LOCUS       NM_153388               2930 bp    mRNA    linear   ROD 28-NOV-2023
DEFINITION  Mus musculus leucine rich repeat and fibronectin type III domain
            containing 4 (Lrfn4), mRNA.
ACCESSION   NM_153388 XM_907068
VERSION     NM_153388.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2930)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2930)
  AUTHORS   Karki S, Shkumatov AV, Bae S, Kim H, Ko J and Kajander T.
  TITLE     Structural basis of SALM3 dimerization and synaptic adhesion
            complex formation with PTPsigma
  JOURNAL   Sci Rep 10 (1), 11557 (2020)
   PUBMED   32665594
  REMARK    GeneRIF: Structural basis of SALM3 dimerization and synaptic
            adhesion complex formation with PTPsigma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2930)
  AUTHORS   Lie E, Ko JS, Choi SY, Roh JD, Cho YS, Noh R, Kim D, Li Y, Kang H,
            Choi TY, Nam J, Mah W, Lee D, Lee SG, Kim HM, Kim H, Choi SY, Um
            JW, Kang MG, Bae YC, Ko J and Kim E.
  TITLE     SALM4 suppresses excitatory synapse development by cis-inhibiting
            trans-synaptic SALM3-LAR adhesion
  JOURNAL   Nat Commun 7, 12328 (2016)
   PUBMED   27480238
  REMARK    GeneRIF: SALM4 cis-interacts with SALM3, inhibits trans-synaptic
            SALM3 interaction with presynaptic LAR family receptor tyrosine
            phosphatases and suppresses SALM3-dependent presynaptic
            differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2930)
  AUTHORS   Lovat F, Fassan M, Gasparini P, Rizzotto L, Cascione L, Pizzi M,
            Vicentini C, Balatti V, Palmieri D, Costinean S and Croce CM.
  TITLE     miR-15b/16-2 deletion promotes B-cell malignancies
  JOURNAL   Proc Natl Acad Sci U S A 112 (37), 11636-11641 (2015)
   PUBMED   26324892
REFERENCE   5  (bases 1 to 2930)
  AUTHORS   Li Y, Zhang P, Choi TY, Park SK, Park H, Lee EJ, Lee D, Roh JD, Mah
            W, Kim R, Kim Y, Kwon H, Bae YC, Choi SY, Craig AM and Kim E.
  TITLE     Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions
            Regulate Excitatory Synapse Development and Locomotion
  JOURNAL   Cell Rep 12 (10), 1618-1630 (2015)
   PUBMED   26321637
REFERENCE   6  (bases 1 to 2930)
  AUTHORS   Mah W, Ko J, Nam J, Han K, Chung WS and Kim E.
  TITLE     Selected SALM (synaptic adhesion-like molecule) family proteins
            regulate synapse formation
  JOURNAL   J Neurosci 30 (16), 5559-5568 (2010)
   PUBMED   20410109
  REMARK    GeneRIF: Expression of SALM family proteins SALM3 and SALM5 in
            nonneural and neural cells induces both excitatory and inhibitory
            presynaptic differentiation in contacting axons.
REFERENCE   7  (bases 1 to 2930)
  AUTHORS   Homma S, Shimada T, Hikake T and Yaginuma H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   8  (bases 1 to 2930)
  AUTHORS   Wang PY, Seabold GK and Wenthold RJ.
  TITLE     Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth
  JOURNAL   Mol Cell Neurosci 39 (1), 83-94 (2008)
   PUBMED   18585462
  REMARK    GeneRIF: Data show that the C-terminal PDZ binding domains of
            synaptic adhesion-like molecules (SALMs)1-3 are required for
            neurite outgrowth, and that the N-termini of SALMs 2 and 4 are
            alsoinvolved in neurite outgrowth.
REFERENCE   9  (bases 1 to 2930)
  AUTHORS   Morimura N, Inoue T, Katayama K and Aruga J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
REFERENCE   10 (bases 1 to 2930)
  AUTHORS   Wang CY, Chang K, Petralia RS, Wang YX, Seabold GK and Wenthold RJ.
  TITLE     A novel family of adhesion-like molecules that interacts with the
            NMDA receptor
  JOURNAL   J Neurosci 26 (8), 2174-2183 (2006)
   PUBMED   16495444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA752061.1, AK163603.1 and AI415633.1.
