LOCUS       NM_178665              15669 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus LIM domain containing preferred translocation partner
            in lipoma (Lpp), transcript variant 1, mRNA.
ACCESSION   NM_178665
VERSION     NM_178665.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 15669)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 15669)
  AUTHORS   Kiepas,A., Voorand,E., Senecal,J., Ahn,R., Annis,M.G., Jacquet,K.,
            Tali,G., Bisson,N., Ursini-Siegel,J., Siegel,P.M. and Brown,C.M.
  TITLE     The SHCA adapter protein cooperates with lipoma-preferred partner
            in the regulation of adhesion dynamics and invadopodia formation
  JOURNAL   J Biol Chem 295 (31), 10535-10559 (2020)
   PUBMED   32299913
  REMARK    GeneRIF: The SHCA adapter protein cooperates with lipoma-preferred
            partner in the regulation of adhesion dynamics and invadopodia
            formation.
REFERENCE   3  (bases 1 to 15669)
  AUTHORS   Leung,C.S., Yeung,T.L., Yip,K.P., Wong,K.K., Ho,S.Y., Mangala,L.S.,
            Sood,A.K., Lopez-Berestein,G., Sheng,J., Wong,S.T., Birrer,M.J. and
            Mok,S.C.
  TITLE     Cancer-associated fibroblasts regulate endothelial adhesion protein
            LPP to promote ovarian cancer chemoresistance
  JOURNAL   J Clin Invest 128 (2), 589-606 (2018)
   PUBMED   29251630
  REMARK    GeneRIF: cancer-associated fibroblasts regulate endothelial LPP via
            a calcium-dependent signaling pathway involving
            microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase
            (FAK), ERK, and LPP
REFERENCE   4  (bases 1 to 15669)
  AUTHORS   Tan,J., Chen,X.J., Shen,C.L., Zhang,H.X., Tang,L.Y., Lu,S.Y.,
            Wu,W.T., Kuang,Y., Fei,J. and Wang,Z.G.
  TITLE     Lacking of palladin leads to multiple cellular events changes which
            contribute to NTD
  JOURNAL   Neural Dev 12 (1), 4 (2017)
   PUBMED   28340616
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15669)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 15669)
  AUTHORS   Petit,M.M., Meulemans,S.M. and Van de Ven,W.J.
  TITLE     The focal adhesion and nuclear targeting capacity of the
            LIM-containing lipoma-preferred partner (LPP) protein
  JOURNAL   J Biol Chem 278 (4), 2157-2168 (2003)
   PUBMED   12441356
  REMARK    GeneRIF: LPP contains specific domains that enable its focal
            adhesion and nuclear targeting capacity [LIM-containing
            lipoma-preferred partner [LPP]
REFERENCE   7  (bases 1 to 15669)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 15669)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 15669)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 15669)
  AUTHORS   Fedele,M., Berlingieri,M.T., Scala,S., Chiariotti,L., Viglietto,G.,
            Rippel,V., Bullerdiek,J., Santoro,M. and Fusco,A.
  TITLE     Truncated and chimeric HMGI-C genes induce neoplastic
            transformation of NIH3T3 murine fibroblasts
  JOURNAL   Oncogene 17 (4), 413-418 (1998)
   PUBMED   9696033
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ166632.1, AK040643.1, AC135567.3, AK085890.1, AK050035.1 and
            BF018106.1.
