LOCUS       NM_029796               1372 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus leucine-rich alpha-2-glycoprotein 1 (Lrg1), mRNA.
ACCESSION   NM_029796
VERSION     NM_029796.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1372)
  AUTHORS   Rathore,M., Curry,K., Huang,W., Wright,M., Martin,D., Baek,J.,
            Taylor,D., Miyagi,M., Tang,W., Feng,H., Li,Y., Wang,Z., Graor,H.,
            Willis,J., Bryson,E., Boutros,C.S., Desai,O., Islam,B.N.,
            Ellis,L.M., Moss,S.E., Winter,J.M., Greenwood,J. and Wang,R.
  TITLE     Leucine-Rich Alpha-2-Glycoprotein 1 Promotes Metastatic Colorectal
            Cancer Growth Through Human Epidermal Growth Factor Receptor 3
            Signaling
  JOURNAL   Gastroenterology 168 (2), 300-315 (2025)
   PUBMED   39393543
REFERENCE   2  (bases 1 to 1372)
  AUTHORS   Okami,N., Wakui,H., Azushima,K., Miyazawa,T., Kubo,E.,
            Tsukamoto,S., Sotozawa,M., Taguchi,S., Urate,S., Ishiga,K.,
            Kinguchi,S., Kanaoka,T. and Tamura,K.
  TITLE     Leucine-rich alpha-2-glycoprotein 1 deficiency suppresses
            ischemia-reperfusion injury-induced renal fibrosis
  JOURNAL   Sci Rep 15 (1), 1259 (2025)
   PUBMED   39779883
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1372)
  AUTHORS   Wang,X., Sun,Z., Fu,J., Fang,Z., Zhang,W., He,J.C. and Lee,K.
  TITLE     LRG1 loss effectively restrains glomerular TGF-beta signaling to
            attenuate diabetic kidney disease
  JOURNAL   Mol Ther 32 (9), 3177-3193 (2024)
   PUBMED   38910328
  REMARK    GeneRIF: LRG1 loss effectively restrains glomerular TGF-beta
            signaling to attenuate diabetic kidney disease.
REFERENCE   4  (bases 1 to 1372)
  AUTHORS   Wang,J., Wang,J., Zhong,J., Liu,H., Li,W., Chen,M., Xu,L.,
            Zhang,W., Zhang,Z., Wei,Z., Guo,J., Wang,X., Sui,J., Liu,X.,
            Zhang,S. and Wang,X.
  TITLE     LRG1 promotes atherosclerosis by inducing macrophage M1-like
            polarization
  JOURNAL   Proc Natl Acad Sci U S A 121 (35), e2405845121 (2024)
   PUBMED   39178231
  REMARK    GeneRIF: LRG1 promotes atherosclerosis by inducing macrophage
            M1-like polarization.
REFERENCE   5  (bases 1 to 1372)
  AUTHORS   Chen,J., Zhang,Z., Feng,L., Liu,W., Wang,X., Chen,H. and Zou,H.
  TITLE     Lrg1 silencing attenuates ischemia-reperfusion renal injury by
            regulating autophagy and apoptosis through the TGFbeta1- Smad1/5
            signaling pathway
  JOURNAL   Arch Biochem Biophys 753, 109892 (2024)
   PUBMED   38246328
  REMARK    GeneRIF: Lrg1 silencing attenuates ischemia-reperfusion renal
            injury by regulating autophagy and apoptosis through the TGFbeta1-
            Smad1/5 signaling pathway.
REFERENCE   6  (bases 1 to 1372)
  AUTHORS   Wu,Y. and Smas,C.M.
  TITLE     Wdnm1-like, a new adipokine with a role in MMP-2 activation
  JOURNAL   Am J Physiol Endocrinol Metab 295 (1), E205-E215 (2008)
   PUBMED   18492766
REFERENCE   7  (bases 1 to 1372)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 1372)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1372)
  AUTHORS   O'Donnell,L.C., Druhan,L.J. and Avalos,B.R.
  TITLE     Molecular characterization and expression analysis of leucine-rich
            alpha2-glycoprotein, a novel marker of granulocytic differentiation
  JOURNAL   J Leukoc Biol 72 (3), 478-485 (2002)
   PUBMED   12223515
  REMARK    GeneRIF: cDNA clones for murine leucine-rich alpha2-glycoprotein
            were isolated. Expression of LRG during differentiation of 32Dcl3G
            cells preceded the expression of lactoferrin and gelatinase but
            followed myeloperoxidase.
REFERENCE   10 (bases 1 to 1372)
  AUTHORS   Saito,K., Tanaka,T., Kanda,H., Ebisuno,Y., Izawa,D., Kawamoto,S.,
            Okubo,K. and Miyasaka,M.
  TITLE     Gene expression profiling of mucosal addressin cell adhesion
            molecule-1+ high endothelial venule cells (HEV) and identification
            of a leucine-rich HEV glycoprotein as a HEV marker
  JOURNAL   J Immunol 168 (3), 1050-1059 (2002)
   PUBMED   11801638
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC030733.1.
