LOCUS       NM_001145952           15462 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus LIM domain containing preferred translocation partner
            in lipoma (Lpp), transcript variant 2, mRNA.
ACCESSION   NM_001145952
VERSION     NM_001145952.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 15462)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 15462)
  AUTHORS   Kiepas,A., Voorand,E., Senecal,J., Ahn,R., Annis,M.G., Jacquet,K.,
            Tali,G., Bisson,N., Ursini-Siegel,J., Siegel,P.M. and Brown,C.M.
  TITLE     The SHCA adapter protein cooperates with lipoma-preferred partner
            in the regulation of adhesion dynamics and invadopodia formation
  JOURNAL   J Biol Chem 295 (31), 10535-10559 (2020)
   PUBMED   32299913
  REMARK    GeneRIF: The SHCA adapter protein cooperates with lipoma-preferred
            partner in the regulation of adhesion dynamics and invadopodia
            formation.
REFERENCE   3  (bases 1 to 15462)
  AUTHORS   Leung,C.S., Yeung,T.L., Yip,K.P., Wong,K.K., Ho,S.Y., Mangala,L.S.,
            Sood,A.K., Lopez-Berestein,G., Sheng,J., Wong,S.T., Birrer,M.J. and
            Mok,S.C.
  TITLE     Cancer-associated fibroblasts regulate endothelial adhesion protein
            LPP to promote ovarian cancer chemoresistance
  JOURNAL   J Clin Invest 128 (2), 589-606 (2018)
   PUBMED   29251630
  REMARK    GeneRIF: cancer-associated fibroblasts regulate endothelial LPP via
            a calcium-dependent signaling pathway involving
            microfibrillar-associated protein 5 (MFAP5), focal adhesion kinase
            (FAK), ERK, and LPP
REFERENCE   4  (bases 1 to 15462)
  AUTHORS   Tan,J., Chen,X.J., Shen,C.L., Zhang,H.X., Tang,L.Y., Lu,S.Y.,
            Wu,W.T., Kuang,Y., Fei,J. and Wang,Z.G.
  TITLE     Lacking of palladin leads to multiple cellular events changes which
            contribute to NTD
  JOURNAL   Neural Dev 12 (1), 4 (2017)
   PUBMED   28340616
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 15462)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 15462)
  AUTHORS   Petit,M.M., Meulemans,S.M. and Van de Ven,W.J.
  TITLE     The focal adhesion and nuclear targeting capacity of the
            LIM-containing lipoma-preferred partner (LPP) protein
  JOURNAL   J Biol Chem 278 (4), 2157-2168 (2003)
   PUBMED   12441356
  REMARK    GeneRIF: LPP contains specific domains that enable its focal
            adhesion and nuclear targeting capacity [LIM-containing
            lipoma-preferred partner [LPP]
REFERENCE   7  (bases 1 to 15462)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 15462)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 15462)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 15462)
  AUTHORS   Fedele,M., Berlingieri,M.T., Scala,S., Chiariotti,L., Viglietto,G.,
            Rippel,V., Bullerdiek,J., Santoro,M. and Fusco,A.
  TITLE     Truncated and chimeric HMGI-C genes induce neoplastic
            transformation of NIH3T3 murine fibroblasts
  JOURNAL   Oncogene 17 (4), 413-418 (1998)
   PUBMED   9696033
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054550.1, AK040643.1, AC135567.3, AK085890.1, AK050035.1 and
            BF018106.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054550.1, BC085321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2981              AK054550.1         4-2984
