LOCUS       NM_001081255            5918 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus leucine-rich repeats and calponin homology (CH) domain
            containing 3 (Lrch3), transcript variant 1, mRNA.
ACCESSION   NM_001081255 XM_619388
VERSION     NM_001081255.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5918)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Lrch3 is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
REFERENCE   2  (bases 1 to 5918)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139244.4 and AC126023.3.
            
            On Feb 6, 2007 this sequence version replaced XM_619388.3.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155550.1, BC151058.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC139244.4         206219-206522
            305-449             AC126023.3         67815-67959
            450-576             AC126023.3         69580-69706
            577-682             AC126023.3         72823-72928
            683-819             AC126023.3         76918-77054
            820-929             AC126023.3         79158-79267
            930-1023            AC126023.3         91403-91496
            1024-1144           AC126023.3         93252-93372
            1145-1293           AC126023.3         96919-97067
            1294-1370           AC126023.3         99351-99427
            1371-1422           AC126023.3         103499-103550
            1423-1572           AC126023.3         104262-104411
            1573-1623           AC126023.3         105954-106004
            1624-1677           AC126023.3         107788-107841
            1678-1749           AC126023.3         111285-111356
            1750-1798           AC126023.3         112471-112519
            1799-1906           AC126023.3         113329-113436
            1907-2013           AC126023.3         114905-115011
            2014-2151           AC126023.3         116027-116164
            2152-2229           AC126023.3         123187-123264
            2230-5918           AC126023.3         129864-133552
FEATURES             Location/Qualifiers
     source          1..5918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 23.46 cM"
     gene            1..5918
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /note="leucine-rich repeats and calponin homology (CH)
                     domain containing 3"
                     /db_xref="GeneID:70144"
                     /db_xref="MGI:MGI:1917394"
     exon            1..304
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2379
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat and calponin homology
                     domain-containing protein 3; DISP complex protein LRCH3"
                     /codon_start=1
                     /product="DISP complex protein LRCH3 isoform 1"
                     /protein_id="NP_001074724.1"
                     /db_xref="CCDS:CCDS37315.1"
                     /db_xref="GeneID:70144"
                     /db_xref="MGI:MGI:1917394"
                     /translation="MAAAGLVAVVAAAEYSGPVASGGNLSGATCGPSPGLGPGPGPGS
                     WSRSVDRALEEAAVTGVLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPMEAC
                     HFVSLESLNLYQNCIRYIPEAVLNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNN
