LOCUS       NM_015763               5581 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus lipin 1 (Lpin1), transcript variant 2, mRNA.
ACCESSION   NM_015763
VERSION     NM_015763.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5581)
  AUTHORS   LaPoint,A., Singer,J.M., Ferguson,D., Shew,T.M., Renkemeyer,M.K.,
            Palacios,H.H., Field,R.L., Yerrathota,S., Kumari,R., Shankaran,M.,
            Smith,G.I., Yoshino,J., He,M., Patti,G.J., Hellerstein,M.K.,
            Klein,S., Brestoff,J.R., Morris,E.M., Finck,B.N. and
            Lutkewitte,A.J.
  TITLE     Adipocyte lipin 1 expression associates with human metabolic health
            and regulates systemic metabolism in mice
  JOURNAL   J Clin Invest 134 (23), e169722 (2024)
   PUBMED   39405118
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5581)
  AUTHORS   Jama,A., Alshudukhi,A.A., Burke,S., Dong,L., Kamau,J.K., Morris,B.,
            Alkhomsi,I.A., Finck,B.N., Voss,A.A. and Ren,H.
  TITLE     Exploring lipin1 as a promising therapeutic target for the
            treatment of Duchenne muscular dystrophy
  JOURNAL   J Transl Med 22 (1), 664 (2024)
   PUBMED   39014470
  REMARK    GeneRIF: Exploring lipin1 as a promising therapeutic target for the
            treatment of Duchenne muscular dystrophy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5581)
  AUTHORS   Prabakaran,A.D., McFarland,K., Miz,K., Durumutla,H.B., Piczer,K.,
            El Abdellaoui Soussi,F., Latimer,H., Werbrich,C., Chung,H.J.,
            Blair,N.S., Millay,D.P., Morris,A.J., Prideaux,B., Finck,B.N. and
            Quattrocelli,M.
  TITLE     Intermittent glucocorticoid treatment improves muscle metabolism
            via the PGC1alpha/Lipin1 axis in an aging-related sarcopenia model
  JOURNAL   J Clin Invest 134 (11), e177427 (2024)
   PUBMED   38702076
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5581)
  AUTHORS   Lin,S., Wang,L., Jia,Y., Sun,Y., Qiao,P., Quan,Y., Liu,J., Hu,H.,
            Yang,B. and Zhou,H.
  TITLE     Lipin-1 deficiency deteriorates defect of fatty acid beta-oxidation
            and lipid-related kidney damage in diabetic kidney disease
  JOURNAL   Transl Res 266, 1-15 (2024)
   PUBMED   37433392
  REMARK    GeneRIF: Lipin-1 deficiency deteriorates defect of fatty acid
            beta-oxidation and lipid-related kidney damage in diabetic kidney
            disease.
REFERENCE   5  (bases 1 to 5581)
  AUTHORS   Wang,F., Liu,Y., Dong,Y., Zhao,M., Huang,H., Jin,J., Fan,L. and
            Xiang,R.
  TITLE     Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and
            obesity by disrupting the expression and nucleocytoplasmic
            localization of Lipin1
  JOURNAL   Front Med 18 (1), 180-191 (2024)
   PUBMED   37776435
  REMARK    GeneRIF: Haploinsufficiency of Lipin3 leads to hypertriglyceridemia
            and obesity by disrupting the expression and nucleocytoplasmic
            localization of Lipin1.
REFERENCE   6  (bases 1 to 5581)
  AUTHORS   Reue,K. and Cohen,R.D.
  TITLE     Acads gene deletion in BALB/cByJ mouse strain occurred after 1981
            and is not present in BALB/cByJ-fld mutant mice
  JOURNAL   Mamm Genome 7 (9), 694-695 (1996)
   PUBMED   8703125
REFERENCE   7  (bases 1 to 5581)
  AUTHORS   Reue,K. and Doolittle,M.H.
