LOCUS       NM_175478               2861 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus leucine rich repeat and fibronectin type III domain
            containing 3 (Lrfn3), mRNA.
ACCESSION   NM_175478
VERSION     NM_175478.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Chen,P., Liu,Z., Zhang,Q., Lin,D., Song,L., Liu,J., Jiao,H.F.,
            Lai,X., Zou,S., Wang,S., Zhou,T., Li,B.M., Zhu,L., Pan,B.X. and
            Fei,E.
  TITLE     DSCAM Deficiency Leads to Premature Spine Maturation and
            Autism-like Behaviors
  JOURNAL   J Neurosci 42 (4), 532-551 (2022)
   PUBMED   34848499
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   Lie,E., Yeo,Y., Lee,E.J., Shin,W., Kim,K., Han,K.A., Yang,E.,
            Choi,T.Y., Bae,M., Lee,S., Um,S.M., Choi,S.Y., Kim,H., Ko,J. and
            Kim,E.
  TITLE     SALM4 negatively regulates NMDA receptor function and fear memory
            consolidation
  JOURNAL   Commun Biol 4 (1), 1138 (2021)
   PUBMED   34588597
  REMARK    GeneRIF: SALM4 negatively regulates NMDA receptor function and fear
            memory consolidation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2861)
  AUTHORS   Kim,D.Y., Park,J.A., Kim,Y., Noh,M., Park,S., Lie,E., Kim,E.,
            Kim,Y.M. and Kwon,Y.G.
  TITLE     SALM4 regulates angiogenic functions in endothelial cells through
            VEGFR2 phosphorylation at Tyr1175
  JOURNAL   FASEB J 33 (9), 9842-9857 (2019)
   PUBMED   31170000
REFERENCE   5  (bases 1 to 2861)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2861)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   7  (bases 1 to 2861)
  AUTHORS   Wang,P.Y., Seabold,G.K. and Wenthold,R.J.
  TITLE     Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth
  JOURNAL   Mol Cell Neurosci 39 (1), 83-94 (2008)
   PUBMED   18585462
  REMARK    GeneRIF: Data show that the C-terminal PDZ binding domains of
            synaptic adhesion-like molecules (SALMs)1-3 are required for
            neurite outgrowth, and that the N-termini of SALMs 2 and 4 are
            alsoinvolved in neurite outgrowth.
REFERENCE   8  (bases 1 to 2861)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   9  (bases 1 to 2861)
  AUTHORS   Morimura,N., Inoue,T., Katayama,K. and Aruga,J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
REFERENCE   10 (bases 1 to 2861)
  AUTHORS   Wang,C.Y., Chang,K., Petralia,R.S., Wang,Y.X., Seabold,G.K. and
            Wenthold,R.J.
  TITLE     A novel family of adhesion-like molecules that interacts with the
            NMDA receptor
  JOURNAL   J Neurosci 26 (8), 2174-2183 (2006)
   PUBMED   16495444
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC149067.3.
            
            On Nov 17, 2006 this sequence version replaced NM_175478.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040916.1, BC094593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-840               AC149067.3         170632-171471       c
            841-2271            AC149067.3         168083-169513       c
            2272-2861           AC149067.3         164213-164802       c
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.41 cM"
     gene            1..2861
                     /gene="Lrfn3"
                     /gene_synonym="A530045B06Rik; SALM4"
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 3"
                     /db_xref="GeneID:233067"
                     /db_xref="MGI:MGI:2442512"
     exon            1..840
                     /gene="Lrfn3"
                     /gene_synonym="A530045B06Rik; SALM4"
                     /inference="alignment:Splign:2.1.0"
     exon            841..2271
                     /gene="Lrfn3"
                     /gene_synonym="A530045B06Rik; SALM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             857..2737
                     /gene="Lrfn3"
                     /gene_synonym="A530045B06Rik; SALM4"
                     /note="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 3; synaptic adhesion-like
                     molecule 4"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 3 precursor"
                     /protein_id="NP_780687.1"
                     /db_xref="CCDS:CCDS21088.1"
                     /db_xref="GeneID:233067"
                     /db_xref="MGI:MGI:2442512"
                     /translation="MAVLPLLLCLLPLAPASSPPQPAISSPCPRRCRCQTQSMPLSVL
                     CPGAGLLFVPPSLDRRAAELRLADNFIAAVRRRDLANMTGLLHLSLSRNTIRHVAAGA
                     FADLRALRALHLDGNRLTSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLED
