LOCUS       NM_001145954           14876 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus LIM domain containing preferred translocation partner
            in lipoma (Lpp), transcript variant 3, mRNA.
ACCESSION   NM_001145954
VERSION     NM_001145954.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 14876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 14876)
  AUTHORS   Kiepas,A., Voorand,E., Senecal,J., Ahn,R., Annis,M.G., Jacquet,K.,
            Tali,G., Bisson,N., Ursini-Siegel,J., Siegel,P.M. and Brown,C.M.
  TITLE     The SHCA adapter protein cooperates with lipoma-preferred partner
            in the regulation of adhesion dynamics and invadopodia formation
  JOURNAL   J Biol Chem 295 (31), 10535-10559 (2020)
   PUBMED   32299913
  REMARK    GeneRIF: The SHCA adapter protein cooperates with lipoma-preferred
            partner in the regulation of adhesion dynamics and invadopodia
            formation.
REFERENCE   3  (bases 1 to 14876)
  AUTHORS   Leung,C.S., Yeung,T.L., Yip,K.P., Wong,K.K., Ho,S.Y., Mangala,L.S.,
            Sood,A.K., Lopez-Berestein,G., Sheng,J., Wong,S.T., Birrer,M.J. and
            Mok,S.C.
  TITLE     Cancer-associated fibroblasts regulate endothelial adhesion protein
            LPP to promote ovarian cancer chemoresistance
  JOURNAL   J Clin Invest 128 (2), 589-606 (2018)
   PUBMED   29251630
  REMARK    GeneRIF: cancer-associated fibroblasts regulate endothelial LPP via
            a calcium-dependent signaling pathway involving
            microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase
            (FAK), ERK, and LPP
REFERENCE   4  (bases 1 to 14876)
  AUTHORS   Tan,J., Chen,X.J., Shen,C.L., Zhang,H.X., Tang,L.Y., Lu,S.Y.,
            Wu,W.T., Kuang,Y., Fei,J. and Wang,Z.G.
  TITLE     Lacking of palladin leads to multiple cellular events changes which
            contribute to NTD
  JOURNAL   Neural Dev 12 (1), 4 (2017)
   PUBMED   28340616
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 14876)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 14876)
  AUTHORS   Petit,M.M., Meulemans,S.M. and Van de Ven,W.J.
  TITLE     The focal adhesion and nuclear targeting capacity of the
            LIM-containing lipoma-preferred partner (LPP) protein
  JOURNAL   J Biol Chem 278 (4), 2157-2168 (2003)
   PUBMED   12441356
  REMARK    GeneRIF: LPP contains specific domains that enable its focal
            adhesion and nuclear targeting capacity [LIM-containing
            lipoma-preferred partner [LPP]
REFERENCE   7  (bases 1 to 14876)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 14876)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 14876)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 14876)
  AUTHORS   Fedele,M., Berlingieri,M.T., Scala,S., Chiariotti,L., Viglietto,G.,
            Rippel,V., Bullerdiek,J., Santoro,M. and Fusco,A.
