LOCUS       NM_001025067            7196 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus leucine-rich repeats and immunoglobulin-like domains 2
            (Lrig2), transcript variant 1, mRNA.
ACCESSION   NM_001025067 XM_194114
VERSION     NM_001025067.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7196)
  AUTHORS   Li,Z.Q., Liao,W.J., Sun,B.L., Luo,Z.W., Zhong,N.S., Wu,J.B.,
            Liu,Z.L. and Liu,J.M.
  TITLE     LRIG2 regulates cell proliferation, migration and apoptosis of
            osteosarcoma
  JOURNAL   BMC Cancer 22 (1), 1029 (2022)
   PUBMED   36183058
  REMARK    GeneRIF: LRIG2 regulates cell proliferation, migration and
            apoptosis of osteosarcoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7196)
  AUTHORS   Roberts,N.A., Hilton,E.N., Lopes,F.M., Singh,S., Randles,M.J.,
            Gardiner,N.J., Chopra,K., Coletta,R., Bajwa,Z., Hall,R.J.,
            Yue,W.W., Schaefer,F., Weber,S., Henriksson,R., Stuart,H.M.,
            Hedman,H., Newman,W.G. and Woolf,A.S.
  TITLE     Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in
            the urinary bladder
  JOURNAL   Kidney Int 95 (5), 1138-1152 (2019)
   PUBMED   30885509
  REMARK    GeneRIF: Mice with homozygous mutations in either Lrig2 or Hpse2
            had increased nerve density within the urinary bladder body and
            decreased nerve density around the urinary outflow tract.
            Observations provide evidence that a peripheral neuropathy is
            central to the pathobiology of functional bladder outlet
            obstruction in urofacial syndrome and emphasize the importance of
            LRIG2 and Hpse2 for nerve patterning in the urinary tract.
REFERENCE   3  (bases 1 to 7196)
  AUTHORS   van Erp,S., van den Heuvel,D.M.A., Fujita,Y., Robinson,R.A.,
            Hellemons,A.J.C.G.M., Adolfs,Y., Van Battum,E.Y., Blokhuis,A.M.,
            Kuijpers,M., Demmers,J.A.A., Hedman,H., Hoogenraad,C.C.,
            Siebold,C., Yamashita,T. and Pasterkamp,R.J.
  TITLE     Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance
            Receptors by ADAM Proteases
  JOURNAL   Dev Cell 35 (5), 537-552 (2015)
   PUBMED   26651291
  REMARK    GeneRIF: Lrig2 has a role in negative regulation of ectodomain
            shedding of axon guidance receptors by ADAM17 protease
REFERENCE   4  (bases 1 to 7196)
  AUTHORS   Stuart,H.M., Roberts,N.A., Hilton,E.N., McKenzie,E.A., Daly,S.B.,
            Hadfield,K.D., Rahal,J.S., Gardiner,N.J., Tanley,S.W., Lewis,M.A.,
            Sites,E., Angle,B., Alves,C., Lourenco,T., Rodrigues,M., Calado,A.,
            Amado,M., Guerreiro,N., Serras,I., Beetz,C., Varga,R.E.,
            Silay,M.S., Darlow,J.M., Dobson,M.G., Barton,D.E., Hunziker,M.,
            Puri,P., Feather,S.A., Goodship,J.A., Goodship,T.H., Lambert,H.J.,
            Cordell,H.J., Saggar,A., Kinali,M., Lorenz,C., Moeller,K.,
            Schaefer,F., Bayazit,A.K., Weber,S., Newman,W.G. and Woolf,A.S.
  CONSRTM   UK VUR Study Group; 4C Study Group
  TITLE     Urinary tract effects of HPSE2 mutations
  JOURNAL   J Am Soc Nephrol 26 (4), 797-804 (2015)
   PUBMED   25145936
REFERENCE   5  (bases 1 to 7196)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7196)
  AUTHORS   Rondahl,V., Holmlund,C., Karlsson,T., Wang,B., Faraz,M.,
            Henriksson,R. and Hedman,H.
  TITLE     Lrig2-deficient mice are protected against PDGFB-induced glioma
  JOURNAL   PLoS One 8 (9), e73635 (2013)
   PUBMED   24023893
  REMARK    GeneRIF: phenotype of Lrig2E12-/- mice showed that Lrig2 was a
            promoter of PDGFB-induced glioma
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7196)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   8  (bases 1 to 7196)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 7196)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 7196)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY205369.1, BC094228.1 and CN532345.1.
