LOCUS       NM_001162926            5563 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus LRAT domain containing 1 (Lratd2), mRNA.
ACCESSION   NM_001162926 XR_035220 XR_035243
VERSION     NM_001162926.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5563)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5563)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5563)
  AUTHORS   Homer-Bouthiette,C., Zhao,Y., Shunkwiler,L.B., Van Peel,B.,
            Garrett-Mayer,E., Baird,R.C., Rissman,A.I., Guest,S.T.,
            Ethier,S.P., John,M.C., Powers,P.A., Haag,J.D., Gould,M.N. and
            Smits,B.M.G.
  TITLE     Deletion of the murine ortholog of the 8q24 gene desert has
            anti-cancer effects in transgenic mammary cancer models
  JOURNAL   BMC Cancer 18 (1), 1233 (2018)
   PUBMED   30526553
  REMARK    GeneRIF: We propose Myc as a candidate susceptibility gene,
            regulated by the gene desert locus, and a potential role for Fam84b
            in modifying breast cancer development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5563)
  AUTHORS   Uslu,V.V., Petretich,M., Ruf,S., Langenfeld,K., Fonseca,N.A.,
            Marioni,J.C. and Spitz,F.
  TITLE     Long-range enhancers regulating Myc expression are required for
            normal facial morphogenesis
  JOURNAL   Nat Genet 46 (7), 753-758 (2014)
   PUBMED   24859337
REFERENCE   5  (bases 1 to 5563)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   6  (bases 1 to 5563)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 5563)
  AUTHORS   Geschwind,D.H., Ou,J., Easterday,M.C., Dougherty,J.D.,
            Jackson,R.L., Chen,Z., Antoine,H., Terskikh,A., Weissman,I.L.,
            Nelson,S.F. and Kornblum,H.I.
  TITLE     A genetic analysis of neural progenitor differentiation
  JOURNAL   Neuron 29 (2), 325-339 (2001)
   PUBMED   11239426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN663980.1, AK139928.1, AK162412.1 and BY426787.1.
            
            On or before Jul 2, 2009 this sequence version replaced
            XR_035220.1, XR_035243.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN663980.1, AK139928.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               CN663980.1         1-120
            121-731             AK139928.1         1-611
            732-1914            AK139928.1         613-1795
            1915-5337           AK162412.1         1-3423
            5338-5563           BY426787.1         144-369
FEATURES             Location/Qualifiers
     source          1..5563
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 25.7 cM"
     gene            1..5563
                     /gene="Lratd2"
                     /gene_synonym="D330050I23Rik; Fam84b"
                     /note="LRAT domain containing 1"
                     /db_xref="GeneID:399603"
                     /db_xref="MGI:MGI:3026924"
     exon            1..567
                     /gene="Lratd2"
                     /gene_synonym="D330050I23Rik; Fam84b"