            
            On Jun 19, 2003 this sequence version replaced NM_029796.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030733.1, BC092077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.17 cM"
     gene            1..1372
                     /gene="Lrg1"
                     /gene_synonym="1300008B03Rik; 2310031E04Rik; Lrg; Lrhg"
                     /note="leucine-rich alpha-2-glycoprotein 1"
                     /db_xref="GeneID:76905"
                     /db_xref="MGI:MGI:1924155"
     exon            1..86
                     /gene="Lrg1"
                     /gene_synonym="1300008B03Rik; 2310031E04Rik; Lrg; Lrhg"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1089
                     /gene="Lrg1"
                     /gene_synonym="1300008B03Rik; 2310031E04Rik; Lrg; Lrhg"
                     /codon_start=1
                     /product="leucine-rich alpha-2-glycoprotein precursor"
                     /protein_id="NP_084072.1"
                     /db_xref="CCDS:CCDS28895.1"
                     /db_xref="GeneID:76905"
                     /db_xref="MGI:MGI:1924155"
                     /translation="MVSWQHQGSLQDLKTCLARTLFLLALLGRVSSLKECLILQSAEG
                     STVSCHGPTEFPSSLPADTVHLSVEFSNLTQLPAAALQGCPGLRELHLSSNRLQALSP
                     ELLAPVPRLRALDLTRNALRSLPPGLFSTSANLSTLVLRENQLREVSAQWLQGLDALG
                     HLDLAENQLSSLPSGLLASLGALHTLDLGYNLLESLPEGLLRGPRRLQRLHLEGNRLQ
                     RLEDSLLAPQPFLRVLFLNDNQLVGVATGSFQGLQHLDMLDLSNNSLSSTPPGLWAFL
                     GRPTRDMQDGFDISHNPWICDKNLADLCRWLVANRNKMFSQNDTRCAGPEAMKGQRLL
                     DVAELGSL"
     exon            87..1353
                     /gene="Lrg1"
                     /gene_synonym="1300008B03Rik; 2310031E04Rik; Lrg; Lrhg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1327..1332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrg1"
                     /gene_synonym="1300008B03Rik; 2310031E04Rik; Lrg; Lrhg"
                     /note="hexamer: AATAAA"
     polyA_site      1353
                     /gene="Lrg1"
                     /gene_synonym="1300008B03Rik; 2310031E04Rik; Lrg; Lrhg"
                     /note="major polyA site"
ORIGIN      
        1 ggtggggact atataaagcc accttcctgg ggtcttgagg acagacatag aggagcagct
       61 atggtctctt ggcagcatca aggaagcctc caggatctca agacctgcct tgccagaacc
      121 ctgtttctcc tggccctctt gggcagggtg tccagcctca aggaatgcct gatactgcag
      181 tcggctgagg gtagcaccgt ctcctgccat ggtcccaccg agtttccgag ctccctccct
      241 gccgacactg tccatctgtc ggtggaattc tccaacctga cgcagctgcc cgccgccgcc
      301 ctgcaagggt gtccgggtct gcgggagctg cacctctcga gcaatcgcct gcaggcgctg
      361 tctcccgagt tgctggcgcc cgtgccccgg ctgcgcgccc tggatctgac ccgcaatgct
      421 ctccgcagcc tgccccccgg gttgttcagc acctcggcca acctgagcac cctggtcctg
      481 agggagaacc agctgcggga ggtgagcgcg caatggcttc agggcctgga cgccctgggc
      541 cacttggacc tggcggagaa ccagctgagt tcgctgccct ccgggctcct cgccagcctc
      601 ggcgccctgc acaccctcga ccttgggtac aacctgctgg agtcgctgcc cgagggactc
      661 ctgcggggcc caaggcggct gcagcgcctg cacctggaag ggaaccgact gcagaggctg
      721 gaggatagcc tgcttgcgcc ccaaccgttc ctgcgcgtcc tgttcctgaa tgacaaccag
      781 ttggtcgggg tggcgaccgg ctccttccag ggcctacagc acctggatat gttggatctg
      841 tccaataact ctctgtccag cacgcccccg ggcctgtggg cgttcctggg gaggccgacc
      901 cgcgacatgc aggacggctt cgacatctcc cacaacccct ggatctgtga caagaacctg
      961 gcggaccttt gccgctggct ggtcgccaac cgaaacaaga tgttctcaca gaacgacacg
     1021 cgctgtgcgg ggcccgaggc catgaagggt cagcggctgc tggacgtggc agagctgggg
     1081 tccctgtgag gatgatggct ggggtgctgg ccaagggcac cccgctcgcc actgagccaa
     1141 tgtggtccca tgtcagtgtg cagattcctc attccctcag ccaggaatgc tattctcgga
     1201 ctccctctct gggtcctctc cactcgccac aactcttcca cctctcactc ttcctgtgcc
     1261 ggcccccagg ccaccttgtg tttatctggc tttgacacgt ctgtttcagg ggtcaccaaa
     1321 gcagttaata aaacggctcc taggctgact gaaaaaaaaa aaaaaaaaaa aa
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