LOCUS       NM_175271               4237 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus lysophosphatidic acid receptor 4 (Lpar4), mRNA.
ACCESSION   NM_175271
VERSION     NM_175271.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4237)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4237)
  AUTHORS   Van Hoose,P.M., Yang,L., Kraemer,M., Ubele,M., Morris,A.J. and
            Smyth,S.S.
  TITLE     Lipid phosphate phosphatase 3 in smooth muscle cells regulates
            angiotensin II-induced abdominal aortic aneurysm formation
  JOURNAL   Sci Rep 12 (1), 5664 (2022)
   PUBMED   35383201
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4237)
  AUTHORS   Uenaka,M., Uyeda,A., Nakahara,T. and Muramatsu,R.
  TITLE     LPA2 promotes neuronal differentiation and neurite formation in
            neocortical development
  JOURNAL   Biochem Biophys Res Commun 598, 89-94 (2022)
   PUBMED   35151977
REFERENCE   4  (bases 1 to 4237)
  AUTHORS   McDonald,W.S., Miyamoto,K., Rivera,R., Kennedy,G., Almeida,B.S.V.,
            Kingsbury,M.A. and Chun,J.
  TITLE     Altered cleavage plane orientation with increased genomic
            aneuploidy produced by receptor-mediated lysophosphatidic acid
            (LPA) signaling in mouse cerebral cortical neural progenitor cells
  JOURNAL   Mol Brain 13 (1), 169 (2020)
   PUBMED   33317583
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4237)
  AUTHORS   Lummis,N.C., Sanchez-Pavon,P., Kennedy,G., Frantz,A.J., Kihara,Y.,
            Blaho,V.A. and Chun,J.
  TITLE     LPA1/3 overactivation induces neonatal posthemorrhagic
            hydrocephalus through ependymal loss and ciliary dysfunction
  JOURNAL   Sci Adv 5 (10), eaax2011 (2019)
   PUBMED   31633020
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4237)
  AUTHORS   Teplyuk,N.M., Galindo,M., Teplyuk,V.I., Pratap,J., Young,D.W.,
            Lapointe,D., Javed,A., Stein,J.L., Lian,J.B., Stein,G.S. and van
            Wijnen,A.J.
  TITLE     Runx2 regulates G protein-coupled signaling pathways to control
            growth of osteoblast progenitors
  JOURNAL   J Biol Chem 283 (41), 27585-27597 (2008)
   PUBMED   18625716
  REMARK    GeneRIF: Affymetrix expression profiling shows that the C terminus
            of Runx2 regulates genes involved in G protein-coupled receptor
            signaling Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and
            Gna13.
REFERENCE   7  (bases 1 to 4237)
  AUTHORS   Lee,C.W., Rivera,R., Dubin,A.E. and Chun,J.
  TITLE     LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing
            G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated
            Rho activation
  JOURNAL   J Biol Chem 282 (7), 4310-4317 (2007)
   PUBMED   17166850
REFERENCE   8  (bases 1 to 4237)
  AUTHORS   Tanaka,M., Okudaira,S., Kishi,Y., Ohkawa,R., Iseki,S., Ota,M.,
            Noji,S., Yatomi,Y., Aoki,J. and Arai,H.
  TITLE     Autotaxin stabilizes blood vessels and is required for embryonic
            vasculature by producing lysophosphatidic acid
  JOURNAL   J Biol Chem 281 (35), 25822-25830 (2006)
   PUBMED   16829511
REFERENCE   9  (bases 1 to 4237)
  AUTHORS   van Meeteren,L.A., Ruurs,P., Stortelers,C., Bouwman,P., van
            Rooijen,M.A., Pradere,J.P., Pettit,T.R., Wakelam,M.J.,
            Saulnier-Blache,J.S., Mummery,C.L., Moolenaar,W.H. and Jonkers,J.
  TITLE     Autotaxin, a secreted lysophospholipase D, is essential for blood
            vessel formation during development
  JOURNAL   Mol Cell Biol 26 (13), 5015-5022 (2006)
   PUBMED   16782887
REFERENCE   10 (bases 1 to 4237)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB619126.1, BC138893.1 and AL670943.14.
