LOCUS       NM_145130               1932 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus lysophosphatidylcholine acyltransferase 3 (Lpcat3),
            transcript variant 1, mRNA.
ACCESSION   NM_145130 XM_289687
VERSION     NM_145130.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1932)
  AUTHORS   Kondreddy,V., Banerjee,R., Devi,B.L.A.P., Muralidharan,K. and
            Piramanayagam,S.
  TITLE     Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration
            and osteoarthritis
  JOURNAL   Cell Commun Signal 22 (1), 189 (2024)
   PUBMED   38519981
  REMARK    GeneRIF: Inhibition of the MALT1-LPCAT3 axis protects cartilage
            degeneration and osteoarthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1932)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1932)
  AUTHORS   Habaxi,K., Wang,W., Taximaimaiti,M. and Wang,L.
  TITLE     Methylation Regulation of LPCAT3 Improves Osteoarthritis by
            Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (2), 77-86 (2024)
   PUBMED   38073444
  REMARK    GeneRIF: Methylation Regulation of LPCAT3 Improves Osteoarthritis
            by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
REFERENCE   4  (bases 1 to 1932)
  AUTHORS   Tian,Y., Lu,W., Shi,R., McGuffee,R., Lee,R., Ford,D.A. and Wang,B.
  TITLE     Targeting phospholipid remodeling pathway improves insulin
            resistance in diabetic mouse models
  JOURNAL   FASEB J 37 (11), e23251 (2023)
   PUBMED   37823674
REFERENCE   5  (bases 1 to 1932)
  AUTHORS   Ferrara,P.J., Rong,X., Maschek,J.A., Verkerke,A.R., Siripoksup,P.,
            Song,H., Green,T.D., Krishnan,K.C., Johnson,J.M., Turk,J.,
            Houmard,J.A., Lusis,A.J., Drummond,M.J., McClung,J.M., Cox,J.E.,
            Shaikh,S.R., Tontonoz,P., Holland,W.L. and Funai,K.
  TITLE     Lysophospholipid acylation modulates plasma membrane lipid
            organization and insulin sensitivity in skeletal muscle
  JOURNAL   J Clin Invest 131 (8) (2021)
   PUBMED   33591957
REFERENCE   6  (bases 1 to 1932)
  AUTHORS   Eto,M., Shindou,H., Koeberle,A., Harayama,T., Yanagida,K. and
            Shimizu,T.
  TITLE     Lysophosphatidylcholine acyltransferase 3 is the key enzyme for
            incorporating arachidonic acid into glycerophospholipids during
            adipocyte differentiation
  JOURNAL   Int J Mol Sci 13 (12), 16267-16280 (2012)
   PUBMED   23208369
  REMARK    GeneRIF: It is possible that enhanced phospholipid remodeling by
            LPCAT3 may be associated with adipocyte differentiation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1932)
  AUTHORS   Li,Z., Ding,T., Pan,X., Li,Y., Li,R., Sanders,P.E., Kuo,M.S.,
            Hussain,M.M., Cao,G. and Jiang,X.C.
  TITLE     Lysophosphatidylcholine acyltransferase 3 knockdown-mediated liver
            lysophosphatidylcholine accumulation promotes very low density
            lipoprotein production by enhancing microsomal triglyceride
            transfer protein expression
  JOURNAL   J Biol Chem 287 (24), 20122-20131 (2012)
   PUBMED   22511767
  REMARK    GeneRIF: hepatic LPCAT3 modulates VLDL production by regulating
            LysoPC levels and MTP expression.
REFERENCE   8  (bases 1 to 1932)
  AUTHORS   Hishikawa,D., Shindou,H., Kobayashi,S., Nakanishi,H., Taguchi,R.
            and Shimizu,T.