  TITLE     Truncated and chimeric HMGI-C genes induce neoplastic
            transformation of NIH3T3 murine fibroblasts
  JOURNAL   Oncogene 17 (4), 413-418 (1998)
   PUBMED   9696033
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029567.1, AK040643.1, AC135567.3, AK085890.1, AK050035.1 and
            BF018106.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. This results in a
            shorter isoform (2) with a distinct N-terminus compared to isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029567.1, AK076989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1808              AK029567.1         2-1809
            1809-2818           AK040643.1         2156-3165
            2819-2819           AC135567.3         45839-45839         c
            2820-3445           AK040643.1         3167-3792
            3446-3855           AK085890.1         368-777
            3856-3856           AC135567.3         44802-44802         c
            3857-4483           AK085890.1         779-1405
            4484-4729           AC135567.3         43929-44174         c
            4730-6511           AK050035.1         134-1915
            6512-14851          AC135567.3         33807-42146         c
            14852-14876         BF018106.1         3-27                c
FEATURES             Location/Qualifiers
     source          1..14876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 16.17 cM"
     gene            1..14876
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:210126"
                     /db_xref="MGI:MGI:2441849"
     exon            1..137
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1599
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="isoform 2 is encoded by transcript variant 3;
                     lipoma-preferred partner homolog; lipoma preferred
                     partner"
                     /codon_start=1
                     /product="lipoma-preferred partner homolog isoform 2"
                     /protein_id="NP_001139426.1"
                     /db_xref="CCDS:CCDS49807.1"
                     /db_xref="GeneID:210126"
                     /db_xref="MGI:MGI:2441849"
                     /translation="MELLGKVGACLKRSTGTLKGSASSIASPPVSTPVTGHKRMVIPQ
                     QPPLTATKKSATKPQPAPQAAPIPVTPIGTLKPQPQPVPASYTTASTSSRPTFNVQVK
                     SAQPSPHYMAGPSSGQIYGPGPRGYNNQPVPVSGQCPPPPTCVGTDYAYIPPSGHPPE
                     SGYGYTSNQGRYYEPYYAAGPSYGGRSEGDTAYGQQVQPNTWKREAAYAPPASGNQNH
                     PGMYPVSGPKKTYITDPVSAPCAPPLQPKGGYPGPMGPPSIPPSFRPEDELEHLTKKM
                     LYDMENPPADDYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIVCDVKLRGQPFYA
                     VEKKAYCEPCYINTLEQCSVCSKPIMERILRATGKAYHPHCFTCVMCHRSLDGIPFTV
                     DACGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDCGG
                     LLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            138..189
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            190..873
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1000
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1170
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1349
