LOCUS       NM_023624               5349 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus lecithin-retinol acyltransferase
            (phosphatidylcholine-retinol-O-acyltransferase) (Lrat), mRNA.
ACCESSION   NM_023624
VERSION     NM_023624.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5349)
  AUTHORS   Shymotiuk,I., Froese,N., Werlein,C., Naasner,L., Szaroszyk,M.,
            Kuhnel,M.P., Jonigk,D.D., Blaner,W.S., Wende,A.R., Abel,E.D.,
            Bauersachs,J. and Riehle,C.
  TITLE     Vitamin A regulates tissue-specific organ remodeling in
            diet-induced obesity independent of mitochondrial function
  JOURNAL   Front Endocrinol (Lausanne) 14, 1118751 (2023)
   PUBMED   36891060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5349)
  AUTHORS   Huh,C.Y.L., Leinonen,H., Nakayama,T., Tomasello,J.R., Zhang,J.,
            Zeitoun,J., Peach,J.P., Halabi,M., Kiser,J.Z., Palczewski,K.,
            Kiser,P.D. and Gandhi,S.P.
  TITLE     Retinoid therapy restores eye-specific cortical responses in adult
            mice with retinal degeneration
  JOURNAL   Curr Biol 32 (20), 4538-4546 (2022)
   PUBMED   36152631
REFERENCE   4  (bases 1 to 5349)
  AUTHORS   Yan,F.Z., Qian,H., Liu,F., Ding,C.H., Liu,S.Q., Xiao,M.C.,
            Chen,S.J., Zhang,X., Luo,C. and Xie,W.F.
  TITLE     Inhibition of protein arginine methyltransferase 1 alleviates liver
            fibrosis by attenuating the activation of hepatic stellate cells in
            mice
  JOURNAL   FASEB J 36 (9), e22489 (2022)
   PUBMED   35959865
REFERENCE   5  (bases 1 to 5349)
  AUTHORS   Gao,H., Jin,Z., Bandyopadhyay,G., Wang,G., Zhang,D., Rocha,K.C.E.,
            Liu,X., Zhao,H., Kisseleva,T., Brenner,D.A., Karin,M. and Ying,W.
  TITLE     Aberrant iron distribution via hepatocyte-stellate cell axis drives
            liver lipogenesis and fibrosis
  JOURNAL   Cell Metab 34 (8), 1201-1213 (2022)
   PUBMED   35921818
REFERENCE   6  (bases 1 to 5349)
  AUTHORS   Liu,L. and Gudas,L.J.
  TITLE     Disruption of the lecithin:retinol acyltransferase gene makes mice
            more susceptible to vitamin A deficiency
  JOURNAL   J Biol Chem 280 (48), 40226-40234 (2005)
   PUBMED   16174770
  REMARK    GeneRIF: LRAT-/- mice are much more susceptible to vitamin A
            deficiency and should be an excellent animal model of vitamin A
            deficiency
REFERENCE   7  (bases 1 to 5349)
  AUTHORS   O'Byrne,S.M., Wongsiriroj,N., Libien,J., Vogel,S., Goldberg,I.J.,
            Baehr,W., Palczewski,K. and Blaner,W.S.
  TITLE     Retinoid absorption and storage is impaired in mice lacking
            lecithin:retinol acyltransferase (LRAT)
  JOURNAL   J Biol Chem 280 (42), 35647-35657 (2005)
   PUBMED   16115871
  REMARK    GeneRIF: LRAT has a role in retinoid absorption and storage
REFERENCE   8  (bases 1 to 5349)
  AUTHORS   Batten,M.L., Imanishi,Y., Maeda,T., Tu,D.C., Moise,A.R.,
            Bronson,D., Possin,D., Van Gelder,R.N., Baehr,W. and Palczewski,K.
  TITLE     Lecithin-retinol acyltransferase is essential for accumulation of
            all-trans-retinyl esters in the eye and in the liver
  JOURNAL   J Biol Chem 279 (11), 10422-10432 (2004)
   PUBMED   14684738
  REMARK    GeneRIF: Lecithin-retinol acyltransferase is essential for
            accumulation of all-trans-retinyl esters in the eye and in the
            liver
REFERENCE   9  (bases 1 to 5349)
  AUTHORS   Zolfaghari,R. and Ross,A.C.