            
            On Mar 21, 2009 this sequence version replaced NM_178665.4.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045288.1, AK169780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               CJ166632.1         2-473
            473-3611            AK040643.1         27-3165
            3612-3612           AC135567.3         45839-45839         c
            3613-4238           AK040643.1         3167-3792
            4239-4648           AK085890.1         368-777
            4649-4649           AC135567.3         44802-44802         c
            4650-5276           AK085890.1         779-1405
            5277-5522           AC135567.3         43929-44174         c
            5523-7304           AK050035.1         134-1915
            7305-15644          AC135567.3         33807-42146         c
            15645-15669         BF018106.1         3-27                c
FEATURES             Location/Qualifiers
     source          1..15669
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 16.17 cM"
     gene            1..15669
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:210126"
                     /db_xref="MGI:MGI:2441849"
     exon            1..255
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            256..365
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            366..475
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            476..541
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            542..743
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     CDS             551..2392
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lipoma-preferred partner homolog; lipoma preferred
                     partner"
                     /codon_start=1
                     /product="lipoma-preferred partner homolog isoform 1"
                     /protein_id="NP_848780.3"
                     /db_xref="CCDS:CCDS28083.1"
                     /db_xref="GeneID:210126"
                     /db_xref="MGI:MGI:2441849"
                     /translation="MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKK
                     YAPVVAPKPKYNPYKQPGGEGDLLPPPPPPLEDPGTIPPGPGHFPPPPPLDEGAFKVQ
                     QGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQGSASSIASPPVSTPVT
                     GHKRMVIPQQPPLTATKKSATKPQPAPQAAPIPVTPIGTLKPQPQPVPASYTTASTSS
                     RPTFNVQVKSAQPSPHYMAGPSSGQIYGPGPRGYNNQPVPVSGQCPPPPTCVGTDYAY
                     IPPSGHPPESGYGYTSNQGRYYEPYYAAGPSYGGRSEGDTAYGQQVQPNTWKREAAYA
                     PPASGNQNHPGMYPVSGPKKTYITDPVSAPCAPPLQPKGGYPGPMGPPSIPPSFRPED
                     ELEHLTKKMLYDMENPPADDYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIVCDV
                     KLRGQPFYAVEKKAYCEPCYINTLEQCSVCSKPIMERILRATGKAYHPHCFTCVMCHR
                     SLDGIPFTVDACGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVH
                     CYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            744..856
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            857..982
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1666
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1793
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1963
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2142
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2263