  TITLE     Naturally occurring mutations in mice affecting lipid transport and
            metabolism
  JOURNAL   J Lipid Res 37 (7), 1387-1405 (1996)
   PUBMED   8827513
  REMARK    Review article
REFERENCE   8  (bases 1 to 5581)
  AUTHORS   Rowe,L.B., Sweet,H.O., Gordon,J.I. and Birkenmeier,E.H.
  TITLE     The fld mutation maps near to but distinct from the Apob locus on
            mouse chromosome 12
  JOURNAL   Mamm Genome 7 (7), 555-557 (1996)
   PUBMED   8672142
REFERENCE   9  (bases 1 to 5581)
  AUTHORS   Langner,C.A., Birkenmeier,E.H., Roth,K.A., Bronson,R.T. and
            Gordon,J.I.
  TITLE     Characterization of the peripheral neuropathy in neonatal and adult
            mice that are homozygous for the fatty liver dystrophy (fld)
            mutation
  JOURNAL   J Biol Chem 266 (18), 11955-11964 (1991)
   PUBMED   2050689
REFERENCE   10 (bases 1 to 5581)
  AUTHORS   Langner,C.A., Birkenmeier,E.H., Ben-Zeev,O., Schotz,M.C.,
            Sweet,H.O., Davisson,M.T. and Gordon,J.I.
  TITLE     The fatty liver dystrophy (fld) mutation. A new mutant mouse with a
            developmental abnormality in triglyceride metabolism and associated
            tissue-specific defects in lipoprotein lipase and hepatic lipase
            activities
  JOURNAL   J Biol Chem 264 (14), 7994-8003 (1989)
   PUBMED   2722772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127780.1, AK014526.1, CX205142.1, AK009789.1 and CK621866.1.
            
            On Jul 22, 2008 this sequence version replaced NM_015763.3.
            
            Transcript Variant: This variant (2) includes an alternate in-frame
            exon in the 5' coding region, compared to variant 1, resulting in a
            longer protein (isoform b), compared to isoform a. Isoform b is
            also known as isoform beta. Variants 2 and 4 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014526.1, SRR10223971.12531.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY127780.1         2-41
            41-4168             AK014526.1         2-4129
            4169-4625           CX205142.1         128-584
            4626-5217           AK009789.1         207-798
            5218-5581           CK621866.1         268-631
FEATURES             Location/Qualifiers
     source          1..5581
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 7.9 cM"
     gene            1..5581
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /note="lipin 1"
                     /db_xref="GeneID:14245"
                     /db_xref="MGI:MGI:1891340"
     exon            1..53
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            54..254
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2837
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /EC_number="3.1.3.4"
                     /note="isoform b is encoded by transcript variant 2;
                     phosphatidate phosphatase LPIN1; fatty liver dystrophy
                     protein"
                     /codon_start=1
                     /product="phosphatidate phosphatase LPIN1 isoform b"
                     /protein_id="NP_056578.2"
                     /db_xref="CCDS:CCDS25822.1"
                     /db_xref="GeneID:14245"
                     /db_xref="MGI:MGI:1891340"
                     /translation="MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGSLQ
