LOCUS       NM_145376               3632 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus lysophosphatidylcholine acyltransferase 1 (Lpcat1),
            transcript variant 1, mRNA.
ACCESSION   NM_145376
VERSION     NM_145376.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3632)
  AUTHORS   Suzuki,T., Taketomi,Y., Yanagida,K., Yoshida-Hashidate,T.,
            Nagase,T., Murakami,M., Shimizu,T. and Shindou,H.
  TITLE     Re-evaluation of the canonical PAF pathway in cutaneous anaphylaxis
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1870 (1), 159563 (2025)
   PUBMED   39332666
REFERENCE   2  (bases 1 to 3632)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3632)
  AUTHORS   Li,Q., Xia,Z., Wu,Y., Ma,Y., Zhang,D., Wang,S., Fan,J., Xu,P.,
            Li,X., Bai,L., Zhou,X. and Xue,M.
  TITLE     Lysophospholipid acyltransferase-mediated formation of saturated
            glycerophospholipids maintained cell membrane integrity for hypoxic
            adaptation
  JOURNAL   FEBS J 291 (14), 3191-3210 (2024)
   PUBMED   38602252
  REMARK    GeneRIF: Lysophospholipid acyltransferase-mediated formation of
            saturated glycerophospholipids maintained cell membrane integrity
            for hypoxic adaptation.
REFERENCE   4  (bases 1 to 3632)
  AUTHORS   Li,Z., Hu,Y., Zheng,H., Li,M., Liu,Y., Feng,R., Li,X., Zhang,S.,
            Tang,M., Yang,M., Yu,R., Xu,Y., Liao,X., Chen,S., Qian,W.,
            Zhang,Q., Tang,D., Li,B., Song,L. and Li,J.
  TITLE     LPCAT1-mediated membrane phospholipid remodelling promotes
            ferroptosis evasion and tumour growth
  JOURNAL   Nat Cell Biol 26 (5), 811-824 (2024)
   PUBMED   38671262
  REMARK    GeneRIF: LPCAT1-mediated membrane phospholipid remodelling promotes
            ferroptosis evasion and tumour growth.
REFERENCE   5  (bases 1 to 3632)
  AUTHORS   Yamamoto,S., Hashidate-Yoshida,T., Yoshinari,Y., Shimizu,T. and
            Shindou,H.
  TITLE     Macrophage/microglia-producing transient increase of
            platelet-activating factor is involved in neuropathic pain
  JOURNAL   iScience 27 (4), 109466 (2024)
   PUBMED   38715939
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3632)
  AUTHORS   Soupene,E., Fyrst,H. and Kuypers,F.A.
  TITLE     Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes
  JOURNAL   Proc Natl Acad Sci U S A 105 (1), 88-93 (2008)
   PUBMED   18156367
  REMARK    GeneRIF: Aytl2 gene is the phosphatidylcholine reacylating enzyme
            in RBCs; this represents the identification of a plasma membrane
            lysophospholipid acyltransferase and establishes the function of a
            LPCAT protein
REFERENCE   7  (bases 1 to 3632)
  AUTHORS   Chen,X., Hyatt,B.A., Mucenski,M.L., Mason,R.J. and Shannon,J.M.
  TITLE     Identification and characterization of a lysophosphatidylcholine
            acyltransferase in alveolar type II cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (31), 11724-11729 (2006)
   PUBMED   16864775
  REMARK    GeneRIF: Results suggest that lysophosphatidylcholine
            acyltransferase (LPCAT) plays a critical role in regulating
            surfactant phospholipid biosynthesis.
REFERENCE   8  (bases 1 to 3632)
  AUTHORS   Nakanishi,H., Shindou,H., Hishikawa,D., Harayama,T., Ogasawara,R.,
            Suwabe,A., Taguchi,R. and Shimizu,T.
  TITLE     Cloning and characterization of mouse lung-type
            acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1).
            Expression in alveolar type II cells and possible involvement in
            surfactant production
  JOURNAL   J Biol Chem 281 (29), 20140-20147 (2006)
   PUBMED   16704971
  REMARK    GeneRIF: acyl-CoA:lysophosphatidylcholine acyltransferase 1
            (LPCAT1) is predominantly expressed in the lung, in particular in
            alveolar type II cells.
REFERENCE   9  (bases 1 to 3632)
  AUTHORS   Chang,B., Hawes,N.L., Hurd,R.E., Wang,J., Howell,D., Davisson,M.T.,
            Roderick,T.H., Nusinowitz,S. and Heckenlively,J.R.
  TITLE     Mouse models of ocular diseases
  JOURNAL   Vis Neurosci 22 (5), 587-593 (2005)
   PUBMED   16332269
REFERENCE   10 (bases 1 to 3632)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154547.3.