            
            [WARNING] On Dec 5, 2023 this sequence was replaced by NM_153388.5.
            
            On Jul 8, 2009 this sequence version replaced NM_153388.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163603.1, BC023156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               CA752061.1         1-143
            144-2918            AK163603.1         2-2776
            2919-2930           AI415633.1         24-35               c
FEATURES             Location/Qualifiers
     source          1..2930
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.07 cM"
     gene            1..2930
                     /gene="Lrfn4"
                     /gene_synonym="Salm3"
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 4"
                     /db_xref="GeneID:225875"
                     /db_xref="MGI:MGI:2385612"
     exon            1..705
                     /gene="Lrfn4"
                     /gene_synonym="Salm3"
                     /inference="alignment:Splign:2.1.0"
     exon            706..2064
                     /gene="Lrfn4"
                     /gene_synonym="Salm3"
                     /inference="alignment:Splign:2.1.0"
     CDS             716..2626
                     /gene="Lrfn4"
                     /gene_synonym="Salm3"
                     /note="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 4; synaptic adhesion-like
                     molecule 3"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 4 precursor"
                     /protein_id="NP_700437.2"
                     /db_xref="CCDS:CCDS29431.1"
                     /db_xref="GeneID:225875"
                     /db_xref="MGI:MGI:2385612"
                     /translation="MAPPLLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPP
                     NVDRRTVELRLADNFIQALGPPDFRNMTGLVDLTLSRNAITRIGARSFGDLESLRSLH
                     LDGNRLVELGSSSLRGPVNLQHLILSGNQLGRIAPGAFDDFLDSLEDLDVSYNNLRQV
                     PWAGIGSMPALHTLNLDHNLIDALPPGVFAQLSQLSRLDLTSNRLATLAPDPLFSRGR
                     DAEASPSPLVLSFSGNPLHCNCELLWLRRLARPDDLETCASPPTLAGRYFWAVPEGEF
                     SCEPPLIARHTQRLWVLEGQRATLRCRALGDPVPTMHWVGPDDRLVGNSSRAWAFPNG
                     TLEIGVTGAGDAGAYTCIATNPAGEATARVELRVLALPHGGNTSAEGGRPGPSDIAAS
                     ARTAAEGEGTLESEPAVQVTEVTATSGLVSWGLGRPADPVWMFQIQYNSSEDETLIYR
                     IVPASSHHFLLKHLVPGADYDLCLLALSPAAGPSDLTATRLLGCAHFSTLPATPLCHA
                     LQAHVLGGTLTVAVGGVLVAALLVFTVALLVRGRGAGNGRLPLKLSHVQSQTNGGTSP
                     MPKSHPPRSPPPRPQRSCSLDLGDTGGCYGYARRLGGAWARRSHSVHGGLLGAGCRGV
                     GGSAERLEESVV"
     exon            2065..2919
                     /gene="Lrfn4"
                     /gene_synonym="Salm3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggttgtgac cttcagtgtg tgtctgcgaa cgcgggggtc ccagtaacag tgcgggtttg
       61 cacccggccc tgcccgtggg tgcggggacg tgtgggtgtg tgggcatatg tgggcgtgtt
      121 ggggagggtg cccagagaca tgtgacaaag acccgtctct gggagatggt aaagaggcct
      181 agagctggcg ctttgtctgg ttgtctgcag agccgcggcg cccgcctgag cggttgcagg
      241 atgcttgggc gccagggtgg ccgagggcgc gcgcgtccgt gccagggtga gtgcgctgcg
      301 gcagcgccgt ggggcagagc ggagggtttg gctgggcctc gggcgtgact gggcgccacc
