LOCUS       NM_177152               4050 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus leucine-rich repeats and immunoglobulin-like domains 3
            (Lrig3), mRNA.
ACCESSION   NM_177152
VERSION     NM_177152.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4050)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4050)
  AUTHORS   De Vincenti,A.P., Alsina,F.C., Ferrero Restelli,F., Hedman,H.,
            Ledda,F. and Paratcha,G.
  TITLE     Lrig1 and Lrig3 cooperate to control Ret receptor signaling,
            sensory axonal growth and epidermal innervation
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34338291
  REMARK    GeneRIF: Lrig1 and Lrig3 cooperate to control Ret receptor
            signaling, sensory axonal growth and epidermal innervation.
REFERENCE   3  (bases 1 to 4050)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4050)
  AUTHORS   Narayanan,R., Pham,L., Kerimoglu,C., Watanabe,T., Castro
            Hernandez,R., Sokpor,G., Ulmke,P.A., Kiszka,K.A., Tonchev,A.B.,
            Rosenbusch,J., Seong,R.H., Teichmann,U., Frahm,J., Fischer,A.,
            Bonn,S., Stoykova,A., Staiger,J.F. and Tuoc,T.
  TITLE     Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal
            Progenitors in Developing Cortex
  JOURNAL   iScience 4, 109-126 (2018)
   PUBMED   30240734
REFERENCE   5  (bases 1 to 4050)
  AUTHORS   Hellstrom,M., Ericsson,M., Johansson,B., Faraz,M., Anderson,F.,
            Henriksson,R., Nilsson,S.K. and Hedman,H.
  TITLE     Cardiac hypertrophy and decreased high-density lipoprotein
            cholesterol in Lrig3-deficient mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 310 (11), R1045-R1052 (2016)
   PUBMED   27009049
  REMARK    GeneRIF: These findings in mice complement the human
            epidemiological results and suggest that Lrig3 may influence heart
            function and plasma lipid levels in mice and humans.
REFERENCE   6  (bases 1 to 4050)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 4050)
  AUTHORS   Abraira,V.E., Satoh,T., Fekete,D.M. and Goodrich,L.V.
  TITLE     Vertebrate Lrig3-ErbB interactions occur in vitro but are unlikely
            to play a role in Lrig3-dependent inner ear morphogenesis
  JOURNAL   PLoS One 5 (2), e8981 (2010)
   PUBMED   20126551
  REMARK    GeneRIF: Results suggest that although both Lrig1 and Lrig3 can
            interact with ErbB receptors in vitro, modulation of Neuregulin
            signaling is unlikely to contribute to Lrig3-dependent processes of
            inner ear morphogenesis.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4050)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   9  (bases 1 to 4050)
  AUTHORS   Abraira,V.E., Del Rio,T., Tucker,A.F., Slonimsky,J., Keirnes,H.L.
            and Goodrich,L.V.
  TITLE     Cross-repressive interactions between Lrig3 and netrin 1 shape the
            architecture of the inner ear
  JOURNAL   Development 135 (24), 4091-4099 (2008)
   PUBMED   19004851
  REMARK    GeneRIF: mutually antagonistic interactions between Lrig3 and Ntn1
            create complementary expression domains that define the future
            shape of the lateral canal. Removal of one copy of Ntn1 from Lrig3
            mutants rescues the circling behavior and the canal malformation.
REFERENCE   10 (bases 1 to 4050)
  AUTHORS   Guo,D., Holmlund,C., Henriksson,R. and Hedman,H.
  TITLE     The LRIG gene family has three vertebrate paralogs widely expressed
            in human and mouse tissues and a homolog in Ascidiacea
  JOURNAL   Genomics 84 (1), 157-165 (2004)
   PUBMED   15203213
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035166.1, BC065142.1 and AC153489.7.