            2982-3404           AK040643.1         2743-3165
            3405-3405           AC135567.3         45839-45839         c
            3406-4031           AK040643.1         3167-3792
            4032-4441           AK085890.1         368-777
            4442-4442           AC135567.3         44802-44802         c
            4443-5069           AK085890.1         779-1405
            5070-5315           AC135567.3         43929-44174         c
            5316-7097           AK050035.1         134-1915
            7098-15437          AC135567.3         33807-42146         c
            15438-15462         BF018106.1         3-27                c
FEATURES             Location/Qualifiers
     source          1..15462
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 16.17 cM"
     gene            1..15462
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="LIM domain containing preferred translocation
                     partner in lipoma"
                     /db_xref="GeneID:210126"
                     /db_xref="MGI:MGI:2441849"
     exon            1..158
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            159..268
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            269..334
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            335..536
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..2185
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="isoform 1 is encoded by transcript variant 2;
                     lipoma-preferred partner homolog; lipoma preferred
                     partner"
                     /codon_start=1
                     /product="lipoma-preferred partner homolog isoform 1"
                     /protein_id="NP_001139424.1"
                     /db_xref="CCDS:CCDS28083.1"
                     /db_xref="GeneID:210126"
                     /db_xref="MGI:MGI:2441849"
                     /translation="MSHPSWLPPKSTGEPLGHVPARMETTHSFGNPSISVSTQQPPKK
                     YAPVVAPKPKYNPYKQPGGEGDLLPPPPPPLEDPGTIPPGPGHFPPPPPLDEGAFKVQ
                     QGNPGGKTLEERRSSLDAEIDSLTSILADLECSSPYKPRPPQGSASSIASPPVSTPVT
                     GHKRMVIPQQPPLTATKKSATKPQPAPQAAPIPVTPIGTLKPQPQPVPASYTTASTSS
                     RPTFNVQVKSAQPSPHYMAGPSSGQIYGPGPRGYNNQPVPVSGQCPPPPTCVGTDYAY
                     IPPSGHPPESGYGYTSNQGRYYEPYYAAGPSYGGRSEGDTAYGQQVQPNTWKREAAYA
                     PPASGNQNHPGMYPVSGPKKTYITDPVSAPCAPPLQPKGGYPGPMGPPSIPPSFRPED
                     ELEHLTKKMLYDMENPPADDYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIVCDV
                     KLRGQPFYAVEKKAYCEPCYINTLEQCSVCSKPIMERILRATGKAYHPHCFTCVMCHR
                     SLDGIPFTVDACGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVH
                     CYRCEDCGGLLSEGDNQGCYPLDGHILCKTCNSARIRVLTAKASTDL"
     exon            537..649
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            650..775
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            776..1459
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1586
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1756
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1935
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2056
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..15442
