LOCUS       NM_173014               2817 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus lysophosphatidylcholine acyltransferase 2 (Lpcat2),
            transcript variant 1, mRNA.
ACCESSION   NM_173014
VERSION     NM_173014.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Suzuki,T., Taketomi,Y., Yanagida,K., Yoshida-Hashidate,T.,
            Nagase,T., Murakami,M., Shimizu,T. and Shindou,H.
  TITLE     Re-evaluation of the canonical PAF pathway in cutaneous anaphylaxis
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1870 (1), 159563 (2025)
   PUBMED   39332666
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Tabe,S., Hikiji,H., Hashidate-Yoshida,T., Shindou,H., Shimizu,T.
            and Tominaga,K.
  TITLE     The role of lysophosphatidylcholine acyltransferase 2 in
            osteoblastic differentiation of C2C12 cells
  JOURNAL   FEBS Open Bio 14 (9), 1490-1502 (2024)
   PUBMED   39075841
  REMARK    GeneRIF: The role of lysophosphatidylcholine acyltransferase 2 in
            osteoblastic differentiation of C2C12 cells.
REFERENCE   3  (bases 1 to 2817)
  AUTHORS   Murano,H., Inoue,S., Hashidate-Yoshida,T., Shindou,H., Shimizu,T.,
            Otaki,Y., Minegishi,Y., Kitaoka,T., Futakuchi,M., Igarashi,A.,
            Nishiwaki,M., Nemoto,T., Sato,M., Kobayashi,M., Sato,K., Hanawa,T.,
            Miyazaki,O. and Watanabe,M.
  TITLE     Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via
            Platelet-activating Factor
  JOURNAL   Am J Respir Cell Mol Biol 70 (6), 482-492 (2024)
   PUBMED   38377392
  REMARK    GeneRIF: Lysophospholipid Acyltransferase 9 Promotes Emphysema
            Formation via Platelet-activating Factor.
REFERENCE   4  (bases 1 to 2817)
  AUTHORS   Cao,N., Zhang,F., Yin,J., Zhang,J., Bian,X., Zheng,G., Li,N.,
            Lin,Y. and Luo,L.
  TITLE     LPCAT2 inhibits colorectal cancer progression via the PRMT1/SLC7A11
            axis
  JOURNAL   Oncogene 43 (22), 1714-1725 (2024)
   PUBMED   38605214
  REMARK    GeneRIF: LPCAT2 inhibits colorectal cancer progression via the
            PRMT1/SLC7A11 axis.
REFERENCE   5  (bases 1 to 2817)
  AUTHORS   Yamamoto,S., Hashidate-Yoshida,T., Yoshinari,Y., Shimizu,T. and
            Shindou,H.
  TITLE     Macrophage/microglia-producing transient increase of
            platelet-activating factor is involved in neuropathic pain
  JOURNAL   iScience 27 (4), 109466 (2024)
   PUBMED   38715939
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2817)
  AUTHORS   Morimoto,R., Shindou,H., Tarui,M. and Shimizu,T.
  TITLE     Rapid production of platelet-activating factor is induced by
            protein kinase Calpha-mediated phosphorylation of
            lysophosphatidylcholine acyltransferase 2 protein
  JOURNAL   J Biol Chem 289 (22), 15566-15576 (2014)
   PUBMED   24742674
  REMARK    GeneRIF: We show a new signaling pathway for rapid biosynthesis of
            PAF that is mediated by phosphorylation of LPCAT2 at Ser-34.
REFERENCE   7  (bases 1 to 2817)
  AUTHORS   Morimoto,R., Shindou,H., Oda,Y. and Shimizu,T.
  TITLE     Phosphorylation of lysophosphatidylcholine acyltransferase 2 at
            Ser34 enhances platelet-activating factor production in
            endotoxin-stimulated macrophages
  JOURNAL   J Biol Chem 285 (39), 29857-29862 (2010)
   PUBMED   20663880
  REMARK    GeneRIF: Specific inhibition of the PAF biosynthetic activity by
            phosphorylated LPCAT2 will provide a novel target for the
            regulation of inflammatory disorders.