      361 cgtgggcgct gcagtggccg cgtgtccccg tgacctcccg agcccggctg gggcccgggt
      421 ggatccctgt gcccctcccg gtccaccttc cacgtgcgtg ttcgcggcgc gcgcgtccgc
      481 cagcgcgcac ccgcctgcct gtcgccgccg ccgccaccgc gaacggcgcg gagaaaaggt
      541 gccgggagcc gagagagccg gggccgaggg cccgagcgcc atgggccgga gggcgcgcgg
      601 ctggcgggcc cggcctcgcc cccgcgagag agcggcctgg agtcggcagg ggccggctgg
      661 gtccgcgggg aggccagccc gcgccccctg agcgacggac accagggcac tcaccatggc
      721 cccgccgctc ctattgctgc tgctggccag tggagccgct gcttgcccgc taccctgtgt
      781 gtgccagaac ctgtcggagt cactcagcac cctttgtgcc caccgaggcc tgctgtttgt
      841 gccacccaac gtggacaggc gcacagttga actgcgcctg gccgacaact tcatccaggc
      901 cctgggacca cctgacttcc gcaacatgac agggctggtg gacctaacat tgtctcgaaa
      961 tgccatcacc cgcattgggg ctcgctcctt tggggacctg gagagcctgc gctccttgca
     1021 cctggatggc aacaggctgg tggagctggg cagcagcagc ctacgggggc ctgtcaacct
     1081 ccagcatctc attctcagtg gcaatcaact gggccgcatc gcccccgggg ccttcgacga
     1141 cttccttgac agtctcgagg acctggatgt gtcctataac aacctccggc aggttccctg
     1201 ggctggcata ggctccatgc ctgccctgca taccctgaac ctggaccata acctcatcga
     1261 tgcactaccc ccaggtgtct ttgctcagct cagccagctc tcccgccttg acctcacctc
     1321 caaccgcctg gccaccctgg cacctgatcc actcttctcc cgaggccggg atgctgaggc
     1381 ctcaccttct cccctggtgc tgagtttcag cgggaaccca ctgcactgca actgtgagct
     1441 gctgtggctg cggcggctgg cccggcccga tgacctggaa acctgcgctt ctccaccaac
     1501 cctggcaggc cgctacttct gggcagtgcc tgagggagag ttctcctgtg agcctccgct
     1561 gattgcccgg cacacacagc gcctgtgggt gctagagggc cagcgggcca ccctacggtg
     1621 cagggccctt ggtgaccctg tacctaccat gcactgggtt ggccctgatg acaggctggt
     1681 tggcaactct tctcgagcct gggctttccc caatgggacc ctagagattg gggtgacggg
     1741 cgctggagat gcaggagcct atacctgcat tgccaccaac cctgctggtg aggccacagc
     1801 ccgagtggag ctccgggtac tggccttgcc ccatggtggg aacaccagtg ctgagggggg
     1861 ccgtcctggg ccttcggaca ttgctgcttc tgctagaact gctgccgaag gcgagggaac
     1921 tttagaatct gaaccagcag tgcaagtgac ggaggtgact gccacctctg gcctggtgag
     1981 ctggggcctg gggcggccag ctgacccagt gtggatgttc caaatccagt acaacagcag
     2041 cgaggatgag accctcatct accggattgt accagcctcc agccaccact tcctgctgaa
     2101 gcacctggtt cccggtgctg actacgacct ctgcctgctg gccctgtcac ctgctgctgg
     2161 gccctccgac ctcacggcca ctagactgct gggctgtgcc cacttctcta cgctaccagc
     2221 cacccccctg tgccatgccc tacaggccca tgtgctgggc gggaccctga ctgtggcagt
     2281 ggggggcgtc ctagtggctg ccttactggt cttcactgtg gccttgctgg ttcggggccg
     2341 gggagctggg aatggccgcc tcccactcaa actcagccat gtccaatccc agaccaatgg
     2401 tggcaccagc cccatgccca agagccaccc accacggagc cctccacccc gtcctcagcg
     2461 cagctgctcc ctggacctag gagacaccgg aggatgctac gggtatgcca ggcgcctggg
     2521 aggagcctgg gcccggcgga gccactctgt acatgggggg ctgctgggag ctgggtgtcg
     2581 gggggtgggg ggcagtgcgg agcggctgga ggagagtgtg gtgtgacaga aagggcagcc
     2641 tcttatgtgc cctgaggaag gagcagtgcc actgttgggc ccaggtggca gcacccagcc
     2701 tgggtgggca gcacggccct gggtcccact ctgcttttta tcctcagtac ctcaggcccc
     2761 catgtacttg gtgggacagc aaaccctttc cttggttttg gcctccagac taaagggaca
     2821 ggtcccacca acaggtgctc agagccacca aggcaggggc tgcagccacc aagagggagt
     2881 cttgtttcta tttataataa aattgttggg gatacttcaa aaaaaaaaaa
//
