LOCUS       NM_027452               3001 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus leucine rich repeat and fibronectin type III domain
            containing 2 (Lrfn2), mRNA.
ACCESSION   NM_027452 XM_128642
VERSION     NM_027452.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3001)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3001)
  AUTHORS   Maekawa,R., Muto,H., Hatayama,M. and Aruga,J.
  TITLE     Dysregulation of erythropoiesis and altered erythroblastic NMDA
            receptor-mediated calcium influx in Lrfn2-deficient mice
  JOURNAL   PLoS One 16 (1), e0245624 (2021)
   PUBMED   33481887
  REMARK    GeneRIF: Dysregulation of erythropoiesis and altered erythroblastic
            NMDA receptor-mediated calcium influx in Lrfn2-deficient mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3001)
  AUTHORS   Eltokhi,A., Santuy,A., Merchan-Perez,A. and Sprengel,R.
  TITLE     Glutamatergic Dysfunction and Synaptic Ultrastructural Alterations
            in Schizophrenia and Autism Spectrum Disorder: Evidence from Human
            and Rodent Studies
  JOURNAL   Int J Mol Sci 22 (1), 59 (2020)
   PUBMED   33374598
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3001)
  AUTHORS   Brouwer,M., Farzana,F., Koopmans,F., Chen,N., Brunner,J.W.,
            Oldani,S., Li,K.W., van Weering,J.R., Smit,A.B., Toonen,R.F. and
            Verhage,M.
  TITLE     SALM1 controls synapse development by promoting
            F-actin/PIP2-dependent Neurexin clustering
  JOURNAL   EMBO J 38 (17), e101289 (2019)
   PUBMED   31368584
  REMARK    GeneRIF: Data show that SALM1 is a presynaptic organizer of synapse
            development by promoting F-actin/PIP2-dependent clustering of
            Neurexin.
REFERENCE   5  (bases 1 to 3001)
  AUTHORS   Li,Y., Kim,R., Cho,Y.S., Song,W.S., Kim,D., Kim,K., Roh,J.D.,
            Chung,C., Park,H., Yang,E., Kim,S.J., Ko,J., Kim,H., Kim,M.H.,
            Bae,Y.C. and Kim,E.
  TITLE     Lrfn2-Mutant Mice Display Suppressed Synaptic Plasticity and
            Inhibitory Synapse Development and Abnormal Social Communication
            and Startle Response
  JOURNAL   J Neurosci 38 (26), 5872-5887 (2018)
   PUBMED   29798891
  REMARK    GeneRIF: These results suggest that SALM1/LRFN2 regulates
            excitatory synapse function, inhibitory synapse development, social
            communication, and acoustic startle behavior.
REFERENCE   6  (bases 1 to 3001)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   7  (bases 1 to 3001)
  AUTHORS   Morimura,N., Inoue,T., Katayama,K. and Aruga,J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
REFERENCE   8  (bases 1 to 3001)
  AUTHORS   Wang,C.Y., Chang,K., Petralia,R.S., Wang,Y.X., Seabold,G.K. and
            Wenthold,R.J.
  TITLE     A novel family of adhesion-like molecules that interacts with the
            NMDA receptor
  JOURNAL   J Neurosci 26 (8), 2174-2183 (2006)
   PUBMED   16495444
REFERENCE   9  (bases 1 to 3001)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 3001)
  AUTHORS   Badiani,P., Corbella,P., Kioussis,D., Marvel,J. and Weston,K.
  TITLE     Dominant interfering alleles define a role for c-Myb in T-cell
            development
  JOURNAL   Genes Dev 8 (7), 770-782 (1994)
   PUBMED   7926766
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC139418.1, AK044375.1 and BY641512.1.