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15420..15425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="hexamer: AATAAA"
     polyA_site      15442
                     /gene="Lpp"
                     /gene_synonym="9430020K16Rik; B130055L10Rik; D630048H16"
                     /note="major polyA site"
ORIGIN      
        1 ttcctctgct cctagttctg gagtctgaag agagagtgcc tcaggtccgt tcccttcagg
       61 ctctgggcca catccctgct gtgttctgtc ctgggcctgg cttggtgaga gggagtcagg
      121 gcagtgaagg ccagctctct gtggcggtga cctcctcagt gggaacacag gctcaaggac
      181 agaaggagag agagcgagcc aggtgcttct gcttttgtta ctttttcacc gttcccccca
      241 ctggagggaa gacattgttc ctcagttgag ctgagcacat cgtctggcta agcctgtgac
      301 cattgtccat tccaaaagcc aaaggctgct ggagatttcc acaatgtctc acccatcttg
      361 gctgccaccc aaaagcactg gtgagcctct tggccacgtg cctgcacgga tggagaccac
      421 ccattctttt gggaacccca gtatctcagt gtcaacacaa cagccaccca agaagtatgc
      481 tccagttgtt gctccgaaac ccaagtataa cccatacaag cagcctggag gagagggtga
      541 tcttctccca ccgccaccac cacctctaga ggatcctggt accatcccac ctggtcccgg
      601 acacttccct cctcctccac cactggatga aggggctttc aaagtgcagc agggaaatcc
      661 tggaggcaag accctggagg aaaggcgctc tagtctagat gcagagatcg actccttgac
      721 cagcatcttg gctgatttgg agtgcagctc accctacaag ccacgtcccc cacagggctc
      781 tgctagttca atagcctctc ctccagtttc tactcctgtc acaggacata agagaatggt
      841 cattccacag cagccacccc tgacagcaac caagaagtcc gcaacaaaac cacagcctgc
      901 accccaggct gcacccatcc cagtgactcc aattggaaca ctcaaacccc agcctcagcc
      961 agttccagcc tcctatacta cggcatccac atcttcaagg cccaccttta atgtgcaagt
     1021 gaagtcagct cagcccagcc cacattacat ggctggtcca tcctctggac aaatatatgg
     1081 tccagggcct cgtggctata acaaccagcc agttcctgta tcgggacagt gtcctcctcc
     1141 tccaacctgt gttggtaccg actatgcata tattccacca tctggacatc cgcctgagtc
     1201 tggatatggg tatacctcca accaaggacg ctattatgaa ccttactatg cagcaggtcc
     1261 tagctatggg ggccgaagtg aaggtgatac tgcttatggg caacaggttc aacctaatac
     1321 ctggaagcgg gaagctgcgt atgcccctcc tgcaagcggg aatcagaacc atcctggcat
     1381 gtatccagtc agtggcccca agaagaccta tatcacagac cctgtttcag cgccctgtgc
     1441 accaccactg cagccaaagg gtggataccc tgggcctatg gggcctcctt ccatcccccc
     1501 atcattccgc ccagaagatg agctcgaaca cttgaccaag aagatgctgt atgacatgga
     1561 gaacccaccc gctgacgatt actttggccg ttgtgcccgc tgtggggaaa atgttgttgg
     1621 agaaggaaca ggatgtactg ccatggatca ggtcttccac gtggattgct tcacctgcat
     1681 tgtctgtgat gtcaagctcc gagggcagcc tttctatgcc gtggagaaga aggcatactg
     1741 cgagccctgc tacattaata ccctggagca gtgcagtgtg tgttcgaagc ccatcatgga
     1801 gcggatcctc cgtgccaccg ggaaggccta ccacccccac tgcttcacct gcgtgatgtg
     1861 ccaccgtagc ctggacggca tcccatttac tgtggatgct tgcggtctca ttcactgcat
     1921 tgaggacttc cacaagaaat ttgccccgcg ctgttctgtg tgcaaggaac ctatcatgcc
     1981 agccccaggc caggaggaga ctgtccgcat tgtggctctg gaccgtgatt tccatgtgca
     2041 ctgctatcgc tgtgaggact gtggtggtct tctgtccgaa ggagacaacc aaggctgcta
     2101 ccccttggat ggacacattc tctgtaagac ctgcaactcg gctcgcatca gggtcttgac
     2161 ggccaaggca agcactgacc tgtagagtca atagccagct cagctgccga gtgcatgcca
     2221 gcaagaagag cgcaacacaa gaaaaagata agagaagaag tagaaaaata gaggcatagc
     2281 tcaaccacta ggatagtctc tgttcttcat gtgctattaa cctttctgta gaagcgcata