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1470
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..14856
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14834..14839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="hexamer: AATAAA"
     polyA_site      14856
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="major polyA site"
ORIGIN      
        1 agagagtgtg ccacagttaa cctagacagt gggctcatgc caagttggct caaggttcca
       61 tagttttaag cgtaagatgt gtataaaaga ttggtgttcc cagctttttg aagaatttga
      121 agggcttaga aaatggagct actggggaaa gtaggggcat gcctgaagag gagcactgga
      181 acactgaagg gctctgctag ttcaatagcc tctcctccag tttctactcc tgtcacagga
      241 cataagagaa tggtcattcc acagcagcca cccctgacag caaccaagaa gtccgcaaca
      301 aaaccacagc ctgcacccca ggctgcaccc atcccagtga ctccaattgg aacactcaaa
      361 ccccagcctc agccagttcc agcctcctat actacggcat ccacatcttc aaggcccacc
      421 tttaatgtgc aagtgaagtc agctcagccc agcccacatt acatggctgg tccatcctct
      481 ggacaaatat atggtccagg gcctcgtggc tataacaacc agccagttcc tgtatcggga
      541 cagtgtcctc ctcctccaac ctgtgttggt accgactatg catatattcc accatctgga
      601 catccgcctg agtctggata tgggtatacc tccaaccaag gacgctatta tgaaccttac
      661 tatgcagcag gtcctagcta tgggggccga agtgaaggtg atactgctta tgggcaacag
      721 gttcaaccta atacctggaa gcgggaagct gcgtatgccc ctcctgcaag cgggaatcag
      781 aaccatcctg gcatgtatcc agtcagtggc cccaagaaga cctatatcac agaccctgtt
      841 tcagcgccct gtgcaccacc actgcagcca aagggtggat accctgggcc tatggggcct
      901 ccttccatcc ccccatcatt ccgcccagaa gatgagctcg aacacttgac caagaagatg
      961 ctgtatgaca tggagaaccc acccgctgac gattactttg gccgttgtgc ccgctgtggg
     1021 gaaaatgttg ttggagaagg aacaggatgt actgccatgg atcaggtctt ccacgtggat
     1081 tgcttcacct gcattgtctg tgatgtcaag ctccgagggc agcctttcta tgccgtggag
     1141 aagaaggcat actgcgagcc ctgctacatt aataccctgg agcagtgcag tgtgtgttcg
     1201 aagcccatca tggagcggat cctccgtgcc accgggaagg cctaccaccc ccactgcttc
     1261 acctgcgtga tgtgccaccg tagcctggac ggcatcccat ttactgtgga tgcttgcggt
     1321 ctcattcact gcattgagga cttccacaag aaatttgccc cgcgctgttc tgtgtgcaag
     1381 gaacctatca tgccagcccc aggccaggag gagactgtcc gcattgtggc tctggaccgt
     1441 gatttccatg tgcactgcta tcgctgtgag gactgtggtg gtcttctgtc cgaaggagac
     1501 aaccaaggct gctacccctt ggatggacac attctctgta agacctgcaa ctcggctcgc
     1561 atcagggtct tgacggccaa ggcaagcact gacctgtaga gtcaatagcc agctcagctg
     1621 ccgagtgcat gccagcaaga agagcgcaac acaagaaaaa gataagagaa gaagtagaaa
     1681 aatagaggca tagctcaacc actaggatag tctctgttct tcatgtgcta ttaacctttc
     1741 tgtagaagcg catagagaat acgatttgtc tacgttctta ccaaatacac atttcacatt
     1801 taatcatgca aggccttggt gagcctttgt tccaaggact tccacatttt tgcacagatt
     1861 atactccgtc ccattcactt ctgcattcct gagactttta atcctcatgt ttgtctcact
     1921 tctcatgtgg ttgaatagat ttttagtgtg gtatttgctg tcacatgatt tttcctgggt
     1981 gaatgtgcca gcctgcaggt gccttaagtc ttgtcctgtc tgtcactttt cctctggctg
     2041 tggctacaaa aggcagtcat tctgttacca ggtattgaaa aggtgaagtt tcccattgca
     2101 ctacacccct gacgtctctt gctaaaataa tggtaggggg atatttttct atgttaagct
     2161 ataaagagtt tatttgaaaa agttaacagg agcccacttt agtctgcaac tatccaaatt
     2221 cagcagtcaa ggctcattgg aaaacattga ttagccaata tctaaaatgt ggggaaataa