            
            On Apr 2, 2009 this sequence version replaced NM_027452.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139418.1, AK017594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               BC139418.1         1-124
            125-2956            AK044375.1         2-2833
            2957-3001           BY641512.1         378-422
FEATURES             Location/Qualifiers
     source          1..3001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 24.66 cM"
     gene            1..3001
                     /gene="Lrfn2"
                     /gene_synonym="5730420O05Rik; mKIAA1246; SALM1"
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 2"
                     /db_xref="GeneID:70530"
                     /db_xref="MGI:MGI:1917780"
     exon            1..237
                     /gene="Lrfn2"
                     /gene_synonym="5730420O05Rik; mKIAA1246; SALM1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..1661
                     /gene="Lrfn2"
                     /gene_synonym="5730420O05Rik; mKIAA1246; SALM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..2628
                     /gene="Lrfn2"
                     /gene_synonym="5730420O05Rik; mKIAA1246; SALM1"
                     /note="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 2"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type-III
                     domain-containing protein 2 precursor"
                     /protein_id="NP_081728.2"
                     /db_xref="CCDS:CCDS28871.1"
                     /db_xref="GeneID:70530"
                     /db_xref="MGI:MGI:1917780"
                     /translation="METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLL
                     FVPPDIDRRTVELRLGGNFIIHIGRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESL
                     RSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADDAFEDFLLTLEDLDLSYNN
                     LHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIF
                     ARSQASLLTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDDDLETCGSPGSLKGRYF
                     WHIREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSS
                     RTAVYDNGTLDILITTSQDSGPFTCIAANAAGEATATVEVSIVQLPHLSNSTSRMAPP
                     KSRLSDITGSSKTSRGGGGSGAGEPPKSTPERAVLVSDVTTTSALVKWSVSKSAPRVK
                     MYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLAMWDDTATTLTATNIV
                     GCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVILMVRYKVCNHDTPG
                     KMAAATVSNVYSQTNGSQPPPLGGIPVGQLPQAPPKVVVRNELMDFSTSLARACDSSS
                     SSSLGSGEAAGLGRGPWRLPPPAPRPKPSLDRLMGAFASLDLKSQRKEELLDSRTPAG
                     RGAGTSSRGHHSDREPLLGPPATRARSLLPLPLEGKAKRSHSFDMGDFAAAAAAVPGG
                     YSPPRRVSNIWTKRSLSVNGMLLPFEESDLVGARGTFGSSEWVMESTV"
     exon            1662..3001
                     /gene="Lrfn2"
                     /gene_synonym="5730420O05Rik; mKIAA1246; SALM1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2957
                     /gene="Lrfn2"
                     /gene_synonym="5730420O05Rik; mKIAA1246; SALM1"
                     /note="major polyA site"
ORIGIN      
        1 ccgccccttc ttcttgctaa atgccatgga tataactgaa taagctgctc agggctctcc
       61 ccgcgtggat ggtccgaggc caccatctgc ctgccttcgc tggatcgctg cagctggagc
      121 gcttagcgtg agcctgtctc cggccaggaa ggatgcgtgg ccgagccaag gagcccgggc
      181 gccctgcgga gccggccttg gagcctcccc gccacgggta gatgccgcct tgcccaggtg