            
            On Feb 15, 2019 this sequence version replaced NM_145376.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171582.1, AK155286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AC154547.3         108030-108316       c
            288-430             AC154547.3         91144-91286         c
            431-645             AC154547.3         86446-86660         c
            646-758             AC154547.3         80633-80745         c
            759-819             AC154547.3         79307-79367         c
            820-878             AC154547.3         76190-76248         c
            879-913             AC154547.3         74157-74191         c
            914-968             AC154547.3         72452-72506         c
            969-1051            AC154547.3         69963-70045         c
            1052-1177           AC154547.3         65426-65551         c
            1178-1331           AC154547.3         64546-64699         c
            1332-1430           AC154547.3         64149-64247         c
            1431-1572           AC154547.3         61586-61727         c
            1573-3632           AC154547.3         59134-61193         c
FEATURES             Location/Qualifiers
     source          1..3632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 39.97 cM"
     gene            1..3632
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /note="lysophosphatidylcholine acyltransferase 1"
                     /db_xref="GeneID:210992"
                     /db_xref="MGI:MGI:2384812"
     exon            1..287
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1757
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /EC_number="2.3.1.51"
                     /EC_number="2.3.1.23"
                     /EC_number="2.3.1.67"
                     /EC_number="2.3.1.25"
                     /note="isoform 1 is encoded by transcript variant 1; LPC
                     acyltransferase 1; acyltransferase-like 2; lysoPC
                     acyltransferase 1; lyso-PAF acetyltransferase;
                     acetyl-CoA:lyso-PAF acetyltransferase;
                     1-acylglycerophosphocholine O-acyltransferase;
                     1-alkylglycerophosphocholine O-acetyltransferase;
                     acetyl-CoA:lyso-platelet-activating factor
                     acetyltransferase; 1-acylglycerol-3-phosphate
                     O-acyltransferase; 1-alkenylglycerophosphocholine
                     O-acyltransferase"
                     /codon_start=1
                     /product="lysophosphatidylcholine acyltransferase 1
                     isoform 1"
                     /protein_id="NP_663351.3"
                     /db_xref="CCDS:CCDS36726.1"
                     /db_xref="GeneID:210992"
                     /db_xref="MGI:MGI:2384812"
                     /translation="MRLRGRGPRAAPSSSSGAGDARRLAPPGRNPFVHELRLSALQKA
                     QVAFMTLTLFPIRLLFAAFMMLLAWPFALLASLGPPDKEPEQPLALWRKVVDFLLKAI
                     MRTMWFAGGFHRVAVKGRQALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDI
                     PIWGTLIRYIRPVFVSRSDQDSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLI
                     TFKPGAFIPGVPVQPVVLRYPNKLDTITWTWQGPGALKILWLTLCQFQNQVEIEFLPV
                     YCPSEEEKRNPALYASNVRRVMAKALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEF
                     ARLVRGLGLKPENLEKDLDKYSESARMKRGEKIRLPEFAAYLEVPVSDALEDMFSLFD
                     ESGGGEIDLREYVVALSVVCRPSQTLATIQLAFKMYGSPEDGSIDEANLSCILKTALG
                     VSELTVTDLFQAIDQEDKGRITFDDFCGFAEMYPDYAEDYLYPDQTHFDSCAQTPPAP
                     TPNGFCIDFSPENSDFGRKNSCKKAD"
     exon            288..430
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            431..645
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            646..758
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            759..819
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            820..878
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            879..913
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            914..968
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1051
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1177
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1331
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1430
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1572
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..3632
                     /gene="Lpcat1"
                     /gene_synonym="2900035H07Rik; Aytl2; LPCAT; LPCAT-1;