REFERENCE   8  (bases 1 to 2817)
  AUTHORS   Harayama,T., Shindou,H., Ogasawara,R., Suwabe,A. and Shimizu,T.
  TITLE     Identification of a novel noninflammatory biosynthetic pathway of
            platelet-activating factor
  JOURNAL   J Biol Chem 283 (17), 11097-11106 (2008)
   PUBMED   18285344
REFERENCE   9  (bases 1 to 2817)
  AUTHORS   Soupene,E., Fyrst,H. and Kuypers,F.A.
  TITLE     Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 88-93 (2008)
   PUBMED   18156367
REFERENCE   10 (bases 1 to 2817)
  AUTHORS   Shindou,H., Hishikawa,D., Nakanishi,H., Harayama,T., Ishii,S.,
            Taguchi,R. and Shimizu,T.
  TITLE     A single enzyme catalyzes both platelet-activating factor
            production and membrane biogenesis of inflammatory cells. Cloning
            and characterization of acetyl-CoA:LYSO-PAF acetyltransferase
  JOURNAL   J Biol Chem 282 (9), 6532-6539 (2007)
   PUBMED   17182612
  REMARK    GeneRIF: Cloned the mouse acetyl-CoA:LYSO-PAF acetyltransferase and
            found that the enzyme catalyzed not only biosynthesis of PAF from
            lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF
            precursor membrane glycerophospholipids.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121604.3 and AK039431.1.
            
            On Oct 26, 2017 this sequence version replaced NM_173014.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039431.1, AB244716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC121604.3         92208-92224         c
            18-2817             AK039431.1         1-2800
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.99 cM"
     gene            1..2817
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /note="lysophosphatidylcholine acyltransferase 2"
                     /db_xref="GeneID:270084"
                     /db_xref="MGI:MGI:3606214"
     exon            1..293
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            294..433
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            434..651
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            652..764
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..825
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..884
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..919
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..974
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1057
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1183
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1337
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1436
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1572
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..2817
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /note="hexamer: AATAAA"
     polyA_site      2038
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /note="major polyA site"
     regulatory      2783..2788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
                     /note="hexamer: AATAAA"
     polyA_site      2808
                     /gene="Lpcat2"
                     /gene_synonym="1-AGPAT 11; A330042H22; Aytl1; Aytl1a;
                     lpafat1; lysoPAFAT; lysoPAFAT/LPCAT2"
ORIGIN      
        1 gcctgcgcag aagccgggag cggcgcctgg ggctgggagt ctctggttct gaggttggga
       61 ctgtgaattc ggccgctctc ttcgggtccc cgctttgctc gggtcgggca cctggatcca
