LOCUS       NM_207206               1920 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus lysophosphatidylcholine acyltransferase 4 (Lpcat4),
            mRNA.
ACCESSION   NM_207206 XM_149200
VERSION     NM_207206.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Shimizu,K., Ono,M., Mikamoto,T., Urayama,Y., Yoshida,S., Hase,T.,
            Michinaga,S., Nakanishi,H., Iwasaki,M., Terada,T., Sakurai,F.,
            Mizuguchi,H., Shindou,H., Tomita,K. and Nishinaka,T.
  TITLE     Overexpression of lysophospholipid acyltransferase,
            LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases
            glucose-stimulated insulin secretion
  JOURNAL   FASEB J 38 (2), e23425 (2024)
   PUBMED   38226852
  REMARK    GeneRIF: Overexpression of lysophospholipid acyltransferase,
            LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases
            glucose-stimulated insulin secretion.
REFERENCE   2  (bases 1 to 1920)
  AUTHORS   Eto,M., Shindou,H., Yamamoto,S., Tamura-Nakano,M. and Shimizu,T.
  TITLE     Lysophosphatidylethanolamine acyltransferase 2 (LPEAT2)
            incorporates DHA into phospholipids and has possible functions for
            fatty acid-induced cell death
  JOURNAL   Biochem Biophys Res Commun 526 (1), 246-252 (2020)
   PUBMED   32204912
  REMARK    GeneRIF: Lysophosphatidylethanolamine acyltransferase 2 (LPEAT2)
            incorporates DHA into phospholipids and has possible functions for
            fatty acid-induced cell death.
REFERENCE   3  (bases 1 to 1920)
  AUTHORS   Tabe,S., Hikiji,H., Ariyoshi,W., Hashidate-Yoshida,T., Shindou,H.,
            Shimizu,T., Okinaga,T., Seta,Y., Tominaga,K. and Nishihara,T.
  TITLE     Lysophosphatidylcholine acyltransferase 4 is involved in
            chondrogenic differentiation of ATDC5 cells
  JOURNAL   Sci Rep 7 (1), 16701 (2017)
   PUBMED   29196633
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1920)
  AUTHORS   Cao,J., Shan,D., Revett,T., Li,D., Wu,L., Liu,W., Tobin,J.F. and
            Gimeno,R.E.
  TITLE     Molecular identification of a novel mammalian brain isoform of
            acyl-CoA:lysophospholipid acyltransferase with prominent
            ethanolamine lysophospholipid acylating activity, LPEAT2
  JOURNAL   J Biol Chem 283 (27), 19049-19057 (2008)
   PUBMED   18458083
REFERENCE   5  (bases 1 to 1920)
  AUTHORS   Soupene,E., Fyrst,H. and Kuypers,F.A.
  TITLE     Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 88-93 (2008)
   PUBMED   18156367
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC068131.1 and AL713853.7.
            
            On Apr 25, 2009 this sequence version replaced NM_207206.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068131.1, SRR11927938.3771983.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1793              BC068131.1         1-1793
            1794-1794           AL713853.7         143951-143951
            1795-1920           BC068131.1         1794-1919
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.96 cM"
     gene            1..1920
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /note="lysophosphatidylcholine acyltransferase 4"
                     /db_xref="GeneID:99010"
                     /db_xref="MGI:MGI:2138993"
     exon            1..217
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..1678
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /EC_number="2.3.1.23"
                     /EC_number="2.3.1.67"
                     /EC_number="2.3.1.n6"
                     /EC_number="2.3.1.n7"
                     /EC_number="2.3.1.121"
                     /note="1-AGPAT 7; acyltransferase-like 3; 1-AGP
                     acyltransferase 7; lysophosphatidylethanolamine
                     acyltransferase 2; -acylglycerol-3-phosphate
                     O-acyltransferase 7 (lysophosphatidic acid
                     acyltransferase, eta); 1-acylglycerol-3-phosphate
                     O-acyltransferase 7 (lysophosphatidic acid
                     acyltransferase, eta); plasmalogen synthase;
                     1-acylglycerophosphoserine O-acyltransferase;
                     1-acylglycerophosphocholine O-acyltransferase;
                     1-alkylglycerophosphocholine O-acetyltransferase;
                     1-alkenylglycerophosphoethanolamine O-acyltransferase"
                     /codon_start=1
                     /product="lysophospholipid acyltransferase LPCAT4"
                     /protein_id="NP_997089.1"
