LOCUS       NM_001163269            2965 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus lysophosphatidic acid receptor 5 (Lpar5), transcript
            variant 2, mRNA.
ACCESSION   NM_001163269
VERSION     NM_001163269.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2965)
  AUTHORS   McConnell,B.B., Liang,Z., Xu,C., Han,Y. and Yun,C.C.
  TITLE     LPA5-Dependent signaling regulates regeneration of the intestinal
            epithelium following irradiation
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (6), G631-G642 (2024)
   PUBMED   38593468
  REMARK    GeneRIF: LPA5-Dependent signaling regulates regeneration of the
            intestinal epithelium following irradiation.
REFERENCE   2  (bases 1 to 2965)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2965)
  AUTHORS   Janovicz,A., Majer,A., Kosztelnik,M., Geiszt,M., Chun,J., Ishii,S.,
            Tigyi,G.J., Benyo,Z. and Ruisanchez,E.
  TITLE     Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial
            dysfunction via reactive oxygen species signaling
  JOURNAL   Exp Biol Med (Maywood) 248 (20), 1887-1894 (2023)
   PUBMED   37837357
  REMARK    GeneRIF: Autotaxin-lysophosphatidic acid receptor 5 axis evokes
            endothelial dysfunction via reactive oxygen species signaling.
REFERENCE   4  (bases 1 to 2965)
  AUTHORS   de Souza,C.O., Paschoal,V.A., Sun,X., Vishvanath,L., Zhang,Q.,
            Shao,M., Onodera,T., Chen,S., Joffin,N., Bueno,L.M., Gupta,R.K. and
            Oh,D.Y.
  TITLE     GPR92 activation in islet macrophages controls beta cell function
            in a diet-induced obesity model
  JOURNAL   J Clin Invest 132 (21), e160097 (2022)
   PUBMED   36066975
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2965)
  AUTHORS   Joshi,L., Plastira,I., Bernhart,E., Reicher,H., Koshenov,Z.,
            Graier,W.F., Vujic,N., Kratky,D., Rivera,R., Chun,J. and Sattler,W.
  TITLE     Lysophosphatidic Acid Receptor 5 (LPA5) Knockout Ameliorates the
            Neuroinflammatory Response In Vivo and Modifies the Inflammatory
            and Metabolic Landscape of Primary Microglia In Vitro
  JOURNAL   Cells 11 (7), 1071 (2022)
   PUBMED   35406635
  REMARK    GeneRIF: Lysophosphatidic Acid Receptor 5 (LPA5) Knockout
            Ameliorates the Neuroinflammatory Response In Vivo and Modifies the
            Inflammatory and Metabolic Landscape of Primary Microglia In Vitro.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2965)
  AUTHORS   Lee,C.W., Rivera,R., Gardell,S., Dubin,A.E. and Chun,J.
  TITLE     GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid
            receptor that increases cAMP, LPA5
  JOURNAL   J Biol Chem 281 (33), 23589-23597 (2006)
   PUBMED   16774927
REFERENCE   7  (bases 1 to 2965)
  AUTHORS   Kotarsky,K., Boketoft,A., Bristulf,J., Nilsson,N.E., Norberg,A.,
            Hansson,S., Owman,C., Sillard,R., Leeb-Lundberg,L.M. and Olde,B.
  TITLE     Lysophosphatidic acid binds to and activates GPR92, a G
            protein-coupled receptor highly expressed in gastrointestinal
            lymphocytes
  JOURNAL   J Pharmacol Exp Ther 318 (2), 619-628 (2006)
   PUBMED   16651401
  REMARK    GeneRIF: GPR92 is highly expressed in the lymphocyte compartment of
            the gastrointestinal tract
REFERENCE   8  (bases 1 to 2965)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 2965)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   10 (bases 1 to 2965)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134529.6.