     2341 gagaatacga tttgtctacg ttcttaccaa atacacattt cacatttaat catgcaaggc
     2401 cttggtgagc ctttgttcca aggacttcca catttttgca cagattatac tccgtcccat
     2461 tcacttctgc attcctgaga cttttaatcc tcatgtttgt ctcacttctc atgtggttga
     2521 atagattttt agtgtggtat ttgctgtcac atgatttttc ctgggtgaat gtgccagcct
     2581 gcaggtgcct taagtcttgt cctgtctgtc acttttcctc tggctgtggc tacaaaaggc
     2641 agtcattctg ttaccaggta ttgaaaaggt gaagtttccc attgcactac acccctgacg
     2701 tctcttgcta aaataatggt agggggatat ttttctatgt taagctataa agagtttatt
     2761 tgaaaaagtt aacaggagcc cactttagtc tgcaactatc caaattcagc agtcaaggct
     2821 cattggaaaa cattgattag ccaatatcta aaatgtgggg aaataaaacc aagtttcacc
     2881 actgtgctaa agaggcagaa ttctaggtgt atctggaagg cccgttgtat ttccacaatc
     2941 ccaccctgag agttagctca ccacactctc tggatataag actgtcaggc ttgcttttgg
     3001 tacatttata aatctatcca actcttcatc cttaaagcac tgtgaaactt cacctaatat
     3061 ataagcatgg ttactgcaat taatatttat cttcagaaag ataagtatta aaatgaatca
     3121 aattcttatc tttctttctt tcactttata gtgacccaaa cctaaatctc ttttgcctga
     3181 aaattgcaaa tcgggacaca taaaatgaaa ttataggacc atgtttcatc ttctttaaaa
     3241 aagagaaaaa aaagctggga aagattgtga aaccagagtt tattattctt acaatcctct
     3301 gtaactcaag tacatactgc aggagacatt ttcctatcat caacgtgaca ttcacaccac
     3361 actttcaaag acaatcgctg aaaaccaaat tgtctttctg aggtaaaaat atgcggaatg
     3421 cctgcctgga atctttatgc gaactcttat tagccagtga aacacttgct tgccaactgg
     3481 agccagttcg cttcgttaag aggagacacc tcgctttgca gttgcagttg gccattattg
     3541 taaagtcagt atctcagaat gagatttctc aaagctttct ttaaatcttc tacagatata
     3601 tacctttaaa ttatggaata ccttaaatat tacagaaagg tataaataat aatataaagg
     3661 tccctctata gctaacaccg ttctagaagt atagtcactt taaatttttt aaactccaca
     3721 aatatctttt tatctctttt atatagtact gggagttgaa ctagggcctc atgtgctcgg
     3781 catgtgccct ggcaccccag catccccagc tcttccgtgt ctttttcttt tttttttaat
     3841 ctttatgaca tgatgatttt ctagtctgac agttttaatt ttaacattta gagcaaaaaa
     3901 aaaaaaaaac ctgtttaatt acttgtgcat gtttaaaatt gcaacccatg cctcaggaat
     3961 tccataaagt ttattttact tgaatagaag tcatcttaaa agtgattaaa agaagccctt
     4021 aggccattgt cacacagccc ctctgggtca gtctgtggct tattgacttt ctccacaggc
     4081 agtttgcctg ttagaatccc caaagctggc attttggggc ctttcccttg ccccctgctc
     4141 tcacctggct tctcttctct tgagattcat ggaggcagcc tgtggatctc agaattcagt
     4201 gggcgctctc tagctctgaa tccctgtgct gcaaatcaaa ggctcacctg tgctggtgac
     4261 ctcgaggaac gctaacagac agtcgaggtg aatacaagcc tgaactgact aaaatgctca
     4321 ccgtgaaata tttcaggaaa tgtctttaag ccaaaagtag agtgcagtat aagtaagggg
     4381 caggagtaat gtctagaaat gtagacagca gaggaagagt ttatgtaata tttatactat
     4441 agagcaataa catcctccat gtttgttaca tgtaactact tgtaaccaga tgtttacatg
     4501 caagatttat aggaaaatgc tgcccattct tccctgaggt gttaagggca gagctccctt
     4561 gctcgtagcc tacccagtgc tttcctgttg agtcacctca gaggatcttt accaaagatt
     4621 tttttaaagt aaatttcttt ttaatataga cttatacttt tataataatg aatgtgcaca
     4681 tactcatata cagaaatatt taggattaga tctttttctt tcacaaggtc tcatgcaata
     4741 aagtatccac cacattattc tccaattact ttaatatata atttacattg ctttctcgtt
     4801 ttcttctact aagcatttga cttaagcaat actaaatact ctgctctttg ctcttttatc
     4861 tacataaaga tttgcctact gtagagatat aaagatctgt taccttaatg attatatgca
     4921 ttgccttttg atatattgcc ttacttatca tttaaataca taaatagaaa gatataatgt