                     KLVSLPEEIGHLRHLTELDVSCNEIQTVPSQIGNLEALRDFNVRRNHLLRLPEELAEV
                     PLIRLDFSCNKITVIPVCYRNLRHLQVITLDNNPLQSPPAQICIKGKIHIFKYLNIQA
                     CKIAPDLPDYERRPLGFGSCHEELYSGRPYGALDSGFNSVDSGDKRWSGNEPTDEFSD
                     LPLRVAEITKEQRLRRESQYQENRSSVAVTNGGVEHDLDQIDYIDSCTTEEEENDVKQ
                     PKSLDTNSLSSQFMAYIEQRRISHEVSPVKPIAVREFQKTEDMKRYSHQNRVPVEPSL
                     VLSMPPSHNQLSHSDLELHQRREQSIECTRREAQLAALQYEEEKIRTKQIQRDAVLDF
                     VKQKASHNPQRQQPPGNGECSFPSRRSQHTDDSALLVSLSGLDGVSCVATRPHSSAFT
                     PLKSENRVDVTSSFPMTETVHHSPAYSFPAATQRNQPQRPESFLFRAAVRAEANKGRA
                     SPLLLSSAPATDPTDAITRQREEELKLIDQLRKHIEYRLKVSLPCDLGAALTDGVVLC
                     HLANHVRPRSVPSIHVPSPAVPKLTMAKCRRNVENFLDACRKIGVPQEQLCLPLHILE
                     EKGLGQVAVTVQALLELAPPKQPPPQQPQQQQPQLSAV"
     exon            305..449
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            450..576
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            577..682
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            683..819
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            820..929
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1023
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1144
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1293
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1370
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1422
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1572
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1623
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1677
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1749
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1798
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1906
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2013
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2151
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2229
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..5918
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5507..5512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /note="hexamer: AATAAA"
     polyA_site      5536
                     /gene="Lrch3"
                     /gene_synonym="2210409B11Rik; Gm1742"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcatgcg cagagccggg ccggagagtt gtcggctggg aaatggcggc cgcgggcttg
       61 gtggctgtgg tagcggctgc ggagtactct ggccctgtgg cgtccggggg aaacctctcc
      121 ggtgcgacct gtgggccgag ccctgggttg ggccctggtc ctggcccggg ctcttggagc
      181 cgctcggtcg accgagccct ggaagaggcg gcggtcaccg gggtgctgag cctgagcggc
      241 cggaaactga gggagtttcc ccggggagcg gccaaccatg acctgacgga caccacccgg
      301 gccgacctgt cacgaaatcg cctctcagaa atccctatgg aagcatgtca ctttgtttcc
      361 ctggaaagtc ttaacctata ccagaattgt attcggtata tcccagaggc tgttctaaac
      421 ttacaagctc tgacattcct aaatattagt cggaatcaac tgtcaacatt gccagtccac
      481 ttgtgtaact taccactgaa agtcttaatc gctagcaata acaaattggt ctcgcttcct
      541 gaagaaattg gacatctcag acatttgaca gaacttgatg taagctgcaa tgaaattcaa
      601 actgtgcctt cccaaattgg taatctggaa gccttgagag acttcaatgt aagaagaaat
      661 catcttctac gcttgcctga agagctggca gaggtgcctt tgatacggct cgacttctcg