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..15649
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15627..15632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="hexamer: AATAAA"
     polyA_site      15649
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="major polyA site"
ORIGIN      
        1 ataccttaca tggacaaatg cgtgcaggca aagtcaggaa ttcaggcccc tgacgtcagc
       61 ctccagcgct cagggcaccg cacgggagac cgcggggagg gggtggggag gaaggagggg
      121 gagagcacca accagcagcc actcccggcc tgctgctgaa gtttcacttt ttgtctgtgg
      181 gttcgctccc ggggcccgct cgagctttcc cgggataagt agcgttagcg gcgggggaga
      241 gccggccgct gcaaggacct gaagagaatc ctgacagcta gagtgttgga agaggcttga
      301 agagaggcca caccctcaga gctgcttggg actcctcttg agggtggtct cccacaggaa
      361 gactggtggg aacacaggct caaggacaga aggagagaga gcgagccagg tgcttctgct
      421 tttgttactt tttcaccgtt ccccccactg gagggaagac attgttcctc agttgagctg
      481 agcacatcgt ctggctaagc ctgtgaccat tgtccattcc aaaagccaaa ggctgctgga
      541 gatttccaca atgtctcacc catcttggct gccacccaaa agcactggtg agcctcttgg
      601 ccacgtgcct gcacggatgg agaccaccca ttcttttggg aaccccagta tctcagtgtc
      661 aacacaacag ccacccaaga agtatgctcc agttgttgct ccgaaaccca agtataaccc
      721 atacaagcag cctggaggag agggtgatct tctcccaccg ccaccaccac ctctagagga
      781 tcctggtacc atcccacctg gtcccggaca cttccctcct cctccaccac tggatgaagg
      841 ggctttcaaa gtgcagcagg gaaatcctgg aggcaagacc ctggaggaaa ggcgctctag
      901 tctagatgca gagatcgact ccttgaccag catcttggct gatttggagt gcagctcacc
      961 ctacaagcca cgtcccccac agggctctgc tagttcaata gcctctcctc cagtttctac
     1021 tcctgtcaca ggacataaga gaatggtcat tccacagcag ccacccctga cagcaaccaa
     1081 gaagtccgca acaaaaccac agcctgcacc ccaggctgca cccatcccag tgactccaat
     1141 tggaacactc aaaccccagc ctcagccagt tccagcctcc tatactacgg catccacatc
     1201 ttcaaggccc acctttaatg tgcaagtgaa gtcagctcag cccagcccac attacatggc
     1261 tggtccatcc tctggacaaa tatatggtcc agggcctcgt ggctataaca accagccagt
     1321 tcctgtatcg ggacagtgtc ctcctcctcc aacctgtgtt ggtaccgact atgcatatat
     1381 tccaccatct ggacatccgc ctgagtctgg atatgggtat acctccaacc aaggacgcta
     1441 ttatgaacct tactatgcag caggtcctag ctatgggggc cgaagtgaag gtgatactgc
     1501 ttatgggcaa caggttcaac ctaatacctg gaagcgggaa gctgcgtatg cccctcctgc
     1561 aagcgggaat cagaaccatc ctggcatgta tccagtcagt ggccccaaga agacctatat
     1621 cacagaccct gtttcagcgc cctgtgcacc accactgcag ccaaagggtg gataccctgg
     1681 gcctatgggg cctccttcca tccccccatc attccgccca gaagatgagc tcgaacactt
     1741 gaccaagaag atgctgtatg acatggagaa cccacccgct gacgattact ttggccgttg
     1801 tgcccgctgt ggggaaaatg ttgttggaga aggaacagga tgtactgcca tggatcaggt
     1861 cttccacgtg gattgcttca cctgcattgt ctgtgatgtc aagctccgag ggcagccttt
     1921 ctatgccgtg gagaagaagg catactgcga gccctgctac attaataccc tggagcagtg
     1981 cagtgtgtgt tcgaagccca tcatggagcg gatcctccgt gccaccggga aggcctacca
     2041 cccccactgc ttcacctgcg tgatgtgcca ccgtagcctg gacggcatcc catttactgt
     2101 ggatgcttgc ggtctcattc actgcattga ggacttccac aagaaatttg ccccgcgctg
     2161 ttctgtgtgc aaggaaccta tcatgccagc cccaggccag gaggagactg tccgcattgt
     2221 ggctctggac cgtgatttcc atgtgcactg ctatcgctgt gaggactgtg gtggtcttct
     2281 gtccgaagga gacaaccaag gctgctaccc cttggatgga cacattctct gtaagacctg
     2341 caactcggct cgcatcaggg tcttgacggc caaggcaagc actgacctgt agagtcaata