     4981 ctgtaacaga aaacttataa agttatacct gaattgttta aatatcaaga gcacaaacat
     5041 ttggttattc tgtataaaat gaaacatata agaaaggaaa aaacccacca tcatgagctc
     5101 tgcagagaac atttaaaata attctctttc tatttctgga gtggtaggga tggatctctg
     5161 aaacttgtgt aaaatagaca agtgctctac cacagctaaa cctcccatcc agagtaagat
     5221 ttcatagctg tttgggttcc catctaagcc tggctcaata tggagtctga ttggcaaaca
     5281 acattgcctt tagaactcaa aaatacaccc tcccaatcct agctcatggc ctcagtacta
     5341 gtgaaatcct gccacctctg cagctcaaag atgtggatgt tttcctgtca atagcacact
     5401 gtccctgtag gaacaacttg tggtcagaat tgctacgtgg gttatatgct gattaaggac
     5461 atgaacttaa aaacactaaa aatgctgcaa caattttatg ttggacttga acagtgtgga
     5521 acatattaac cataaagagc tctcttgcat ttgggccgtt ggaaggggag agtgctctgt
     5581 gaggctgcag cagagcttta ataggcagga ttctgaaaac acaactacca agcatcttca
     5641 gagttactac aaatcctatt aatgtgaacc agtcaggaat aacagtgtta tttctatttg
     5701 atgtggttta ggcttctctt gtcagatctg tgtcggttgc cccctgatcc ttccattctc
     5761 aagttttgaa gggtgtcagg gaaattatgg cagctgctag ggagatctga gaaacgctga
     5821 tgtaacctcc cagcctctca ccatccctct tggcttggaa aggctttttt tccccatata
     5881 catttctaga aatattgcca ttctacctta gcatttcaca tttgtagatt aaacaagtga
     5941 ttgtccatct gttgcctaca gctacagtac atgtgtgtta tgaatgaaat atgacagcat
     6001 gttccatacc cccgcttcag ccatctgtag aaaaccagca accgaaaaag atacctctgc
     6061 aaaatgtgcc tcaagtcctt gtcctgggat ggctcttctg gtgtgctttc acaagagaca
     6121 atcaaaagca atccactatt gtgccttatt ttttaaaaaa aaatctgttt acacttctat
     6181 gactattgct cagtaatgga aatgctacac acacacacac acacacacac acacacacac
     6241 acacacacac accccaatct caaaagatcg gtgagaaaaa gacagagaga cagagaggag
     6301 aggacgagaa cacacttcca tcttactgta ccagtttgga tggacctcat agctctaaca
     6361 tatgcgagca tgctcacggt tgaggcgatg tgtcggctgt tactagtcct taggctttgg
     6421 tctccccctg agtttagggg gatactaaag gcagagactt gcacctgccg gaccccttct
     6481 gcactcacat ttttacattg tattatttgt ttgacttagg gataaacaat tttgatttct
     6541 gagcaagtta tcatcgtggc acgaccttga ctatttcagg ccacgtgact taattggctg
     6601 gtcattggaa tgaagctgct tgtgatgctg gaggttggct agtatggctt tatttccgac
     6661 ctttaaaatg aatctggaca aagctactgt gatctaatgc aagtgtttca cccctcgctc
     6721 ccttgctttc tcctcttctc tcctttcctg cctcccttta acctctctct ctactgtgcc
     6781 aactaatgct gccctgtttg gccttctagt aagtttagtt aggatacaac agcactatga
     6841 actcattaag ggagaatggc taccaggaca tatacctacc agccagaaaa aaaaaacaaa
     6901 actgctttat gtggacatac tctttagctt gtgcttattc ctagagggag gggtgctcct
     6961 tcaggtgtac tttaatgaat ctgtatcagg gtcttagcta atggggtatt gctttaaaat
     7021 tatctgtata ttcctcacct atatgtaaag tgatcattct aaggctagac taggatgctg
     7081 tgggtttttt tttttttttg gtttgttttt ttaaattaga tattttcttc atttacactt
     7141 caaatgctat cccctttcct agtttcctct ccaaaaatcc cctataccct cccctctccc
     7201 cctgctctcc aacccaccca ctcctgcttc ctggccctgg cattccccta tactggggca
     7261 tagaatcttt gaaagaccaa ggtcctctcc tcccattgat ggccgactag gccatcctct
     7321 gctacatatg cagctcgaga aacaagctct gggggtactg gttagttcat attattgttc
     7381 ctaggatgct gtttttaaac tcaaagtcac tttcaccaca aaatacttaa tttttttttt
     7441 tcgagacagg gtttctctgt gtagccttgg ctgtcctgga actcactcta tagaccaggc
     7501 tggcctcgaa ctcagaaatc cacctgcctc ttcctcccaa atactgggat taaaggcgtg
     7561 tgccataact acccagctta atatttttta ataagagaac atcattttgt cccactgcaa