            
            On May 30, 2009 this sequence version replaced NM_175271.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051709.1, BC052178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               BB619126.1         2-200
            200-1712            BC138893.1         1-1513
            1713-4237           AL670943.14        178856-181380
FEATURES             Location/Qualifiers
     source          1..4237
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.39 cM"
     gene            1..4237
                     /gene="Lpar4"
                     /gene_synonym="5730485F04Rik; Gpr23; LPA4; p2y9"
                     /note="lysophosphatidic acid receptor 4"
                     /db_xref="GeneID:78134"
                     /db_xref="MGI:MGI:1925384"
     exon            1..365
                     /gene="Lpar4"
                     /gene_synonym="5730485F04Rik; Gpr23; LPA4; p2y9"
                     /inference="alignment:Splign:2.1.0"
     exon            366..467
                     /gene="Lpar4"
                     /gene_synonym="5730485F04Rik; Gpr23; LPA4; p2y9"
                     /inference="alignment:Splign:2.1.0"
     exon            468..4237
                     /gene="Lpar4"
                     /gene_synonym="5730485F04Rik; Gpr23; LPA4; p2y9"
                     /inference="alignment:Splign:2.1.0"
     CDS             550..1662
                     /gene="Lpar4"
                     /gene_synonym="5730485F04Rik; Gpr23; LPA4; p2y9"
                     /note="G protein-coupled receptor 23; P2Y purinoceptor 9;
                     LPA-4; LPA receptor 4; purinergic receptor 9"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 4"
                     /protein_id="NP_780480.2"
                     /db_xref="CCDS:CCDS30345.1"
                     /db_xref="GeneID:78134"
                     /db_xref="MGI:MGI:1925384"
                     /translation="MGDRRFIDFQFQDLNSSLRPRLGNATANNTCIVDDSFKYNLNGA
                     VYSVVFILGLITNSASLFVFCFRMKMRSETAIFITNLALSDLLFVCTLPFKIFYNFNR
                     HWPFGDTLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCA
                     GVWILVLSGGISASLFSTTNVNNATTTCFEGFSKRVWKTYLSKITIFIEVVGFIIPLI
                     LNVSCSSVVLRTLRKPATLSQIGTNKKKVLKMITVHMAVFVVCFVPYNSVLFLYALVR
                     SQAITNCLLERFAKIMYPITLCLATLNCCFDPFIYYFTLESFQKSFYINTHIRMESLF
                     KTETPLTPKPSLPAIQEEVSDQTTNNGGELMLESTF"
ORIGIN      
        1 agagttcccc cggcggccct cggctccagc aagactttgg gccttttctt gtgtcctgtt
       61 tgttaaaggc atgcgggctc cagcattaaa gagggctagt ccttaacaaa gggaaagcga
      121 taaatgtaaa taagctcaca ttttcagaat gagcggtttg cagtaaggag ctgcggcagc
      181 ccagagtctg ctctttttgg gctgggctaa cctttccctg ttttttgttt tttgttttgt
      241 tttgtttttg ttttttatgg ataaaaatat gcgcttccga agtgcgagtt gccagtttac
      301 acgtttatta gctaactatc tacaggcatg agcacattct ctcatctagc acactctttc
      361 ttgggcactc aattgaggaa ctctctgatc gtctgcctcc agaaaattca ttgattatcc
      421 aagtctcaga taaatctggt gccagagttt ggtttgaact aactaatgaa gaaagcattc
      481 tctactggtc ctcagtctca agagtggtga acccctgcac ctagcaggct ctctgggaaa
      541 aaaaaatcca tgggtgacag aagatttatt gacttccaat tccaagattt aaattcaagt
      601 ctcagaccca ggttgggaaa tgcaactgcc aataatactt gcattgttga tgattccttc
      661 aagtataatt tgaatggtgc tgtctatagt gttgtattca tcctgggtct aataaccaac
      721 agtgcctccc tgtttgtctt ctgcttccgc atgaaaatga gaagtgagac ggctattttc
      781 atcaccaacc tggccctctc tgatttgctt tttgtttgta ccctaccttt caaaatattt
      841 tacaacttta atcgccactg gccttttggt gacaccctct gtaagatctc agggactgcg
      901 ttcctcacca acatctatgg gagcatgctc ttcctcacct gcatcagtgt ggatcgtttc
      961 ctagccattg tctatccctt ccgatcgcgt accatcagga ccaggaggaa ttccgccatt
     1021 gtgtgcgctg gagtctggat cctagtcctc agtggtggta tttcagcttc tttgttctcc
     1081 accactaatg tcaacaatgc gaccaccact tgctttgaag gcttctccaa acgtgtctgg