  TITLE     Discovery of a lysophospholipid acyltransferase family essential
            for membrane asymmetry and diversity
  JOURNAL   Proc Natl Acad Sci U S A 105 (8), 2830-2835 (2008)
   PUBMED   18287005
REFERENCE   9  (bases 1 to 1932)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   10 (bases 1 to 1932)
  AUTHORS   Ansari-Lari,M.A., Oeltjen,J.C., Schwartz,S., Zhang,Z., Muzny,D.M.,
            Lu,J., Gorrell,J.H., Chinault,A.C., Belmont,J.W., Miller,W. and
            Gibbs,R.A.
  TITLE     Comparative sequence analysis of a gene-rich cluster at human
            chromosome 12p13 and its syntenic region in mouse chromosome 6
  JOURNAL   Genome Res 8 (1), 29-40 (1998)
   PUBMED   9445485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164157.3.
            
            On Jul 25, 2022 this sequence version replaced NM_145130.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006753.1, AY028317.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC164157.3         59000-59231
            233-340             AC164157.3         93942-94049
            341-447             AC164157.3         95111-95217
            448-541             AC164157.3         95879-95972
            542-579             AC164157.3         96113-96150
            580-758             AC164157.3         96545-96723
            759-867             AC164157.3         97341-97449
            868-954             AC164157.3         98108-98194
            955-1121            AC164157.3         98284-98450
            1122-1269           AC164157.3         98878-99025
            1270-1428           AC164157.3         99099-99257
            1429-1561           AC164157.3         99367-99499
            1562-1932           AC164157.3         99672-100042
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..1932
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /note="lysophosphatidylcholine acyltransferase 3"
                     /db_xref="GeneID:14792"
                     /db_xref="MGI:MGI:1315211"
     exon            1..232
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1545
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /EC_number="2.3.1.23"
                     /EC_number="2.3.1.n6"
                     /EC_number="2.3.1.n7"
                     /note="LPC acyltransferase 3; lyso-PE acyltransferase;
                     lyso-PS acyltransferase; lyso-PC acyltransferase 3;
                     lysophosphatidylserine acyltransferase;
                     1-acylglycerophosphoserine O-acyltransferase;
                     lysophosphatidylethanolamine acyltransferase;
                     O-acyltransferase domain-containing protein 5"
                     /codon_start=1
                     /product="lysophospholipid acyltransferase 5"
                     /protein_id="NP_660112.1"
                     /db_xref="CCDS:CCDS20523.1"
                     /db_xref="GeneID:14792"
                     /db_xref="MGI:MGI:1315211"
                     /translation="MASTADGDMGETLEQMRGLWPGVEDLSLNKLATSLGASEQALRL
                     IFSIFLGYPLALFYRHYLFYKDSYLIHLFHTFTGLSIAYFNFGHQFYHSLLCVVLQFL
                     ILRLMGRTVTAVITTLCFQMAYLLAGYYYTATGDYDIKWTMPHCVLTLKLIGLCIDYY
                     DGGKDGNSLTSEQQKYAIRGVPSLLEVAGFSYFYGAFLVGPQFSMNHYMKLVRGQLTD
                     IPGKMPNSTIPALKRLSLGLVYLVGYTLLSPHITDDYLLTEDYDNRPFWFRCMYMLIW
                     GKFVLYKYVTCWLVTEGVCILSGLGFNGFDENGTVRWDACANMKVWLFETTPRFNGTI
                     ASFNINTNAWVARYIFKRLKFLGNKELSQGLSLLFLALWHGLHSGYLICFQMEFLIVI
                     VEKQVSSLIRDSPALSSLASITALQPFYYLVQQTIHWLFMGYSMTAFCLFTWDKWLKV
