LOCUS       NM_008377               4989 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus leucine-rich repeats and immunoglobulin-like domains 1
            (Lrig1), transcript variant 1, mRNA.
ACCESSION   NM_008377
VERSION     NM_008377.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4989)
  AUTHORS   Liu,S., Li,Y., Huang,D., Liu,M., Zhang,X., Zhao,H., Liu,H., Li,Q.
            and Chen,Z.
  TITLE     Single-Cell RNA-Seq and Histological Analysis Reveals Dynamic Lrig1
            Expression During Salivary Gland Development
  JOURNAL   J Cell Physiol 240 (1), e31487 (2025)
   PUBMED   39587709
REFERENCE   2  (bases 1 to 4989)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4989)
  AUTHORS   De Vincenti,A.P., Bonafina,A., Ledda,F. and Paratcha,G.
  TITLE     Lrig1 regulates cell fate specification of glutamatergic neurons
            via FGF-driven Jak2/Stat3 signaling in cortical progenitors
  JOURNAL   Development 151 (17) (2024)
   PUBMED   39250533
  REMARK    GeneRIF: Lrig1 regulates cell fate specification of glutamatergic
            neurons via FGF-driven Jak2/Stat3 signaling in cortical
            progenitors.
REFERENCE   4  (bases 1 to 4989)
  AUTHORS   Ford,N.C., Benedeck,R.E., Mattoon,M.T., Peterson,J.K., Mesler,A.L.,
            Veniaminova,N.A., Gardon,D.J., Tsai,S.Y., Uchida,Y. and Wong,S.Y.
  TITLE     Hair follicles modulate skin barrier function
  JOURNAL   Cell Rep 43 (7), 114347 (2024)
   PUBMED   38941190
REFERENCE   5  (bases 1 to 4989)
  AUTHORS   Ta,H.M., Roy,D., Zhang,K., Alban,T., Juric,I., Dong,J.,
            Parthasarathy,P.B., Patnaik,S., Delaney,E., Gilmour,C., Zakeri,A.,
            Shukla,N., Rupani,A., Phoon,Y.P., Liu,C., Avril,S., Gastman,B.,
            Chan,T. and Wang,L.L.
  TITLE     LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell
            responses
  JOURNAL   Sci Immunol 9 (95), eadi7418 (2024)
   PUBMED   38758807
  REMARK    GeneRIF: LRIG1 engages ligand VISTA and impairs tumor-specific
            CD8[+] T cell responses.
REFERENCE   6  (bases 1 to 4989)
  AUTHORS   Nilsson,J., Vallbo,C., Guo,D., Golovleva,I., Hallberg,B.,
            Henriksson,R. and Hedman,H.
  TITLE     Cloning, characterization, and expression of human LIG1
  JOURNAL   Biochem Biophys Res Commun 284 (5), 1155-1161 (2001)
   PUBMED   11414704
REFERENCE   7  (bases 1 to 4989)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   8  (bases 1 to 4989)
  AUTHORS   Barbieri,A.M., Lupo,G., Bulfone,A., Andreazzoli,M., Mariani,M.,
            Fougerousse,F., Consalez,G.G., Borsani,G., Beckmann,J.S.,
            Barsacchi,G., Ballabio,A. and Banfi,S.
  TITLE     A homeobox gene, vax2, controls the patterning of the eye
            dorsoventral axis
  JOURNAL   Proc Natl Acad Sci U S A 96 (19), 10729-10734 (1999)
   PUBMED   10485894
REFERENCE   9  (bases 1 to 4989)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 4989)
  AUTHORS   Suzuki,Y., Sato,N., Tohyama,M., Wanaka,A. and Takagi,T.
  TITLE     cDNA cloning of a novel membrane glycoprotein that is expressed
            specifically in glial cells in the mouse brain. LIG-1, a protein
            with leucine-rich repeats and immunoglobulin-like domains
  JOURNAL   J Biol Chem 271 (37), 22522-22527 (1996)
   PUBMED   8798419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155330.3 and AC122272.4.
