LOCUS       NM_001141921            2584 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus leucine rich repeat and fibronectin type III domain
            containing 1 (Lrfn1), transcript variant 1, mRNA.
ACCESSION   NM_001141921
VERSION     NM_001141921.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2584)
  AUTHORS   Chen P, Liu Z, Zhang Q, Lin D, Song L, Liu J, Jiao HF, Lai X, Zou
            S, Wang S, Zhou T, Li BM, Zhu L, Pan BX and Fei E.
  TITLE     DSCAM Deficiency Leads to Premature Spine Maturation and
            Autism-like Behaviors
  JOURNAL   J Neurosci 42 (4), 532-551 (2022)
   PUBMED   34848499
REFERENCE   2  (bases 1 to 2584)
  AUTHORS   Lie E, Ko JS, Choi SY, Roh JD, Cho YS, Noh R, Kim D, Li Y, Kang H,
            Choi TY, Nam J, Mah W, Lee D, Lee SG, Kim HM, Kim H, Choi SY, Um
            JW, Kang MG, Bae YC, Ko J and Kim E.
  TITLE     SALM4 suppresses excitatory synapse development by cis-inhibiting
            trans-synaptic SALM3-LAR adhesion
  JOURNAL   Nat Commun 7, 12328 (2016)
   PUBMED   27480238
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2584)
  AUTHORS   Gu Z, Imai F, Kim IJ, Fujita H, Katayama Ki, Mori K, Yoshihara Y
            and Yoshida Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2584)
  AUTHORS   Nam J, Mah W and Kim E.
  TITLE     The SALM/Lrfn family of leucine-rich repeat-containing cell
            adhesion molecules
  JOURNAL   Semin Cell Dev Biol 22 (5), 492-498 (2011)
   PUBMED   21736948
  REMARK    Review article
REFERENCE   5  (bases 1 to 2584)
  AUTHORS   Homma S, Shimada T, Hikake T and Yaginuma H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   6  (bases 1 to 2584)
  AUTHORS   Wang PY, Seabold GK and Wenthold RJ.
  TITLE     Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth
  JOURNAL   Mol Cell Neurosci 39 (1), 83-94 (2008)
   PUBMED   18585462
  REMARK    GeneRIF: Data show that the C-terminal PDZ binding domains of
            synaptic adhesion-like molecules (SALMs)1-3 are required for
            neurite outgrowth, and that the N-termini of SALMs 2 and 4 are
            alsoinvolved in neurite outgrowth.
REFERENCE   7  (bases 1 to 2584)
  AUTHORS   Yoshida Y, Han B, Mendelsohn M and Jessell TM.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   8  (bases 1 to 2584)
  AUTHORS   Morimura N, Inoue T, Katayama K and Aruga J.
  TITLE     Comparative analysis of structure, expression and PSD95-binding
            capacity of Lrfn, a novel family of neuronal transmembrane proteins
  JOURNAL   Gene 380 (2), 72-83 (2006)
   PUBMED   16828986
REFERENCE   9  (bases 1 to 2584)
  AUTHORS   Wang CY, Chang K, Petralia RS, Wang YX, Seabold GK and Wenthold RJ.
  TITLE     A novel family of adhesion-like molecules that interacts with the
            NMDA receptor
  JOURNAL   J Neurosci 26 (8), 2174-2183 (2006)
   PUBMED   16495444
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149606.6.