                     YRSIYFLGHVFFLSLLFILPYIHKAMVPRKEKLKKRE"
     exon            233..340
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            341..447
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            448..541
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            542..579
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            580..758
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            759..867
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            868..954
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1121
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1269
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1428
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1561
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1932
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1901..1906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /note="hexamer: GATAAA"
     polyA_site      1932
                     /gene="Lpcat3"
                     /gene_synonym="C3f; Grcc3f; Lpcat; Lpeat; Lplat5; Lpsat;
                     Mboat5; Moact5; Oact5; PTG"
                     /note="major polyA site"
ORIGIN      
        1 ggaattgggg gtgaagccac cgcgttctgc ccacattcgg ggcgcggagc tgggggtccc
       61 cggggggcgc ccgcagttaa gatggcgtct acagcggacg gggacatggg agagacgctg
      121 gagcagatgc gggggctgtg gccgggtgtc gaggatctga gccttaacaa gttggcgacg
      181 tctctgggcg cgtcggaaca ggcgctgcgg ctcatcttct ccatcttcct gggctacccg
      241 ttggctctgt tttaccggca ttaccttttc tacaaggaca gctacctcat ccatctcttc
      301 cacaccttca cgggcctctc aattgcttat ttcaactttg gccaccagtt ctaccactcc
      361 ttgctatgtg tcgtgcttca gttcctcatc ctgcgactca tgggccgcac cgtcactgcc
      421 gttattacta ccctttgctt ccagatggcc taccttcttg ccggatatta ctacacagcc
      481 accggtgact acgatatcaa gtggacaatg ccacattgtg tcttgacact gaagctaatt
      541 gggctgtgta ttgactacta cgatggaggc aaagacggga attccttgac ctctgagcaa
      601 cagaaatatg ccatacgggg tgtcccttca ttgctggaag ttgctggctt ctcctacttc
      661 tatggagcct tcttggtagg gccccaattt tcaatgaacc actacatgaa gctggtgcgg
      721 ggacagctga ctgacatacc agggaagatg ccaaacagca ccatacctgc tctcaagcgc
      781 ctgagtctgg gccttgtcta cctggtgggc tacaccctgc tgagccccca catcacagac
      841 gactatctcc tcacagaaga ctatgataac cgccctttct ggttccgctg catgtacatg
      901 ctgatctggg gcaaatttgt gctgtacaaa tacgtcacct gctggctggt cacagaagga
      961 gtgtgcattc tgtcgggcct gggctttaat ggcttcgatg aaaatgggac cgtgagatgg
     1021 gatgcctgtg ccaacatgaa agtgtggctc tttgaaacca cccctcgctt caatggcacc
     1081 atcgcctctt tcaacatcaa taccaatgcc tgggtagccc gttacatctt caaacgcctc
     1141 aagttccttg gaaataaaga gctctcacaa ggtctctcct tgctgttctt ggccctctgg
     1201 catggcctac actcaggata cctgatttgc ttccagatgg aattcctcat tgttatcgtg
     1261 gaaaagcagg tcagcagtct aattcgggac agccctgccc tgagcagcct ggcctccatc
     1321 actgccctac agcccttcta ctacttggtg caacagacca tccactggct gttcatgggt
     1381 tactctatga ctgccttctg cctcttcaca tgggacaaat ggcttaaggt gtacagatcc
     1441 atctatttcc ttggacatgt cttcttcttg agcctactat tcatattgcc ttatatccac
     1501 aaagcaatgg tgccaagaaa agaaaagtta aaaaagaggg aatgatctct gtctttccct
     1561 ggtggccgag agctggactg gtgcagaaac tacttgtctc ccttctcaca gcactcctca
     1621 ccccagcaga gacgccagga gctggaagtc acagcactcc cagctgtgcc tctgcgacag
     1681 ccaaagggga agctcttgtg ggaggagcag aggggctgca ccccctttgg actcccccat
     1741 gcacgttgcc ttatctctcc cctctagcca ggaatctgtt gtttctcttc tgccaatcta
     1801 ctacgattgt atatgtgccg ataccgccac cccccccatg gggggaggga agggtacaag
     1861 gccctgcctg ctccactttt tctatcttgg aactatacca gataaaatca cttctgtttg
     1921 ttcagttttt ca
//