            
            On Jul 27, 2022 this sequence version replaced NM_008377.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141300.1, SRR7345562.3448194.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-707               AC155330.3         165243-165949       c
            708-779             AC155330.3         129708-129779       c
            780-854             AC155330.3         120628-120702       c
            855-992             AC155330.3         95883-96020         c
            993-1136            AC155330.3         93741-93884         c
            1137-1280           AC155330.3         92150-92293         c
            1281-1424           AC155330.3         90711-90854         c
            1425-1568           AC122272.4         208179-208322       c
            1569-1649           AC122272.4         205817-205897       c
            1650-1721           AC122272.4         202810-202881       c
            1722-1793           AC122272.4         201953-202024       c
            1794-1957           AC122272.4         199128-199291       c
            1958-2278           AC122272.4         196936-197256       c
            2279-2560           AC122272.4         195181-195462       c
            2561-2980           AC122272.4         194273-194692       c
            2981-3106           AC122272.4         193604-193729       c
            3107-3253           AC122272.4         192856-193002       c
            3254-3514           AC122272.4         191667-191927       c
            3515-4989           AC122272.4         190093-191567       c
FEATURES             Location/Qualifiers
     source          1..4989
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 43.15 cM"
     gene            1..4989
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /note="leucine-rich repeats and immunoglobulin-like
                     domains 1"
                     /db_xref="GeneID:16206"
                     /db_xref="MGI:MGI:107935"
     exon            1..707
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..779
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..854
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..992
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1136
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1280
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1424
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1568
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1649
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1721
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1793
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1957
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2278
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2560
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2980
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3106
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3253
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3514
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..4989
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4964..4969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /note="hexamer: AATAAA"
     polyA_site      4989
                     /gene="Lrig1"
                     /gene_synonym="D6Bwg0781e; Img; LIG-1"
                     /note="major polyA site"
ORIGIN      
        1 gattgttcgc agcgctgagg cacggtgcgc tccggccgct ccgggacggg caggcgcgtg
       61 gggtccacgg ctatcatcag ctcagcgccc tcagtgagat gcccgcccgc gccacgcgca
      121 gaggccgagg ctaagcgttt tcagtcctca gaggcggcgg ctctcggcgt gcgcccgagc
      181 tctgaaggcg actctcagcg cggcgggaag gacgagcagc ggcggccggg cactcactgc
      241 gggactccac agagttcgcc gcgcgcgggg ctcggcccgg atgggcgcgg gggtggcggt
      301 ccccgcaggg tgctgcgaag cggcccgggc agagcgtgcc ggctgagcgc cgcggccccg
      361 gagccgactg gagtcgggcg tccatgtccc ggcgcggagc ctagctccga gcgcagcccg
      421 cgcccgcggc cgcccgcacc tcgcagccct cgctccccgg cttcgcggcg cgttccagac
      481 aagatggcgc ggcccggtcc gggagtgctc ggagccccgc gccttgcgcc tcgccttctg
      541 ctctggctgc tcttgctgct actgcaatgg ccggagtcag cgggcgccca ggctggcccg
      601 cgggccccct gcgcggccgc ctgcacttgc gccggggact cgctggactg cagtgggcgc
      661 gggctggcga cgctgccccg ggacctgccc tcctggacgc gcagcctaaa cctgagttat
      721 aacagactct ccgagatcga ctctgctgct tttgaggact tgacgaatct gcaggaagtg
      781 tacctcaaca gcaatgagct gacagccata ccatcactgg gcgctgcttc cataggagtt
      841 gtctctctct ttttgcagca caacaagatc cttagtgtgg atgggagcca gctgaagtcg
      901 tacctgtcct tggaagtgct ggatctgagt tccaacaaca tcacggaaat tcggagctcc
      961 tgtttcccga acggcctgcg tataagggaa ctcaacttgg cgagcaaccg catcagcatc
     1021 ctggagtctg gagcatttga tggtctgtcg cggtcactgc tgactctccg tctgagcaaa
     1081 aacaggatca cccagcttcc tgtgaaagcg ttcaagctac ccaggctgac acaactagac
