LOCUS       NM_175116               2468 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus lysophosphatidic acid receptor 6 (Lpar6), mRNA.
ACCESSION   NM_175116
VERSION     NM_175116.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2468)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 2468)
  AUTHORS   Lee,S., Bondaruk,J., Wang,Y., Chen,H., Lee,J.G., Majewski,T.,
            Mullen,R.D., Cogdell,D., Chen,J., Wang,Z., Yao,H., Kus,P.,
            Jeong,J., Lee,I., Choi,W., Navai,N., Guo,C., Dinney,C.,
            Baggerly,K., Mendelsohn,C., McConkey,D., Behringer,R.R., Kimmel,M.,
            Wei,P. and Czerniak,B.
  TITLE     Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal
            urothelial differentiation program, contributing to bladder
            carcinogenesis
  JOURNAL   Cell Rep 43 (5), 114146 (2024)
   PUBMED   38676926
REFERENCE   3  (bases 1 to 2468)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2468)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 2468)
  AUTHORS   Spencer,S.A., Suarez-Pozos,E., Soto-Verdugo,J., Wang,H.,
            Afshari,F.S., Li,G., Manam,S., Yasuda,D., Ortega,A., Lister,J.A.,
            Ishii,S., Zhang,Y. and Fuss,B.
  TITLE     Lysophosphatidic acid signaling via LPA6 : A negative modulator of
            developmental oligodendrocyte maturation
  JOURNAL   J Neurochem 163 (6), 478-499 (2022)
   PUBMED   36153691
REFERENCE   6  (bases 1 to 2468)
  AUTHORS   Kihara,Y., Maceyka,M., Spiegel,S. and Chun,J.
  TITLE     Lysophospholipid receptor nomenclature review: IUPHAR Review 8
  JOURNAL   Br J Pharmacol 171 (15), 3575-3594 (2014)
   PUBMED   24602016
  REMARK    Review article
REFERENCE   7  (bases 1 to 2468)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 2468)
  AUTHORS   Furuta,D., Yamane,M., Tsujiuchi,T., Moriyama,R. and Fukushima,N.
  TITLE     Lysophosphatidic acid induces neurite branch formation through LPA3
  JOURNAL   Mol Cell Neurosci 50 (1), 21-34 (2012)
   PUBMED   22465231
REFERENCE   9  (bases 1 to 2468)
  AUTHORS   Millien,G., Beane,J., Lenburg,M., Tsao,P.N., Lu,J., Spira,A. and
            Ramirez,M.I.
  TITLE     Characterization of the mid-foregut transcriptome identifies genes
            regulated during lung bud induction
  JOURNAL   Gene Expr Patterns 8 (2), 124-139 (2008)
   PUBMED   18023262
REFERENCE   10 (bases 1 to 2468)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154718.2.
            
            On Dec 10, 2009 this sequence version replaced NM_175116.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK032901.1, BC145940.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2468              AC154718.2         24105-26572
FEATURES             Location/Qualifiers
     source          1..2468
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 38.75 cM"
     gene            1..2468
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
                     /note="lysophosphatidic acid receptor 6"
                     /db_xref="GeneID:67168"
                     /db_xref="MGI:MGI:1914418"
     exon            1..2468
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
                     /inference="alignment:Splign:2.1.0"
     CDS             711..1745
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
                     /note="purinergic receptor (family A group 5); purinergic
                     receptor P2Y, G-protein coupled, 5; LPA-6; LPA receptor 6;
                     P2Y purinoceptor 5; purinergic receptor 5;
                     oleoyl-L-alpha-lysophosphatidic acid receptor"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 6"
                     /protein_id="NP_780325.1"
                     /db_xref="CCDS:CCDS27268.1"
                     /db_xref="GeneID:67168"
                     /db_xref="MGI:MGI:1914418"
                     /translation="MVSSNGSQCPYDDSFKYTLYGCMFSMVFVLGLISNCVAIYIFIC
                     ALKVRNETTTYMINLAMSDLLFVFTLPFRIFYFATRNWPFGDLLCKISVMLFYTNMYG
                     SILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCIAVWFTVMGGSAPAVFFQSTHSQ
                     GNNTSEACFENFPAATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLRTLNKPVTLS
                     RSKMNKTKVLKMIFVHLVIFCFCFVPYNINLILYSLMRTQTFVNCSVVAAVRTMYPIT
                     LCIAVSNCCFDPIVYYFTSDTIQNSIKMKNWSVRRSDSRFSEVQGTENFIQHNLQTLK