      721 tgcaataaaa tcacagtgat ccctgtttgt taccggaacc tccggcacct ccaggtgatc
      781 accttggaca acaacccgct tcagtcgcct cctgcacaga tatgtataaa aggcaaaatc
      841 cacatattta aatacctgaa catacaagct tgtaagattg ctccagatct gccagattat
      901 gaacggaggc ccttgggatt tggatcctgc catgaagaac tgtactcagg ccgtccttac
      961 ggagccctgg attcaggctt caatagtgtg gatagtggtg ataagagatg gtcagggaat
     1021 gagcctacag atgaattttc ggatctgcct cttcgagtgg cagagattac caaagagcaa
     1081 agactgcgga gagaaagcca gtaccaggag aatcgcagca gtgtggcggt cacaaatggt
     1141 ggagtggagc atgatctgga tcagattgac tacattgaca gctgtactac agaagaagaa
     1201 gaaaacgacg tgaaacaacc caaaagcctg gacacgaaca gtctcagctc acagtttatg
     1261 gcatatattg aacaacggag aatctcacat gaggtttcac cagtaaagcc aatagccgtt
     1321 agagagtttc aaaaaacaga agacatgaaa agatactcac atcaaaacag ggttccagtt
     1381 gagccatctt tggtgttatc aatgccacca agtcacaatc agctttcaca ttcagacttg
     1441 gagcttcatc agaggagaga gcagtctatt gagtgcactc ggagagaggc acagcttgct
     1501 gccctgcagt acgaggagga gaaaataagg accaagcaga ttcagagaga tgctgtccta
     1561 gactttgtca aacagaaagc atcacacaac ccacagagac agcagccccc tgggaatggc
     1621 gagtgttcct tcccatccag aaggtcccag cacactgatg acagtgcctt gctagtgtca
     1681 ctgtcagggt tggatggagt gagctgcgtg gctacccggc ctcattcttc tgccttcaca
     1741 cctctcaaga gcgaaaacag agttgatgtc acctcaagct ttcctatgac agagacagtc
     1801 catcattccc ctgcgtattc ctttcctgct gctacccaga gaaatcagcc ccagcgccct
     1861 gaaagcttcc ttttccgagc tgctgtcagg gcagaagcta ataaaggtcg tgcatccccg
     1921 cttctcctgt catctgcacc tgcaactgat cctacagatg ctataacaag acagagagaa
     1981 gaagagctga aattaataga tcagctacga aaacacattg agtaccggtt gaaagtctct
     2041 ttgccctgtg accttggagc agctctaact gacggtgttg tactttgcca cttggccaat
     2101 catgttcggc ctcgatctgt cccaagcatt catgtcccat ccccagccgt gcctaaatta
     2161 acgatggcaa agtgcaggcg gaatgtggag aacttcctgg atgcttgcag aaaaatcggt
     2221 gtaccccagg agcaattgtg cttgcctctg cacattttag aagagaaagg gttgggccag
     2281 gttgcagtga cagtccaggc cctcctggag cttgccccac ccaagcagcc gccaccgcag
     2341 cagccgcagc agcagcagcc acagctctct gctgtctgag gactcccagg gccctgcatg
     2401 ttggcaccat gatggcacag ccaaaacaag gagcaggaag acttgattgc tggcactgcc
     2461 tgctcagggc gagcccggtg tgttcctaga agcactgtct tcatgattcc tgccaggaat
     2521 attgtgttcc ttttctccat tttaggggag attaaacccg tttccactat ttttcgtttt
     2581 taatgaagac acagtttttt taagtggaac ttggattact gaagacctat catggaagac
     2641 taagctggct gtgctttctt catagggagc aggctcgctt tccatgccag agccagtatt
     2701 ttcatagttg gatggtaagc tctcttagag gacagacata ttatctctgc cagttcccag
     2761 gtgtctacag ctcaatggtt tccacaactg gacttcattc tctggagcat ttgtgaaatc
     2821 cagatttgca tcaaaggttg ggatgtggcc ggagaacctg catttctaca gacattgttt
     2881 ttctcaggca gtggagacca ctgtttgaag gcacacagtt ctgtggtttg agggcaccac
     2941 ccctactgca ttttcaacca catttcaatc aaaagctgta ttatgatgac ttggactttt
     3001 ctgtcaaaga gagcaaaacc atggagaagc cctaggttct gctcagtata acaggtaact
     3061 aaggccagta cccaggccct tccccaggct tgcccaccac caccccatct ttttctagac
     3121 agtggttcct tgctcaccct gctgtttcct gaacagacac actccacaca cagttgtaag
     3181 ctctgaagtg tagcatgcac tgcccagcaa tgtttgcatt tgccttggtg aaccctgcgt
     3241 tctgatccca ggctcctgga ccaggcacag cagactcggc tcctgctcct gggactgaac