                     CSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEIIPMY
                     LATSPILSEGAARMESQLKRNSVDRIRCLDPTTAAQGLPPSDTPSTGSLGKKRRKRRR
                     KAQLDNLKRDDNVNTSEDEDMFPIEMSSDEDTAPMDGSRTLPNDVPPFQDDIPKENFP
                     SISTYPQSASYPSSDREWSPSPSSLVDCQRTPPHLAEGVLSSSCPLQSCHFHASESPS
                     GSRPSTPKSDSELVSKSADRLTPKNNLEMLWLWGELPQAAKSSSPHKMKESSPLGSRK
                     TPDKMNFQAIHSESSDTFSDQSPTMARGLLIHQSKAQTEMQFVNEEDLESLGAAAPPS
                     PVAEELKAPYPNTAQSSSKTDSPSRKKDKRSRHLGADGVYLDDLTDMDPEVAALYFPK
                     NGDPGGLPKQASDNGARSANQSPQSVGGSGIDSGVESTSDSLRDLPSIAISLCGGLSD
                     HREITKDAFLEQAVSYQQFADNPAIIDDPNLVVKVGNKYYNWTTAAPLLLAMQAFQKP
                     LPKATVESIMRDKMPKKGGRWWFSWRGRNATIKEESKPEQCLTGKGHNTGEQPAQLGL
                     ATRIKHESSSSDEEHAAAKPSGSSHLSLLSNVSYKKTLRLTSEQLKSLKLKNGPNDVV
                     FSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIA
                     KLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALH
                     REVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVN
                     PKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSCDFPCSDTFSNFTFWREPLPPF
                     ENQDMHSASA"
     exon            255..350
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..658
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..784
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            785..883
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1013
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1320
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1414
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1605
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1699
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1769
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1862
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1942
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2069
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2218
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2305
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2458
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2573
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2677
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     exon            2678..5581
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5269..5274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /note="hexamer: AACAAG"
     polyA_site      5296
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
                     /note="major polyA site"
     polyA_site      5316
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
     polyA_site      5336
                     /gene="Lpin1"
                     /gene_synonym="fld; Lipin1"
ORIGIN      
        1 gtttgcatac aaaggcagcc acacgcgtgc gcgcctgctc gtgaatcctc ttggttcaga
       61 caatgaatta cgtggggcag ctggccggcc aggtgtttgt gacggtgaag gagctctaca
      121 agggactgaa ccccgccacg ctgtcgggat gcatcgacat cattgtcatc cggcagccca
      181 atggcagtct gcagtgctcc cctttccacg tccgcttcgg caagatgggt gtcctccgct
      241 cccgagagaa agtggtggac atagaaatca atggggagtc cgtggatttg cacatgaagt
      301 tgggagacaa cggagaagca ttttttgttc aagagactga caacgatcag gaaatcatcc