     2281 aaccaagttt caccactgtg ctaaagaggc agaattctag gtgtatctgg aaggcccgtt
     2341 gtatttccac aatcccaccc tgagagttag ctcaccacac tctctggata taagactgtc
     2401 aggcttgctt ttggtacatt tataaatcta tccaactctt catccttaaa gcactgtgaa
     2461 acttcaccta atatataagc atggttactg caattaatat ttatcttcag aaagataagt
     2521 attaaaatga atcaaattct tatctttctt tctttcactt tatagtgacc caaacctaaa
     2581 tctcttttgc ctgaaaattg caaatcggga cacataaaat gaaattatag gaccatgttt
     2641 catcttcttt aaaaaagaga aaaaaaagct gggaaagatt gtgaaaccag agtttattat
     2701 tcttacaatc ctctgtaact caagtacata ctgcaggaga cattttccta tcatcaacgt
     2761 gacattcaca ccacactttc aaagacaatc gctgaaaacc aaattgtctt tctgaggtaa
     2821 aaatatgcgg aatgcctgcc tggaatcttt atgcgaactc ttattagcca gtgaaacact
     2881 tgcttgccaa ctggagccag ttcgcttcgt taagaggaga cacctcgctt tgcagttgca
     2941 gttggccatt attgtaaagt cagtatctca gaatgagatt tctcaaagct ttctttaaat
     3001 cttctacaga tatatacctt taaattatgg aataccttaa atattacaga aaggtataaa
     3061 taataatata aaggtccctc tatagctaac accgttctag aagtatagtc actttaaatt
     3121 ttttaaactc cacaaatatc tttttatctc ttttatatag tactgggagt tgaactaggg
     3181 cctcatgtgc tcggcatgtg ccctggcacc ccagcatccc cagctcttcc gtgtcttttt
     3241 cttttttttt taatctttat gacatgatga ttttctagtc tgacagtttt aattttaaca
     3301 tttagagcaa aaaaaaaaaa aaacctgttt aattacttgt gcatgtttaa aattgcaacc
     3361 catgcctcag gaattccata aagtttattt tacttgaata gaagtcatct taaaagtgat
     3421 taaaagaagc ccttaggcca ttgtcacaca gcccctctgg gtcagtctgt ggcttattga
     3481 ctttctccac aggcagtttg cctgttagaa tccccaaagc tggcattttg gggcctttcc
     3541 cttgccccct gctctcacct ggcttctctt ctcttgagat tcatggaggc agcctgtgga
     3601 tctcagaatt cagtgggcgc tctctagctc tgaatccctg tgctgcaaat caaaggctca
     3661 cctgtgctgg tgacctcgag gaacgctaac agacagtcga ggtgaataca agcctgaact
     3721 gactaaaatg ctcaccgtga aatatttcag gaaatgtctt taagccaaaa gtagagtgca
     3781 gtataagtaa ggggcaggag taatgtctag aaatgtagac agcagaggaa gagtttatgt
     3841 aatatttata ctatagagca ataacatcct ccatgtttgt tacatgtaac tacttgtaac
     3901 cagatgttta catgcaagat ttataggaaa atgctgccca ttcttccctg aggtgttaag
     3961 ggcagagctc ccttgctcgt agcctaccca gtgctttcct gttgagtcac ctcagaggat
     4021 ctttaccaaa gattttttta aagtaaattt ctttttaata tagacttata cttttataat
     4081 aatgaatgtg cacatactca tatacagaaa tatttaggat tagatctttt tctttcacaa
     4141 ggtctcatgc aataaagtat ccaccacatt attctccaat tactttaata tataatttac
     4201 attgctttct cgttttcttc tactaagcat ttgacttaag caatactaaa tactctgctc
     4261 tttgctcttt tatctacata aagatttgcc tactgtagag atataaagat ctgttacctt
     4321 aatgattata tgcattgcct tttgatatat tgccttactt atcatttaaa tacataaata
     4381 gaaagatata atgtctgtaa cagaaaactt ataaagttat acctgaattg tttaaatatc
     4441 aagagcacaa acatttggtt attctgtata aaatgaaaca tataagaaag gaaaaaaccc
     4501 accatcatga gctctgcaga gaacatttaa aataattctc tttctatttc tggagtggta
     4561 gggatggatc tctgaaactt gtgtaaaata gacaagtgct ctaccacagc taaacctccc
     4621 atccagagta agatttcata gctgtttggg ttcccatcta agcctggctc aatatggagt
     4681 ctgattggca aacaacattg cctttagaac tcaaaaatac accctcccaa tcctagctca
     4741 tggcctcagt actagtgaaa tcctgccacc tctgcagctc aaagatgtgg atgttttcct