            
            On Mar 8, 2019 this sequence version replaced NM_001163269.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 both encode the same
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131863.1, BC117528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC134529.6         111947-112003
            58-2965             AC134529.6         125164-128071
FEATURES             Location/Qualifiers
     source          1..2965
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.21 cM"
     gene            1..2965
                     /gene="Lpar5"
                     /gene_synonym="Gm1072; Gpr92; GPR93; LPA5"
                     /note="lysophosphatidic acid receptor 5"
                     /db_xref="GeneID:381810"
                     /db_xref="MGI:MGI:2685918"
     exon            1..57
                     /gene="Lpar5"
                     /gene_synonym="Gm1072; Gpr92; GPR93; LPA5"
                     /inference="alignment:Splign:2.1.0"
     exon            58..2965
                     /gene="Lpar5"
                     /gene_synonym="Gm1072; Gpr92; GPR93; LPA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1393
                     /gene="Lpar5"
                     /gene_synonym="Gm1072; Gpr92; GPR93; LPA5"
                     /note="G protein-coupled receptor 92; LPA-5; LPA receptor
                     5"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 5"
                     /protein_id="NP_001156741.2"
                     /db_xref="GeneID:381810"
                     /db_xref="MGI:MGI:2685918"
                     /translation="MFANSSANTTSTNSSVLQCPDYRDTHRLHMVVYSLVLATGLPLN
                     ALALWVFLRVLRVHSVVSVYMCNLAASDLLFTLSLPLRLSYYAQHHWPFPGFLCQTSG
                     AIFQMNMYGSCLFLMLINVDRYAAIVHPLRLRHLRRPRVARRLCLGVWALILLFAVPA
                     ARVHSPSHCTYKNITVRLCFESFSDELWKGRLLPLLLLAEILGFLLPLAAVVYSSGRV
                     FWTLARPDATQSQRRRKTVRLLLANLIIFLLCFVPYNSTLAVYGLLRANLVKNSIQDR
                     DQVRGVLMIMVLLAGANCVLDPLVYYFSAEGFRNTLRNLGAPLNTRPLATNGAAGVLT
                     ELPSESTQNTGQDATSQVLLQPATLGTPPDNCSQDSAL"
     regulatory      2349..2354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar5"
                     /gene_synonym="Gm1072; Gpr92; GPR93; LPA5"
                     /note="hexamer: ATTAAA"
     polyA_site      2369
                     /gene="Lpar5"
                     /gene_synonym="Gm1072; Gpr92; GPR93; LPA5"
                     /note="major polyA site"
     regulatory      2930..2935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar5"
                     /gene_synonym="Gm1072; Gpr92; GPR93; LPA5"
                     /note="hexamer: ATTAAA"
     polyA_site      2961
                     /gene="Lpar5"
                     /gene_synonym="Gm1072; Gpr92; GPR93; LPA5"
                     /note="major polyA site"
ORIGIN      
        1 agagtgtcag cggaagcagg cttggggcag cggcagagga agagcaaccg atcacaggtc
       61 tccactgctg aagaagttgc agcaccaagg gcttccagcc ttggccagtc atctgcccct
      121 gaggtcacag cccacgtgcc catgtcttgc ttctgcttgc ctggggacag agtctgtatt
      181 gccaccaggc taccaccctg gaggtgaaag tcatgctctg accttgttgt tccctacgat
      241 gcctcagact aatttctctt cccacctgga catgatgttt gccaattctt cagccaacac
      301 gacttctacc aacagctctg tgctccagtg ccctgactat cgagatacac atcgtttgca
