LOCUS       NM_008509               4049 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus lipoprotein lipase (Lpl), mRNA.
ACCESSION   NM_008509 XM_909793 XM_921447
VERSION     NM_008509.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4049)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   2  (bases 1 to 4049)
  AUTHORS   Farley,A., Gao,Y., Sun,Y., Zohrabian,S., Pu,W.T. and Lin,Z.
  TITLE     Activation of VGLL4 Suppresses Cardiomyocyte Maturational
            Hypertrophic Growth
  JOURNAL   Cells 13 (16), 1342 (2024)
   PUBMED   39195232
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4049)
  AUTHORS   Guo,P., Lim,R.C., Rajawasam,K., Trinh,T., Sun,H. and Zhang,H.
  TITLE     A methylation-phosphorylation switch controls EZH2 stability and
            hematopoiesis
  JOURNAL   Elife 13, e86168 (2024)
   PUBMED   38346162
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4049)
  AUTHORS   Yang,Y., Beigneux,A.P., Song,W., Nguyen,L.P., Jung,H., Tu,Y.,
            Weston,T.A., Tran,C.M., Xie,K., Yu,R.G., Tran,A.P., Miyashita,K.,
            Nakajima,K., Murakami,M., Chen,Y.Q., Zhen,E.Y., Kim,J.R., Kim,P.H.,
            Birrane,G., Tontonoz,P., Ploug,M., Konrad,R.J., Fong,L.G. and
            Young,S.G.
  TITLE     Hypertriglyceridemia in Apoa5-/- mice results from reduced amounts
            of lipoprotein lipase in the capillary lumen
  JOURNAL   J Clin Invest 133 (23), e172600 (2023)
   PUBMED   37824203
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4049)
  AUTHORS   Kobayashi,K., Iwasa,K., Azuma-Suzuki,R., Kawauchi,T. and
            Nabeshima,Y.I.
  TITLE     Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15
            axis is essential for fetal growth
  JOURNAL   Life Sci Alliance 6 (10), e202301916 (2023)
   PUBMED   37541847
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4049)
  AUTHORS   Gimble,J.M., Youkhana,K., Hua,X., Bass,H., Medina,K., Sullivan,M.,
            Greenberger,J. and Wang,C.S.
  TITLE     Adipogenesis in a myeloid supporting bone marrow stromal cell line
  JOURNAL   J Cell Biochem 50 (1), 73-82 (1992)
   PUBMED   1339460
REFERENCE   7  (bases 1 to 4049)
  AUTHORS   Hua,X.X., Enerback,S., Hudson,J., Youkhana,K. and Gimble,J.M.
  TITLE     Cloning and characterization of the promoter of the murine
            lipoprotein lipase-encoding gene: structural and functional
            analysis
  JOURNAL   Gene 107 (2), 247-258 (1991)
   PUBMED   1748295
REFERENCE   8  (bases 1 to 4049)
  AUTHORS   Zechner,R., Newman,T.C., Steiner,E. and Breslow,J.L.
  TITLE     The structure of the mouse lipoprotein lipase gene: a B1 repetitive
            element is inserted into the 3' untranslated region of the mRNA
  JOURNAL   Genomics 11 (1), 62-76 (1991)
   PUBMED   1765386
REFERENCE   9  (bases 1 to 4049)
  AUTHORS   Fletcher,C., Norman,D.J., Germond,E. and Heintz,N.
  TITLE     A multilocus linkage map of mouse chromosome 8
  JOURNAL   Genomics 9 (4), 737-741 (1991)
   PUBMED   2037298
REFERENCE   10 (bases 1 to 4049)
  AUTHORS   Brownstein,D.G., Bhatt,P.N., Gras,L. and Jacoby,R.O.
  TITLE     Chromosomal locations and gonadal dependence of genes that mediate
            resistance to ectromelia (mousepox) virus-induced mortality
  JOURNAL   J Virol 65 (4), 1946-1951 (1991)
   PUBMED   2002550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK152014.1, AK150375.1 and AC158236.2.