            
            On Jan 6, 2010 this sequence version replaced NM_177152.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY505341.1, BC065142.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AK035166.1         3-36
            35-3715             BC065142.1         1-3681
            3716-4050           AC153489.7         127401-127735       c
FEATURES             Location/Qualifiers
     source          1..4050
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 73.66 cM"
     gene            1..4050
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /note="leucine-rich repeats and immunoglobulin-like
                     domains 3"
                     /db_xref="GeneID:320398"
                     /db_xref="MGI:MGI:2443955"
     exon            1..493
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..3611
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /note="leucine-rich repeats and immunoglobulin-like
                     domains protein 3; LIG-3"
                     /codon_start=1
                     /product="leucine-rich repeats and immunoglobulin-like
                     domains protein 3 precursor"
                     /protein_id="NP_796126.4"
                     /db_xref="CCDS:CCDS24219.1"
                     /db_xref="GeneID:320398"
                     /db_xref="MGI:MGI:2443955"
                     /translation="MGAPGLRAATAALGLLLCAGLGRAGPAGSGGHGAPGQLLDDDAQ
                     RPCPAACHCLGDLLDCSRRRLVRLPDPLPAWVTRLDLSHNRLSFIQTSSLSHLQSLQE
                     VKLNNNELETIPNLGSISANIRQLSLAGNAIDKILPEQLEAFQSLETLDLSNNNISEL
                     RTAFPPLQLKYLYINNNRVSSMEPGYFDNLASTLLVLKLNRNRISAIPPKMFKLPQLQ
                     HLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEVLQLDHNNLT
                     EITKGWLYGLLMLRELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGL
                     SLLNALHIGNNKVSYIADCAFRGLTSLKTLDLRNNEISWTIEDMSGAFSGLDRLRQLI
                     LQGNRIRSITKKAFAGLDTLEHLDLSGNAIMSLQSNAFSQMKKLQQLHLNTSSLLCDC
                     QLRWLPQWVAENNFQSFVNASCAHPQLLKGRSIFTVSPDGFVCDDFPKPQITVQPETQ
                     SAIKGSDVSFTCSAASSSDSPMTFAWKKDNEALQDAEMENYAHLRAQGGELMEYTTIL
                     RLRNVEFTSEGKYQCVISNHFGSSYSVKAKLTINMLPSFTKTPMDLTIRAGAMARLEC
                     AAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSA
                     GSVSANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPRLNWTKDDSPLVVT
                     ERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPHMTAP
                     SLDGDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPS
                     YLSSQGTLADRQDGYISSESGSHHQFVTSSGGGFFLPQHDGAGTCHFDDSSEADVEAA
                     SDPFLCPFVGSTGPVYLQGNLYSPDPFEVYLPGCSSDPRTALMDHCESSYVKQDRFSC
                     ARPSEEPCERSLKSIPWPHSRKLTDSTYPPNEGHTVQTLCLNKSSVDFSTGPEPGSAT
                     SSNSFMGTFGKPLRRPHLDAFSSSAQPPDCQPRPCHGKSLSSPELDSESEENDKERTD
                     FREENHRCTYQQIFHTYRTPDCQPCDSDT"
     exon            494..565
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            566..640
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            641..772
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            773..916
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1060
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1204
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1348
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1429
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1501
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1573
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1737
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..2058
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2340
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2793
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2952
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            2953..3096
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3366
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..4050
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3901..3906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /note="hexamer: TATAAA"
     polyA_site      3926
                     /gene="Lrig3"
                     /gene_synonym="9030421L11Rik; 9130004I02Rik;
                     9430095K15Rik; mKIAA3016"
                     /note="major polyA site"
ORIGIN      
        1 gccgcaggcg gaaaagtttc tcggcgtgcc atcccgttct cggacgccgc tcgggctgcc
       61 ttcaccgtgg ctgccggtcc tccgctgctg gctctcccgc tgtgcagggg catgcgaggc
      121 cttcagtgcg gggactgagc caccaggagc acgaggcggc gatcggcgtg tccagcccgg
      181 tctgggagtc ggtgcttttg ggggtgcgcg aggttgtaga gctccgggcc gaaccggagg
      241 cggcggggcg cgcggcgatg ggtgctcccg gactccgagc ggccaccgcg gcgctgggac