            
            [WARNING] On Apr 27, 2023 this sequence was replaced by
            NM_001141921.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660815.129387.1, AB243740.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849379, SAMN00849383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC149606.6         61008-61106         c
            100-132             AC149606.6         58815-58847         c
            133-187             AC149606.6         55331-55385         c
            188-1624            AC149606.6         53281-54717         c
            1625-2584           AC149606.6         45796-46755         c
FEATURES             Location/Qualifiers
     source          1..2584
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..2584
                     /gene="Lrfn1"
                     /gene_synonym="SALM2; Semo1"
                     /note="leucine rich repeat and fibronectin type III domain
                     containing 1"
                     /db_xref="GeneID:80749"
                     /db_xref="MGI:MGI:2136810"
     exon            1..99
                     /gene="Lrfn1"
                     /gene_synonym="SALM2; Semo1"
                     /inference="alignment:Splign:2.1.0"
     exon            100..132
                     /gene="Lrfn1"
                     /gene_synonym="SALM2; Semo1"
                     /inference="alignment:Splign:2.1.0"
     exon            133..187
                     /gene="Lrfn1"
                     /gene_synonym="SALM2; Semo1"
                     /inference="alignment:Splign:2.1.0"
     exon            188..1624
                     /gene="Lrfn1"
                     /gene_synonym="SALM2; Semo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2519
                     /gene="Lrfn1"
                     /gene_synonym="SALM2; Semo1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leucine-rich repeat and fibronectin type III
                     domain-containing protein 1; synaptic differentiation
                     enhancing molecule 1; synaptic adhesion-like molecule 2"
                     /codon_start=1
                     /product="leucine-rich repeat and fibronectin type III
                     domain-containing protein 1 isoform 1 precursor"
                     /protein_id="NP_001135393.1"
                     /db_xref="CCDS:CCDS52163.1"
                     /db_xref="GeneID:80749"
                     /db_xref="MGI:MGI:2136810"
                     /translation="MAPGPFSSGLFSPPPAALPFLLLLWAGASRGQPCPGRCICQNVA
                     PTLTMLCAKTGLLFVPPAIDRRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIG
                     QVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGNNQIRKVESAAFDAF
                     LSTVEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMT
                     SNRLHKLPPDGLFLRSQGGGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCA
                     TPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALVVEGQAVSLRCRAVGDPEPVVHWV
                     APDGRLLGNSSRTRVRGDGTLDVTITTLRDSGTFTCIASNAAGEATAPVEVCVVPLPL
                     MAPPPAAPPPLTEPGSSDIATPGRPGANDSTSERRLVAAELTSSSVLIRWPAQRPVPG
                     IRMYQVQYNSSADDSLVYRMIPSTSQTFLVNDLAAGRAYDLCVLAVYDDGATALPATR
                     VVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGGVIVASVLVFIVLLMIRYKVYGDGD
                     SRRIKGTSRTPPRVSHVCSQTNGAGAQQASAPPAPDRYEALREVAVPAAIEAKAMEAE
                     ATSTELEVVLGRSLGGSATSLCLLPSEETSGEESRAMTGPRRSRSGALGPPTSAPPTL