                     /inference="alignment:Splign:2.1.0"
     exon            568..5563
                     /gene="Lratd2"
                     /gene_synonym="D330050I23Rik; Fam84b"
                     /inference="alignment:Splign:2.1.0"
     CDS             664..1596
                     /gene="Lratd2"
                     /gene_synonym="D330050I23Rik; Fam84b"
                     /note="family with sequence similarity 84, member B"
                     /codon_start=1
                     /product="protein LRATD2"
                     /protein_id="NP_001156398.1"
                     /db_xref="CCDS:CCDS49613.1"
                     /db_xref="GeneID:399603"
                     /db_xref="MGI:MGI:3026924"
                     /translation="MGNQVEKLTHLSYKEVPTADPTGVDRDDGPRIGVSYIFSNDDED
                     VEPQPPPQGLDGGALSDSGDRPPLPPPQPYDPRQHEVECSVFYRDECIYQKSFAPGSA
                     ALSTYTPENLLNKCSPGDLVEFVSQAQYPHWAVYVGNFQVVHLHRLEVSNSFLTDASQ
                     GRRGRVVNDLYRYKPLSPSAVVRNALAHVGAKERELSWRNSESFAAWCRYGKREFKIG
                     GELRIGKQPYRLQIQLSAQRSHTLEFQSLEDLIMEKRRNDQIGRAAVLQELATHLHPA
                     EPDEGDSDATRTTPSPLRPPASGSEEENGDSVVH"
     regulatory      5218..5223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lratd2"
                     /gene_synonym="D330050I23Rik; Fam84b"
                     /note="hexamer: AATAAA"
     polyA_site      5243
                     /gene="Lratd2"
                     /gene_synonym="D330050I23Rik; Fam84b"
                     /note="major polyA site"
     regulatory      5318..5323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lratd2"
                     /gene_synonym="D330050I23Rik; Fam84b"
                     /note="hexamer: AATAAA"
     polyA_site      5338
                     /gene="Lratd2"
                     /gene_synonym="D330050I23Rik; Fam84b"
ORIGIN      
        1 cagcccgatt taaacccgct acggaggggg cacggtcctg gaagggcgga gcagccctag
       61 tgggcggggc gggggcgggg ctccgaggga ctaagctggg tacaggaaag accggagctc
      121 tcagagccac gtctgtctct ttaaatgcca cgggctgcac tcccgcccgg gagccccgag
      181 ccggatctac aatcccgtcc ctcccgctcc ggcgcttgtt gctcgcctag cccgagcggg
      241 agctgcggcc cccgggaaac ccagctagct ccttcggctt ccctcctcgt gccccacctt
      301 cctggaaatc tgcgtgaggg gtcgtgcagc aacgatcgtg aacaggcatt gccccccatc
      361 ttcaagtctt ggggctctac acaaccgcgg ggggcggcga gggagaaatg cgtccttccc
      421 cgaagcccag cttcgccttg gtctgcgctg ggagaggagg cactgcggag cccacacctg
      481 cgaactcgcc ctagaagtct cgggtgcggc agggtgcccc tcccggtccc ctagggcttc
      541 tacctctcgg ggagagagtc cgcgcaggtg gctttagccc ctgcccgggc accagtgcca
      601 atgactctga cggtggtttc gctttctcct cttgaagtct tgtgaacgag agtccacagc
      661 gtaatgggca accaggtgga aaaactgacc cacctaagtt ataaggaagt tcccacggcc
      721 gacccgaccg gcgtggatcg agacgatggg ccccgcatcg gagtctctta tattttctcc
      781 aatgacgacg aggatgtgga acctcagcca ccgccccagg ggcttgatgg cggagctttg