      121 tcatgaaccg atgcgccgag gcggccgctg tggcggctac ggtcccgggt tcgggcgtcg
      181 gggacgccgg gctgcggcca cccatggtac ctcgccaggc gtccttcttc ccgccgccgg
      241 tgcccaaccc cttcgtccag cagactacga tcagtgcctc ccgaaggctg cagatgtttc
      301 ttcttggaat tattctgctc ccagtccgtg ctttactggt tggaataatt ttgctgctcg
      361 catggccatt tgctgtcatt tcaacagcat gctgtcctga aaagctgacc catccaataa
      421 gcaattggag gaggaagatc actcggcccg ctttgacatt tctggcgcgt gccatgttct
      481 tctccatggg gtttacggtt accgtgaaag gaaaggttgc aagccctctg gaagcgccca
      541 tttttgtcgt cgctcctcat tccacgttct tcgacggaat tgcctgtgta gtagctgggc
      601 tgccttcgct ggtatcacgg aatgagaatg cacagacccc tctggttggc agactgttac
      661 gggctttgca gccagttttg gtatcccgtg ttgaccctga ctcccgaaaa aacacaatca
      721 atgaaatcaa aaagcgagcg acatcaggtg gagaatggcc ccagatacta gttttcccag
      781 aaggtacttg tactaatcgc tcctgtttga ttacttttaa accaggagcc ttcatcccag
      841 gagttccagt gcagcccgtc ctcctcagat acccaaacaa gttggatact gtgacctgga
      901 cctggcaagg ctatacattc ctccagctgt gtgtgctcac tttctgtcaa ctcttcacga
      961 aggtggagat tgagtttatg cctgtgcaag cacccagtga ggaagagaag aacgatcctg
     1021 tccttttcgc cagtagaatc cggaacttaa tggctgaagc attggaaata cccgtgacgg
     1081 atcacaccta cgaagactgc aggctgatga tctcagcggg acagctcacg ttgcctatgg
     1141 aggccgggct ggtagaattt tcaaagatta gccggaaact gaaattagac tgggatggta
     1201 tccggaagca cttggatgaa tatgcgtcta tcgcaagctc ttccaaagga ggcagaattg
     1261 gaatcgagga gtttgcggaa tacttgaagc tacctgtttc cgatgtcctg agacaacttt
     1321 ttgcactctt tgacaggaat aatgatggca gtattgactt ccgagagtat gtgatcggcc
     1381 tggctgtctt gtgcaaccct gccaatacag aagagatcat ccaggtggca tttaagctct
     1441 ttgatgttga tgaggacggc tacataacag aggaggagtt ttgcaccatt ctgcaggctt
     1501 ctcttggagt gcctgacctt aatgtttctg gtctcttcag agaaattgcc caacgggact
     1561 ctgtttccta cgaggaattc aaaagtttcg ccctaaagca cccagaatat gccaagatat
     1621 ttaccacata cctagacctc cagacatgcc atgtattctc cttgccagaa gaggtccaga
     1681 cagctccctc tgttgctagt aataaagtca gtcctgagag ccaggaggag ggcacctcag
     1741 acaaaaaggt ggactgagcc agtgttccca gtgaggaaag gcgacgcggg agagctgttc
     1801 actggccaca ttgtgaatgt gtttatcaac taatgttgtt cacgatagaa agcttttttt
     1861 tttactaaga tgacatattt tcttccaaaa gtgtttttta ttaacctgcc tgtatcaagt
     1921 aagctccttt catctcacat tgtgccctac tggttgtgtt gactgaggct aagtactgta
     1981 tattttttaa tgaaaatttt cagtttactt ttcataataa ataaatccat cagtcttact
     2041 ctccactggt cagcaattaa tcaacaccgc gtgtttagca agtgcaaaca attttcagtc
     2101 gtttcacatg taatcatgta cgttttctct agtcccttcc ctttctggaa gcaaggatgg
     2161 gaatgtggaa aaaaactgca gggttttgta cctccatctt taccggctta aatttccatt
     2221 taaattttag tttcctggct gagactttct aagcgcacac gctccccttg acttgcatct
     2281 ggatagcaga tcctttcgca ctctccatag tatagaaggg accttgtttt aaagacgatt
     2341 gcagtgggcc ataagctggg aattgcctta ttgaagggaa cagtgattgc ctaatgagaa
     2401 aatgaattgt ttgctacaga gctgaattga atttaagttg gctggttccg aagatagcac
     2461 tttcccaata agcaaatcag atttgttctt ttttacataa tggccaaatt ggtgtatttt
     2521 accgtgcagt ccaagagaga gctttgtcct gttaattttt cctcacaaac tttagagttt
     2581 gtcagaaatt tccacatgga aaagagaagc ctccagcatg ttgccaagag ccaaagaatc
     2641 aaaaagctta gtttgttaac gtgtggctgt gtctaccccc aggcaggaat accacctaag
     2701 ctaagcaaaa atttcttcaa atgacatttt tattgatacc catgtctgca tactcttgct
     2761 atcacttaca tttgaggttt tgaataaaga accgatttat taaaagaatg cacaaag
//