      361 ccatgtacct ggccacgtcc cccatcctgt cagaaggagc tgcgagaatg gaaagccagc
      421 tgaagaggaa ctctgtagac agaatcaggt gcctggatcc cactacagct gcccagggcc
      481 tgcctcccag cgacacccca tccactggtt ctctggggaa gaagagaagg aaaaggagga
      541 ggaaggccca gttggacaat ctcaaaagag atgacaatgt caacacatct gaggatgagg
      601 acatgtttcc catagagatg agctcggatg aggacacagc accgatggat ggaagcagaa
      661 ctcttcctaa tgatgtacca ccattccaag atgatattcc taaggaaaac ttcccctcga
      721 tttcaacgta cccccagtca gcatcgtatc ccagttcgga cagagaatgg tcccccagcc
      781 ccagcagcct ggtagattgc cagaggactc cccctcacct ggccgaggga gttctctcta
      841 gctcttgtcc tctgcagtct tgccacttcc atgcttcgga aagtccttca ggctcccggc
      901 cctcaacacc aaaaagtgac tctgagctgg tcagtaagtc tgcagacagg ttgacgccaa
      961 agaataacct ggaaatgctc tggctgtggg gtgaattgcc acaggctgca aagtcctctt
     1021 ctccacacaa gatgaaagag tccagcccct tagggagccg gaagactcct gataaaatga
     1081 attttcaggc cattcacagc gagtcttcag atacttttag tgaccagtcg ccaacaatgg
     1141 cccggggact gctcatccac cagagtaagg cccagacgga aatgcagttt gtgaacgagg
     1201 aggatctcga gtccttgggg gcggcagccc caccttcacc cgtggccgaa gagctcaagg
     1261 ccccatatcc caacaccgca cagtcgtcga gcaagacaga ttccccttcc aggaagaaag
     1321 ataaacggag ccgacacctt ggagctgatg gtgtttatct ggacgacctc acggacatgg
     1381 accctgaagt ggcagccctg tatttcccca agaatgggga tcctggtggg ctccccaaac
     1441 aagccagtga caacggagcc aggtcagcca accagtcacc acagtctgtg ggaggctcgg
     1501 gcatcgacag tggtgtggag agcacctccg acagcctgag ggacctgcca tccatcgcca
     1561 tctccctctg cggtggcctc agtgaccaca gagagatcac caaagatgca tttttggaac
     1621 aagccgtgtc atatcagcaa tttgccgaca accctgctat catcgatgac cccaacctcg
     1681 tggtcaaggt tggcaataag tattacaact ggacaacagc agctcctcta cttctggcga
     1741 tgcaggcttt ccagaaacct ttgccaaagg ccactgtgga atccatcatg agagataaga
     1801 tgcccaaaaa gggaggaaga tggtggtttt cctggagagg aagaaatgcc acaatcaaag
     1861 aggaaagcaa gcctgaacag tgcctgactg ggaaaggcca caataccgga gagcagcctg
     1921 cccagcttgg cctggccacc aggataaagc atgagtcatc ctccagtgat gaagagcacg
     1981 cagccgccaa gccatcaggt tcgagccacc tctctctctt gtccaacgtc agctacaaaa
     2041 agaccctgcg gctcacgtcg gagcagctga aaagcttgaa gttgaagaac ggccccaatg
     2101 atgtggtgtt cagtgtcact acccagtacc agggcacctg tcgctgcgag ggcaccatct
     2161 acctgtggaa ttgggacgac aaagtcatca tctcagatat cgatgggacc atcacaagat
     2221 ctgatactct tggtcacatt ttgcccacgc tgggaaagga ttggactcac cagggcattg
     2281 caaagctgta ccacaaagta agccagaatg gctacaagtt tctctattgt tcggcacgtg
     2341 ccattgggat ggcggacatg acgaggggct acctgcactg ggtcaacgag aggggcacgg
     2401 tgcttccaca gggcccgctt ctgctcagcc cgagcagcct cttctccgcc ttgcacagag
     2461 aagtgattga aaagaagcca gaaaagttca aagtccagtg tttgacagac atcaagaacc
     2521 tgtttttccc aaacacagaa cccttctatg ctgcttttgg gaaccggcct gctgatgtgt
     2581 attcctacaa gcaagtggga gtgtccctga ataggatctt cactgtgaac cccaagggtg
     2641 agctggtgca ggagcatgcc aagaccaaca tcagctcgta cgtgcggctc tgcgaagtgg
     2701 tcgatcacgt cttcccattg ctaaagagaa gccattcctg tgacttcccc tgttcagaca
     2761 ctttcagtaa cttcaccttt tggagagagc cactgccacc ttttgaaaac caggacatgc
     2821 attcagcctc agcttgacgc gaccgagcat taaaggatag gttgtgggga ccctggagct
     2881 gctgggaagg ctgatatgtg gccacctgcc taagagagaa gcatttctcc ctcggctcgc