      841 tccgactccg gggatcggcc tcccctgccc ccgccgcagc cctacgaccc gcggcagcac
      901 gaggtggaat gctcggtgtt ttatcgtgat gagtgcatct atcagaaaag cttcgcgcca
      961 ggatcggcgg ctctgagcac ctacacaccg gagaacttgc tcaacaagtg cagtccgggt
     1021 gacctggtgg agtttgtatc gcaggctcaa tacccgcact gggctgtcta cgtgggcaat
     1081 ttccaggtgg tgcatttgca ccggctggag gtgagcaaca gcttcctgac cgatgcgagc
     1141 cagggccggc gcggccgcgt ggtcaacgat ctgtatcgct acaagccact gagccctagc
     1201 gctgtagtgc gcaacgcgct ggcccacgtg ggcgccaagg agcgcgagct cagctggcgc
     1261 aactccgaga gctttgcggc ctggtgccgc tatggcaaac gcgagttcaa gatcggtggc
     1321 gagctgcgca tcggcaagca gccctaccgt ttgcagattc agctctcggc tcagcgcagc
     1381 cacactctcg agttccagag cctggaggac ttgatcatgg agaagcggcg caacgaccag
     1441 atcggacgcg cggcggtgct acaggagctc gccacgcacc tgcacccggc tgagccggat
     1501 gagggcgaca gcgacgcgac tcggactaca ccgtcccccc tgcgtccccc agcatcgggc
     1561 tccgaggagg agaacggaga ctcggtcgtg cactgatact tgaactgggc tcagagctac
     1621 aaaaggaagc tgtttgctgc agccacgccc tcttcctccc gctcttctcc cccccccaac
     1681 acttgggccc catttagtat tcctgggcct tttggaaaaa gcggagttgg tgaaatgtac
     1741 tgcaggcttt ggacagggga ggaggaaggg gacttaggga gcaggtagga ttggctggtg
     1801 ggtggccatg ggatgctttt tcttcaggcc ctctcagtcc accttccttt cccaggtggg
     1861 gtaaagtggg aacttgcttg cggcttcaac cctatcagat ctgggaccaa atttaaccct
     1921 tcgtatacaa gcaggcttgg gggaaatctc agagcacatt tgccctgcat tctgtctctc
     1981 tggatccctc actacactca gcttggagga tgcagggtac aaaggccgga gaggattggg
     2041 gaggagccgc ttcgggtctg ctgggagaac tgcttatctg cttcccccgc tgagctgtgc
     2101 ttgggatcct agaagctgga gtgatttatt tttatgggat tcccggggca caaggctgct
     2161 gaaactacaa gatctgggat cagcagacca aaaccaaaca gccccgtatt aagtgcagca
     2221 aatactttag caaactcagg ctacaggcta caaaaggatt tcactacctc cccctcccta
     2281 tccccaagta cctcctcttg ggaagctggc tctaagcgga gtctttggct tagactccaa
     2341 ttccttcccc cggttacaag taaatcattg tcaagggcca gccagggaaa ggattcaatt
     2401 aaggtgccat tctgcctcct gtgtttttgg cctgctgttg tggactctta gagctatggt
     2461 gttgttatca ggggaggcaa tagccctttg tgtctctgat ctaattaaac ctgtttggcg
     2521 tgttcatctg caggtcacag atggggttgg cttgtgccac cccataaagt atcctctagg
     2581 gaatcaacca gtgctaccct ggaaagaatt aaatctctcc ttgtcccctt gctaagtggt
     2641 gaaagtaacc ctttaaaaac caagctggac ctagggttcg ttttgctttt tgtttttctc
     2701 tccctggtct cccttcctcg acagacagtt gctgtggtag ggtgagggtt actttgccat
     2761 ccatgatggg tgaagtttaa agtacaaagt cttgtcatat gtacccaatt tctttgtggc
     2821 ttggagaaca tccgattcag aaccctttac taagggtggt ggcatcagac acagatccca
     2881 tgtagtactg tcagaagaga tttgatgaca gtcccaaacg taggttggtg gtggcggcat
     2941 tcggacaggc tgaagaggta gcaattgtgt ctgcaactga acttccgtgc actttagtac
     3001 aaggctttaa gactgcgaca gcctggtgcc tgaaccgaag gcagaccttt gactgccgag
     3061 ggcttatagg cagtctgtca actgctttca aaaactgagc atacttaaag gcctttgctg
     3121 cttccaccag tttttataac actggaacta gttcttagat tggaacaaaa tcttacttga
     3181 gtgtcctgaa gccacggtca ttgttgggct tcttgcttgg ggaatctttg aactccccct