     2401 gccagctcag ctgccgagtg catgccagca agaagagcgc aacacaagaa aaagataaga
     2461 gaagaagtag aaaaatagag gcatagctca accactagga tagtctctgt tcttcatgtg
     2521 ctattaacct ttctgtagaa gcgcatagag aatacgattt gtctacgttc ttaccaaata
     2581 cacatttcac atttaatcat gcaaggcctt ggtgagcctt tgttccaagg acttccacat
     2641 ttttgcacag attatactcc gtcccattca cttctgcatt cctgagactt ttaatcctca
     2701 tgtttgtctc acttctcatg tggttgaata gatttttagt gtggtatttg ctgtcacatg
     2761 atttttcctg ggtgaatgtg ccagcctgca ggtgccttaa gtcttgtcct gtctgtcact
     2821 tttcctctgg ctgtggctac aaaaggcagt cattctgtta ccaggtattg aaaaggtgaa
     2881 gtttcccatt gcactacacc cctgacgtct cttgctaaaa taatggtagg gggatatttt
     2941 tctatgttaa gctataaaga gtttatttga aaaagttaac aggagcccac tttagtctgc
     3001 aactatccaa attcagcagt caaggctcat tggaaaacat tgattagcca atatctaaaa
     3061 tgtggggaaa taaaaccaag tttcaccact gtgctaaaga ggcagaattc taggtgtatc
     3121 tggaaggccc gttgtatttc cacaatccca ccctgagagt tagctcacca cactctctgg
     3181 atataagact gtcaggcttg cttttggtac atttataaat ctatccaact cttcatcctt
     3241 aaagcactgt gaaacttcac ctaatatata agcatggtta ctgcaattaa tatttatctt
     3301 cagaaagata agtattaaaa tgaatcaaat tcttatcttt ctttctttca ctttatagtg
     3361 acccaaacct aaatctcttt tgcctgaaaa ttgcaaatcg ggacacataa aatgaaatta
     3421 taggaccatg tttcatcttc tttaaaaaag agaaaaaaaa gctgggaaag attgtgaaac
     3481 cagagtttat tattcttaca atcctctgta actcaagtac atactgcagg agacattttc
     3541 ctatcatcaa cgtgacattc acaccacact ttcaaagaca atcgctgaaa accaaattgt
     3601 ctttctgagg taaaaatatg cggaatgcct gcctggaatc tttatgcgaa ctcttattag
     3661 ccagtgaaac acttgcttgc caactggagc cagttcgctt cgttaagagg agacacctcg
     3721 ctttgcagtt gcagttggcc attattgtaa agtcagtatc tcagaatgag atttctcaaa
     3781 gctttcttta aatcttctac agatatatac ctttaaatta tggaatacct taaatattac
     3841 agaaaggtat aaataataat ataaaggtcc ctctatagct aacaccgttc tagaagtata
     3901 gtcactttaa attttttaaa ctccacaaat atctttttat ctcttttata tagtactggg
     3961 agttgaacta gggcctcatg tgctcggcat gtgccctggc accccagcat ccccagctct
     4021 tccgtgtctt tttctttttt ttttaatctt tatgacatga tgattttcta gtctgacagt
     4081 tttaatttta acatttagag caaaaaaaaa aaaaaacctg tttaattact tgtgcatgtt
     4141 taaaattgca acccatgcct caggaattcc ataaagttta ttttacttga atagaagtca
     4201 tcttaaaagt gattaaaaga agcccttagg ccattgtcac acagcccctc tgggtcagtc
     4261 tgtggcttat tgactttctc cacaggcagt ttgcctgtta gaatccccaa agctggcatt
     4321 ttggggcctt tcccttgccc cctgctctca cctggcttct cttctcttga gattcatgga
     4381 ggcagcctgt ggatctcaga attcagtggg cgctctctag ctctgaatcc ctgtgctgca
     4441 aatcaaaggc tcacctgtgc tggtgacctc gaggaacgct aacagacagt cgaggtgaat
     4501 acaagcctga actgactaaa atgctcaccg tgaaatattt caggaaatgt ctttaagcca
     4561 aaagtagagt gcagtataag taaggggcag gagtaatgtc tagaaatgta gacagcagag
     4621 gaagagttta tgtaatattt atactataga gcaataacat cctccatgtt tgttacatgt
     4681 aactacttgt aaccagatgt ttacatgcaa gatttatagg aaaatgctgc ccattcttcc
     4741 ctgaggtgtt aagggcagag ctcccttgct cgtagcctac ccagtgcttt cctgttgagt
     4801 cacctcagag gatctttacc aaagattttt ttaaagtaaa tttcttttta atatagactt
     4861 atacttttat aataatgaat gtgcacatac tcatatacag aaatatttag gattagatct
     4921 ttttctttca caaggtctca tgcaataaag tatccaccac attattctcc aattacttta
     4981 atatataatt tacattgctt tctcgttttc ttctactaag catttgactt aagcaatact