      361 tatggtggtc tacagcctgg tattggcgac tggtctccct ctcaacgctc tggctctctg
      421 ggtcttcctg cgtgtactgc gcgtacactc agtggtgagc gtgtacatgt gcaacctggc
      481 agccagcgac ttgctcttca ccctgtcact tcccctgcgc ctctcctact atgcacagca
      541 ccactggcct tttccaggct tcctgtgcca gacgtcgggc gccatcttcc agatgaacat
      601 gtacggcagc tgtctctttc tgatgctcat caacgtggac cgctatgcgg ccatcgtgca
      661 cccgctgaga ctgcgccacc tacggcggcc ccgtgtggca cggcggctct gcctgggcgt
      721 gtgggctctc atcctgctgt tcgctgtgcc cgccgcccgc gtgcacagcc cgtcccactg
      781 cacgtacaag aacatcactg tgcgcctgtg cttcgagagc ttcagcgatg aactgtggaa
      841 gggcaggctg ctgccgctcc tgctgctggc cgagatacta ggctttctgc tgcccctggc
      901 ggctgtcgtc tattcgtctg gcagagtctt ctggacactg gcgaggcccg acgccactca
      961 gagccaacgg cgacggaaga ccgtgcgcct cctgctggcc aatctcatca tcttcctgct
     1021 gtgcttcgtg ccctataact ccacgctggc tgtatatggg ttgctacggg ccaacttggt
     1081 gaagaacagt attcaggacc gcgatcaggt gcgcggggtg ctgatgataa tggtgctgct
     1141 ggccggcgcc aactgcgtgc tggatccact ggtttactac ttcagtgccg agggtttccg
     1201 taacaccctt cgcaacctgg gcgccccgct gaataccagg cctttggcta ccaatggggc
     1261 tgcaggcgtg ctcaccgaac taccctcaga aagcacccaa aacactgggc aggatgccac
     1321 aagtcaggtt ctactccagc ctgccactct gggtacaccc ccggacaact gctcccagga
     1381 ttcggctctc tgagaggacg cagtctaagt gaacgtagac ttgtgcctcc ctcagaggct
     1441 tagggtgtac atttgaggga ggtgggctgg gtacttggac tttgaaacaa ctccagctct
     1501 agtgtgcaga agggaacaag tgtgtaagca aggaaaagaa gagtgccact gctgacagct
     1561 ttagcttctg attatcacac agagaaaccc tgctccagta tgtaggaagc caagcagtga
     1621 gcatgcgcat ggctaagagc tggtacatgg agcagaagag agatctccta ggtcgtcagt
     1681 ctgagagcta aagatctggt gaccttggtg aatcaactac acagacgctc atctgtcatc
     1741 ttcaaaaata aaactctggg ctggtggtgg aaccgagaac ccacagcccg cacatgctgg
     1801 gccagtacat tcccactgta ttgtatccca gccttacctg ctggcttttg tgtttactca
     1861 agggtgatgg ccactgtgtc accagccctg gcttccctgt tcagatggga ggtataacac
     1921 aaaggtttat ttgctatgga ccaaatagtt ctgacccatt tcccaacttg taacaatttc
     1981 gacttgacac ctggcatgtg gtggctgggg cagggcagag ccatgcttgg agtccctctc
     2041 acttgctagt tcttggttcc ttttctaagt catccttttc ccttctgcag ctctcggggc
     2101 ctcttccatc ctggatcttt aatattcagt ctcacttccc tctctttccc accccgttcc
     2161 ttctcctcac cccgccccct tatatagtac atagcagagt ctggccttga actctttttg
     2221 ttttgttctg ttttcaaggc aagagtccca ctatgtagtt cttgatgtcc tggaactcat
     2281 tctgtacact aggctggcct tgaactaaca cacagagatc tgctggcctc tgcctcctaa
     2341 atgctgggat taaagctgtc tgccactaag acagactttg gtctttttgt tgtctttttg
     2401 ttttgttttt gttttttcaa gactgggttg ggatttgtct gtgtaataac ctggttatcc
     2461 agaaactcac tggtgtagac caggctggct tcaaactcac agaggtccac ctgcctctgc
     2521 ctctgcctcc tgagtgctga gagtagaggt gcgcccagca tgctggtgag cctccggttt
     2581 cagcatttca tacatgctgg ggttacaagc ccagctgcag tcagtatttt atgaaatttg
     2641 tatcttttga aaaccgctct ctctacatgg ccaccacact ttgcttctct gtctcttaac
     2701 tcattctctc tatcccccat cctgggcctc ctccctctcc ctcccttccc tcgatcctct
     2761 cctccctccc cctccctctt ctcttccctc tcctcctctg acctttacca tttttgcagt
     2821 caaacgtcag tcctcaaact gtttggtctc aaatcccttt gtgcaaggaa cgagggagcc
     2881 gacagagctt ttgttctttc cttttcttat gatgctcacc atgttattaa ttaaagctga
     2941 catgtttctg agacatggaa ataca
//