     7621 tgagcttgat aattttcttt gtggcaacaa gaattgactc agtacttgta aggggtagtt
     7681 tcagcactag gattttcttt ttgtagagta tacattattt tgtgggcata ttttccctta
     7741 gtacagaata gaaagatacg aatttacttt tctgttttaa ttttttcttc cttatgcaaa
     7801 gttttttaga caatatttta gttagccgcc atgcataatg actaattgta gagatctttg
     7861 taaaggacat atttttatcc atcttactgg gaaaaaaatg ctcaaatctt tgttctttgc
     7921 ttctgattgg tatttgtttt atagcagggt ctaggcagga tgataagtag ctctgtctca
     7981 tagcatttat taaaaattac catactacaa gtactcaaat tattttacaa tacttaggat
     8041 caatggctga gctaaatttt ccaagctacc catccactta gggacaagat aaaacttaat
     8101 tcatctgact gatagtcatc tcctgtgccc caataggata ttgttaaata gctgccagtg
     8161 tactccatga acttgtcttt gaacataact tctaatttca gctttcagtc ctaaaagcag
     8221 aatgctgtat taggaatgca gatgtcacca tgtcaccttg tgctcaagcc aagtgctagg
     8281 aggtcttgtt gaacatatac tcaggtgctg tacctgggtg tacagaccta tggtccttgt
     8341 aaagagctgc cttctctatt gctttcatga ccgatggccg tagcatttat taatgaatat
     8401 gatggccagt gtggaatcca ctcaaggcaa cccaggctac ctgatgaact acataaaatc
     8461 tcctaaattc cagactcgtc acctttgtgg gtttgatacc accaagtact tcagcttgtc
     8521 atttattgac agtgcatgtt atcttctgat tccagtgaca ttacctacta gtttcctgac
     8581 tatttccgga ttctctttgc atctactctg tgacccagct actactgtct gtcaaggcag
     8641 atcaaagcac tttgcttcag attgaaaggg aaaggtatat gaatccttct agggccactg
     8701 gtggcctcca tggaagggga ttccctccta atgatagagc taggaaaaga caggtcagcc
     8761 aagctgagaa tacagccctc tttatcttct gggctgattt ttgtaatcat atctcactgc
     8821 tggttttgat gccaatagaa tcagagtcct caggaaggga ggaagtgagc taaagcattt
     8881 tccatctaca agagccctct ctgcctcata aagtcctttc cctttcgcac cgtcttctca
     8941 aggataacac ttgtctgtat ttccatgatg gatagagaaa caagttcttg acacttagca
     9001 agttctgcac caatattagt cgttggtttt aaactcatcc atttattact aatatttgtg
     9061 tctaaagcaa cttctgtgat cagtttatac tccccttaag acagccaagg ctgagagaaa
     9121 ccctatcttg aaaaaacaaa aaacaaaaaa gtggagttta tgatttaaat tttgtcccct
     9181 cagtatctta gttccttaac tgattttgtt ttaacggcca ttgttggatc taagaggctc
     9241 aggctgactg cattaagatc caatagtcag ttcagacttc ttcctagaaa tgagtgaggc
     9301 atgtgaaaga cctcttcaca gaggcctctg tgggagttca gggagatcat ggaagtgagg
     9361 acacctgagc ttgcttactg ctgactgcat tgggacgtca tagttaaggc ccacaaggac
     9421 aacctaggct catttctgca aggatgccct ggccagggta tggattcaga agtcttcata
     9481 gcagggaaaa ctttcatata ttcatgcttc ttgagagggg aaaggcacca agaaaaccga
     9541 ctgttgatct cttctcatca cgattacagc ggaggagggg tggctgggca gacacaagaa
     9601 acccatacag tataggtagg aaatagcacc ctgtggtctt tgttggtgca aatgcatttt
     9661 tattggacca cactacattc tcctctcttg tagcaaatgt gctggacttt tgaaccctca
     9721 aaaacgaaca agtgggctct ctctgcgtct ttcttcttct aggaacatag ttaaggctcc
     9781 cagccatctg ctttacttgg tgttccagtt ccgtcacgac tccttgctgc atggtgaagt
     9841 ttgcttaaat agggcctgtg tcaagaaact catcagcttg ggaggaagtc ctgttgtttc
     9901 agctaccttg gtcattaaaa ccagtcttcg gctctgtttt ttcctcgatt ctcaaaacta
     9961 acccacgaaa cataataaaa tcctggcctc cccttttttc ttcttccact gtatttgttt
    10021 tgttttttaa cgctgtatta cttttaaaaa caacttccat ttttagctga agagtacaag
    10081 tgcttcaaat ttaagcaccc actaaaaaaa gtcaagaaga tttccaacag tcagatatta
    10141 gaatttgtgt aagttttgtt ggtgtatttc tatccagaaa acaaaatgtt ctgacagtta