     3301 acaaagctga gaggactgaa ggaaagacgg ttcttacagt ccatgcaggt aacagccagt
     3361 ttccatagct acaagaaagc accgagaaca gcttcctgtc tttcacctgt cccctcccta
     3421 agaccctcca ctgtgagcag agaacagaag gtccaagggc tccagcacag cggaggagcc
     3481 ttcatttaaa cacagcacag agccttctct gccccagagt ttggactctt tagttgttgt
     3541 atctttggtg tttgctgcag ttagaaccca aatacagtaa ttacataaag ctgtttgttc
     3601 tatagggttt tccctatagt tgttaacttt tgtgggtttc ttcccaaggc ttgcatttca
     3661 gaatagtatt accctgcaca gcacctaaaa gtaactttaa gactggacca gggttccatc
     3721 cccagcatca cctgaaaaaa ggttcagaga gacgcgtggc ctgggattcc caacatccca
     3781 aaagtggaag ctggaggatc aggatttgaa gcccacacca ggcgatgcaa gccaccgccc
     3841 actgggctgt attagacttt ggctggagag ctggctcagt aggtaagagc acttactgct
     3901 ctggcaggtc agggttcagt ttccaacacc cacaagtcgg ttcacaactg cttgtaaccc
     3961 caagggtcca ctgcactcta ctggcttctg caggtaccag gcacatgcat ggtctacatt
     4021 tatacatgaa ggtaaaacac tcatgaataa aagtaagtat taaaaatata tattcttcct
     4081 ctgaaagtga ctttgaacca aatcattttg aatatctagt caaaataata tttctccttg
     4141 ttcgtgcaga aaagtattca ttagaacgct gccactttta ttcaagtttc aaagcatgta
     4201 acagcagcca ggcacggtgg ctcatgcctg taactcaggc gactagagct ctcgagaaaa
     4261 agtaagtcta acctagagca tcgtagtcct cacagaagag tagaaccaga gctcagagcc
     4321 tagcccgttc accagcagac cgcagagtgg cagccagagc ttgcctatga ccagctgtgc
     4381 tgctggaccg cagatttgct tcctctaggc agcattaaac ctcagcatca tttctaaatt
     4441 ccatatttaa ttgtacagaa aatgggccca gaagacatta cataatacaa cacttggaat
     4501 ggctacaaga gttcctaaaa gttgacatta ccgagcaggg tggcacatgc ttttactccc
     4561 agcttttgag tgacagagga gacagatctt attcacatat tgagttccag gacagccagg
     4621 gctccatagt gagaccctcc ctcagaaaga ggaggaggac attttaacac tgcggctttc
     4681 ctgagacctt acttaatgca cttaccaaac taatgcaact ctgaagggtt aggatacagt
     4741 tgcgcagtgt gagtcagcac acagcaggtc agtgcttctg ttgggccctg tggcttctta
     4801 caggtttcca aattggaaag gacaactcat ttggatattt aaccttgcta gaccccagcg
     4861 ggaaataaag ataaagttag ccatgtcata gtcccctgac cagcaatggc taccttgcca
     4921 atggtaaggt agatgagcca agtgtctgcc tggctctgcc ctgccacctg cagagatgtt
     4981 atgtcagcag tctgcaggct gccaggcact ctgaccagga ttcccctgta atgagcaggt
     5041 ctgatgaact ttccagagga actttcctat ctgcctagaa cagactagaa aaggcagagc
     5101 agtgggtggc ttccaatcca gcagctctgt aaatacatcc ttgcaactaa tgaaggagcc
     5161 tgctgtttct ttgcctctag tcagcagtga ctaataatgt ggtatgctga cgagtctgat
     5221 ggacttttaa gaactaagta cttagatggt tgtagaaatg aaggaaaact tggttattta
     5281 gaagcctttt tcattgcagt gagatggttt acagcagatt ttatttctga agtgttataa
     5341 acatgtaatt aataagtttt tgtaaacatt gtcctatatt tgtatgtttg taaatatttg
     5401 tgtaagttct aagtataaat atgtcagtac tgtgtatgtt attttaaatt gcctgtatgt
     5461 catcttatat gtggacatta aaagccaata tactccagta gcatgtaata aacactttaa
     5521 attgttccag cctaaagcat ggttttcttg ccagagacca gtcatggaaa ggccatttat
     5581 ctggctcact gaacctttga ggctcacagt ctctttctta aagaggtaca gatagcaggc
     5641 tggcctgcgt aggcagtgga tgagaaggct ccactcaggc tggggctgga gtacagtcag
     5701 aagtgtgcct actagcatgc atggagtcca agttccattc ccaacgctgc ataaaccagg
     5761 tatggtcact cgcccctgta gttctagcac ttaggaggca caacatgagg ttcaaggcca
     5821 ctagactacg tagtgaattt gaaaccaacc tgggccacat gagaccctgc atcaaaaagt
     5881 ttaaatttta tattcatgaa atatgtgaga cacattaa
//