     4801 gtcaatagca cactgtccct gtaggaacaa cttgtggtca gaattgctac gtgggttata
     4861 tgctgattaa ggacatgaac ttaaaaacac taaaaatgct gcaacaattt tatgttggac
     4921 ttgaacagtg tggaacatat taaccataaa gagctctctt gcatttgggc cgttggaagg
     4981 ggagagtgct ctgtgaggct gcagcagagc tttaataggc aggattctga aaacacaact
     5041 accaagcatc ttcagagtta ctacaaatcc tattaatgtg aaccagtcag gaataacagt
     5101 gttatttcta tttgatgtgg tttaggcttc tcttgtcaga tctgtgtcgg ttgccccctg
     5161 atccttccat tctcaagttt tgaagggtgt cagggaaatt atggcagctg ctagggagat
     5221 ctgagaaacg ctgatgtaac ctcccagcct ctcaccatcc ctcttggctt ggaaaggctt
     5281 tttttcccca tatacatttc tagaaatatt gccattctac cttagcattt cacatttgta
     5341 gattaaacaa gtgattgtcc atctgttgcc tacagctaca gtacatgtgt gttatgaatg
     5401 aaatatgaca gcatgttcca tacccccgct tcagccatct gtagaaaacc agcaaccgaa
     5461 aaagatacct ctgcaaaatg tgcctcaagt ccttgtcctg ggatggctct tctggtgtgc
     5521 tttcacaaga gacaatcaaa agcaatccac tattgtgcct tattttttaa aaaaaaatct
     5581 gtttacactt ctatgactat tgctcagtaa tggaaatgct acacacacac acacacacac
     5641 acacacacac acacacacac acacacccca atctcaaaag atcggtgaga aaaagacaga
     5701 gagacagaga ggagaggacg agaacacact tccatcttac tgtaccagtt tggatggacc
     5761 tcatagctct aacatatgcg agcatgctca cggttgaggc gatgtgtcgg ctgttactag
     5821 tccttaggct ttggtctccc cctgagttta gggggatact aaaggcagag acttgcacct
     5881 gccggacccc ttctgcactc acatttttac attgtattat ttgtttgact tagggataaa
     5941 caattttgat ttctgagcaa gttatcatcg tggcacgacc ttgactattt caggccacgt
     6001 gacttaattg gctggtcatt ggaatgaagc tgcttgtgat gctggaggtt ggctagtatg
     6061 gctttatttc cgacctttaa aatgaatctg gacaaagcta ctgtgatcta atgcaagtgt
     6121 ttcacccctc gctcccttgc tttctcctct tctctccttt cctgcctccc tttaacctct
     6181 ctctctactg tgccaactaa tgctgccctg tttggccttc tagtaagttt agttaggata
     6241 caacagcact atgaactcat taagggagaa tggctaccag gacatatacc taccagccag
     6301 aaaaaaaaaa caaaactgct ttatgtggac atactcttta gcttgtgctt attcctagag
     6361 ggaggggtgc tccttcaggt gtactttaat gaatctgtat cagggtctta gctaatgggg
     6421 tattgcttta aaattatctg tatattcctc acctatatgt aaagtgatca ttctaaggct
     6481 agactaggat gctgtgggtt tttttttttt tttggtttgt ttttttaaat tagatatttt
     6541 cttcatttac acttcaaatg ctatcccctt tcctagtttc ctctccaaaa atcccctata
     6601 ccctcccctc tccccctgct ctccaaccca cccactcctg cttcctggcc ctggcattcc
     6661 cctatactgg ggcatagaat ctttgaaaga ccaaggtcct ctcctcccat tgatggccga
     6721 ctaggccatc ctctgctaca tatgcagctc gagaaacaag ctctgggggt actggttagt
     6781 tcatattatt gttcctagga tgctgttttt aaactcaaag tcactttcac cacaaaatac
     6841 ttaatttttt tttttcgaga cagggtttct ctgtgtagcc ttggctgtcc tggaactcac
     6901 tctatagacc aggctggcct cgaactcaga aatccacctg cctcttcctc ccaaatactg
     6961 ggattaaagg cgtgtgccat aactacccag cttaatattt tttaataaga gaacatcatt
     7021 ttgtcccact gcaatgagct tgataatttt ctttgtggca acaagaattg actcagtact
     7081 tgtaaggggt agtttcagca ctaggatttt ctttttgtag agtatacatt attttgtggg
     7141 catattttcc cttagtacag aatagaaaga tacgaattta cttttctgtt ttaatttttt
     7201 cttccttatg caaagttttt tagacaatat tttagttagc cgccatgcat aatgactaat
     7261 tgtagagatc tttgtaaagg acatattttt atccatctta ctgggaaaaa aatgctcaaa