            
            On Jul 17, 2015 this sequence version replaced NM_001025067.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094228.1, SRR10223971.4256.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               BY205369.1         2-239
            239-4822            BC094228.1         114-4697
            4823-4834           CN532345.1         636-647
            4835-7196           BC094228.1         4710-7071
FEATURES             Location/Qualifiers
     source          1..7196
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.62 cM"
     gene            1..7196
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /note="leucine-rich repeats and immunoglobulin-like
                     domains 2"
                     /db_xref="GeneID:269473"
                     /db_xref="MGI:MGI:2443718"
     exon            1..463
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..3392
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leucine-rich repeats and immunoglobulin-like
                     domains protein 2"
                     /codon_start=1
                     /product="leucine-rich repeats and immunoglobulin-like
                     domains protein 2 isoform 1 precursor"
                     /protein_id="NP_001020238.1"
                     /db_xref="CCDS:CCDS17701.1"
                     /db_xref="GeneID:269473"
                     /db_xref="MGI:MGI:2443718"
                     /translation="MAAAPRGIWEQRRLGCGLGPLARLLILAQALRLLPAARAGLCPA
                     PCACRLPLLDCSRRKLPAPSWRALSGPLPSDISSLDLSHNRLSNWNNTLESQTLQEVK
                     MNYNELTEIPYFGEPTPNITLLSLVHNLIPEINAEAFELYSALESLDLSSNIISEIKT
                     SSFPRMSLKYLNLSNNRISTLEAGCFDNLSDSLLVVKLNRNRISMIPPKVFKLPHLQF
                     LELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTG
                     VNKGWLYGLRMLQQLYMSQNAIEKISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLS
                     LLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNDISWAIEDASEAFSGLKSLTKLIL
                     QGNRIKSVTQKAFIGLESLEYLDLNNNAIMSIQENAFSQTHLKGLVLNTSSLLCDCHL
                     KWLLQWLVDNNFHHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPESTIA
                     LRGVNVTLTCTAVSSSDSPMSTIWRKDSEILYDVDIENFVRYRQQDGEALEYTSVLRL
                     FSVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAA
                     EGHPTPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNIAGG
                     LSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTER
                     HFFAAANQLLIIVDAGLEDAGKYTCLMSNTLGTERGHIYLNVISSPNCDSSQSSIGHE
                     DDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLS
                     SQGTLSEPQEGYSNSEAGSHQQLMPPANGYTHRGTDGGAGTRVICSDCYDNANIYSRT
                     REYCPYTYIAEEDVLDQALSSLMVQMPKETFLSHPPQDAANLESLIPSAEREPAAFPT
                     NHERMTENLPFSQRSSEIFQRPLWNMNRELGLLPFSQQPVLESPELTERDPNCSSPVT
                     CRRLHDHAFDFSRTRIIQDGTEGT"
     exon            464..529
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..604
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..739
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..883
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1027
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1171
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1315
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1396
