LOCUS       NM_001134829            7069 bp    mRNA    linear   ROD 14-MAR-2023
DEFINITION  Mus musculus lysophosphatidylglycerol acyltransferase 1 (Lpgat1),
            transcript variant 1, mRNA.
ACCESSION   NM_001134829
VERSION     NM_001134829.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7069)
  AUTHORS   Kawana H, Ozawa M, Shibata T, Onishi H, Sato Y, Kano K, Shindou H,
            Shimizu T, Kono N and Aoki J.
  TITLE     Identification and characterization of LPLAT7 as an sn-1-specific
            lysophospholipid acyltransferase
  JOURNAL   J Lipid Res 63 (10), 100271 (2022)
   PUBMED   36049524
  REMARK    GeneRIF: Identification and characterization of LPLAT7 as an
            sn-1-specific lysophospholipid acyltransferase.
REFERENCE   2  (bases 1 to 7069)
  AUTHORS   Xu Y, Miller PC, Phoon CKL, Ren M, Nargis T, Rajan S, Hussain MM
            and Schlame M.
  TITLE     LPGAT1 controls the stearate/palmitate ratio of
            phosphatidylethanolamine and phosphatidylcholine in sn-1 specific
            remodeling
  JOURNAL   J Biol Chem 298 (3), 101685 (2022)
   PUBMED   35131264
  REMARK    GeneRIF: LPGAT1 controls the stearate/palmitate ratio of
            phosphatidylethanolamine and phosphatidylcholine in sn-1 specific
            remodeling.
REFERENCE   3  (bases 1 to 7069)
  AUTHORS   Hiramine Y, Emoto H, Takasuga S and Hiramatsu R.
  TITLE     Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an
            important role in hepatic triacylglycerol secretion
  JOURNAL   J Lipid Res 51 (6), 1424-1431 (2010)
   PUBMED   20018982
  REMARK    GeneRIF: LPGAT1, a newly identified MGAT enzyme, plays a
            significant role in hepatic triacylglycerol synthesis and secretion
            in db/db mice.
REFERENCE   4  (bases 1 to 7069)
  AUTHORS   Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S,
            Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H,
            Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY731977.1, AK172914.1, AC157810.4 and EL961234.1.
            
            [WARNING] On May 11, 2023 this sequence was replaced by
            NM_001134829.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172914.1, SRR7974084.23291.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY731977.1         1-50
            51-2786             AK172914.1         1-2736
            2787-6931           AC157810.4         149012-153156
            6932-7069           EL961234.1         247-384
FEATURES             Location/Qualifiers
     source          1..7069
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..7069
                     /gene="Lpgat1"
                     /gene_synonym="LPLAT7"
                     /note="lysophosphatidylglycerol acyltransferase 1"
                     /db_xref="GeneID:226856"
                     /db_xref="MGI:MGI:2446186"
     exon            1..203
                     /gene="Lpgat1"
                     /gene_synonym="LPLAT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1343
                     /gene="Lpgat1"
                     /gene_synonym="LPLAT7"
                     /EC_number="2.3.1.22"
                     /EC_number="2.3.1.62"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acyl-CoA:lysophosphatidylglycerol acyltransferase 1;
                     acyl-CoA:monoacylglycerol acyltransferase LPGAT1;
                     lysophospholipid acyltransferase 7;
                     stearoyl-CoA:1-lyso-2-acyl-PE acyltransferase;
                     2-acylglycerophosphocholine O-acyltransferase"
                     /codon_start=1