     3241 cccccctttt tttaataagc ctaaatcttc atagtacctc agtatgaaac ggtttcgtta
     3301 gttataaagg catcaaatgc tctttctgct tttataatgc ttaccaagca agtccttgtt
     3361 ctttgaatgt caaagatgag ctacctacac actagccttg gtttcagaca ttggaggaga
     3421 accattttct agttaggagt atggatctga tttccctgtt taatgagctc ataggtattt
     3481 gattacatag tcttgtccat ggaacagcag agagaataaa cacagaggat attatttagg
     3541 gaaacctatg tctaacagat ttgtgaaagt ggaaattgat gcccgctgtg tagactgcag
     3601 gaggggagga atcagaatgg ctgtccacca gcagctctgg aatagcaaac tctcccggct
     3661 ctcccatcct tgccttcttt ctcagacctc aaagaccata ctaagtgtag caggtaactt
     3721 gtgttatata tgaagtacct gcaaaggaag aactcctaag gtccacccca cctgtagcat
     3781 tcctctttga aagttgatct gtttcagacg atggtttctg gaatgtgctg ccagcagttt
     3841 tgctgggtac taataatgcc aaatatgtaa tacttaggaa gagctaacac gctgaaagtt
     3901 ttcttagggg gtagaaagtc taaggcagtg gtcctcaacc tgtgggtcct gatccttttg
     3961 gatgttgcat gctaggtatt tgcattacgg ttcataacag tagcaaaatt atagttatga
     4021 agtaacaaca gaataattct gtggttgagg gtcactacaa cctgagaaag taaccatatt
     4081 taagggtcat aggattcggt cgagaaccat tgctctaaag taaagaacat caatttaggg
     4141 ctctaagata cagtgtcgtg tcatctcttg ctttttaaga ctgcagtgtt gtggggaaaa
     4201 cattttttta ctttaatgtt ctggcaatgg ctacatctgg cactttaggg ggaaaaaagt
     4261 atattaataa tttttgtctc tctttaggaa taagacatag aactattttg tactgtgaat
     4321 tatggacact ctttgaagga aagaaatatt aattccagtg tttttctgaa gctctggaaa
     4381 gggataataa gcaagacccc gtggaacacg tacaaaaaga gaaaccagac aaattctatt
     4441 ttcttacccg agcaaatatt ttattgagac tgcttatgta tgtcaaagga gcctacaact
     4501 tcagctacac aactttttgt attgaaagaa ctcgtacttt tgtagctttt attccacatt
     4561 taatttaaaa atgactttgt aacactaaag tgtctagcaa aagactttat tccagatctt
     4621 gaagaaaatt tttagttttt atggaaatgg ttcagtggtt cagcttctca aagctgcggt
     4681 gctcctggcc ctcctggcac catgggacaa ggacaaccac gtgacaacat atttttttgg
     4741 aagcaaaact ttaattttat atgacatata ctatgaaaag ctaagaaaat ttaaggacta
     4801 ctagtttcct ttttctttct ttcttttttt tttcttttta aaatgggatc cactgtgttg
     4861 aagactcttg atatcatgtg cttgtctaga cattttaaaa aaacaattta aatagaattg
     4921 agcgtgatca tagttatcca atggatttgt ttggagaatt agattttatt tgtgaattgt
     4981 ttaaaaaaaa tcaggatact gataaatttg actgtttttt tctcttctca ttatgtttta
     5041 ttcttggtta tgaatcagga tatatactcc aggcattttc tttcccagca aattgtagga
     5101 actttaattt gattggcagt tgtatgttaa atcagttttc tttcaccact tcttgagaag
     5161 gcggttccag tttgaaattg tatcatttcc ttcaaaatga agggccgtac ttagttaaat
     5221 aaaagattga tgacatcttt taagccgctt cctctttact ctgtcttatt aaaatgaaag
     5281 ctgtcaagtc cttttgaaaa atgttatgag ggttcccaat aaaccatcta ttattagagc
     5341 tcagtgtatg actttctcca catagacacc ctttcttttg acgttttttt atatcaattc
     5401 aagctgttca acttactgta atattagtgg gtgtcatcct tgcattgctc agtgaatagt
     5461 ttgttgggtc cggttagtgg cccaaactct tatatttatc acgtgggaat tatgctgtct
     5521 gtgttcacga aaagtatctt attttcaata caacagttac aat
//