  TITLE     Lecithin:retinol acyltransferase from mouse and rat liver. CDNA
            cloning and liver-specific regulation by dietary vitamin a and
            retinoic acid
  JOURNAL   J Lipid Res 41 (12), 2024-2034 (2000)
   PUBMED   11108736
REFERENCE   10 (bases 1 to 5349)
  AUTHORS   Ghyselinck,N.B., Bavik,C., Sapin,V., Mark,M., Bonnier,D.,
            Hindelang,C., Dierich,A., Nilsson,C.B., Hakansson,H., Sauvant,P.,
            Azais-Braesco,V., Frasson,M., Picaud,S. and Chambon,P.
  TITLE     Cellular retinol-binding protein I is essential for vitamin A
            homeostasis
  JOURNAL   EMBO J 18 (18), 4903-4914 (1999)
   PUBMED   10487743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158935.4.
            
            On Mar 21, 2008 this sequence version replaced NM_023624.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF255061.2, BC141375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-802               AC158935.4         74703-75504         c
            803-5349            AC158935.4         64112-68658         c
FEATURES             Location/Qualifiers
     source          1..5349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 36.81 cM"
     gene            1..5349
                     /gene="Lrat"
                     /gene_synonym="1300010A18Rik"
                     /note="lecithin-retinol acyltransferase
                     (phosphatidylcholine-retinol-O-acyltransferase)"
                     /db_xref="GeneID:79235"
                     /db_xref="MGI:MGI:1891259"
     exon            1..802
                     /gene="Lrat"
                     /gene_synonym="1300010A18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..958
                     /gene="Lrat"
                     /gene_synonym="1300010A18Rik"
                     /EC_number="2.3.1.135"
                     /note="phosphatidylcholine--retinol O-acyltransferase"
                     /codon_start=1
                     /product="lecithin retinol acyltransferase"
                     /protein_id="NP_076113.1"
                     /db_xref="CCDS:CCDS17430.1"
                     /db_xref="GeneID:79235"
                     /db_xref="MGI:MGI:1891259"
                     /translation="MKNPMLEAASLLLEKLLLISNFKLFSVSVPGGGTGKNRPYEISS
                     FVRGDVLEVSRTHFIHYGIYLGENRVAHLMPDILLALTNDKERTQKVVSNKRLLLGVI
                     CKVASIRVDTVEDFAYGADILVNHLDGTLKKKSLLNEEVARRAEQQLGLTPYSLLWNN
                     CEHFVTYCRYGSRISPQAEKFYDTVKIIIRDQRSSLASAVLGLASIVYTGLASYMTLP
                     AICIPFCLWMMSG"
     exon            803..5349
                     /gene="Lrat"
                     /gene_synonym="1300010A18Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcaccgcc cccaggcaca ctacctcttc agctcctcaa gcgcgggtgc cactgttccc
       61 acagccgacc gacactactt cctttctttg accccctgca ctgggtggct gagccaagca
      121 ctttggcttc tcctctgatc tcttgctctc ctggctctgg gcagccgcag cggtgctccg
      181 caggtgagca gcgctgcagc gcggcgatcc ggagagctca cctcgtacag aacagttgca
      241 gccagtggtt ggttgcctta ggatgaagaa cccaatgctg gaagctgcgt ccctcctcct
      301 ggagaaactg ctccttattt ccaacttcaa gctctttagc gtgagcgtcc cgggaggagg