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1468
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1537
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1701
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2022
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2304
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2754
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2904
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3192
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..7174
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4014..4019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /note="hexamer: AATAAT"
     polyA_site      4034
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
     regulatory      5300..5305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /note="hexamer: AACAAA"
     polyA_site      5320
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
     regulatory      7157..7162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /note="hexamer: AATAAA"
     polyA_site      7174
                     /gene="Lrig2"
                     /gene_synonym="4632419I10Rik; LIG-2"
                     /note="major polyA site"
ORIGIN      
        1 gttgcgtcgc ggggcggggc ggacgagcgg tgtctgtcag ggtttcagct ctacgccccc
       61 gaccgccgcc ccctcccctg cggtagcgtc gtttcctcct ctcgcccgct ctgagagggg
      121 acaagtgaca gcccgggctc cgggtggcgg tttagcctcc gggcatctct cctcagccga
      181 ctctctgagc tagctgctgt tctcgagcgg gtcccggcca ggggaagatg gcggccgcgc
      241 cccgcggcat ctgggagcag cggcgcctgg gctgtgggtt gggacccctc gcacggttgc
      301 tcatccttgc gcaggcgctg cggctgctgc ccgctgcccg agccggcctg tgcccggcgc
      361 cctgcgcctg ccgtcttcct ctgctggact gcagtcgcag gaagctgccc gcgcccagct
      421 ggagggcact gtcgggcccg ctgccctccg acatctccag cctggatttg agtcataacc
      481 ggttgtctaa ctggaacaac accttggaat cacaaacatt acaagaagtg aaaatgaatt
      541 acaatgagct aacagagata ccatattttg gagaaccaac acctaatatt actctacttt
      601 cattggtgca taatttaatc ccagaaataa atgcagaagc attcgagctt tattctgctc
      661 ttgagagttt agacctcagt tccaatataa tatcagaaat caagacatct tcatttcctc
      721 gaatgtcact gaaatacctg aatttgagca ataataggat aagcaccttg gaggctggct
      781 gctttgacaa cttatcagat tctttattag tggtaaaact gaaccggaac cgaattagca
      841 tgattccacc caaggtcttc aagctgcctc atctccagtt cttggaactg aaaagaaaca
      901 ggattaaaat tgtagaaggc cttaccttcc aagggcttga ttctttacgc tcattgaaaa
      961 tgcagcggaa tggaattagc aaactcaaag atggagcatt ttttggcttg aataatatgg
     1021 aagaattaga actggaacat aataacctta caggagtgaa caaggggtgg ctatatggct
     1081 tgcgaatgtt acagcaactg tatatgagcc agaatgctat tgaaaaaatc agccccgatg
     1141 catgggagtt ctgccagaga ctgtctgaac tggatttgtc ctataaccag ctgacccgcc
     1201 ttgatgaatc tgcctttgtg ggtctgagct tactggagag attgaattta ggggacaata
     1261 gagtcactca cattgctgat ggtgtattta ggtttctttc caatcttcag acattagatt
     1321 tgagaaacaa tgacatttca tgggccatag aagatgctag cgaagccttt tctggactca
     1381 aaagtctcac taagttaatc ttgcaaggaa accggattaa gtcagttaca cagaaagcat
     1441 tcattggcct tgagtccctt gagtatctag atttgaacaa caatgctata atgtctatcc
     1501 aagaaaatgc tttttctcag actcacttaa agggacttgt tctgaacaca agcagtttgc
     1561 tctgcgattg tcatttgaag tggttacttc agtggctggt ggataacaat ttccatcatt
     1621 ctgtgaatgt aagctgtgca catcctgaat ggttagcggg gcaaagcatc ttgaatgtgg
     1681 acctgaaaga ttttgtctgt gatgattttc tgaagcctca gataaggaca caccctgaaa
     1741 gcacaattgc attaagaggt gttaatgtga cactgacgtg cactgcagtg agcagcagcg