    10201 tcatatagcc tcatgcccta ccttagtaac tgtcttgtga acaatttgtt tcatttatca
    10261 gatccactga taatgacctt taaaaaattt gggaaacatc actgtcgatt ctccagcttt
    10321 tacaaagaaa aggtcaaaaa caaaattcag tggtactgtt actaaactca ctacttctga
    10381 tcagctcttc agtacaaaag gatactgttc ttaaggaaag ggattgggtg atgctatggt
    10441 ttatgtaaaa gtatataaat tctctcactg ttgcccaggg ttacagttta gctagcaacc
    10501 attagccttt ggaagaacag ggttttttgt cccttctgta tcagctttga atttgagagc
    10561 cctgtcgcca gaggctgcta tccgcccttg ggtaggcagc acctatgggt ggatttctaa
    10621 gctgtgaaat aataaaattc ctgagagagt ttccaagctg ctttcacaca tagaagagcc
    10681 ctgggaggat ggttattaat agccctgtcc tagaagcaag gctgaggttc agaatcctta
    10741 agtgtcttgc caaaagcaat ctagctggta agtgtgagat gtgggtattt acctacccct
    10801 tgtcacacaa ggccctgtta gaaaaatatc catggaaacc cacaaccatc tagttatcag
    10861 tggcaggtgg tatatgtgta tcatattgct gcagattatt aagagattgc acatgtctgt
    10921 gtcatcttgt gagaagccat gggtctctgt gatcacctct atggtgatac cccctgagca
    10981 aaggccactg aaaacagaca tctgtgcaga agcacattgc agcaaaattt cccagagagt
    11041 tgctttacat tcactggaaa catctctgga cctgtcaggt tcaggatatc aattgagact
    11101 atattatttc aaatatagta gtgtgcagag gttacctgag ttttaggaaa tctctccctc
    11161 caatggaccg caatgtatat cccaaagaga cagaagctgc tataggttaa aaaaacaaaa
    11221 caaaaaccat gattctctct gtcagcccaa gagtgtgctg aggcaaccag gagtttctaa
    11281 tcaaacaaac ccaagtccag aggccttgaa atgtctaaac aagtgctatt gaatgaacag
    11341 acctcctgaa atgtaccctt cattgtatct atgggattaa tctaccctca tcacaaggag
    11401 catgacactg tattcttagc accaacaaaa accctgcttg gagcaccctg ggtacattct
    11461 agaagtcagc cgacattgca ggtcaacaaa tcaacactct tcttagagct gacttcctcg
    11521 tgaatatgcc ttccaggtgc agtcttggct ttcctttttc tatcttctgg ttgtttgcta
    11581 caagttgaaa atccgttgac taattaagaa aatattctct gtccacatta aatctgtcct
    11641 caatctagaa accctttcaa atgccctagt ttgtaagtta ggcatttgtc ttccctagag
    11701 cctctcctcc atcagaccaa gattaccgct cataaaaaag aaatcttatt ttaaaagact
    11761 ttagcttttt agaccaggaa attaataatt cctaaacctg acccattttc atagcttcca
    11821 gaaaggaaaa gaaaaagcta cttaaatttt gtgtggatct gtttatctct taaaatatgt
    11881 ccaggcaatt tgacgcaggg gtagaacggg aggtgtttat ctctcttgct tgattccttc
    11941 tgtttctatg gggaaagcgg taaagacgaa ggacccagtg ttctttgggg ctgggttgcc
    12001 attttttatc ccatctgctt tgcttcatcg tgatgaggag taattcctag ttgctctcat
    12061 aaatcctcat cctccatcac aatggagtaa atatattaaa tctgaatatc tttgctcacc
    12121 aaattactta gctccatttc tcagtgggga aatataaagc aggcagagct ggccttcaat
    12181 tatacactta actccttcaa gccctttttg ctttatttct taggggagac tgtgtgaaag
    12241 agaaacaacc tagtccctcc tcatcttttg gagccatgat gctcacttag gaattacagg
    12301 aaaagaatgg cttggcttgg ccaggtcatg tgatctgcct aacgtgtttc attccttcaa
    12361 acacagactg agaaaaaagg gagtttcatc atttaaatac catcaatggg aacggtctca
    12421 ttttgcctaa gatgggagct aatctagttg ggtagtattg cattgtagta accttttgag
    12481 ttgtgcttgg ttactaaaag agtggcagat acatcagcct atgggattac actaccaaaa
    12541 gccatagtgc cacagacctc aatcgctcac tggcaaactg aattaccctg gaccttcctt
    12601 ctacttcaag tgatatgtgt tccaaactga tatgtgtccc agatgaaata gagactgatc
    12661 taatcaaaaa aaaaaaaaaa aaaaaaggtt tggcagggaa gcagtagcaa aatcatttct
    12721 cagtgactgt cctttaccca tgtgtgcact tgggacacct ggggacacta gcagactacc
    12781 taagacatct ttcctcatga atgaagggta gaagagttcc cctctaagcg ttggagtcaa