     5041 aaatactctg ctctttgctc ttttatctac ataaagattt gcctactgta gagatataaa
     5101 gatctgttac cttaatgatt atatgcattg ccttttgata tattgcctta cttatcattt
     5161 aaatacataa atagaaagat ataatgtctg taacagaaaa cttataaagt tatacctgaa
     5221 ttgtttaaat atcaagagca caaacatttg gttattctgt ataaaatgaa acatataaga
     5281 aaggaaaaaa cccaccatca tgagctctgc agagaacatt taaaataatt ctctttctat
     5341 ttctggagtg gtagggatgg atctctgaaa cttgtgtaaa atagacaagt gctctaccac
     5401 agctaaacct cccatccaga gtaagatttc atagctgttt gggttcccat ctaagcctgg
     5461 ctcaatatgg agtctgattg gcaaacaaca ttgcctttag aactcaaaaa tacaccctcc
     5521 caatcctagc tcatggcctc agtactagtg aaatcctgcc acctctgcag ctcaaagatg
     5581 tggatgtttt cctgtcaata gcacactgtc cctgtaggaa caacttgtgg tcagaattgc
     5641 tacgtgggtt atatgctgat taaggacatg aacttaaaaa cactaaaaat gctgcaacaa
     5701 ttttatgttg gacttgaaca gtgtggaaca tattaaccat aaagagctct cttgcatttg
     5761 ggccgttgga aggggagagt gctctgtgag gctgcagcag agctttaata ggcaggattc
     5821 tgaaaacaca actaccaagc atcttcagag ttactacaaa tcctattaat gtgaaccagt
     5881 caggaataac agtgttattt ctatttgatg tggtttaggc ttctcttgtc agatctgtgt
     5941 cggttgcccc ctgatccttc cattctcaag ttttgaaggg tgtcagggaa attatggcag
     6001 ctgctaggga gatctgagaa acgctgatgt aacctcccag cctctcacca tccctcttgg
     6061 cttggaaagg ctttttttcc ccatatacat ttctagaaat attgccattc taccttagca
     6121 tttcacattt gtagattaaa caagtgattg tccatctgtt gcctacagct acagtacatg
     6181 tgtgttatga atgaaatatg acagcatgtt ccataccccc gcttcagcca tctgtagaaa
     6241 accagcaacc gaaaaagata cctctgcaaa atgtgcctca agtccttgtc ctgggatggc
     6301 tcttctggtg tgctttcaca agagacaatc aaaagcaatc cactattgtg ccttattttt
     6361 taaaaaaaaa tctgtttaca cttctatgac tattgctcag taatggaaat gctacacaca
     6421 cacacacaca cacacacaca cacacacaca cacacacacc ccaatctcaa aagatcggtg
     6481 agaaaaagac agagagacag agaggagagg acgagaacac acttccatct tactgtacca
     6541 gtttggatgg acctcatagc tctaacatat gcgagcatgc tcacggttga ggcgatgtgt
     6601 cggctgttac tagtccttag gctttggtct ccccctgagt ttagggggat actaaaggca
     6661 gagacttgca cctgccggac cccttctgca ctcacatttt tacattgtat tatttgtttg
     6721 acttagggat aaacaatttt gatttctgag caagttatca tcgtggcacg accttgacta
     6781 tttcaggcca cgtgacttaa ttggctggtc attggaatga agctgcttgt gatgctggag
     6841 gttggctagt atggctttat ttccgacctt taaaatgaat ctggacaaag ctactgtgat
     6901 ctaatgcaag tgtttcaccc ctcgctccct tgctttctcc tcttctctcc tttcctgcct
     6961 ccctttaacc tctctctcta ctgtgccaac taatgctgcc ctgtttggcc ttctagtaag
     7021 tttagttagg atacaacagc actatgaact cattaaggga gaatggctac caggacatat
     7081 acctaccagc cagaaaaaaa aaacaaaact gctttatgtg gacatactct ttagcttgtg
     7141 cttattccta gagggagggg tgctccttca ggtgtacttt aatgaatctg tatcagggtc
     7201 ttagctaatg gggtattgct ttaaaattat ctgtatattc ctcacctata tgtaaagtga
     7261 tcattctaag gctagactag gatgctgtgg gttttttttt ttttttggtt tgttttttta
     7321 aattagatat tttcttcatt tacacttcaa atgctatccc ctttcctagt ttcctctcca
     7381 aaaatcccct ataccctccc ctctccccct gctctccaac ccacccactc ctgcttcctg
     7441 gccctggcat tcccctatac tggggcatag aatctttgaa agaccaaggt cctctcctcc
     7501 cattgatggc cgactaggcc atcctctgct acatatgcag ctcgagaaac aagctctggg
     7561 ggtactggtt agttcatatt attgttccta ggatgctgtt tttaaactca aagtcacttt
     7621 caccacaaaa tacttaattt ttttttttcg agacagggtt tctctgtgta gccttggctg
     7681 tcctggaact cactctatag accaggctgg cctcgaactc agaaatccac ctgcctcttc