     1801 attcacccat gtccaccata tggcgcaagg acagtgagat cctgtatgat gtggatattg
     1861 agaattttgt tcgttatcgg cagcaggatg gagaagctct agaatatact agtgtcttgc
     1921 gcctcttcag tgtgaacttc acagatgaag ggaaatacca gtgcattgtt actaatcact
     1981 ttggttctaa ttattctcag aaagccaaat tgactgtaaa tgagatgccg tcttttttga
     2041 aaactccaat ggatctaact attcgcactg gtgccatggc aagattagaa tgtgctgcag
     2101 aggggcaccc tacacctcag atttcctggc agaaggatgg tggcactgat tttcctgcag
     2161 cccgagaaag acgcatgcat gtcatgcctg aggatgatgt cttcttcatt gccaatgtga
     2221 agatagaaga tatgggaatc tatagctgca tggcacagaa tatagcagga ggcctctcag
     2281 caaacgcctc actcacagtg ttagagacac cctcgtttat taggcctctg gaggacaaga
     2341 ccgtcacccg aggtgagaca gcggtattgc agtgcatcgc tggaggaagt cctgctcctc
     2401 gcctcaattg gaccaaggat gatgggccac tcctagtaac agaacgacac ttctttgctg
     2461 cagccaatca gcttctcatc attgtagatg ctgggctaga agatgctgga aaatatacct
     2521 gccttatgtc taacactctt gggacagaac ggggacatat ttacttaaat gtcatttcat
     2581 cccccaattg tgactcttct cagagtagca ttgggcatga ggatgatggt tggaccacag
     2641 ttggcattgt catcattgtt gtggtctgct gtgtcgtggg cacatctttg atctgggtca
     2701 ttgtcattta ccacatgaga aggaaaaatg aagactacag catcacaaac acagaggagc
     2761 ttaatttgcc tgcagacatt cccagctatt tgtcttcaca aggaacattg tctgaaccac
     2821 aggaaggcta cagcaactct gaggcaggca gccatcagca acttatgcct cctgccaacg
     2881 ggtacacaca cagaggcact gacggtggcg ctggtacccg ggtgatctgt tcagattgtt
     2941 acgacaatgc caacatctac tcgaggacca gagagtactg tccatatacc tatattgctg
     3001 aggaggatgt gttagatcag gcactctcca gcctcatggt ccagatgccc aaggagacgt
     3061 ttttgtcaca tcctccccaa gatgctgcta atctggagag tctgatacca tcagcagaga
     3121 gagagccggc tgcctttccc accaaccatg agaggatgac tgagaacctt cccttctcac
     3181 agaggagcag tgaaatattt cagcggcctc tttggaacat gaacagagaa ctgggcctac
     3241 ttcccttctc ccagcagcct gtccttgagt caccagagct gacagagagg gatccaaatt
     3301 gctcttcacc tgtgacttgc cgcaggttac atgaccatgc ttttgatttt agtaggactc
     3361 ggatcattca agatggtact gagggcacat gaagcccgtt gaggaggaag tctgagcaaa
     3421 gactcaagtt agttatttac tacctcagaa ttgagaagaa aagtcagtat ttgtatttct
     3481 ctttgcttca agttacatct gaccacatca gcgtagctct ggtgtttggg cttacacctg
     3541 gcaaagagaa ggtagtggct gacagaagtg taccacagaa atgtgtacca cgttgaaagt
     3601 gcacagccct ggcagaagac aacatgggca ggtgtccttc ctgatcccca ccgggatgtg
     3661 cccaggcatg cactgcctgt catgaagagt cattgctgct tagcctactg gattgttcca
     3721 gtcctcagaa tggtcctgag aaagcgtctc tactttgata tcctactttg cttggaaaag
     3781 cacagggcag agatatcttc tgagctttcc taagtataac aaggattctc cagtggtgtt
     3841 gagcagagaa gagctgctga ggctttgata ttcaaggtct ttagctagaa tctaagtttc
     3901 accaactggt agtaccagat caaaggcttt tgtattcttt gtgtgtgtgt gtgtggtggg
     3961 tttgttttgt ctgtataact ggggatgtca ttgtaaatat atgtgcattc ataaataatt
     4021 tttctactca ttgaccttgt gtgttggata cagtgtaaat atttttgata tgcccaaatt
     4081 atatataatg tctgtctggt tactgtatgg gcagcggctt ctccagatca cagattttat
     4141 ataacttagt gtagtgaggt ctgcaaactc tgtttaaagt tctagaattg tgtgttacca
     4201 cgtgtatgta taaaggcagg gtacttagtg attgtgtgct catagactca gtcttggtat
     4261 aattaactgc ctgcttcatg cctgaagttc tgtgcatctt gtacttactg tctctttaca
     4321 agtgccaggt gatcctcttg tcttgctctt ccagagccca gcagtgttgc cacagccctg
     4381 tgagcacaga agatgactta tttcagcaaa atactttgat gacaaggaaa ccaaagattg
     4441 gcctttttta tgtttactct gttttcagtc tccttcacga atgtagcata ttaagaaggg