     7321 tctttgttct ttgcttctga ttggtatttg ttttatagca gggtctaggc aggatgataa
     7381 gtagctctgt ctcatagcat ttattaaaaa ttaccatact acaagtactc aaattatttt
     7441 acaatactta ggatcaatgg ctgagctaaa ttttccaagc tacccatcca cttagggaca
     7501 agataaaact taattcatct gactgatagt catctcctgt gccccaatag gatattgtta
     7561 aatagctgcc agtgtactcc atgaacttgt ctttgaacat aacttctaat ttcagctttc
     7621 agtcctaaaa gcagaatgct gtattaggaa tgcagatgtc accatgtcac cttgtgctca
     7681 agccaagtgc taggaggtct tgttgaacat atactcaggt gctgtacctg ggtgtacaga
     7741 cctatggtcc ttgtaaagag ctgccttctc tattgctttc atgaccgatg gccgtagcat
     7801 ttattaatga atatgatggc cagtgtggaa tccactcaag gcaacccagg ctacctgatg
     7861 aactacataa aatctcctaa attccagact cgtcaccttt gtgggtttga taccaccaag
     7921 tacttcagct tgtcatttat tgacagtgca tgttatcttc tgattccagt gacattacct
     7981 actagtttcc tgactatttc cggattctct ttgcatctac tctgtgaccc agctactact
     8041 gtctgtcaag gcagatcaaa gcactttgct tcagattgaa agggaaaggt atatgaatcc
     8101 ttctagggcc actggtggcc tccatggaag gggattccct cctaatgata gagctaggaa
     8161 aagacaggtc agccaagctg agaatacagc cctctttatc ttctgggctg atttttgtaa
     8221 tcatatctca ctgctggttt tgatgccaat agaatcagag tcctcaggaa gggaggaagt
     8281 gagctaaagc attttccatc tacaagagcc ctctctgcct cataaagtcc tttccctttc
     8341 gcaccgtctt ctcaaggata acacttgtct gtatttccat gatggataga gaaacaagtt
     8401 cttgacactt agcaagttct gcaccaatat tagtcgttgg ttttaaactc atccatttat
     8461 tactaatatt tgtgtctaaa gcaacttctg tgatcagttt atactcccct taagacagcc
     8521 aaggctgaga gaaaccctat cttgaaaaaa caaaaaacaa aaaagtggag tttatgattt
     8581 aaattttgtc ccctcagtat cttagttcct taactgattt tgttttaacg gccattgttg
     8641 gatctaagag gctcaggctg actgcattaa gatccaatag tcagttcaga cttcttccta
     8701 gaaatgagtg aggcatgtga aagacctctt cacagaggcc tctgtgggag ttcagggaga
     8761 tcatggaagt gaggacacct gagcttgctt actgctgact gcattgggac gtcatagtta
     8821 aggcccacaa ggacaaccta ggctcatttc tgcaaggatg ccctggccag ggtatggatt
     8881 cagaagtctt catagcaggg aaaactttca tatattcatg cttcttgaga ggggaaaggc
     8941 accaagaaaa ccgactgttg atctcttctc atcacgatta cagcggagga ggggtggctg
     9001 ggcagacaca agaaacccat acagtatagg taggaaatag caccctgtgg tctttgttgg
     9061 tgcaaatgca tttttattgg accacactac attctcctct cttgtagcaa atgtgctgga
     9121 cttttgaacc ctcaaaaacg aacaagtggg ctctctctgc gtctttcttc ttctaggaac
     9181 atagttaagg ctcccagcca tctgctttac ttggtgttcc agttccgtca cgactccttg
     9241 ctgcatggtg aagtttgctt aaatagggcc tgtgtcaaga aactcatcag cttgggagga
     9301 agtcctgttg tttcagctac cttggtcatt aaaaccagtc ttcggctctg ttttttcctc
     9361 gattctcaaa actaacccac gaaacataat aaaatcctgg cctccccttt tttcttcttc
     9421 cactgtattt gttttgtttt ttaacgctgt attactttta aaaacaactt ccatttttag
     9481 ctgaagagta caagtgcttc aaatttaagc acccactaaa aaaagtcaag aagatttcca
     9541 acagtcagat attagaattt gtgtaagttt tgttggtgta tttctatcca gaaaacaaaa
     9601 tgttctgaca gttatcatat agcctcatgc cctaccttag taactgtctt gtgaacaatt
     9661 tgtttcattt atcagatcca ctgataatga cctttaaaaa atttgggaaa catcactgtc
     9721 gattctccag cttttacaaa gaaaaggtca aaaacaaaat tcagtggtac tgttactaaa
     9781 ctcactactt ctgatcagct cttcagtaca aaaggatact gttcttaagg aaagggattg