      301 tgctgctgtg cgcggggctg gggcgcgcgg gcccggcggg aagcggaggc cacggggctc
      361 ccgggcagct cttggacgac gatgcgcagc gcccgtgtcc agccgcctgc cactgcctcg
      421 gggacctgct ggactgcagc cggcggcggc tggttcgcct tcccgatcct ctcccggcct
      481 gggtcacacg gctggacctg agtcacaaca gattatcttt tatccagacg agttccctga
      541 gccaccttca aagccttcaa gaagtgaagc tgaacaacaa tgaattagag accattccaa
      601 acctgggatc catctctgca aatattagac agctatcctt ggctgggaac gccatcgaca
      661 aaatcctccc tgaacagctg gaagcctttc agtcccttga gactttggac ctcagcaaca
      721 ataatatttc agaactgaga actgcctttc cacccttaca actcaagtat ctgtatatca
      781 ataacaaccg agtgtcgtcc atggaaccag ggtattttga caatttggcg agcacgctcc
      841 tggtgctgaa gctgaacagg aaccgcatct cagccatccc tcccaagatg tttaaactgc
      901 ctcagctgca gcaccttgag ctgaacagaa acaagattaa gaacgtggat ggactcacat
      961 tccaaggact tggtgcactg aagtctctga aaatgcaaag aaacggagtg acaaagctga
     1021 tggatggagc tttttggggg ctgagcaaca tggaagtcct gcagctggac cataacaacc
     1081 taaccgagat taccaaaggc tggctctatg gcttgttgat gctgcgggaa cttcatctga
     1141 gccagaacgc catcaacagg atcagcccgg atgcctggga gttctgccag aaactcagtg
     1201 agctagacct gactttcaac cacttatcaa ggctagacga ttccagcttc ctgggcctaa
     1261 gcctactaaa tgccctccac attgggaata acaaagtcag ctacattgct gactgtgcct
     1321 tccgggggct taccagttta aagactttgg atctgaggaa caatgaaatc tcatggacca
     1381 tcgaagacat gagtggggca ttctctgggc tggacagatt gaggcaacta attctccagg
     1441 gaaaccggat tcgatctatt accaaaaagg ccttcgctgg tttggacaca ttggaacacc
     1501 tggacctgag tggcaacgcc atcatgtctc tacagagcaa tgcgttttcc caaatgaaga
     1561 aacttcagca gctgcattta aatacgtcga gccttttgtg tgactgccag ctgagatggc
     1621 tcccacagtg ggtggcggag aacaactttc agagcttcgt aaatgccagt tgtgcccacc
     1681 ctcagctgct gaaagggagg agcattttca ctgtcagccc agatggcttt gtgtgtgatg
     1741 attttcccaa accccagatc accgtccagc cagaaacgca gtcggcaata aagggctccg
     1801 acgtgagttt tacctgctcg gctgctagca gcagtgactc ccctatgacg ttcgcttgga
     1861 agaaagacaa cgaagcgctt caggatgcag agatggagaa ctacgcacac ctgcgggccc
     1921 agggaggcga gctgatggag tataccacca tcctgaggct gcgcaatgtg gaattcacca
     1981 gcgaagggaa gtaccagtgt gtcatctcca accacttcgg ttcgtcatac tccgtcaaag
     2041 ccaagctcac catcaacatg ttgccttcct ttaccaagac ccccatggac ctcaccatcc
     2101 gtgccggggc catggcccgc ctggagtgtg ctgccgtggg gcacccagcc ccacagatag
     2161 cctggcagaa ggatggaggc acggacttcc cggccgcccg agagagacgc atgcacgtga
     2221 tgcccgagga tgacgtcttc ttcatcgtgg acgtgaagat cgaggacatc ggggtttaca
     2281 gctgcacagc tcagaacagt gcagggagcg tctctgcaaa cgcaaccctg actgtgctag
     2341 agacgccgtc atttttgcgg cccctgttag acagaaccgt caccaaggga gaaacagcgg
     2401 tcctgcagtg cattgctgga gggagcccgc cccctcggct gaactggacg aaagatgaca
     2461 gccctttggt ggtgaccgag aggcactttt ttgcagcagg caaccagctg ctgatcatcg
     2521 tggactcgga cgtcagcgac gccgggaaat acacgtgtga gatgtccaat acccttggca
     2581 ccgagagagg caacgttcgc ctcagtgtga tccctactcc gacctgcgac tcccctcaca
     2641 tgactgcccc atcgctggac ggcgatggat gggccaccgt gggcgtggtg atcatagctg
     2701 tggtttgctg tgtggtgggc acatccctcg tgtgggtggt catcatatac cacacaaggc
     2761 ggaggaacga agactgcagc attaccaaca cagatgagac caacttgccg gctgacatcc
     2821 ctagttatct atcatctcag ggaacactag ctgacaggca ggacgggtac atctcctcag
     2881 aaagcggaag tcaccaccag ttcgtgactt cttcgggagg cggatttttc ttaccacaac
     2941 acgacggtgc tgggacctgc cattttgacg acagcagtga ggctgatgtg gaagccgctt
     3001 ctgacccgtt tctttgccca ttcgtgggct ccacaggccc tgtgtatcta caggggaatc
     3061 tgtacagccc agatccattt gaagtttatc ttccaggttg cagctctgac ccgaggaccg
     3121 ctttaatgga tcactgtgag tccagctacg tgaagcagga ccgcttctcc tgtgctcgtc
     3181 cctcagagga accctgtgaa cggagcctca agagcatccc atggccacat tccagaaagc
     3241 tcaccgactc cacatatcct ccgaatgagg gacacacagt tcagactctg tgtctaaaca
     3301 agtcctccgt ggatttcagt acagggccgg aaccaggatc ggctacttca agtaactcat
     3361 tcatgggaac cttcggaaaa cctctgagga gaccacacct ggatgccttt tcaagctccg
     3421 cacaaccgcc agactgtcag ccaaggccct gtcacgggaa atcgctttcc tcgccagagc
     3481 tggactctga atcagaagaa aatgacaaag aaaggacaga ttttcgggaa gagaatcaca
     3541 ggtgtactta tcaacagata ttccacactt acaggactcc agattgccag ccttgtgatt
     3601 cagacacata gaccagaagg gaccaagaaa aagcttccac acgctacctc agctgggctt
     3661 ctatttaaag gagacagaat cctaggtttt taaacagact tacaaagttt aaaaaggaaa
     3721 aaaaaaaaga tgctttattt atatagatga accaaaatta caaaacgtta taaaaatttt
     3781 ataccgggaa taactttcat ataaaaaaat acgtctttaa aagtatttta taactttgtt
     3841 ttatatgaaa atagcttatg taaattaatg gtatgagtcc atgactattt tatgtatttt
     3901 tataaaacca gatttctttt tatggagtac tgaagttttt tcaataaccc cgtcttaact
     3961 cgcttttctg agtggcggtc gctcgctccc tacaattcca cacaccatgt taataaaatg
     4021 tgccattggg tgccacgccc catttatacc
//