    12841 gtctttactc ccttccagaa aatatgtcaa ggagaaaata gaattataga tggcacatga
    12901 ctgtctggct cttgtcttaa gaatgctgtg tggaattatg tgccttacgc aaaacctgaa
    12961 acttagaagc caagttttgt gcagcggaag ggagcactga gctctgtggt ggctccgcga
    13021 agtgacttag cctgggtttt gcattgcctt gtctggatct atgcctttat cgttacttaa
    13081 cagatttggg gcttttcttt ctttaccgct aagcatgggc atgtgtgcaa ttatgaggtg
    13141 aactttctaa gtagtaagcc cttgccacaa agtagacgtt acacaaaggc acagagccca
    13201 gggatagtaa tcttgcctga gctgctcgca caggcttctt attccatggc tttgtcgcag
    13261 gcttttctct ttctgtgcca tcacctttga gaaacatgat tgcaccttct ccaactctgc
    13321 ctttttaaca gcttcagttg agttggcaag actttcccag ctctgaatat agccatttcc
    13381 cgactccggc ctctgcgaga ctgatttcaa atctgtgatc ttctgttcag cgtacacatc
    13441 agcaaagtga gaagttgggt gctaaatata ggctctatta actttacttt tagatgtgct
    13501 gccttcaaag agtgcctatt ctgagcaacg taaacgttat tcctacatat gtatgtacac
    13561 acggtacccg gactcacact gttcgggctt cacaaacacc atcagcaggg gtaggtgctg
    13621 agataaggaa gcatcgccaa attgaagagg gtggctcatt tccaatctcc ccttcagtgg
    13681 ctaccatgaa atgggctaaa acaagagtct cctgcacttc ctgctgacac agccactttg
    13741 catttatatc ccaggaatag tggcaaattg ctgaggaacc cgtatttcat ggaaataata
    13801 caatcatgaa catttcatca ggagagggaa aggcaattaa tatgtgtcat gtgtgtttta
    13861 aaaactaagt attgctaagt tttgagtgtc agcaggtttc ttttatctta caggctaaca
    13921 tagagaaaac taacgtcttg gctataggga gtgtaagctc agggggccag gcatccctgc
    13981 cagctccttg aagcattttt actccagctc ctaagaatac cagtccatgc tatttgaggg
    14041 cttttgttcc tggagctctc tctgtcagcg acaggaactc taggtatttt tgaggaggca
    14101 gcagcatagc ctgggagggt gagtggttac ccagcagtcg tgctcggagg tgagccaggt
    14161 agatgtgctg aggtacatgg agataccgta tgatcgtaca agggttgaac ggaggacatg
    14221 attccaaaaa agattgttct caatgtgtcg tctgactcaa ccagctggca gattacactt
    14281 gccaagtcgc ttcctttcct tctaagtcat ttggctccat attcccttga atatgcctgt
    14341 gaggaaagta agatgtgtcg ccccatccac ttagccttcc tgaaaggaca ttagtgatgc
    14401 cctagtggtc accaagctac catgaaatgc caccactcct actcagttgt accaaatgca
    14461 agtagagggg acaaactgtg ggagacagat ttagtgccat cgtggttgtc tgccactctg
    14521 cccagtatga tcccagcaac ccacgagatc tgaaggaaca ggactggtga gtagctttag
    14581 ggctatggcc gtacttcttt aggaacgtca tgattggagt caggttgatt tttttttttt
    14641 ctttttagag gtgggcagta ctttttccca tttctcctgt tacctatctt ttgatctcta
    14701 tctaatctca acactaataa ttttctgctg ttgacctgat cagatttcag tgctagaaaa
    14761 gaattctaaa atctcttgtg tgctgtcctc aagtctttgg gatacacagg tactcctcct
    14821 tgggaacaaa caaactgaga cagacacagt gtggccttgc tctgagtttc agtctggtga
    14881 cttgtggcca tgagagagag cttgatatga aagctaagtc atgtttaatg ggacagggta
    14941 aggacaggag agaaaagctg ttaggctttc cctgtgctaa acctatctcc tgggagcagg
    15001 cacttcctcc tagctagcca ccatcacagc ctcaccagca gcagcctcaa gactcagtaa
    15061 catttccaac ttaggaaaag ctacacagac gcatagagga tatgacattg ttcatctgca
    15121 tgatcctgac agagccttgg tattttcaca gtgtaagcaa attgcatatc tttgctgtct
    15181 cataaaccat cgctgacatc cccacgggag cacacataat cctttctgaa aatcagaagt
    15241 tgtgttacaa gaaagtggtt tgggtaattt cttttgtatt tacacattat tcaattatat
    15301 taaaacatga ttttatttac attctatcag ttttgattgt gtttccccag tgctcaatga
    15361 gaataaatat gaaaatcaca gttttttctg taaaagaatt actttatatt taaaaatcca
    15421 ataaacttct cattccactt aaaaaaaaaa aaaaaaaaaa aa
//