                     NKIFDNESAI"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
                     /note="hexamer: ATTAAA"
     polyA_site      1892
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
                     /note="major polyA site"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
                     /note="hexamer: ATTAAA"
     regulatory      1958..1963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
                     /note="hexamer: CATAAA"
     polyA_site      1963
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
     polyA_site      1981
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
     polyA_site      2052
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
     polyA_site      2080
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
     regulatory      2135..2140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
                     /note="hexamer: ATTAAA"
     polyA_site      2167
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
     regulatory      2433..2438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
                     /note="hexamer: AATAAA"
     polyA_site      2457
                     /gene="Lpar6"
                     /gene_synonym="2610302I02Rik; P2ry5; P2y5"
ORIGIN      
        1 gattaaagga actgcaaaca actgggttga agccttcctt tgtccaaacc cagcctcttc
       61 ttcctgtgat gtcatattac aaatctggga aggctttctt gctcacttca gagacagccc
      121 atctcacaat acagctggca acctccgaaa ggcctctcca ttcagcaagc gcgaacatgc
      181 ttaggaattt atctgggatc ccttaaacga ctgcctatcg ccgtccggaa tcaatgtaga
      241 aatacaaagt ttgagaataa aaagaaggaa gaagtacccg aggacgacgg gcggacggac
      301 gcacggcgag tgtttgtgac tgaagtaaag ctggtttgga ccctggcggc tgaagcacaa
      361 gtttccacgc ggactggtct ggtccgactt ggaacagttt ttccttacac tttcagcttt
      421 atgggttggc ttccttgact gcattttctg tcagttaact aaactccaga ctcatggatt
      481 ttctcgacca gaaaatcaga ctattttcct gaataatcta ctagaaactt ttacggaaca
      541 catttcatgt ttcctttgaa gagttaagag aagaaagtat ttgtaagaac aggaaaagaa
      601 acaaatactt tgcaaataaa ctggctgctg ctgtgaccac atctgaatag caaaggcgat
      661 cgatcaagcg ctgcggacaa aaggcctcct gtaagctgca ctgcctgaca atggtaagct
      721 ccaatggctc ccagtgccct tatgacgact cctttaagta cactctgtac gggtgcatgt
      781 tcagcatggt cttcgtgctt gggctgatat ccaactgtgt tgcgatatac attttcatct
      841 gtgccctcaa agtgagaaat gaaactacaa cgtacatgat taacctggca atgtcagatt
      901 tacttttcgt ctttactttg ccatttcgga ttttttactt tgcaacacgg aattggccat
      961 ttggagatct actctgtaag atttcagtaa tgctgtttta caccaatatg tatggaagca
     1021 ttctgttctt aacctgtatc agtgtagatc gatttctggc aattgtctac ccatttaagt
     1081 caaagacttt aagaacgaaa cgaaatgcaa agatcgtttg cattgctgtg tggttcacag
     1141 tgatgggagg aagtgcgcct gcagttttct ttcagtcgac ccactctcag gggaacaata
     1201 cctcagaagc ctgctttgag aactttccag cggccacatg gaaaacttat ctctccagga
     1261 ttgtgatttt cattgaaata gtgggctttt ttatccctct cattttgaac gtaacttgtt
     1321 ctagtatggt gctaagaact ttaaataaac ctgttacatt aagtagaagc aaaatgaaca
     1381 aaactaaggt tttaaaaatg atttttgtcc acttggtcat cttctgtttc tgttttgtgc
     1441 cctacaacat caacctcatt ttgtactcgc tcatgaggac acagaccttt gttaactgct
     1501 ctgtggtggc ggcagtgagg accatgtacc cgatcactct ctgcatcgct gtttccaact
     1561 gctgctttga ccctattgtt tactacttca cctcagacac aattcagaac tcaataaaaa
     1621 tgaaaaactg gtcggttaga agaagtgact ccaggttctc tgaagttcag ggcactgaga
     1681 attttatcca acacaaccta cagaccttaa aaaataagat atttgataat gaatctgcaa
     1741 tataagctgc ctgactaagc cactgggact gctccgtgtt caactgtgaa aactgtgttc
     1801 ttgggaacta tctctccggc tccaacagaa aatattttta aaggaagttt gtgtctgatg
     1861 tgttaaacat taaaatatat tctattcttg tatgcacgcc attttacttt cttgaaccac
     1921 tttaacgtgt tttttcctca ttaaaaaaaa aaaactccat aaagttaagg tctaaaagca
     1981 attatgattt aaataatgtg atatatctgt acgtttaaaa ttttgtatat catgaaatga
     2041 tttaatcaga aatctgttaa atggttttat actgaaccga gatgttgttt acggaatagt
     2101 ttactaagta gatttcactt atattttatt ttagattaaa agtacttatc atgccttaaa
     2161 ctgtaaacag tgaagaaaac cagtttgaac tagtcacaca gttttagagc atttcctcca
     2221 agagactact gcagttttct gcatgacatt ttatcttttt aggcaactca taaaaaagaa
     2281 aaggtatcta actatatagt atattttgaa attactattt tgatttatat tctggctgca
     2341 acacccaatt tcaaaatgat atatagtata aaaacttagc ataaagaaac taatgaaatg
     2401 ttatcttgct aggtaaatta ttttgaaagt acaataaaaa ccttgtattt tcaagaatgt
     2461 tggtctag
//