     1141 ctgaatcgga atcggattcg gctgattgaa ggcctcacgt tccaggggct cgacagctta
     1201 gaggtgctga ggcttcagag gaacaacatc agcaggctga cggacggggc cttctggggg
     1261 ctgtctaaga tgcacgtgct gcacctggag tacaacagtc tggtggaagt gaacagtggc
     1321 tccctctatg gcctcacagc cctgcaccag ctgcacctca gcaacaactc catctctcga
     1381 attcagcgtg atggctggag cttctgccaa aagctgcatg agttgattct gtccttcaac
     1441 aacctcacgc ggctggatga ggagagtcta gcggagttga gcagcctcag tatcctgcgc
     1501 ctcagtcaca acgccatcag tcacattgct gaaggcgcct tcaagggact caagagtctg
     1561 cgggtcttgg acctggacca taacgagatc tcgggtacaa tcgaggatac cagtggtgcc
     1621 tttacggggc ttgacaacct cagcaagctg actctgtttg gaaacaagat caaatctgtg
     1681 gctaagagag ccttctcggg cctggaaagc ctggaacacc tgaaccttgg agagaatgca
     1741 atcaggtctg tccagtttga tgcctttgca aagatgaaga accttaaaga gctctacatc
     1801 agcagtgaga gcttcctgtg tgactgccag ctcaagtggc tgcccccatg gctaatgggt
     1861 aggatgctgc aggcctttgt gacagccacc tgtgcccatc cagagtcgct gaagggccag
     1921 agcattttct cagtgctgcc agacagcttt gtgtgtgatg actttccaaa gccacagatc
     1981 atcacccagc ctgagacgac catggctgtg gtgggcaagg acatccgttt cacatgctcc
     2041 gcagccagca gcagcagctc accaatgacc ttcgcctgga agaaggacaa tgaggtcctg
     2101 gccaatgcag acatggagaa ctttgcccac gtccgtgcac aggacggcga agtgatggag
     2161 tataccacta tcctgcacct ccgtcacgtc acctttgggc acgagggccg ctaccagtgt
     2221 atcatcacaa accactttgg ctccacatac tcccacaaag ccaggctcac tgtgaatgtg
     2281 ttgccatcat tcactaaaat accccatgac attgccatcc ggactggcac cacagcccgc
     2341 ctcgagtgtg ctgccacggg ccaccctaac cctcagattg cctggcagaa ggatggaggc
     2401 accgatttcc cggcagctcg tgagcgacgc atgcatgtta tgccagacga tgatgtgttc
     2461 ttcatcactg atgtgaaaat agacgacatg ggggtctaca gctgcactgc ccagaactcg
     2521 gcaggctcgg tttcagccaa cgctaccctc acagtcttag aaactccatc cttggcagtg
     2581 cctctggaag accgtgtggt aactgtggga gaaacagtgg ccttccagtg caaagcaacc
     2641 gggagcccca caccacgcat cacctggctt aagggaggtc gcccattgag cctcacagag
     2701 cgccaccatt tcactccagg caaccagctg ctggttgttc agaatgtgat gatagacgat
     2761 gcagggcggt atacctgtga gatgtctaat cccctgggca ctgagcgagc acatagccag
     2821 ctgagcattt tacctacccc tggctgccgg aaggatggga ccaccgtagg catcttcacc
     2881 attgctgtgg tgtgcagtat tgtcctgacc tcgctggtgt gggtgtgcat catctaccag
     2941 accaggaaga agagcgagga gtacagcgtc actaacacag atgaaaccat tgtgcctcca
     3001 gatgttccaa gctacctctc ctctcaggga accctttctg accggcagga aactgtggtc
     3061 aggactgagg gtggtcatca ggccaatggg cacattgaaa gcaatggtgt gtgtctgaga
     3121 gacccgagcc tcttcccaga ggtcgacatt catagcacta catgcaggca gcccaagctg
     3181 tgtgttggat acactagaga gccctggaag gtgacggaga aagccgacag gacagctgcc
     3241 ccacatacaa cagcacacag tggctctgct gtatgtagtg actgcagtac tgacacagcc
     3301 taccatcccc agcctgtgcc cagagacagt gggcagccag gcacagcgag cagccaagag
     3361 ctcaggcagc atgaccggga atattctcca caccatcctt acagtgggac tgcggatggg
     3421 tctcataccc tctctggggg gtccctctat ccaagcaacc atgacagaat actgccatcc
     3481 ttgaagaaca aggcggcgtc tgcagatggg aacggagatt cctcttggac tttagcaaag
     3541 ttacatgaag cagactgcat agacctaaag ccttctccta cgttagcttc aggcagccca
     3601 gagctcatgg aagacgccat atctactgaa gcccagcact tgcttgtttc caatggccac
     3661 ctccccaagg cctgtgactc cagccctgaa tctgtgccac tgaaagggca gatcactggg
     3721 aaacggaggg gaccactgct attggcaccg agaagctagg cttcatctac ctcagctctt
     3781 ttaaagcagt cgctacagga aagaggtagg agaggccgtg gaaagcttgt gtccagacgt
     3841 cactccggac agtccgactt ccgtgtggaa tgtcagtcag tcggctagag gagtggcatc
     3901 tggagctcag aaacgtgaga gactatttgt gtacaaaagg caggaaaaag tatttgatac
     3961 cactgtacat aagagttttc agagatttca tatatattat atatctttta cagagactat
     4021 tttaatcctt agcgcatggg tcccgctttt ggtgatattt tcacattagg ttgctgtcta
     4081 attttggaga gggtcaggaa tcgttctggt gccttaatgc acagctggaa ttcaggtaaa
     4141 cacatcagct gttgctggcg gttggaaagg agggcatctt ggctgtgtgg cacttagtgg
     4201 tcagattcga gtgcactggc cagacctatg caggcgtggt gttggcagcc tcactgtaga
     4261 gcagggtgca cgggtctgta gttgaggacg agattgagag ctgttaatcc accaaatgca
     4321 atggctcaga acaattaagc actgcctttc gtctttcttt gtaactcact tggtaaaagc
     4381 aaatgtcttg tctccttcag tggttctttg aagcttagtg aggcggaggc tgccagtgtt
     4441 ggtacctgtg gattttccaa tagtgagggt tagctctgcc tccagggccc gctaagttct
     4501 gctgagcagg cctgtccacg ctgttcctta ccggtgagac tgggcttgga ctgtacaaga
     4561 cttgagtcct agacctgggt gtatttgcac tttggggccc tgttgctagc catcttgtga
     4621 gtgccaatgt ataatgcagt aaagactaca tggaaacaca aactcagtcc ttaaaacccc
     4681 aggagttgag gggaagtgtt ggcacagtga tggcctgtgt caccgtgtag tgtcataggc
     4741 catcactgtg ccagagcaag cacgctgaga aggctagtct ccatagttga tggttaatgt
     4801 tacttccaca aaatatgtga atttgctgct tctgagaggc aatgtgaaag aggaagtatt
     4861 actttttatg tacagagtta tttatttata gaaattttgg tacagtgtac attgaaaaca
     4921 tgtaaaatat tgaagtgtct aacaaatggc ataaagtgtc tttaataaag gttcatttat
     4981 aaatactaa
//