                     LDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTT
                     IPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAREDDLEACASPP
                     ALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAVGDPEPRVRWVSPQG
                     RLLGNSSRARAFPNGTLELLVTEPEDGGTFTCIAANAAGEATAAVELTVGPPPPPQLA
                     NSTSCDPPRDGEPDALTPPSAASASAKVADTVAPTDRGVQVTEHGATAALVQWPDQRP
                     VPGIRMYQIQYNSSADDILVYRMIPADSRSFLLTDLASGRTYDLCVLAVYEDSATGLT
                     ATRPVGCARFSTEPALRPCAAPHAPFLGGTMIIALGGVIVASVLVFIFVLLLRYKVHG
                     GQPPGKAKATAPVSSVCSQTNGALGPVPSAPAPEPAAPRAHTVVQLDCEPWGPSHEPA
                     GP"
     exon            2272..2861
                     /gene="Lrfn3"
                     /gene_synonym="A530045B06Rik; SALM4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgacatcggg gtgtgcttgc agccggcgat cggatccaga tattctgaaa cccccaagcg
       61 tgggaccctg atttgggatc agcaccttga gctcctgcca tggaacccta agactcggac
      121 cttgaacctc aatatctggg gctggaatcc cgacatccgt ctctgggacc ccaagatttg
      181 gaagccgaac cccattattt tggagcatgg atcccaatat ttggacctgg gaccccaaga
      241 tttggcgtcc aagcccccaa aattggagct gaactctgaa ttgtctgact gatacgttga
      301 catctgggag cgaattccca aatctatacc tgggacccca ctattctggg aaataaaccc
      361 tgggatgcag gccttcaatt ccaagatctg aactgtggaa ttctgtgggg gagcctgaag
      421 tccttgctgc agacataagt gctgaaatct ggggctagag acctccaagt cttgactcag
      481 caccctagta tctgaacagg atcccagttt cggatgccag aactggactc gggattcaga
      541 ccctaaactt ccccttctgg ctgttcggtg tctcaagcct ggcactgaga gagcctgagc
      601 ctgaaaaacc actggggcct tggtctctca agctggactc tcgaggccca gtgttagggg
      661 tctggaaccc cgagagtcaa gtttggagac tccataacca cagaccagac ctggggcaag
      721 acagttcctt cccagaggcc ctgaggacag gggagtcttg acctgatgcc tcctccagag
      781 ttctgacctc acccccttgg agcctaagga cactgctccc tggggtggct tccagttcag
      841 gccacccctg cccgcgatgg ccgtccttcc actactcctt tgcctgctac cgctggcccc
      901 cgcctcatct ccaccccagc cggccatatc cagcccctgt ccccgccgtt gccgctgcca
      961 gacccagtcg atgcccctaa gcgtgttgtg cccaggggcg ggccttctat tcgtaccgcc
     1021 atcactggat cgccgcgctg cagaactgcg cctggcagac aacttcatcg cggcagtgcg
     1081 tcgtcgagac ctggccaaca tgacaggcct gctgcatctg agcttgtcta gaaacaccat
     1141 ccgccatgtg gcagctggcg ccttcgccga cctacgtgcc ctgcgtgccc tgcacctaga
     1201 tggtaataga ctgacctcgc tgggcgaggg tcagttgcgc ggcttagtca acttgcgcca
     1261 cctcatcctg agcaacaacc agctagcagc cctggcagct ggtgccctag acgactgtgc
     1321 cgagaccctg gaggacctcg atctctctta taataacctt gagcagcttc cctgggaggc
     1381 tttagggcgc ctaggcaacg tcaacacgtt gggccttgac cacaatttgt tggcttcagt
     1441 gcccgctgga gccttttccc gcctgcacaa gttggcacga ctggacatga cctccaaccg
     1501 cctaaccacc atccctcctg acccactctt ctcacgtttg ccactgcttg cccggcctcg
     1561 aggctcgcca gcctctgctc tggtgctggc ctttggggga aacccccttc actgcaactg
     1621 tgagctggtg tggctgcgac gcctggctcg ggaggacgac ctcgaggcct gtgcctcgcc
     1681 acctgctctg gggggccgct acttctgggc tgtgggtgag gaggagtttg tgtgtgagcc
     1741 acctgtggtg acccaccgct cacctcccct ggcagtgccc gcaggtcggc cagctgccct
     1801 gcgatgccgg gcagtagggg acccagagcc acgagtgcgt tgggtatcac cccagggtcg
     1861 gctgctgggc aactccagcc gtgctcgtgc cttccctaat gggaccctgg agctactggt
     1921 cactgagccg gaagatggcg gcactttcac ttgcattgca gccaatgccg ctggcgaggc
     1981 cactgctgct gttgagctga ccgtgggtcc ccctccaccc ccccagctag ccaatagcac
     2041 cagctgtgac cccccgcggg acggggaacc cgatgccctc accccgccct ctgcggcttc
     2101 agcctccgcc aaagtggcgg acactgtggc ccctaccgac cgtggcgtcc aagtgactga
     2161 gcatggggcc acagcggctc ttgttcagtg gccagatcaa cggcctgtcc caggcatccg
     2221 catgtaccag atccagtaca acagctcggc cgacgacatc cttgtctaca ggatgatccc
     2281 agcggacagt cgctccttcc tgctgaccga tctggcgtca ggccgtacct atgatctatg
     2341 tgtgctcgca gtctatgagg acagcgccac cgggctaacg gccacgcggc cagtgggctg
     2401 cgctcggttc tccacggagc ccgcacttcg gccttgtgct gcaccgcacg cacccttcct
     2461 gggcggcacc atgatcatag cgctgggagg tgtcatcgtc gcttctgttc tggtcttcat
     2521 cttcgtgctg cttctacgtt acaaggtgca cggaggccag ccgcccggca aggccaaggc
     2581 tacggcacct gtcagcagcg tttgctccca gaccaacgga gcgctcgggc ccgtgcccag
     2641 tgcgcctgcc cctgagcctg ctgcacccag ggcccatact gtggtccaat tggactgtga
     2701 gccctggggg cccagtcacg aacctgcagg accctagcca agggcccacc tctatggttc
     2761 ctctggtccc agggacaccc ctcgggacct ggcctcagac tcaccaaatt gctcacggtt
     2821 tttaaaactc tgatggggag ggtgtcgggg gcaccggggc a
//