     1141 aagacatacc tgtccaagat cactatattc attgaagttg ttggattcat cattcctctg
     1201 atattgaatg tttcttgttc ttctgtggtg cttagaaccc tccgcaagcc tgcaacattg
     1261 tctcagattg ggaccaataa aaaaaaagtg ttgaagatga tcacagtgca tatggcagtg
     1321 tttgtggtat gctttgtacc atacaactcc gttctctttt tatatgcctt ggtacgctcc
     1381 caagccatta ctaattgctt attggaaagg tttgcaaaga tcatgtaccc aattaccttg
     1441 tgccttgcaa ctctgaattg ttgctttgat ccttttatct attacttcac tcttgaatcc
     1501 tttcagaagt ccttttatat caatacacat ataaggatgg agtcgctgtt taagactgag
     1561 acacctctga cccccaaacc ttcccttcca gctatccaag aggaagttag tgatcaaaca
     1621 acaaataatg gtggtgaatt aatgctggaa tccaccttct aggtaccaga attgtctttc
     1681 aggttcagct acagtgtctc ttatgatttt tttcctatgc tataaatagg agaaacaaat
     1741 tgaagctaat gatactgaga atagagtaat gtaccaaatg cagtcagata catttgtttg
     1801 aacactattg tacatattct gttttgttca gtaattatag gtcaagtcta attacaacaa
     1861 ccaaaacaga tcagcctctt ctgttgagtt gacttttcat tacctaaatg accagtggtc
     1921 ttgactttta gtgatgtgag ggttattttt aaacttaaaa aaaaaggcat tccagtaatt
     1981 ttggtaattg ggttgggcct ataaatatag aacaaattca gggattattt aaaaacatct
     2041 gtgttactac tgatatatgc tagtattttt ttcctttttt gaattaatat tgaatttatt
     2101 ttaaaaaaag aactattttt acctaatctt aataagacat actgagaaag agaaatgtgt
     2161 tgaattttaa aatattggca aattttacct agattttaaa aacctaaatg aagtgtttga
     2221 atgaatatgg gtgggaaatt tggaatttag acaacattta cgcatttata ataaccacaa
     2281 ttagtgtcag cttttaaaac tttcttttta aaataattct agaattttca tatgaaattg
     2341 ttaatcctga aaggtgctac ttatgtgcct ggcaggtata aaatggaaaa ctcataaaat
     2401 taacagtgtc aatttaaaaa aaaaaaaact ttaagcaaca ctatattatt tcttaagatt
     2461 ttcatttatc ctttatgggg gtggggattg gcttgtagaa aatatttatt cttcatgtta
     2521 aatgttgggg acacattaca gccagagagc tacagtattt gtgcccaggt caggagtaaa
     2581 ttgaaaaagt aagtgaatag aatagtagca gcaagatatc ttagagctta tattagtagt
     2641 ttttaaggtg gtggttagat agctgtaatt ttgaaatcca tactctcttc tgtacatttt
     2701 ggagcacatt gtagccaagg cgctgctgaa tttgtgctca ggtcgggagc atattgaaaa
     2761 agatgtgtac ataaaaaaaa aaaaaaaaga aaagaaaaat taacaaaaat accccataaa
     2821 attagaaaag aaaaaaaaaa acaaataaga aaaaaaatag ttcctaacac ttgcttcttt
     2881 gttttattat ttttaaagtt ctataaactt aaaaatacta tgccatttta ataaacattt
     2941 tagcataatt ctattagaaa tctgataaaa ttgtgtccca gacaggattg aattatagaa
     3001 aaatgcataa tttataaaac tcaaagtgct acaatttaga gatgatgcct tgtatcaaaa
     3061 tgcagctagg caactgctca actgtcacca agtttgagag gaaatgaata aaaacatcat
     3121 tttatatgaa gaaaaatatc taataaaagt atataacaaa aaattaaatt tataaaagaa
     3181 tcttttttgt aactcacttg aacaacacaa acaagaatct tcaaaatgtt gtttttctgt
     3241 tgtatacagt agatgtactc taaatatgca tcagtcagtt taaataatat gtacaaaatg
     3301 tggcaattaa aaaatgccca gaattttcaa gtaaatgtcc aggaataaca catcttgtat
     3361 attgctgaac ttgtgccaga gagtggttaa attaaaaacc acaaaacaag gataaaatgg
     3421 taaaaaaaaa aaaatccaaa acaatgaata aattcttgaa attccttaat ctgtgtttct
     3481 ttctagtgat atgtaggctt aaaaataatc ataaaagtta aattaaaaat tagtgcacat
     3541 aatgcagtgt taaaagctgc tgaatttggg cttgggttag gaactagcta aaaaaaaaca
     3601 ttgctaaaac aatagaacaa tagtaaaaat gaattcatga tttaaatgcc taaaaataac
     3661 tatgcgttat attgtcttgc aaagaaaggt aattgttgga atacataagg ctgtaggctc
     3721 agttagagaa aagtaggtta agttagatga ggttcagttg ttaggttaat actgtaagtt
     3781 cagactagaa atccaagtat aaaaacttgc ttgtttcctt cagcatttct ttttcttttt
     3841 ttttttatat tgaactatat gtgattctgt actcttagct gttaaaatta tgaaatttta
     3901 gtattatggt atcacatcat tgaattggat gttaactgaa ttcacgtgaa atacatttaa
     3961 aaattatttg tgttttgcat aatttccatg tttaatgatg cttactcttt catattttac
     4021 ttttatcttg ggttaatttt catgttttat atttaatata acttgctagt aataaaaatg
     4081 gtgatgtgaa taatatagcc aacaattcgt aatgtatatc aaattgtaaa gttgaattta
     4141 ttttacattt ataagcacag gtaatcctta agctgtaatt acaactttca tttaaatgtt
     4201 tattaaatat aataaaacgt atttggatta ttaaggt
//