                     lysoPAFAT; mLPCAT1; rd11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgcgcct ccgggcggcc gcgcatccta ggccctctcc cgcgcgctct gctagctctg
       61 ctgctctcgg ctcttctgtg cttggctcgg ttcagctgag ctcggtcggc tgagctccat
      121 ctgctctact ccttgctcag gcgcgggcag ccatgaggct gcggggccgc gggccgcggg
      181 ccgccccctc ctccagctct ggggcaggcg acgcgcggcg cctagcgccc ccggggcgga
      241 accccttcgt gcacgagctg cgactgagcg ccctgcagaa ggcccaggtg gctttcatga
      301 cgttgacgct gttccccatc cggctcctgt tcgctgcttt catgatgctg ctggcctggc
      361 cctttgcact cctggcttcc ctgggacctc ctgataagga gccagagcag cccctggcct
      421 tatggaggaa ggtcgtggac ttcctgctca aggccatcat gcgcaccatg tggtttgctg
      481 gcggcttcca ccgtgtagct gtgaaggggc ggcaggccct gcctactgag gctgctatcc
      541 tcaccttggc tccacattcc tcctactttg atgccatccc ggtcaccatg accatgtcct
      601 ccattgtgat gaaggcagag agcagagaca tcccaatctg gggaactctg ataagataca
      661 tcaggccagt gttcgtgtcc cgctctgacc aggactcgcg aaggaagaca gtggaggaga
      721 tcaagcgacg ggcacagtcg aatggaaagt ggcctcagat aatgattttt ccagaaggaa
      781 cttgtacaaa taggacctgc ctcattacct tcaaacctgg tgcgttcatt cctggagttc
      841 ctgtccagcc cgtggtgcta cgctacccaa acaaattgga caccatcaca tggacgtggc
      901 aaggacctgg agcgttgaaa atcctgtggc tcactctgtg ccagtttcaa aaccaagtgg
      961 aaattgaatt tctgcctgtg tattgccctt ctgaagagga gaagaggaat cctgccctgt
     1021 atgccagcaa tgtgaggcgt gtcatggcca aggccctggg tgtctcagta accgactata
     1081 catttgagga ctgccagctg gctctggcag aaggacaact tcgcttgcct gctgacacct
     1141 gcctgctaga gtttgccagg cttgtgaggg gcctcggact aaaaccagaa aatcttgaaa
     1201 aagatctaga caaatattca gaaagtgcga ggatgaagag aggagagaaa atccgccttc
     1261 cagagtttgc ggcctacttg gaagttcctg tctcagatgc actggaagac atgttctcgc
     1321 tttttgacga gagtggtggt ggtgagattg accttcgtga atatgtggtc gccttgtctg
     1381 tggtgtgcag gccatcccag accttagcca ccatccagct ggcattcaag atgtacggat
     1441 ctcctgagga tggcagcata gatgaggcca acctgtcctg catcctcaag actgcactgg
     1501 gtgtatcaga attaacagtg accgacttgt tccaggctat tgaccaagag gacaagggaa
     1561 gaatcacctt tgatgacttc tgcgggtttg cggaaatgta ccccgactac gcagaggact
     1621 acttgtaccc tgatcagaca catttcgaca gctgtgcaca gacaccccca gcaccaactc
     1681 ccaatggctt ctgcattgac ttcagccctg agaactcaga ctttgggaga aagaattctt
     1741 gtaagaaagc ggactagaat ggaagattcc ggagggatga ggcccctccc gcatcaccac
     1801 ctgcctccag tggcctggag cctgattgtg tgttgcgcct tctacctttc cctgtctctc
     1861 tatgtctgca ggcctgaggt ccaagagact tgtgatgtta tttgttttct gtaaagtctg
     1921 tctcagggcc cagctgggca tttgcaggga agctgtatgt gtgtcccatc tgcccattgc
     1981 aggcaggcag gcgggcgggc ggctgctcgg ggcctccctg tggggcagga ctccacaggc
     2041 tgagtgggca caggtatggc tgtgtgctca cctagaatac gctggtcttg agtttgtgtc
     2101 tgtctttccc ctctttgttt gtgcggtgtg cacaatgcag gacctctgtg cgtgcgctgc
     2161 acataccctc cctggaacag tcagtcacct tgtcctaatt tagtgcctct gccgtctctg
     2221 gctcacgtga cgggggcatc atcggattct aagtgtttct gtgtcggtgc aggaggtcgt
     2281 gactctttta taaacctcac ttaagtactt tgaaaacatt caaccttttt ttaaaaaaaa
     2341 aaaagaaaag aaaattggtt ttctacttca tttttcacct taacgaaagg atatttattt
     2401 ccaggcttgc ttttgataga ctctgagacg tcctggtggc cgcagcgtaa ggggcctcac
     2461 tgccctgctc ccattgaagt catgggacat ttagccacaa agaccggccc cggggtcctt
     2521 ttctgctttc cttaagcctt cttgaatctc catctttttt ataaacattg ccagtttggt
     2581 atttcagttt caatatgaca aagtctactt catgtatcta gtaaaagcat tgaatgtggg
     2641 ttaaagagtc agccagaggg aaagaactgg aaagtgtccc cttatctttg tgctgatttt
     2701 agccctctga gcagacatac tgagaaggcc aggaggtcct gcccaaagcc catcaccctc
     2761 tctttgcact ggttgccatg gtgacttagg gaaagcagcc accatctgag cgtaggtggc
     2821 tttactctgt gggggtgaca gctgaagggg acaggccaca gagtttgctg tgcttggccc
     2881 ttcatgagat caggaaggaa cagggtccag gctgtcacct tcagcattac ctggtttcct
     2941 ctttttttat gacaagactt atccgtaaag cacagtgact gtaggtttag tttgtttcct
     3001 aagctttgga atcttgtttt ttactcctaa gctagatttt tttttttttt ctcatttggg
     3061 gcattgctat aggaaatgac caccaagcca gtaaatgcag gaaagctgtt ttctgagttt
     3121 ctcagaggga gtgtcagtat gtgctttccc caagagaggt cacataaaca aaacttgtca
     3181 acctcagtca cacagcgcca cactgccgcg ggatgggcag ggagatggat ttctgagctc
     3241 ttagctggtt aggtatggat gaaatgtgaa cacagccttt gtagctaacg ggttggtttt
     3301 ataactgtag agtacaaatt ttcagaagag aaaagccact aaaaggccaa tgaaggagac
     3361 agatgaactg agatgtcccg aggcttgggc tctgccctgc catctgcaag tgatggattc
     3421 ctgaggaatg gccactggtc atgttgaagg aatcctgagc agacctggga cggatgttca
     3481 tcctcctgat gactctctct agtaacctca gtccgcgcat cagaactgtg aatgtacata
     3541 ccgggcaggg gaaggggcag tgcccgccct gtctgcgggc gcctttgggg tgcgggcttc
     3601 aggttttcag tggaataaac atgacacgac gt
//