     9841 ggtgatgcta tggtttatgt aaaagtatat aaattctctc actgttgccc agggttacag
     9901 tttagctagc aaccattagc ctttggaaga acagggtttt ttgtcccttc tgtatcagct
     9961 ttgaatttga gagccctgtc gccagaggct gctatccgcc cttgggtagg cagcacctat
    10021 gggtggattt ctaagctgtg aaataataaa attcctgaga gagtttccaa gctgctttca
    10081 cacatagaag agccctggga ggatggttat taatagccct gtcctagaag caaggctgag
    10141 gttcagaatc cttaagtgtc ttgccaaaag caatctagct ggtaagtgtg agatgtgggt
    10201 atttacctac cccttgtcac acaaggccct gttagaaaaa tatccatgga aacccacaac
    10261 catctagtta tcagtggcag gtggtatatg tgtatcatat tgctgcagat tattaagaga
    10321 ttgcacatgt ctgtgtcatc ttgtgagaag ccatgggtct ctgtgatcac ctctatggtg
    10381 ataccccctg agcaaaggcc actgaaaaca gacatctgtg cagaagcaca ttgcagcaaa
    10441 atttcccaga gagttgcttt acattcactg gaaacatctc tggacctgtc aggttcagga
    10501 tatcaattga gactatatta tttcaaatat agtagtgtgc agaggttacc tgagttttag
    10561 gaaatctctc cctccaatgg accgcaatgt atatcccaaa gagacagaag ctgctatagg
    10621 ttaaaaaaac aaaacaaaaa ccatgattct ctctgtcagc ccaagagtgt gctgaggcaa
    10681 ccaggagttt ctaatcaaac aaacccaagt ccagaggcct tgaaatgtct aaacaagtgc
    10741 tattgaatga acagacctcc tgaaatgtac ccttcattgt atctatggga ttaatctacc
    10801 ctcatcacaa ggagcatgac actgtattct tagcaccaac aaaaaccctg cttggagcac
    10861 cctgggtaca ttctagaagt cagccgacat tgcaggtcaa caaatcaaca ctcttcttag
    10921 agctgacttc ctcgtgaata tgccttccag gtgcagtctt ggctttcctt tttctatctt
    10981 ctggttgttt gctacaagtt gaaaatccgt tgactaatta agaaaatatt ctctgtccac
    11041 attaaatctg tcctcaatct agaaaccctt tcaaatgccc tagtttgtaa gttaggcatt
    11101 tgtcttccct agagcctctc ctccatcaga ccaagattac cgctcataaa aaagaaatct
    11161 tattttaaaa gactttagct ttttagacca ggaaattaat aattcctaaa cctgacccat
    11221 tttcatagct tccagaaagg aaaagaaaaa gctacttaaa ttttgtgtgg atctgtttat
    11281 ctcttaaaat atgtccaggc aatttgacgc aggggtagaa cgggaggtgt ttatctctct
    11341 tgcttgattc cttctgtttc tatggggaaa gcggtaaaga cgaaggaccc agtgttcttt
    11401 ggggctgggt tgccattttt tatcccatct gctttgcttc atcgtgatga ggagtaattc
    11461 ctagttgctc tcataaatcc tcatcctcca tcacaatgga gtaaatatat taaatctgaa
    11521 tatctttgct caccaaatta cttagctcca tttctcagtg gggaaatata aagcaggcag
    11581 agctggcctt caattataca cttaactcct tcaagccctt tttgctttat ttcttagggg
    11641 agactgtgtg aaagagaaac aacctagtcc ctcctcatct tttggagcca tgatgctcac
    11701 ttaggaatta caggaaaaga atggcttggc ttggccaggt catgtgatct gcctaacgtg
    11761 tttcattcct tcaaacacag actgagaaaa aagggagttt catcatttaa ataccatcaa
    11821 tgggaacggt ctcattttgc ctaagatggg agctaatcta gttgggtagt attgcattgt
    11881 agtaaccttt tgagttgtgc ttggttacta aaagagtggc agatacatca gcctatggga
    11941 ttacactacc aaaagccata gtgccacaga cctcaatcgc tcactggcaa actgaattac
    12001 cctggacctt ccttctactt caagtgatat gtgttccaaa ctgatatgtg tcccagatga
    12061 aatagagact gatctaatca aaaaaaaaaa aaaaaaaaaa ggtttggcag ggaagcagta
    12121 gcaaaatcat ttctcagtga ctgtccttta cccatgtgtg cacttgggac acctggggac
    12181 actagcagac tacctaagac atctttcctc atgaatgaag ggtagaagag ttcccctcta
    12241 agcgttggag tcaagtcttt actcccttcc agaaaatatg tcaaggagaa aatagaatta
    12301 tagatggcac atgactgtct ggctcttgtc ttaagaatgc tgtgtggaat tatgtgcctt