     4501 aagtgtgctc ttgggagtag atcacacaaa agttcctgta ctctgtcaat ttagtgtggt
     4561 tctgtcttta tacaagtatt atttaagcca aacagctttc tgaatttttg atagcaaaaa
     4621 gctttatgta aacaaagaat gttaacacta atgaaatgtc atgtgctttc agtctgtcct
     4681 atgagtataa taccagcttc ctgctctcaa cttttaaagg tgtctattta taagtaactg
     4741 tatatataca gagttccaaa ctcacagctt cttagctttt tgtcagaaag ttcaggtgaa
     4801 tttctgacat ttttttccca tgcttttttt ttcaaaccta agttttcttc ctcagacagc
     4861 agcactgttt gcttttgaaa ctttcgcttt ttatttaaac atgttttctt catttccact
     4921 ttgaacattt aaaatgtata gtgctctcat ctgtttagac tgtatgcctt cttttaggct
     4981 gtattccagg ttttttactg gtatgacaag gcattaagag cctgctccct tggcactgct
     5041 cgtgctggct gtgtgtctga gtcttactga tagaaagaga ctgtttatta gctgctctaa
     5101 gctgctctcc agttcccgcc aggaaccaaa gaggattgtg ccacttgagt gaagagctgc
     5161 ctttgtgaac tgttagctag atcaagggtg atgctgctcc atctaacttg agctgtattt
     5221 atcttgccaa tacaagactt aacggtctaa gacatgctca ggggaggaaa aaatgttctg
     5281 cttctaaaca ctgtcagtaa acaaaaaact cacatccgaa ttggaaaagt tgtcttttgt
     5341 ctggaagctg ctgctcacag gaggctcagg atggaggtat acagcagctc atttatagct
     5401 ggccatccca ctttgtctgt ggtcagagtt ctgtgccctc acggagagcc cagggtagtc
     5461 agggtagaga gcaggccttg acctggtcct ctagaaacac cttacccaag atatcgcctc
     5521 caagctccag ctgtggccct tctgctgcgg tgtccattgg atctcctgag aattggggag
     5581 atgttgacct gcctgcgctt ccagatccct ggctggcctg agtaactgat taggaaccca
     5641 tttacagacg agaagagcct gcctctgctc ctgaaataac aacagaagat tcttacccta
     5701 gagaatttgg tttcacgttt gaccatagga ctagtgtctg cttagttaac aaaataatct
     5761 tctctgtgtt cacaactaaa aacatgaaat tatggcatca tttttctgaa aaacaaaacc
     5821 aatcctacat ttcagataca aatgtcagtg acaaacaatt taagtatatg ttgtattata
     5881 catctttact cttgatttta atttttttat ttttagcagc cactggcctt gaactctctt
     5941 gtctctccct cccaaatgtg gagactagat atatctggct agattgattt ttgttcttgc
     6001 ctatagagcc agctggagtg gtattggtat tacagtgttc agtttatatt ttaccaagtg
     6061 tgtgaggatg gccttttctc ataacacact acaggagtaa ggagtagtaa cagggaaatg
     6121 tggctgtttc cctcaggact gggattcaac catcaggttc ctgaatgccc ggtacatgtc
     6181 ctcccactca actcaggccc tgtatttgtt ctccttaagt gagatatagt tcatctttgg
     6241 gccttttttc caggcttttg gcattcctag gtattaaacc tatagcttcc tatataccag
     6301 gcaagtgttc tacctctaag ctgcagcctc agctgaactg ttgttcaaat taatgggtgg
     6361 ttataagaac aatggggcca tgaatagttg agctgtttgc ttctgttaga tctctttccc
     6421 agtccagtgt ggaggtatgc tcccatctac tttcagcttt ttgtttggaa catggttaaa
     6481 tatacagcag ttagtctaga tttcctctcc tctcctctcc tctctgctcc tttcctttcc
     6541 tttccccctt tttttttttt tttttttgga catctgtctg gttcattggc agaagtacca
     6601 agttcctgag gtaaggctgt attggggaca tctgaaaatg gaagaattac ttgcaggatt
     6661 gtgagaaggt gggaggtgaa agggttggtg tatgatgtcc taggagtcaa gcccaggcaa
     6721 gtgctctcaa ggccggtgtg ctgtaagtta gggtttggat cctctccctc tcatttgtat
     6781 attgtttcct cgaagtcctg ataatcaggt gaagagcagc gtggcttgtc tgcgcatgtt
     6841 gttgggtgtg aagtgatctt gtagcacctg taactgtttt caaagaggag ctgatcttca
     6901 ggtggccaag tgtccttgaa gtattacctg gctgctggag acgcctcttc acccctgcct
     6961 gacttatact ccctgccacc ctctgttctc ttgcccatta gagggtgtca ggctgagcag
     7021 ccctggtgta aggcgcctct aaagggaagt acaagccaag tggtctcatg tggctgtttc
     7081 ctggtatcct ttatattttc tcacataaga atgtatattt tacagagcat gtgttcgtcc
     7141 tgtctactgt aatgtcaata aagctaagac attaaaaaaa aaaaaaaaaa aaaaaa
//