     7741 ctcccaaata ctgggattaa aggcgtgtgc cataactacc cagcttaata ttttttaata
     7801 agagaacatc attttgtccc actgcaatga gcttgataat tttctttgtg gcaacaagaa
     7861 ttgactcagt acttgtaagg ggtagtttca gcactaggat tttctttttg tagagtatac
     7921 attattttgt gggcatattt tcccttagta cagaatagaa agatacgaat ttacttttct
     7981 gttttaattt tttcttcctt atgcaaagtt ttttagacaa tattttagtt agccgccatg
     8041 cataatgact aattgtagag atctttgtaa aggacatatt tttatccatc ttactgggaa
     8101 aaaaatgctc aaatctttgt tctttgcttc tgattggtat ttgttttata gcagggtcta
     8161 ggcaggatga taagtagctc tgtctcatag catttattaa aaattaccat actacaagta
     8221 ctcaaattat tttacaatac ttaggatcaa tggctgagct aaattttcca agctacccat
     8281 ccacttaggg acaagataaa acttaattca tctgactgat agtcatctcc tgtgccccaa
     8341 taggatattg ttaaatagct gccagtgtac tccatgaact tgtctttgaa cataacttct
     8401 aatttcagct ttcagtccta aaagcagaat gctgtattag gaatgcagat gtcaccatgt
     8461 caccttgtgc tcaagccaag tgctaggagg tcttgttgaa catatactca ggtgctgtac
     8521 ctgggtgtac agacctatgg tccttgtaaa gagctgcctt ctctattgct ttcatgaccg
     8581 atggccgtag catttattaa tgaatatgat ggccagtgtg gaatccactc aaggcaaccc
     8641 aggctacctg atgaactaca taaaatctcc taaattccag actcgtcacc tttgtgggtt
     8701 tgataccacc aagtacttca gcttgtcatt tattgacagt gcatgttatc ttctgattcc
     8761 agtgacatta cctactagtt tcctgactat ttccggattc tctttgcatc tactctgtga
     8821 cccagctact actgtctgtc aaggcagatc aaagcacttt gcttcagatt gaaagggaaa
     8881 ggtatatgaa tccttctagg gccactggtg gcctccatgg aaggggattc cctcctaatg
     8941 atagagctag gaaaagacag gtcagccaag ctgagaatac agccctcttt atcttctggg
     9001 ctgatttttg taatcatatc tcactgctgg ttttgatgcc aatagaatca gagtcctcag
     9061 gaagggagga agtgagctaa agcattttcc atctacaaga gccctctctg cctcataaag
     9121 tcctttccct ttcgcaccgt cttctcaagg ataacacttg tctgtatttc catgatggat
     9181 agagaaacaa gttcttgaca cttagcaagt tctgcaccaa tattagtcgt tggttttaaa
     9241 ctcatccatt tattactaat atttgtgtct aaagcaactt ctgtgatcag tttatactcc
     9301 ccttaagaca gccaaggctg agagaaaccc tatcttgaaa aaacaaaaaa caaaaaagtg
     9361 gagtttatga tttaaatttt gtcccctcag tatcttagtt ccttaactga ttttgtttta
     9421 acggccattg ttggatctaa gaggctcagg ctgactgcat taagatccaa tagtcagttc
     9481 agacttcttc ctagaaatga gtgaggcatg tgaaagacct cttcacagag gcctctgtgg
     9541 gagttcaggg agatcatgga agtgaggaca cctgagcttg cttactgctg actgcattgg
     9601 gacgtcatag ttaaggccca caaggacaac ctaggctcat ttctgcaagg atgccctggc
     9661 cagggtatgg attcagaagt cttcatagca gggaaaactt tcatatattc atgcttcttg
     9721 agaggggaaa ggcaccaaga aaaccgactg ttgatctctt ctcatcacga ttacagcgga
     9781 ggaggggtgg ctgggcagac acaagaaacc catacagtat aggtaggaaa tagcaccctg
     9841 tggtctttgt tggtgcaaat gcatttttat tggaccacac tacattctcc tctcttgtag
     9901 caaatgtgct ggacttttga accctcaaaa acgaacaagt gggctctctc tgcgtctttc
     9961 ttcttctagg aacatagtta aggctcccag ccatctgctt tacttggtgt tccagttccg
    10021 tcacgactcc ttgctgcatg gtgaagtttg cttaaatagg gcctgtgtca agaaactcat
    10081 cagcttggga ggaagtcctg ttgtttcagc taccttggtc attaaaacca gtcttcggct
    10141 ctgttttttc ctcgattctc aaaactaacc cacgaaacat aataaaatcc tggcctcccc
    10201 ttttttcttc ttccactgta tttgttttgt tttttaacgc tgtattactt ttaaaaacaa
    10261 cttccatttt tagctgaaga gtacaagtgc ttcaaattta agcacccact aaaaaaagtc
    10321 aagaagattt ccaacagtca gatattagaa tttgtgtaag ttttgttggt gtatttctat