                     /product="acyl-CoA:lysophosphatidylglycerol
                     acyltransferase 1 isoform 1"
                     /protein_id="NP_001128301.1"
                     /db_xref="CCDS:CCDS48488.1"
                     /db_xref="GeneID:226856"
                     /db_xref="MGI:MGI:2446186"
                     /translation="MTATPGPGTPAAAAAAGPRPCRRSPLAPTEKDRTDANVRMAVTV
                     EEAPWLGWIVAKALMRFAFMVANNLVAIPSYICYVIILQPLRVLDSKRFWYIEGLMYK
                     WLLGMVASWGWYAGYTVMEWGEDIKAIAKDEAVMLVNHQATGDVCTLMMCLQDKGPVV
                     AQMMWLMDHIFKYTNFGIVSLIHGDFFIRQGRAYRDQQLLVLKKHLEHNYRSRDRKWI
                     VLFPEGGFLRKRRETSQAFAKKNNLPFLTHVTLPRFGATNIILKALVARQENGSPAGG
                     DARGLECKSRGLQWIIDTTIAYPKAEPIDIQTWILGYRKPTVTHVHYRIFPIGDVPLE
                     TEDLTSWLYQRFIEKEDLLSHFYKTGAFPPPQGQKEAVCREMTLSNMWIFLIQSFAFL
                     SGYLWYHIIQYFYHCLF"
     exon            204..468
                     /gene="Lpgat1"
                     /gene_synonym="LPLAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            469..587
                     /gene="Lpgat1"
                     /gene_synonym="LPLAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            588..683
                     /gene="Lpgat1"
                     /gene_synonym="LPLAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            684..957
                     /gene="Lpgat1"
                     /gene_synonym="LPLAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1084
                     /gene="Lpgat1"
                     /gene_synonym="LPLAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1191
                     /gene="Lpgat1"
                     /gene_synonym="LPLAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..7064
                     /gene="Lpgat1"
                     /gene_synonym="LPLAT7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctctgag tccccaccgc gcctctgtcc gcaggcagcc gcgaggggac tagggcgccc
       61 gcgcgcccgc tcgcgccgcg cctcgggccg cctgggccgc cgcagccgcg tccatgaccg
      121 cgacccccgg gccagggact cccgccgccg ccgccgccgc cggccctcgg ccctgtcgcc
      181 gctcgccgct cgcgcccact gagaaagaca ggaccgacgc caatgtaaga atggccgtga
      241 ccgtggaaga agctccgtgg ctgggctgga ttgtagcgaa agccctgatg agatttgcct
      301 tcatggtcgc caacaacctg gtcgctattc catcctacat ctgctatgta attatactgc
      361 agccactccg agtgctggac agtaagcgct tctggtatat cgaaggactc atgtacaaat
      421 ggcttttagg aatggtggct tcctggggct ggtatgctgg atacacagtg atggaatggg
      481 gggaagatat taaagcaatc gctaaagatg aagcagtgat gttggtgaac caccaggcaa
      541 ctggagatgt gtgtacattg atgatgtgcc tacaggataa aggaccggtt gtcgctcaga
      601 tgatgtggct gatggatcat attttcaagt atacaaactt tggaattgtt tctcttattc
      661 atggagactt ctttataaga cagggaagag cctaccgcga ccaacagctg ctggttctca
      721 agaagcacct tgaacataat tacaggagca gagatcgaaa atggatcgtt ttgtttccgg
      781 aagggggctt cctcaggaag aggcgagaaa caagccaggc atttgccaag aaaaataact
      841 tgccatttct tacacatgtc actttgccaa ggtttggggc aacaaacatt attttgaagg
      901 cacttgtagc acggcaggaa aatggaagcc cagcaggagg agacgctaga ggcttagaat
      961 gcaaatcaag aggcctccag tggataatag atacaaccat agcttatccc aaagctgaac
     1021 caatagacat tcagacctgg atcctggggt acaggaaacc aacagtcact catgtccatt
     1081 acaggatttt cccaattgga gatgtgccct tggagaccga ggacctcacc agctggctct
     1141 atcagcgctt tattgagaag gaggacctcc tgtcccattt ttataagaca ggagcctttc
     1201 ctcctcccca gggccagaag gaagctgtgt gcagagagat gaccctcagc aacatgtgga
     1261 tattcctcat ccagtccttt gcgtttttgt caggctatct gtggtaccac atcattcagt
     1321 atttttacca ttgtctattt taggaattga cttggacttg ctacatagga gttcagactt