                     ALVPGGAPARPRPQQRYSFDGDYGALFQSHSYPRRARRTKRHRSTPHLDGAGGGAAGE
                     DGDLGLGSARARLAFTSTEWMLESTV"
     exon            1625..2584
                     /gene="Lrfn1"
                     /gene_synonym="SALM2; Semo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtgtgcat gtgtgcgtgt gtgcgcgcgt gtgtcccaca cactccgggg cgccggatct
       61 ggggggctgt ggcgcgcccg tccgaggggc tgtgtgcagg taccggccca ggccctgact
      121 ccttgaagag agatgaagaa accgagattc agagaggttc agacacttgc cccaggtcac
      181 acagctagtc tctcccattc ctgcctcccc cctgcaccat ggctccaggc cccttctcct
      241 ccgggctctt ttcgccacca cctgctgctc ttccctttct gctgttgctc tgggcaggag
      301 catctcgagg ccagccctgc cctggtcgct gcatctgtca gaacgtggca cctacgctga
      361 ccatgctgtg tgcgaagacg ggcctgctct ttgtgccacc cgccatcgac aggcgtgtgg
      421 tagagctgcg gctcactgac aacttcattg cggctgtgcg tcgtcgagac ttcgccaata
      481 tgaccagcct ggtccacctc accctgtctc gcaacaccat tggccaggta gcagccggcg
      541 cctttgctga cctccgggct ctccgggccc tgcaccttga cagcaaccgc ctggcagagg
      601 tgcgagggga tcagctccgg ggcttgggta acctccgcca cttgatcctc ggcaacaatc
      661 agatccgtaa ggtggagtcg gcagcctttg acgccttcct gtccaccgtg gaggacctgg
      721 atctatccta caacaacctg gaggcactgc catgggaggc ggtgggtcag atggtgaact
      781 tgaacaccct cacgctggac cacaacctca ttgatcacat tgcggagggc accttcgtgc
      841 agctgcacaa actcgtgcgc ttggacatga cctccaaccg tctacataaa ttgccccccg
      901 acggactgtt cctgaggtcc cagggcggtg ggcccaagcc acccacccca ttgacggtca
      961 gcttcggtgg caacccgctg cactgcaact gtgaactgct ctggcttcgg cgcctgacca
     1021 gggaggacga cttggagacg tgtgccacgc ccgagcatct cactgaccgc tatttctggt
     1081 ccatcccgga ggaggaattt ctatgtgagc ccccgctcat cacacggcaa gcagggggcc
     1141 gggccctggt ggtagagggc caggctgtca gtctgcgctg ccgggctgtg ggtgaccccg
     1201 agcccgtggt gcattgggtg gcacctgatg gacggctgct ggggaactcc agccggactc
     1261 gggtccgtgg tgacggaacg ctggatgtga ctatcaccac cctgagggac agcggtacct
     1321 tcacttgcat agcctccaat gctgcggggg aagccacagc acctgtggag gtatgtgtgg
     1381 tacctctgcc actgatggcg cccccacccg ctgccccgcc gcctctcact gaacctggtt
     1441 cttctgacat cgccacacca ggcagacctg gtgccaacga ctcaaccagt gagcgcaggc
     1501 ttgtggctgc tgaactcacg tctagctctg tgctcatccg ctggccggcc cagaggccag
     1561 tgcctggcat ccgtatgtac caagtgcaat acaacagctc tgcagatgac tccctagtct
     1621 acaggatgat cccttctacc agccagacct tcctagtgaa tgacctggcg gctggccgcg
     1681 cctatgattt gtgtgtgttg gcagtctatg acgacggggc caccgctctg ccggctacca
     1741 gagtggtggg ctgtgtgcaa ttcaccaccg cgggagatcc tgcaccatgc cgcccgctga
     1801 gggcccattt cttgggcggc accatgatca tcgccatcgg gggcgtcatc gtagcctcgg
     1861 tcctcgtttt catcgttctg ctcatgattc gctacaaggt gtacggagat ggggacagcc
     1921 gccgcatcaa ggggacgtcc aggacgcccc ctcgggtcag ccacgtgtgc tctcagacca
     1981 acggcgcagg tgcgcagcag gcctccgccc caccagctcc agaccgctac gaggcgctgc
     2041 gggaggtggc tgtccctgcg gccatcgagg caaaggccat ggaggccgag gcgacttcca
     2101 ctgagctaga ggtggtgctt ggacgctctc tgggtggctc cgccacctcg ctgtgcttgc
     2161 tgccctccga ggaaacttct ggggaggaat ctagggccat gaccggccct cgaaggagcc
     2221 gttcgggggc cttggggcct ccaacttcag cgcccccaac gctagctctg gttcctgggg
     2281 gagccccggc ccgaccgagg ccacaacaac gctattcctt cgacggggac tacggggcgc
     2341 tgttccagag tcacagttac ccgcgccgcg cccggcggac aaagcgccac cggtccacgc
     2401 cacacctgga cggggccgga gggggcgcgg ccggggagga cggagacctg gggctgggct
     2461 ccgcccgggc acgcctggcc ttcaccagca ccgaatggat gctggagagt accgtgtgag
     2521 cgacgggcgc acgggcaccg ggacgcctgt gggccgcact tagttgccca gcccggccgg
     2581 atgc
//
