agtgagctta gtgccctcat gctcaggggc ctgagacgcc
      421 tacgagagct gcggctgcct gggaaccgcc tggtcacgtt cccctgggct gcgctgaggg
      481 acactccgca gctgcagctg ctggacctgc aggccaatcg cctctcgacc ttgccacccg
      541 aggctgcaca cttcctggag aaccttactt tcctggacct gtccaataac cagctgatga
      601 ggcttcctga ggagctactg gacgtgtggg ctcacctgaa gaccgggccc ttcctttccg
      661 gccatcatgc caggctaatc ttagggcttc aggacaaccc ctgggtgtgt gactgtcggc
      721 tctatgacct ggttcatctt ctagatggct gggtttcttc aaacctgatc ttcatcgagg
      781 ctagactgag atgtgccagt ccacgcagcc tggctggagt ggccttcagc cagctggagc
      841 taagaaagtg tcagagccca gagctccgtc caggggtgac cagcatcata tcccctttgg
      901 gtagcacagt attgctacgt tgtggagcaa ctgggatccc aggacctgag atgagctgga
      961 gaagggccaa tggacgacca ctcaatggca cagtacacca ggaagtctcc agtgacggct
     1021 caagttggac tttgctagat ttgcctgttg tgtctctctt tgactctggg gactacatct
     1081 gccaagccaa gaacttcctg ggagcttctg aaaccctgat ctccttgatt gtcactgagc
     1141 cacagacttc taccggatac agtgggattc caggtgtcct gtgggcaaga acaggggagg
     1201 gggcagaagc tgctgcctac aacaacaagc tggtggccag gcatgttcct catatgcccg
     1261 agcatgtagc cctggctacc aagccctcaa tgcccagcat aaaggaggag ctggctctcc
     1321 agaactttca gatggatgtc ccaggagagt tctccagaga gccatcagaa caccaggagg
     1381 cacagatggt caggtctctc aaggtagtag gagatactta ccacagtgtg tctttggtgt
     1441 ggaaggcccc tcaagctggg aacacaaccg cctttagtgt cctttatgca gtctttgggc
     1501 atcgagacat gagaaggatg actgtggagc ctgggaagac tagtgtcact atcgagggac
     1561 ttgctccaaa gaccaagtat gtggcatgtg tctgtgtgcg gggcttggtg cctacgaagg
     1621 agcaatgtgt catcttctct actgatgagg tagtggatgc agagggcacc cagcgactca
     1681 tcaacatggt ggtgatcagc gtggccgcca tcatcgcgct gcctcccacc ctgctggttt
     1741 gctgtggggc tctccgaaga cgctgccaca agtgccgcac tgggggttct gcagaggcct
     1801 ctggggccta tgttaatttg gaaagactgg gccatagtga ggacagctca gaagttctgt
     1861 ccaggagcag cctcagtgag ggagataggc ttctctcagc ccgttccagc ctggactccc
     1921 aggtcttggg tgtcaggggc ggcagacgca tcaatgagta cttctgctga gtctgagtcc
     1981 ctgttcacac ctgccatccc tcttcagtct catacactta cttttatacc tgactgtgtg
     2041 ctcagtcacc ctgattgttt ggatatttgg taacttgtcc atttacatca acaatagtta
     2101 acacagggtt ttaagcactt actgtgtgcc agcaagcatc caaagtactt cataggtatt
     2161 tactcactta actttcataa taaccattta tatcaggcat catttttctc tctcttttcc
     2221 aggagaagaa acaggtgttg agtatttagc ttgtatcggt cagtttctgc tgtctaacaa
     2281 atgaaagcaa aaactctctg gtatgcatca tttagatatg tatttttaca ctatgtgtct
     2341 gtaggttgac tggcatggct ctgctacatg tgttccactg gggctccgag gtggagaaca
     2401 acaatggcta cttggggcag acttttctca gatgccataa gagggaagag caaaaccatg
     2461 caacacctct gaatgtcttc atgtgagact ggcatgttgc tgttgctcat gtccatattg
     2521 tacctgccaa agacagtctc atggccaaag gcaatgttaa cgaggcaagc agagacacta
     2581 atcctctgaa gacaacgatg gaagacaaaa cattttcgga acaaatttac tacatggccc
     2641 acttatagta ctgccactgg acaatggcag cctagctttg gaccaggcag ttggacaatt
     2701 ggttctactg aaaagtcttt accaacctct atactcttac atcatgtttg cacttatacc
     2761 agttcatgca cacatataca caggttctct atacattagc catgtttttg aacacacgca
     2821 cacttcaccc acacgcatcc ccctcattga attctaacat ttatcctttg gggttctggg
     2881 agataatctt ggagagattc ttggagaatt tacttgtaat aaattctaaa gactgctgct
     2941 cttttattct cagtatgcca gactggagag agccaagggg tttctacaac tgaaggcacc
     3001 atcatagtca gtcttgtctc acactcagcc catgctcatg gaggagcctt tgcagggttt
     3061 tctgaaattt tcttggtttt ggagagtatg taggagcttt tctggtcacc caccatgcga
     3121 gtagcaggag aattcttgct gagtttcgcc tatggcatag attgctgaga tgcttgtgca
     3181 caggagtgag tgaacgttcc tactgaaaac tctgtttatt gtttgcctac tgagaagatg
     3241 ggtagcaagt cctttggtaa caattgtgga cttccacagt cagaagtgat ccgaggaaag
     3301 tatttaacca gcaccactca agataattga tatcatgtga atattgacta gatgtaaatc
     3361 cccttattat ttccaaaaga cctcacaaca tgcccctaac agcccattct agaggttggt
     3421 aattttgatt tttgatttta cagatgaaga aactaagaac caagtatatg tgcagacagg
     3481 agaaatgaat tttctttgga atccatgtct ttgacaagtt tttggatgct atgtcttact
     3541 cattaatgat ctttgaagta tggcccacag tttactatga aaactgaatt tttggtagtc
     3601 accgaaacct ggaattagaa ccacaagaac acaggtgcac acggacatta gagtcaccaa
     3661 acttgatatt tttctgtcac ctccatgaag gttgtatttg attataactt gtgggtcatt
     3721 accattagca agaaaagcta cttggttgga cagtaatggc cttgtctgca tcagggatca
     3781 acatgatatt ttttggcaaa caaaacttga taatgaatat tacaagctct gtcattgcta
     3841 atggaatggg gaaaaatata gactacaggt gagttaatgg gcatggatgt gatccaataa
     3901 aatgtttaca aaaacagata acaaactgga atcaatatcc aattagcttt actgcatttt
     3961 gtaaaaggaa aaccaggaac ttgaaagcaa tatatatata tatatatata tatatatgta
     4021 tatatacacc caatattgac tgagaaacag aggaggagaa aggagcagag aaagagaaaa
     4081 aaatagggat gggatcaaat tttccagcag tctaggaggg ctgccttcag ggtgtgggtg
     4141 atcattgcct ctaagatgtc cagattcttg atctcaatgt atcaactttc ctacctgtgt
     4201 tctgtcttcc ctgagttttc tcttgtaggg aagagtcttc tggagtgttc ttgtgggtat
     4261 ttatgttact aaaacaaact cctctgacaa atgaataaat aaatggtatc tgatttaaaa
     4321 aaaaaaaaaa aaaaaaa
//