                     /db_xref="CCDS:CCDS16548.1"
                     /db_xref="GeneID:99010"
                     /db_xref="MGI:MGI:2138993"
                     /translation="MSQGSPGAWAPLDPTSGSSASPNPFVHELHLSGLQRVKFCLLGV
                     LLAPIRVLLAFIVLFLLWPFAWLQVAGLTEEQLQEPITGWRKTVCHNGVLGLSRLLFF
                     LLGFLRIRVRGQRASRLEAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGA
                     LLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPG
                     AFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYQPSL
                     EESKDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGQLKVALEPQLWELAKVLQ
                     KAGLSPGFVDMGAEPGRSRMISQEAFAQQLQLSDPQTVAGAFSYFQQDAKGLVDFRNV
                     ALALAALDGGRSLEELTRLAFELFAEEQAEGSDRLLYKDGFSTILHLLLGSPRPAATT
                     LHAELCQPGCSQGLSLCQFQNFSLHDPLYGKLFSAYLRPPHKPRSTSQIPNASSPSSP
                     TALANGTVQAPKQKGD"
     exon            218..360
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            361..581
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            582..694
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            695..755
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..814
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..849
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            850..904
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..987
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1113
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1246
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1345
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1502
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1902
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1880..1885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /note="hexamer: AATAAA"
     polyA_site      1902
                     /gene="Lpcat4"
                     /gene_synonym="Agpat7; Aytl3; LPEAT2"
                     /note="major polyA site"
ORIGIN      
        1 gctgccagtg ccgcacgagc cgcgctgctc tgcagagccg gaccgggagc ggggcccggg
       61 ccgggagcgg ggggtcgcgg ccctcgctcg accttctccc accatgagcc agggaagtcc
      121 tggggcctgg gcccccctgg atcccacctc tgggtcctct gcgtccccaa acccgttcgt
      181 gcatgagtta cacctctccg gcctccagag ggttaagttc tgcctcctgg gggtactgct
      241 ggccccaatc cgagtacttc tagcttttat tgtcctcttt ctcctctggc ccttcgcgtg
      301 gctccaagta gcaggtctca ctgaagagca gcttcaggaa ccaattacag gatggaggaa
      361 gactgtatgc cacaacgggg ttcttggtct gagccgcctg ctatttttcc tgcttggctt
      421 ccttcggatc cgtgttcggg gtcaaagggc ctctcgcctc gaagcccctg tcctggttgc
      481 tgccccccac tcaactttct ttgacccaat tgtcctgcta ccctgtgacc tgcccaaggt
      541 tgtgtctcga gctgagaatc tttctgtgcc tgtcattgga gcactccttc gatttaatca
      601 agccatccta gtctcccggc atgaccccgc ctctcggcgc agagtggttg aggaggtcag
      661 aaggcgggct acttcaggag gcaagtggcc tcaggtacta ttttttcctg aaggcacctg
      721 ttccaacaag aaggctctgc tgaagttcaa accaggagcc ttcatcgcag gggtgcccgt
      781 gcagcccgtc ctcatccgat accccaacag tctggacacc accagctggg catggagggg
      841 ccccggcgta ctcaaagttc tctggctcac cgcctctcag ccctgcagca tcgtggatgt
      901 agagttcctc cctgtctatc agcccagcct ggaggagagt aaggacccca ccctttatgc
      961 caacaacgtc cagagagtca tggcacaggc cctgggcatt ccagccactg aatgtgagtt
     1021 tgtagggagc ttgcctgtga ttgtggtggg ccagctgaag gtagcgttgg agccgcagct
     1081 ctgggagctg gcaaaggtgc tacagaaggc tgggctgtcc cctggctttg tggacatggg
     1141 ggcagagcca ggccggagtc gaatgatcag ccaagaggcc tttgcccaac agttacagct
     1201 ctcggatcct cagacagtgg ctggtgcctt cagctacttc cagcaggatg ccaagggttt
     1261 ggttgacttc cgaaatgtgg ccctagcgct agcggccctg gacgggggca ggagcctgga
     1321 ggagctgact cgcctggcct ttgagctctt tgctgaagag caggcagaag gatctgaccg
     1381 gctgctgtac aaagacggct tcagcaccat cctgcacctg ttgctgggtt caccccgccc
     1441 cgctgccacg actttgcatg ccgagctgtg ccagcctgga tgcagccagg gcctctccct
     1501 ctgtcagttc cagaacttct ccctccacga ccctctgtac ggcaagcttt tcagcgccta
     1561 cctacgcccc ccacacaagc ctcgaagcac ctcccagata ccaaatgcct catcccccag
     1621 cagccccact gccctggcca acgggactgt gcaggccccc aagcagaagg gagactgagc
     1681 gcctcagctt cccactttcc tcagctcaaa cccagccctg ctctcaggac ggcgtcagag
     1741 gcctacccta tgcctcaacc ccacctctgc tcctgtttga tttttttttt ttttggttat
     1801 cttttttttt tttcattttt ttgtttggtg gggtcttttt gtaaaagact attttatata
     1861 taaatataaa tatatatcta ataaaaaaaa acctgaagct tgaaaaaaaa aaaaaaaaaa
//