            
            On Mar 8, 2007 this sequence version replaced NM_008509.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003305.1, AK150328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK152014.1         2-4
            4-2129              AK150375.1         3-2128
            2130-4049           AC158236.2         95739-97658
FEATURES             Location/Qualifiers
     source          1..4049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.88 cM"
     gene            1..4049
                     /gene="Lpl"
                     /note="lipoprotein lipase"
                     /db_xref="GeneID:16956"
                     /db_xref="MGI:MGI:96820"
     exon            1..286
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1623
                     /gene="Lpl"
                     /EC_number="3.1.1.34"
                     /EC_number="3.1.1.32"
                     /note="O 1-4-5; phospholipase A1"
                     /codon_start=1
                     /product="lipoprotein lipase precursor"
                     /protein_id="NP_032535.2"
                     /db_xref="CCDS:CCDS40357.1"
                     /db_xref="GeneID:16956"
                     /db_xref="MGI:MGI:96820"
                     /translation="MESKALLLVVLGVWLQSLTAFRGGVAAADAGRDFSDIESKFALR
                     TPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKR
                     EPDSNVIVVDWLYRAQQHYPVSAGYTKLVGNDVARFINWMEEEFNYPLDNVHLLGYSL
                     GAHAAGVAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPG
                     RSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVDQLVKCSHERSIHLFI
                     DSLLNEENPSKAYRCNSKEAFEKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRS
                     QMPYKVFHYQVKIHFSGTEDGKQHNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFL
                     IYTEVDIGELLMMKLKWISDSYFSWPDWWSSPSFVIERIRVKAGETQKKVIFCAREKV
                     SHLQKGKDSAVFVKCHDKSLKKSG"
     exon            287..447
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            448..627
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            628..739
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            740..973
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1216
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1337
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1520
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1622
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..4049
                     /gene="Lpl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3693..3698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpl"
                     /note="hexamer: AATAAA"
     polyA_site      3714
                     /gene="Lpl"
     regulatory      4023..4028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpl"
                     /note="hexamer: AATAAA"
     polyA_site      4049
                     /gene="Lpl"
                     /note="major polyA site"
ORIGIN      
        1 gtcagactct cgatttctcc tcctactcct cctccgagga attctgcccc ttgtaactgt
       61 tctgccctcc cctttaaagg ttgacttgcc ctacggcgct ccaccgcgct ccagtcctct
      121 tgcgcctcct gctcaacccg ctcctgactg ccccacgccg cgtagttcca gcagcaaagc
      181 agaagggtgc accgggagat ggagagcaaa gccctgctcc tggtggtcct gggagtttgg
      241 ctccagagtt tgaccgcctt ccgaggaggg gtggccgcag cagacgcggg aagagatttc
      301 tcagacatcg aaagcaaatt tgccctaagg acccctgaag acacagctga ggacacttgt
      361 catctcattc ctggattagc agactctgtg tctaactgcc acttcaacca cagcagcaag
      421 accttcgtgg tgatccatgg atggacggta acgggaatgt atgagagttg ggtgcccaaa
      481 cttgtggccg ccctgtacaa gagagaacct gactccaatg tcattgtagt agactggttg
      541 tatcgggccc agcaacatta tccagtgtca gctggctaca ccaagctggt gggaaatgat
      601 gtggccagat tcatcaactg gatggaggag gagtttaact accccctaga caacgtccac
      661 ctcttagggt acagccttgg agcccatgct gctggcgtag caggaagtct gaccaataag
      721 aaggtcaata gaattactgg tttggatcca gctgggccta actttgagta tgcagaagcc
      781 cccagtcgcc tttctcctga tgacgctgat tttgtagatg tcttacacac atttaccagg