      361 cacagggaag aaccgtccct atgaaatcag ctctttcgtc cggggcgacg tgttggaggt
      421 gtcacggacc cattttatcc actatgggat ctacctgggg gaaaaccgtg tcgcccatct
      481 aatgcctgac atcctgttgg ccctgaccaa tgacaaggaa cgcactcaga aggtggtctc
      541 caacaagcgt ctcctcctgg gagtcatttg caaggtggct agcatccgtg tggacacagt
      601 agaggacttt gcctacggag cagacatcct agtcaatcac ctagacggga ctctcaagaa
      661 gaagtcctta ctcaatgagg aggtggcacg cagagctgag cagcagttgg gactgactcc
      721 atacagccta ctgtggaaca actgcgaaca ctttgtgact tactgcagat atggctctcg
      781 gatcagtcca caggctgaga agttctatga caccgtgaag ataatcattc gtgatcagag
      841 aagcagtctt gcttcggctg tcttgggatt agcatctatt gtctacacag gcctggcatc
      901 atatatgacc cttcctgcaa tctgtatccc attctgcttg tggatgatgt ctggctagct
      961 tccagtccac aggtcaacgt gtatgtattt tgtgtagaaa tgtgtttata tttatagagc
     1021 acaaaacatt ataagcattg ttgttaaaaa tgtggcccac aacactgtgt tctcgataaa
     1081 aaacaacaac aacaacaaga aaccaagtga ttaagaatca taccacgtgc ttgccatgta
     1141 agccaaacaa agtctttctg agtcctctca ggcagctctg ctgcagagca ccacgagccc
     1201 ctggaagcgt gtgtcagcct gtcagaagtc agcagccgga ggaagtggca cctgaggtga
     1261 cagccacagg agattctgta ggttattctt ttcctcctgt catcatcctg ctgttaggct
     1321 tatctgttga gatcactaac tttattgtaa tgtattctta tttaatgact gacattaaag
     1381 tgaaagtttc ccctcatttg gatgaatata tgtttgaaaa ttagctaaaa ggaaaccaat
     1441 tagtcttttt aaaaattcgc ctttctttat gtaataatct aatcttaagt aagtcaagaa
     1501 tattattttc atgttttgag accattgttg aaagagttta ctgagagtga ctgttcagaa
     1561 agcagttact agcaatggag aaacagtgac agacagtagc tatttatatt tacttttgaa
     1621 tagcctgata ctgtattgtt cttccttcct ttttgtatgc ctatatgacc aatttaaaag
     1681 atgtaaatga atataggatt gagatgattc tggtattaga tatgcatatg tgtcatataa
     1741 atacacaata tctgcactca catagattga taggtaaact atatttctgg ttgctttatt
     1801 acactagcgc catttattaa tgaggatcta caaacataaa atcaagccca gtgtcttttc
     1861 ctgtgccctt gagtctgtat gtgaatatgt gtatagatat atttgtcact ggatagttac
     1921 ttttaaagct aaatttacta atgtcctttt aaaaaatgtc agatttgctt tacagtcatt
     1981 tttccacttt tagtatcatt tataaacaca atagaggtgt gtcacagcag tataaaagcc
     2041 taaataagta gggccaaaaa tttattctga gaactagtaa tgtcaagcat tgaaggtgtg
     2101 tttcctcact ccactgggtc agagtggaga cctagcagtg tttaaagcat gcctccaaga
     2161 ctgtcacgaa aaatgaccca tgttggagtc acatttctgg tactgaactg ttttaccaga
     2221 ggaggtacat gcaacacctg tacttaaaag gttgaaccag cagattgaga gctccagacc
     2281 tgtgtgggct gcagcacaat actgtctgct gtctgttaac tgtcaaaagt tacacagcag
     2341 gcatcgaaga gatgactccg caccgaagag ctattgctac tcttgaagag gaccaggatt
     2401 tagttaccag cagctcctgg tggcttataa ccttctgtaa ctccaattcc agaagattca
     2461 acaccctctt ctggcctcca tgtgtacaac atacatggta gacagacata cacacacaca
     2521 cacacaatta aaaataaaac ttaaaaaaaa atcacagaat agccaagcat gtaatcacac
     2581 cccttgggat gtggaggcag gaagattggg agttcaagac tagcctgctc acacagaggg
     2641 tttaagactt gtttgcattg cccagagggg tcgaaggcca gcttgtacta cataggtagt
     2701 tcaagaccag tctggctaca tgagacaaaa gaatcacagt acagtgactc ttatggcaga
     2761 aaggaggatt tgttttagtc agtgagccaa cctgaacaaa ggagagaaca gcgtttagtt
     2821 taactgaggt cttattaccc agtgttctcc tacaacaaat ttagttggag tataatgata