     2941 tcgctcgctc gctcgctcgc cccagggtga cacttctaag catggagggc ggagagaggc
     3001 tgcatctcat cccataggct gcaagaggat tgggtgcact aggagtgtgc agagcagccc
     3061 tctgtttggg tttagcacac ctcatgctgc accctccagt cccgtctgct ccagcaatta
     3121 gttaatgtgc aatacgggtg atgacccctt atcagcgggc aggccacctg agagcctgtc
     3181 tcagtatcac tgtgccccta ccccctggaa ctctgatgtg catagggatc agtagcatca
     3241 gggacacatt tccacgacag agacatccat gccaccttct gcacacaggc tgtgtcccga
     3301 gtctaagtga agggaacatg ggcctcgctg ggtctcagcc ctagccttgg ctttgacttt
     3361 ttagacgttc ccttgcagta ttgccgactg tctcacttta ggtgataagc tctttaattg
     3421 ctttggttaa aggtggcctg tgacgcagct gcatctctcc ccattcctca tagctcaagg
     3481 ctgggctatt tatgccttaa cgcatctgca gcaggcattt ccttagcgtg cactgtctag
     3541 ctctccgtaa ctgcaatgcc ttaccttaca agggtagtcc ctaaggcagc gtgtgtccgc
     3601 ggcatctcag caccttctgc gtcctgctac ccagcaagga ggagccacta gtgtggactc
     3661 agcagcactt acgcccacca ggaaggatgc cgctaaagac actggttgtt tttttttaag
     3721 aaacatagtt tccggaagtt aaattatttt ctttgcagat attatttatt tctttactgt
     3781 cactgggctg ctgttgtgag catcctagcc agatccttag gcttatagcc gtcatgaatg
     3841 cattaaaagt taagtgtgat agacagtcca aagagcctca ttctgtggat gtcacactct
     3901 gatcttctag aatctccgaa tcactcattt ttcttagttt tttttccccc cacagtctaa
     3961 gggaaagaaa aaaaagtaat aatttgagca atgttcttta agctgataga aggttgctgt
     4021 gaactgtctc agaacaatgt gaaaaatgaa aagtattttg ctaaaagagt tgctttactt
     4081 tgaaagtatt atttttctta aagggtgttt tactccaaag acagatcttt ctatttaaat
     4141 ttcattgtta gggtcagagg agacaggaac aaaaaaaaaa aaaaaaaaag gaaaagatag
     4201 aaagaagagt taaaaaagaa aaaaagcagt agaatggact gttactcttt ctgtgaaaga
     4261 aaacctagag tcactgccct tgtagtcact gggctctgtt aaggtctcat gtggtccaca
     4321 tagttcacag gaatgtaatg aaagccactg tcatctgctg tgggcgccca ctgatggaga
     4381 aactcggccc tgagtgtgtg gctccctctg ggagtcagga aagccattaa gctcctggct
     4441 tgttctctcg tgacctttgg aggccatggt aacccttctg ccaccacggt ggttttgtgt
     4501 gtattttgat tgctgtggac tgtatacgag ctcactggcc tgcagaggtt cacggccgtc
     4561 tccctcatgc ccaggggaag ctctggcatc tcttttcaaa tgccctctgc agcccgctgt
     4621 ccaggtggct ccctgatgcc atgttaggac ttgagccaga gtctctatag ccaaggctgg
     4681 tctacaatgc accatcttag acatacagca gtccttccac ctggcttggg aacctagttt
     4741 tgatatacct taaacttccc tgtcactcta ccctgaaaca gagcacacct cccacaaaac
     4801 cacactctat gatctctgtg aaaatcttca ggagccctgt ccaggcagtg atgtggacgt
     4861 ctactgttag gctccctgtg agatccaaat gagagctgca ccccggttct ctcaagttgc
     4921 ttatttgcat ctgcacttaa acccagaggc cccaaggtca cgtgttagga tactatatgg
     4981 gtaccataca tttcaaagtt gctcatggaa atgagcgact tgctccatag taacatgtcc
     5041 tcaaatggcg atcccacatg atgaaggaga acccacctgg cgcatctgag acaggcttct
     5101 gtcgtcagat actttccttt tggatttcag gttcggatca ctacttcaga atattttact
     5161 tacaacgttg gctgtgtgtt tgcaaatgcc ggtgcgatga ttaaaaaaaa aatcaatata
     5221 atatttcact gtgttgtgct tgatgcagag ctagaaattt ctgtaataaa caagatggat
     5281 gaaagacttc tgaaaatcag gcatatgaac tttaaattat ttttataagt tcttaaggtg
     5341 ctcttatttt tttctggttt cttatataca atacttagtt atttacttga agggggaaaa
     5401 aacccttagt gtgggctagg gaaatggctc aggcagtaag agtacttgcc atgcaagcaa
     5461 gcacatccaa gttctatccc cattatccat gaatgaggcc taatgacagt gtgcattgtt
     5521 ataccagtgc ccgggagatg aggatgggtg gatccgtggt gctggctaga cagacagccc
     5581 a
//