      841 gggtcacctg gtcgaagtat tggaatccag aaaccagtag ggcatgttga catttatccc
      901 aatggaggca ctttccagcc aggatgcaac attggagaag ccatccgtgt gattgcagag
      961 agaggactcg gagacgtgga ccagctggtg aagtgctcgc acgagcgctc cattcatctc
     1021 ttcattgact ccctgctgaa tgaagaaaac cccagcaagg catacaggtg caactccaag
     1081 gaagcctttg agaaagggct ctgcctgagt tgtagaaaga atcgctgtaa caatctgggc
     1141 tatgagatca acaaggtcag agccaagaga agcagcaaga tgtacctgaa gactcgctct
     1201 cagatgccct acaaagtgtt ccattaccaa gtcaagattc acttttctgg gactgaggat
     1261 ggcaagcaac acaaccaggc cttcgagatt tctctgtacg gcacagtggc cgagagcgag
     1321 aacattccct tcaccctgcc cgaggtttcc acaaataaaa cctactcctt cttgatttac
     1381 acggaggtgg acatcggaga actgctcatg atgaagctta agtggataag cgactcctac
     1441 ttcagctggc ctgactggtg gagcagcccc agcttcgtca tcgagaggat ccgagtgaaa
     1501 gccggagaga ctcagaaaaa ggtcatcttc tgtgctaggg agaaagtttc tcatctgcag
     1561 aagggaaagg actcagcagt gtttgtgaaa tgccatgaca agtctctgaa gaagtctggc
     1621 tgacactgga caaacaaaca agagaagaaa gcatctgagt tctttgaaga cagaagaaaa
     1681 caaagtaaat ttaatttaaa aaaataatac ccttgtttgg gtgtttgaaa gtgggttttc
     1741 ctgagtatta atcccagctc tatcttgtta gttaaacaga agacagtctc aaatattaaa
     1801 cggtggctaa cccagggtga ggaatctaat ggcccatagc aggtcttcca gcattagaag
     1861 acagcaggca ggagaaacat gctgtcttgt atcccttaag aaggaatcat ttgctcccaa
     1921 caatataaga ctccatcatg tgacccattt ggtcatggtc taaaattagt aagaactctg
     1981 aggttttata ttgagacctt ttcaaagttt tctcaaagtc taatatagac aatatttttt
     2041 gtggcataag tcaggtccat ttctttagtg attgaaacac ctggcctttg caactagttt
     2101 ttttaccatt gggatatatt ccccccacca aaaaaaaaaa aaaaaaaaaa gtaaccagga
     2161 acgtgtgact tggcaaaagc agttgaagac atggctcatg aagtcctgac ccttggtccc
     2221 accacaacaa agtacaagtc aacagagata caaaacctag actgagtaat tcttaataga
     2281 cttgaatttt tatgacttaa tccttctatc ttttaaatat ttgtcagata ttttaacatt
     2341 gttctctgga gcttgtaagc tgggcaatgg tggcactcac ctttaatccc agcacttggc
     2401 aggcagaggc aggaggattt ctgagttcaa ggccagcctg gtttacagag tgagttccag
     2461 gacgtccaga gctacacaga gaaaccctgt cttgggaaaa aaaaaagaag aagaaggaga
     2521 agaagaagag ggagggaggg agggagggag ggagggaggg agggagggag ggagggaggg
     2581 agggagggag ggagggagaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa
     2641 ggaaggaagg aaggaaggaa ggaaggaaag aaagaaagaa agaaagaaag aaagaaagaa
     2701 agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa
     2761 agaaagaaag aaagaaaatg agcttgtaat tgaggtgaca cataaatttt gctgaaagac
     2821 aaaaatgcct aggttgattt tacttcttct cttttttgct ttcttgaaaa aagtcacaat
     2881 tgtcccatgc tgtaaccaag tctggcctcg aactaaacta tgtatttcag gctggccttg
     2941 aactctcaac catcctgcct tagcttcctg tgtcctggga gcttgagaac tgtaatttta
     3001 ttatcagatt tttcttactt gttttcatca atttgaaatg cccaatatcc aatactttgt
     3061 atttcatttg agactcatct ccgccatgcc tctgtcacac ttctaacaca tcacattaat
     3121 ttctagttta gatgtgatca agttcaaatt ctgcactgtg caaagtacaa gttttagagc
     3181 aggaccattt ttttttatca cataaaagtt gaaattacta gaaaatgtgc atatggatgc
     3241 ttgtaaactg ctgtgcaaag agaagagccc tcaactgtaa tagctataga aagtaccagg
     3301 attgttgccg ctgttttgtt ttaccttaac aacaacaaca acaaaaatca ataatgaaga
     3361 attatttatg aacgagatct cacattttca gattgctttt attattcatt aatgtaaaat
     3421 gataaagaag atctatctca gaggctatag ctgggagcag aaactgtgaa atttgtgggt
     3481 atctgaacac caacccacat gcaaagcccc acaagtgtag tcgtcattca atgtgattca
     3541 gaaaggaaag agtcaaggga tatactggaa tatgttagag aagtagttcc agatatgctg
     3601 gaatgttagc ccttgctagg agaaagctgg ttgtgcctat gtaatatagg acaaaggtga
     3661 ccgatttcat caagtttgga gtcaattcta acaataaaaa tatgtataat ttgtcaccgg
     3721 catccccatt attgctaatt cattacagta tatacacatc catgcataca tatgtcaatg
     3781 atgctttagc tttcaattta tttattagct gtaaataatg tgtgggtatg taagaatgct
     3841 tgtaaacact ggaaagtctg ttgtggttat ctgcagtata gatttgtggt gctaactttg
     3901 tgtccgtctc catccatgat tgtctgtctc actgagccaa cttaactctg atgaaacagt
     3961 acaatgaaat aggcttttga aagaagaaaa ctcacctgtg tgaagaaatg gtatctgctt
     4021 tcaataaaac tgagaacatt ttatcatga
//