    10381 ccagaaaaca aaatgttctg acagttatca tatagcctca tgccctacct tagtaactgt
    10441 cttgtgaaca atttgtttca tttatcagat ccactgataa tgacctttaa aaaatttggg
    10501 aaacatcact gtcgattctc cagcttttac aaagaaaagg tcaaaaacaa aattcagtgg
    10561 tactgttact aaactcacta cttctgatca gctcttcagt acaaaaggat actgttctta
    10621 aggaaaggga ttgggtgatg ctatggttta tgtaaaagta tataaattct ctcactgttg
    10681 cccagggtta cagtttagct agcaaccatt agcctttgga agaacagggt tttttgtccc
    10741 ttctgtatca gctttgaatt tgagagccct gtcgccagag gctgctatcc gcccttgggt
    10801 aggcagcacc tatgggtgga tttctaagct gtgaaataat aaaattcctg agagagtttc
    10861 caagctgctt tcacacatag aagagccctg ggaggatggt tattaatagc cctgtcctag
    10921 aagcaaggct gaggttcaga atccttaagt gtcttgccaa aagcaatcta gctggtaagt
    10981 gtgagatgtg ggtatttacc taccccttgt cacacaaggc cctgttagaa aaatatccat
    11041 ggaaacccac aaccatctag ttatcagtgg caggtggtat atgtgtatca tattgctgca
    11101 gattattaag agattgcaca tgtctgtgtc atcttgtgag aagccatggg tctctgtgat
    11161 cacctctatg gtgatacccc ctgagcaaag gccactgaaa acagacatct gtgcagaagc
    11221 acattgcagc aaaatttccc agagagttgc tttacattca ctggaaacat ctctggacct
    11281 gtcaggttca ggatatcaat tgagactata ttatttcaaa tatagtagtg tgcagaggtt
    11341 acctgagttt taggaaatct ctccctccaa tggaccgcaa tgtatatccc aaagagacag
    11401 aagctgctat aggttaaaaa aacaaaacaa aaaccatgat tctctctgtc agcccaagag
    11461 tgtgctgagg caaccaggag tttctaatca aacaaaccca agtccagagg ccttgaaatg
    11521 tctaaacaag tgctattgaa tgaacagacc tcctgaaatg tacccttcat tgtatctatg
    11581 ggattaatct accctcatca caaggagcat gacactgtat tcttagcacc aacaaaaacc
    11641 ctgcttggag caccctgggt acattctaga agtcagccga cattgcaggt caacaaatca
    11701 acactcttct tagagctgac ttcctcgtga atatgccttc caggtgcagt cttggctttc
    11761 ctttttctat cttctggttg tttgctacaa gttgaaaatc cgttgactaa ttaagaaaat
    11821 attctctgtc cacattaaat ctgtcctcaa tctagaaacc ctttcaaatg ccctagtttg
    11881 taagttaggc atttgtcttc cctagagcct ctcctccatc agaccaagat taccgctcat
    11941 aaaaaagaaa tcttatttta aaagacttta gctttttaga ccaggaaatt aataattcct
    12001 aaacctgacc cattttcata gcttccagaa aggaaaagaa aaagctactt aaattttgtg
    12061 tggatctgtt tatctcttaa aatatgtcca ggcaatttga cgcaggggta gaacgggagg
    12121 tgtttatctc tcttgcttga ttccttctgt ttctatgggg aaagcggtaa agacgaagga
    12181 cccagtgttc tttggggctg ggttgccatt ttttatccca tctgctttgc ttcatcgtga
    12241 tgaggagtaa ttcctagttg ctctcataaa tcctcatcct ccatcacaat ggagtaaata
    12301 tattaaatct gaatatcttt gctcaccaaa ttacttagct ccatttctca gtggggaaat
    12361 ataaagcagg cagagctggc cttcaattat acacttaact ccttcaagcc ctttttgctt
    12421 tatttcttag gggagactgt gtgaaagaga aacaacctag tccctcctca tcttttggag
    12481 ccatgatgct cacttaggaa ttacaggaaa agaatggctt ggcttggcca ggtcatgtga
    12541 tctgcctaac gtgtttcatt ccttcaaaca cagactgaga aaaaagggag tttcatcatt
    12601 taaataccat caatgggaac ggtctcattt tgcctaagat gggagctaat ctagttgggt
    12661 agtattgcat tgtagtaacc ttttgagttg tgcttggtta ctaaaagagt ggcagataca
    12721 tcagcctatg ggattacact accaaaagcc atagtgccac agacctcaat cgctcactgg
    12781 caaactgaat taccctggac cttccttcta cttcaagtga tatgtgttcc aaactgatat
    12841 gtgtcccaga tgaaatagag actgatctaa tcaaaaaaaa aaaaaaaaaa aaaggtttgg
    12901 cagggaagca gtagcaaaat catttctcag tgactgtcct ttacccatgt gtgcacttgg
    12961 gacacctggg gacactagca gactacctaa gacatctttc ctcatgaatg aagggtagaa