    12361 acgcaaaacc tgaaacttag aagccaagtt ttgtgcagcg gaagggagca ctgagctctg
    12421 tggtggctcc gcgaagtgac ttagcctggg ttttgcattg ccttgtctgg atctatgcct
    12481 ttatcgttac ttaacagatt tggggctttt ctttctttac cgctaagcat gggcatgtgt
    12541 gcaattatga ggtgaacttt ctaagtagta agcccttgcc acaaagtaga cgttacacaa
    12601 aggcacagag cccagggata gtaatcttgc ctgagctgct cgcacaggct tcttattcca
    12661 tggctttgtc gcaggctttt ctctttctgt gccatcacct ttgagaaaca tgattgcacc
    12721 ttctccaact ctgccttttt aacagcttca gttgagttgg caagactttc ccagctctga
    12781 atatagccat ttcccgactc cggcctctgc gagactgatt tcaaatctgt gatcttctgt
    12841 tcagcgtaca catcagcaaa gtgagaagtt gggtgctaaa tataggctct attaacttta
    12901 cttttagatg tgctgccttc aaagagtgcc tattctgagc aacgtaaacg ttattcctac
    12961 atatgtatgt acacacggta cccggactca cactgttcgg gcttcacaaa caccatcagc
    13021 aggggtaggt gctgagataa ggaagcatcg ccaaattgaa gagggtggct catttccaat
    13081 ctccccttca gtggctacca tgaaatgggc taaaacaaga gtctcctgca cttcctgctg
    13141 acacagccac tttgcattta tatcccagga atagtggcaa attgctgagg aacccgtatt
    13201 tcatggaaat aatacaatca tgaacatttc atcaggagag ggaaaggcaa ttaatatgtg
    13261 tcatgtgtgt tttaaaaact aagtattgct aagttttgag tgtcagcagg tttcttttat
    13321 cttacaggct aacatagaga aaactaacgt cttggctata gggagtgtaa gctcaggggg
    13381 ccaggcatcc ctgccagctc cttgaagcat ttttactcca gctcctaaga ataccagtcc
    13441 atgctatttg agggcttttg ttcctggagc tctctctgtc agcgacagga actctaggta
    13501 tttttgagga ggcagcagca tagcctggga gggtgagtgg ttacccagca gtcgtgctcg
    13561 gaggtgagcc aggtagatgt gctgaggtac atggagatac cgtatgatcg tacaagggtt
    13621 gaacggagga catgattcca aaaaagattg ttctcaatgt gtcgtctgac tcaaccagct
    13681 ggcagattac acttgccaag tcgcttcctt tccttctaag tcatttggct ccatattccc
    13741 ttgaatatgc ctgtgaggaa agtaagatgt gtcgccccat ccacttagcc ttcctgaaag
    13801 gacattagtg atgccctagt ggtcaccaag ctaccatgaa atgccaccac tcctactcag
    13861 ttgtaccaaa tgcaagtaga ggggacaaac tgtgggagac agatttagtg ccatcgtggt
    13921 tgtctgccac tctgcccagt atgatcccag caacccacga gatctgaagg aacaggactg
    13981 gtgagtagct ttagggctat ggccgtactt ctttaggaac gtcatgattg gagtcaggtt
    14041 gatttttttt ttttcttttt agaggtgggc agtacttttt cccatttctc ctgttaccta
    14101 tcttttgatc tctatctaat ctcaacacta ataattttct gctgttgacc tgatcagatt
    14161 tcagtgctag aaaagaattc taaaatctct tgtgtgctgt cctcaagtct ttgggataca
    14221 caggtactcc tccttgggaa caaacaaact gagacagaca cagtgtggcc ttgctctgag
    14281 tttcagtctg gtgacttgtg gccatgagag agagcttgat atgaaagcta agtcatgttt
    14341 aatgggacag ggtaaggaca ggagagaaaa gctgttaggc tttccctgtg ctaaacctat
    14401 ctcctgggag caggcacttc ctcctagcta gccaccatca cagcctcacc agcagcagcc
    14461 tcaagactca gtaacatttc caacttagga aaagctacac agacgcatag aggatatgac
    14521 attgttcatc tgcatgatcc tgacagagcc ttggtatttt cacagtgtaa gcaaattgca
    14581 tatctttgct gtctcataaa ccatcgctga catccccacg ggagcacaca taatcctttc
    14641 tgaaaatcag aagttgtgtt acaagaaagt ggtttgggta atttcttttg tatttacaca
    14701 ttattcaatt atattaaaac atgattttat ttacattcta tcagttttga ttgtgtttcc
    14761 ccagtgctca atgagaataa atatgaaaat cacagttttt tctgtaaaag aattacttta
    14821 tatttaaaaa tccaataaac ttctcattcc acttaaaaaa aaaaaaaaaa aaaaaa
//
