LOCUS       NM_022983               2494 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus lysophosphatidic acid receptor 3 (Lpar3), mRNA.
ACCESSION   NM_022983
VERSION     NM_022983.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2494)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2494)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   3  (bases 1 to 2494)
  AUTHORS   Hwang,S.H., Kim,H.G. and Lee,M.
  TITLE     Paradoxical downregulation of LPAR3 exerts tumor-promoting activity
            through autophagy induction in Ras-transformed cells
  JOURNAL   BMC Cancer 22 (1), 969 (2022)
   PUBMED   36088312
  REMARK    GeneRIF: Paradoxical downregulation of LPAR3 exerts tumor-promoting
            activity through autophagy induction in Ras-transformed cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2494)
  AUTHORS   Uenaka,M., Uyeda,A., Nakahara,T. and Muramatsu,R.
  TITLE     LPA2 promotes neuronal differentiation and neurite formation in
            neocortical development
  JOURNAL   Biochem Biophys Res Commun 598, 89-94 (2022)
   PUBMED   35151977
REFERENCE   5  (bases 1 to 2494)
  AUTHORS   Yin,Y., Haller,M.E., Chadchan,S.B., Kommagani,R. and Ma,L.
  TITLE     Signaling through retinoic acid receptors is essential for
            mammalian uterine receptivity and decidualization
  JOURNAL   JCI Insight 6 (17), e150254 (2021)
   PUBMED   34292881
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2494)
  AUTHORS   Brauer,A.U., Savaskan,N.E., Kuhn,H., Prehn,S., Ninnemann,O. and
            Nitsch,R.
  TITLE     A new phospholipid phosphatase, PRG-1, is involved in axon growth
            and regenerative sprouting
  JOURNAL   Nat Neurosci 6 (6), 572-578 (2003)
   PUBMED   12730698
REFERENCE   7  (bases 1 to 2494)
  AUTHORS   Di Palma,F., Belyantseva,I.A., Kim,H.J., Vogt,T.F., Kachar,B. and
            Noben-Trauth,K.
  TITLE     Mutations in Mcoln3 associated with deafness and pigmentation
            defects in varitint-waddler (Va) mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14994-14999 (2002)
   PUBMED   12403827
REFERENCE   8  (bases 1 to 2494)
  AUTHORS   McGiffert,C., Contos,J.J., Friedman,B. and Chun,J.
  TITLE     Embryonic brain expression analysis of lysophospholipid receptor
            genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in
            angiogenesis
  JOURNAL   FEBS Lett 531 (1), 103-108 (2002)
   PUBMED   12401212
REFERENCE   9  (bases 1 to 2494)
  AUTHORS   Contos,J.J. and Chun,J.
  TITLE     The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic
            structure, chromosomal localization, and expression pattern
  JOURNAL   Gene 267 (2), 243-253 (2001)
   PUBMED   11313151
  REMARK    Erratum:[Gene 2001 Jul 11;272(1-2):345]
REFERENCE   10 (bases 1 to 2494)
  AUTHORS   Contos,J.J., Fukushima,N., Weiner,J.A., Kaushal,D. and Chun,J.
  TITLE     Requirement for the lpA1 lysophosphatidic acid receptor gene in
            normal suckling behavior
  JOURNAL   Proc Natl Acad Sci U S A 97 (24), 13384-13389 (2000)
   PUBMED   11087877
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122513.5 and AK042084.1.