     2881 attaaacttt gtttaatatc caaattaaac atttaattgc ttaaatgttt catatcagta
     2941 aaacactgaa tggaaaaaaa attaaagaat ataggtgttc tttgggcctg ttccaaccac
     3001 ctaaattacc tgaagtatct gtgcatctga caggcattgg ttagtgcctt tttcctcttc
     3061 accatggaag ttgtttacat gaattcatta tagcacgccc ccctccagac atcagtattg
     3121 taggtaatag gaaatgctgt ttgaaactaa atctgtgttc acagatagtg gttcctcctt
     3181 acctactaag gggattcttg gggctagaat taacataagt aatcctgact ttcttcatat
     3241 cattagacca agactcattt gtcattcatt ggatgctcat tctgtgctaa gcacttaagt
     3301 actgcaacgt catgttctgg tattatttta cacttttttg agacaggttc tcactcaatg
     3361 ggtgagattt gcctagaagg aattccctaa gagagctgtg tgcctcagct tcccaagtgc
     3421 tggggttaaa ggtatgctca ccactccagg cctaatatta cttttatcca gctataacag
     3481 catgcattca ctgtggtggg aaatacagac agaagagcaa gcaattctgc ctcaggagtc
     3541 aggcacttta cttgaaggag gcaataataa ccaggaagct gacccactga ggtaattttg
     3601 taacactgac atcattctac tctctttggg aagagaggaa aagaaggaag gatctatttg
     3661 gcaaatgtta cacaacacca gaatcattga acttgtagat aagagaatct ctttcgtttt
     3721 tttttttttt tccatttgat agaaataaag acgtcggtta tggaggaaac cttgggccaa
     3781 gcatttgttt cctaacctga ggtggcaagt cgtggatttc tctagacttt atcagtcaaa
     3841 gcttatatta tgatccaagt tcatgatatt atagtacttc tgttctgtct tgtacagtga
     3901 tagctaagtc atgtctggtg atgttttcat ctcttgatgt gttctttgca tagatagggg
     3961 ccacaggact tgctgggttt aagatgactt catgcaagta tcagggagta ggctgtgtat
     4021 ggaatgaaaa gatatatgag atgtggccta aaatatctgg tctaataggc acagttgcac
     4081 tggagtttga gtgattgaca tcttaataga gctaactgaa ggcacacaga gagaagggac
     4141 taattttagc tgatgaaacc aaaatcaggc aggggtactg agaatacaat gattggacaa
     4201 atttgcacag gacattccac acatgggaac ggcatgggga atgaatggaa actgcctaca
     4261 atatgcatca tgaatagctt gaggtattct atgtcaggta aatgcaagtg gtctaggggc
     4321 tgctgagcaa gggtggtgac tagacataca gaaacacaaa gcaaggctga gatggtgtaa
     4381 gtcttttgta gatcaagaag tttggacttt atggataggc agtagagagt tgggggatag
     4441 aaagataact tccaagaata aagcagaagg gtggggctgg ggcaggatag agagacctga
     4501 gagatttagc gaagtaaggt ctttgtctgt cagataagtg tctagatcag tggttctcaa
     4561 cctccctagt gctgcgatcc tttaatgcag ttcctcatgt tgtggtgaca cccccccaca
     4621 ccccgcaacc ataaaattat cttcattgct acttcacaac tgtaattttg ttactgtttt
     4681 gagtcataat gcaaatatct gatatgtagg ttatctaata ggtgacccct gtgaaagact
     4741 tgttagatgc cccaaagcgt cctgacccac aggtcgagaa tcaccggcat agatggtgag
     4801 atggctcagt gaggaagtat accttctgca aagcctgatg acccaagttc aagtaagggt
     4861 ctacacttgc aagtcgagaa agcagtatgt cagagaagtg ccaaacaact ggaagcactt
     4921 agatttgact gatgaacgac tctgatggag tgttagggaa tatcatgtct ccttgatttt
     4981 cctgagaagg cgttgattac tgcaaaataa attaacttta caactgtgca tacactccta
     5041 acattcactc ggctaggtgt gctcctttct aaggacatgt aaggaagttt ggatttgttg
     5101 ttttcatttt atcagaacct atttcttact tccctgtttc ctatttcata ttgtttatgt
     5161 ccaagactaa aagctgcttt tcaggaacat ggtattactg taatggcaat cttttgttat
     5221 ggataagaag cacatgggca gagattttat tttatataat ctatctaggg tgttaatcaa
     5281 cttagatatt ttagttaaac taagtttata ttgatacaca tgtattttga ataaaatcag
     5341 ttctacata
//