    13021 gagttcccct ctaagcgttg gagtcaagtc tttactccct tccagaaaat atgtcaagga
    13081 gaaaatagaa ttatagatgg cacatgactg tctggctctt gtcttaagaa tgctgtgtgg
    13141 aattatgtgc cttacgcaaa acctgaaact tagaagccaa gttttgtgca gcggaaggga
    13201 gcactgagct ctgtggtggc tccgcgaagt gacttagcct gggttttgca ttgccttgtc
    13261 tggatctatg cctttatcgt tacttaacag atttggggct tttctttctt taccgctaag
    13321 catgggcatg tgtgcaatta tgaggtgaac tttctaagta gtaagccctt gccacaaagt
    13381 agacgttaca caaaggcaca gagcccaggg atagtaatct tgcctgagct gctcgcacag
    13441 gcttcttatt ccatggcttt gtcgcaggct tttctctttc tgtgccatca cctttgagaa
    13501 acatgattgc accttctcca actctgcctt tttaacagct tcagttgagt tggcaagact
    13561 ttcccagctc tgaatatagc catttcccga ctccggcctc tgcgagactg atttcaaatc
    13621 tgtgatcttc tgttcagcgt acacatcagc aaagtgagaa gttgggtgct aaatataggc
    13681 tctattaact ttacttttag atgtgctgcc ttcaaagagt gcctattctg agcaacgtaa
    13741 acgttattcc tacatatgta tgtacacacg gtacccggac tcacactgtt cgggcttcac
    13801 aaacaccatc agcaggggta ggtgctgaga taaggaagca tcgccaaatt gaagagggtg
    13861 gctcatttcc aatctcccct tcagtggcta ccatgaaatg ggctaaaaca agagtctcct
    13921 gcacttcctg ctgacacagc cactttgcat ttatatccca ggaatagtgg caaattgctg
    13981 aggaacccgt atttcatgga aataatacaa tcatgaacat ttcatcagga gagggaaagg
    14041 caattaatat gtgtcatgtg tgttttaaaa actaagtatt gctaagtttt gagtgtcagc
    14101 aggtttcttt tatcttacag gctaacatag agaaaactaa cgtcttggct atagggagtg
    14161 taagctcagg gggccaggca tccctgccag ctccttgaag catttttact ccagctccta
    14221 agaataccag tccatgctat ttgagggctt ttgttcctgg agctctctct gtcagcgaca
    14281 ggaactctag gtatttttga ggaggcagca gcatagcctg ggagggtgag tggttaccca
    14341 gcagtcgtgc tcggaggtga gccaggtaga tgtgctgagg tacatggaga taccgtatga
    14401 tcgtacaagg gttgaacgga ggacatgatt ccaaaaaaga ttgttctcaa tgtgtcgtct
    14461 gactcaacca gctggcagat tacacttgcc aagtcgcttc ctttccttct aagtcatttg
    14521 gctccatatt cccttgaata tgcctgtgag gaaagtaaga tgtgtcgccc catccactta
    14581 gccttcctga aaggacatta gtgatgccct agtggtcacc aagctaccat gaaatgccac
    14641 cactcctact cagttgtacc aaatgcaagt agaggggaca aactgtggga gacagattta
    14701 gtgccatcgt ggttgtctgc cactctgccc agtatgatcc cagcaaccca cgagatctga
    14761 aggaacagga ctggtgagta gctttagggc tatggccgta cttctttagg aacgtcatga
    14821 ttggagtcag gttgattttt tttttttctt tttagaggtg ggcagtactt tttcccattt
    14881 ctcctgttac ctatcttttg atctctatct aatctcaaca ctaataattt tctgctgttg
    14941 acctgatcag atttcagtgc tagaaaagaa ttctaaaatc tcttgtgtgc tgtcctcaag
    15001 tctttgggat acacaggtac tcctccttgg gaacaaacaa actgagacag acacagtgtg
    15061 gccttgctct gagtttcagt ctggtgactt gtggccatga gagagagctt gatatgaaag
    15121 ctaagtcatg tttaatggga cagggtaagg acaggagaga aaagctgtta ggctttccct
    15181 gtgctaaacc tatctcctgg gagcaggcac ttcctcctag ctagccacca tcacagcctc
    15241 accagcagca gcctcaagac tcagtaacat ttccaactta ggaaaagcta cacagacgca
    15301 tagaggatat gacattgttc atctgcatga tcctgacaga gccttggtat tttcacagtg
    15361 taagcaaatt gcatatcttt gctgtctcat aaaccatcgc tgacatcccc acgggagcac
    15421 acataatcct ttctgaaaat cagaagttgt gttacaagaa agtggtttgg gtaatttctt
    15481 ttgtatttac acattattca attatattaa aacatgattt tatttacatt ctatcagttt
    15541 tgattgtgtt tccccagtgc tcaatgagaa taaatatgaa aatcacagtt ttttctgtaa
    15601 aagaattact ttatatttaa aaatccaata aacttctcat tccacttaaa aaaaaaaaaa
    15661 aaaaaaaaa
//