      241 cagaggctga gtgaccagac catggagact ctgcttggtg ggctgctggc ttttggcatg
      301 gcgtttgctg tggtcgatgc ctgccccaag tactgcgtct gccagaatct gtctgagtca
      361 ctggggaccc tgtgtccctc caaggggctc ctctttgtgc cccctgacat tgaccggagg
      421 acggtggagc tgcgtctggg tggcaacttc atcatccaca ttggccgcca agactttgcc
      481 aacatgacag ggctggtgga tctgaccttg tccaggaaca ccatcagcca tatccagccc
      541 ttctccttcc tggaccttga gagcctccgc tccctgcacc ttgacagcaa ccggctacct
      601 agccttgggg aggacacact ccggggtctg gtcaacctgc aacaccttat tgtgaacaat
      661 aaccagctgg gtggcatcgc tgatgatgcc tttgaagact tcttgctgac tttagaagac
      721 ctggacctat cttacaacaa cctccacgga cttccctggg attccgtacg gcgcatggtc
      781 aacctccatc agctgagtct ggaccacaat ctgctggacc acattgctga gggcactttt
      841 gcagacctgc agaaactggc ccgcctggac ctcacatcca atcggctgca gaaacttccc
      901 ccggacccca tctttgcccg ctcccaggct tccttgctaa ctgccacgcc ctttgcccca
      961 cccctgtctt ttagttttgg agggaacccg ctgcactgca attgtgagct tctctggctg
     1021 cggaggctgg agagggatga tgacctggag acctgtggat cccccggaag tctcaagggt
     1081 cgctactttt ggcatattcg tgaggaggag tttgtgtgtg agccgcctct catcacccag
     1141 cacacacaca agctgctggt tctggagggc caggcagcca ctcttaagtg caaggccatt
     1201 ggggacccca gccctttgat ccactgggtt gcccccgatg accgcttggt gggaaactct
     1261 tccaggactg ctgtatatga caatggcacc ctggacattc taattaccac ctctcaggac
     1321 agtggaccct ttacctgcat cgcagccaat gcagcaggag aggctacggc cactgtagag
     1381 gtctccattg tgcagctccc acaccttagt aacagcacta gccggatggc accccccaag
     1441 tctcgccttt cggacatcac aggttccagc aagaccagcc ggggaggggg aggtagtggg
     1501 gctggggagc ctcccaaaag caccccagag agggctgtgc ttgtgtccga tgttaccacc
     1561 acatctgccc tggtcaagtg gtctgtcagc aagtcagcac ccagggtgaa gatgtatcag
     1621 ctgcagtaca actgttctga tgatgaggtg ctgatctaca ggatgatccc agcctctaac
     1681 aaggccttcg tggtcaacaa cctggtgtcc ggaacgggct acgacttgtg cgtactggct
     1741 atgtgggacg acacagccac gacgctcaca gccaccaaca ttgtgggctg tgcccagttc
     1801 ttcaccaagg ccgactaccc acaatgccag tctatgcaca gtcagatcct ggggggcacc
     1861 atgattctgg tcatcggagg tatcattgtg gccacactgc tggtcttcat tgtaatcctc
     1921 atggtgcggt acaaggtctg caaccacgac accccaggaa aaatggcagc cgccactgtc
     1981 agcaatgtgt actcgcagac caatgggtct cagcctccac ctctgggtgg gatacccgtt
     2041 ggccagcttc ctcaggcacc acccaaagtt gtggtgcgaa atgagttgat ggacttcagt
     2101 accagcctgg ccagggcctg tgactcctct tcttccagct cactgggcag cggggaagcc
     2161 gcggggctgg gccggggtcc ctggaggctc ccacccccag ctcctcgtcc caagcccagc
     2221 cttgaccgct tgatgggagc ctttgcctcc ctggacctca agagtcaaag gaaagaagaa
     2281 cttctagact ccaggactcc agcaggcaga ggggcaggga catcatccag aggccaccac
     2341 tcagaccgag agccactgct ggggcccccg gccacccgtg ccaggagtct tctccctttg
     2401 cccctggagg gcaaggccaa acgaagccac tcttttgaca tgggggactt tgcagctgca
     2461 gctgcagctg ttcctggtgg ctacagtccc cctaggcggg tctcaaacat ctggacgaag
     2521 cgcagcctgt ctgtcaatgg catgctcttg ccctttgagg agagtgacct ggtgggagcc
     2581 cgggggacat ttggcagctc agagtgggta atggaaagta ctgtgtagcc agggaaggag
     2641 taccctccct cccaccctca aagtgggaga ggaaggagtc ggagtcagca ctggcaagta
     2701 tttgtggagt ttccatggtg atgtttacat ccagggacag tcttgtctcc ctgtcaacag
     2761 cctcatgtcc ttctgcccag ctacaccccc ttccccatgt caccttccca ggcctgtccc
     2821 caccacccag cggggtgtgc tcagggaatg ggactcgctc atgtgtcaga ctgagccctg
     2881 agtgtttgga gaggccaaca actgcctttc tattcacaaa tgtagcgaca agcaagcggc
     2941 ttcggattgc ttatggatcc agtgttgttt tgatttctta atttattttt ccatttccca
     3001 g
//