     1381 cttcatacat gtgcattatt ttacatgtgc aaatcaaaat atataaaaag aaaaggaaat
     1441 tcaatggatg gattaatgtt tatccccctt tgggatattt taaaactcta ctacaatgag
     1501 gatcagtaat acaatgatgt gctaatatat tttaagaact tttttgtgtt ttaaagagat
     1561 acactctacc atacatttac gcaagcatca cactgggaga agaggaaatg ataaaatcct
     1621 agaagactcg gaaagaaact ctcgccacca gatgcactta gtcagcccct gtgacctgct
     1681 tgtgaccttt agttcaggtt cagaagctat gctcctcttt cctaggacag agcgccacaa
     1741 cattaatgtg tctacccttc atgctgaggt actggtagcc tggagagctg gtgggcacat
     1801 cctgaggagt ggcctcacca tctagcaacc ctggctaagg tgcagcgttg gcattctctg
     1861 tggggagcag tgtccactgt ccacatgaca tcactgtgtc ccttgaaagg ctagctcagc
     1921 ccagtaccat gtttacatgt gctagtgctt tccctcagca gaggagagca cccactttct
     1981 cttttgtata gaaagcatat catagaagga taattgtatt ttacaagatg cacttttatc
     2041 agatgcaaat atagcaaagg atagtaacct agcctgaagc aaagggaagc ctcatccgtg
     2101 agcaggctcc caggaggctt tcctgtctgt gcttgcccat gatgctctag taccacctcc
     2161 atcggccacc tccctgaacc cactcccgtt ctggtagctg gatcccctcc ctctgatttt
     2221 gatatcatag taccaagtgt atttgggggc ggttaaagca aattaacata aaacatttaa
     2281 atgaccagtt tcagggaact agagtagctt attaggaaat aagaggtaga accagatgtt
     2341 ggcttgcaat attgacaagg cttcttgtgg gccctggggt ctgtatgttc tgtcattatg
     2401 tcaagcagct gcctctctca gggtggcagg acctggagac agcagctcaa aaacacttcc
     2461 cagtctcttc cagtcgtctt ctaagagggc aaagccaagc aagtttctgt tcatcgtaga
     2521 aaccttttga aagatttgtc cttttgttca tgtgatttac ctcacaggag aaccagactt
     2581 tacaaaaatc agtgttgaga cagaggatgg gtttggttta ggacagtgaa actcctaagc
     2641 ttgaaaaaca gtaagtcagc agtagttttc tgtggcatga acgaacacta gattccccta
     2701 ttgttactaa caacacaaat aacaattctg agaaataggt tgtaaaacaa aaataaagac
     2761 taatgttttc tgttttcaaa taaaccaaaa agagaaaaag gaaagatgtg aattttcccc
     2821 agttgtacag gaacagttga ccaacaccaa ataaaagccc atagtagctt catctttagc
     2881 aaaccccaag cacgtacaga agagagagac gttacctgaa atacctcact ggtaccacac
     2941 cactgctggt aaactgaaga aggcatttga tttgttagca gttgttataa aaacctaagc
     3001 actttactct ggttagcagg gacagtgaat aagggaaagc agtctcaatc cagaaacgag
     3061 gggaagccag agagaagcta cgcagtgcct ctgttgaggc ccaggaaaaa ctgttcagtt
     3121 tcaggatgaa ttgaattgag acattagttg attgtctggg ggagaagttg ctcattgtca
     3181 agtatagcat gtagtcctag ctagcagacc catttcctca ttgcaaagca agccacaggc
     3241 tacagtggcc agttcctata aggatgtata tatccatata tgtgcgtaca cagaaatgtg
     3301 actggcccac ttttaccact gctgtgctcc agaggaacat gacagttaag tatatgtaca
     3361 tgctgagttc actcttctaa gatgtgttac tttcaaatgc agttttgttt ccacagtctc
     3421 tagagtgaca ataactgtag acttgtgaac tgacttctga tagtagagat gagctataaa
     3481 tagatgtgct tggtctgtct atcccacacc tctccagttc aacatgtctt ctgtgtacaa
     3541 acaatcagac atgtttgttg agagtattgg cagtgcttcc ttgtcatagc tggagtccac
     3601 ctgcttatac tagggaactg gaagagagaa taaataggtg ttctttatgg ccatctcagg
     3661 aagccacaca atgccattgt agagagctgg atagaactcc ccatttgtat ttagtgtgga
     3721 aagtgggatg caaggaagtt attgattgta ttaagtcggg gggcaggggg aggtaagcaa
     3781 agccatgcca gtttacaccg gcgtccttta ggactgcagc tctttttgcc ctcagctgca
     3841 ttgcctggct tcctaccaca cacaggctgg gcgacaggtg ggaccaagcg acagctcacc
     3901 tcacttcaga aagggctgtg tgcgatgaca gagaagcctg tgagcagagg aggcaggaac
     3961 agcaagaacg cctgtgagca gaggaagcag gaacagcaag aacggaatga aacttgaaca
     4021 gataaacaag ttagacggga atttaatagg aaggttgaaa ttaatagctg tgggttcaga
     4081 tctgtcatgt gattagttct taatttccta cagtaagaaa ctagggaata ctgaagtcat
     4141 caattacagg gtagttaatc cagtattaag tcataggaag ccaaaaattc agttttctga
     4201 aggaatttct gattttttaa ttctcattga acttttcctt ctgaggatgc ttactacttt
     4261 aaacgttggc tttagttctt tccctgacta atttctgtct gtgcattatg cctgtgttaa
     4321 tgggtagtta agtaacaaga agtcaagact acaagcaaga ggagaaacac caaagccagc
     4381 gggcttaacc tgaggactgc aaaagacaaa agttggtgca gctgtaattg tcccagaggt
     4441 agagtcctaa gtcagccatt gtggccctcg ggtgcagctg tcacgttgct gaggatgctc
     4501 tctcactcac gccttgtgga ttccttctca ttaatttgtc ttagtgatgt attttgacaa
     4561 tcggtacctt aaagacttgc tcaactagtt gttcctagtt ataatcacag agaatagtct
     4621 ttgatcatag gttgtcttct gtatcttgag tatgttttaa aagaaaatgt ttgtttgcat
     4681 taccgaatag gaagggttaa ctgatctttt ctgtggtttt ttgtcctttt ctttgaagtc
     4741 actacacaac aatgaacaca ggatatcact caaaagttgc cattacaaaa agtgtattcg
     4801 gctctggttc aaaaggatga atggtaatgg cctttgatgg gaattttgcc ctccaagtgc
     4861 tctgggcctt atagctatca gcaggcaaga gagaggcaga tgagactgtg tagcaggtgt
     4921 gctagttccc ggcatgaggg tagagactaa tgtgtttggg accaaaagca cctaagttgg
     4981 gaatttctgg atcacataag agcctggggt gctctgaagc agccactggc tggtgctggt
     5041 tgatgtcatg ttgcaccagc tctcagtaat ctcaaagtgg gctctgagac tactctgcaa
     5101 gttcccagct gttgggggag aagggctatg gtcaaatgaa agatgcactg tggagttttc
     5161 tgcagaaatt ccatctgaga atttttacat ttaatatttt tttttaaaca atctaaagag
     5221 caaaaaaaaa tgtacgtgta ttctagttgc aaagtatgca aatgcttcag atggctttgt
     5281 ttttattgtg taaaactgtt gaacacaact gtggtgcaca aattctttcc atgtaaggag
     5341 tctatgcatt ttacaggaac atatcttatg attgggtaat gagacagtta tacattcaac
     5401 tgccattatt tttattaagt gctttcactt tctttacagt tattacaaag ttatatttat
     5461 tttctacaga tgggtttctg ttttcatgat gctgtaatgt ttacttcagc ttgttgagct
     5521 ttctttgtga tctgcatgtc acaatgtgtg ctctaaggtg actgtcaatg ctgtgacaac
     5581 tgtaacttgc tttgtaaagg gctggtcacc tgtggatctg gtttatgaat gcatcgggat
     5641 gattttacca gatcaccttt tcagaaattt agatgttgta aacaccaaaa gaagcatttt
     5701 ctcagcaaaa attaatagct ggttctattt tttttaaatg tagagaaaat aaagttgatt
     5761 tccttttttc caaaaacaat gcttttaatt cttactaatg ggggtgggtg tctgctgggc
     5821 ggagcccctc agcactcact gctgtggcac gtgcccagag ctcggcattc atgaccggtg
     5881 aggaaaacca cccggttcct tctttgctta caaaggcttg ctccttcctc cagtcttctc
     5941 atttggtatg agctcttggg aaaatttatg taaatgtaca tccatgtata atatattttg
     6001 ctgataacat atttaatgca attagcaaat aataaaatat aagtaattga tccttacaat
     6061 ataattatca ttgctgaacc ctcggagcca acctgtgaca atatcaacca tgattgctag
     6121 cattatgccc tgataaacta accatctcca gataaactca tttagtctag tgtatgattt
     6181 atagtaaacg cttacccttg tacagaatct ccttttagtc tcagcattaa ttggaagttt
     6241 agataattta tttttaatcc tattaaaccc tagaattaaa tgatcagctc ttagagacaa
     6301 gctggagcta ccgtcatcac cacagtcctg gtctttgtgt tttgatttgt tttaattact
     6361 agtgttgaat aaaattctca gaattgattt gctcactggt ccaagaaaac tcctatcatt
     6421 ggcctttgcg ggttttaaaa tggaaaagga ctgagagcac attgagcgag ggagcgctct
     6481 atcctggaaa gtctaaggag atcaggggca cagggccggt acgctgcgtt ctcagagctg
     6541 agtaaatgtg tacacctata ctgagatttt tttttttctt aacattaaaa acattgatgg
     6601 tttagtcatt tgtttgtaga atgtttgacc cattttgaaa acttttaatg tgttaaaatg
     6661 tcttgcacaa tcctaccaaa taagttgaat agttacagtt gagtctacct cttcttttct
     6721 tggctggatt taggctgctg gttgggtgag gctgcggctt tatttcccct ctacagtact
     6781 ttatgtggga gacagatcta gggcctggaa gcagacttga agcgttttga gatctgttgc
     6841 tgaccagccc tcttccccga gagtctgggg aaagccattg tttttaatgc ccacttaata
     6901 tgaaaatgtt tgttttaaaa aatgtttctt gctggtgaaa aatgtatttt taaaacgaaa
     6961 aaccaaatcc tcttttggtc tgagaagtca gctgtatgag caggtgtgac cgtatcataa
     7021 catgctgatg tcatagaaat caataaattt ttacctctca ggaaaaaaa
//