            
            On Jun 18, 2009 this sequence version replaced NM_022983.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042084.1, AK132289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC122513.5         55602-55625
            25-2311             AK042084.1         2-2288
            2312-2494           AC122513.5         120673-120855
FEATURES             Location/Qualifiers
     source          1..2494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 71.03 cM"
     gene            1..2494
                     /gene="Lpar3"
                     /gene_synonym="Edg7; lpA3"
                     /note="lysophosphatidic acid receptor 3"
                     /db_xref="GeneID:65086"
                     /db_xref="MGI:MGI:1929469"
     exon            1..187
                     /gene="Lpar3"
                     /gene_synonym="Edg7; lpA3"
                     /inference="alignment:Splign:2.1.0"
     exon            188..944
                     /gene="Lpar3"
                     /gene_synonym="Edg7; lpA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1273
                     /gene="Lpar3"
                     /gene_synonym="Edg7; lpA3"
                     /note="LPA-3; LPA receptor 3; lysophosphatidic acid
                     receptor Edg-7; endothelial differentiation,
                     lysophosphatidic acid G-protein-coupled receptor 7"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 3"
                     /protein_id="NP_075359.1"
                     /db_xref="CCDS:CCDS17901.1"
                     /db_xref="GeneID:65086"
                     /db_xref="MGI:MGI:1929469"
                     /translation="MNECHYDKRMDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFI
                     FFSNSLVIAAVITNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRW
                     FLRQGLLDTSLTASLANLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMG
                     AVPTLGWNCLCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVAVYVRIYMYVKRKTN
                     VLSPHTSGSISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKR
                     WFLLLALLNSVMNPIIYSYKDEDMYNTMRKMICCALQDSNTERRPSRNPSTIHSRSET
                     GSQYLEDSISQGPVCNKNGS"
     exon            945..2494
                     /gene="Lpar3"
                     /gene_synonym="Edg7; lpA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2221..2226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar3"
                     /gene_synonym="Edg7; lpA3"
                     /note="hexamer: AATAAA"
     polyA_site      2242
                     /gene="Lpar3"
                     /gene_synonym="Edg7; lpA3"
                     /note="major polyA site"
     regulatory      2428..2433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar3"
                     /gene_synonym="Edg7; lpA3"
                     /note="hexamer: AATACA"
     polyA_site      2450
                     /gene="Lpar3"
                     /gene_synonym="Edg7; lpA3"
ORIGIN      
        1 gcaaagttgc ccgggactcc cggcgcgtcg ccgcggacgc tggagagcag gcgcttggct
       61 ctgcctgctc cgcgtcttcc gctgctggct ggccggagcc tgctcgcccc gtcgcgctcc
      121 cccgagggca tgcgacagcg gcgggacgct cggctcccgg gctcggcggc gcgggcgagc
      181 gacagcggag gcacagttct tgtccaccat gaatgagtgt cactatgaca agcgcatgga
      241 ctttttctac aacaggagca acacagacac agcggacgag tggacaggga caaagcttgt
      301 gatcgtcctg tgcgtgggga cgttcttctg cctctttata tttttttcta actccctggt
      361 cattgctgcg gtgatcacaa accggaagtt ccactttccc ttctactacc tgctggctaa
      421 cttagctgct gcggatttct tcgccggaat cgcttacgtg ttcctgatgt ttaacactgg
      481 cccggtgtcg aaaacgttga ccgtcaaccg ctggttcctc cgccaggggc tcctagacac
      541 cagcctgact gcctccctgg ccaatttgct ggttattgct gtggaaagac acatgtccat
      601 catgaggatg agagtccaca gcaacttgac caaaaagcgg gtgacgctgc tcattctgct
      661 ggtgtgggcc atcgccatct tcatgggggc cgtccccacg ctgggatgga attgcctctg
      721 caacatctcg gcctgctctt ctctggctcc catttacagt aggagttacc tcattttctg
      781 gactgtgtcc aacctcctgg ccttcttcat catggtggcg gtatacgtac gcatctacat
      841 gtatgttaaa aggaaaacca acgtcttatc tccacacacc agtggctcca tcagccgccg
      901 gagggctccc atgaagctaa tgaagacagt gatgaccgtc ttaggcgcct tcgtggtgtg
      961 ctggaccccg ggtctggtgg ttctgctgct ggacggcctg aactgcaagc agtgtaacgt
     1021 gcaacacgtg aagcgctggt tcctgctgct cgcactgctc aactccgtca tgaaccccat
     1081 catctactcg tacaaggacg aggacatgta caacaccatg cggaagatga tctgctgtgc
     1141 cctgcaggac agcaataccg agaggcgccc ctcccgcaac ccctccacca tccacagcag
     1201 gagcgagacg ggcagccagt acctggagga cagcatcagc cagggcccgg tgtgcaataa
     1261 aaacggctcc taagccacgg acgcctccgc cctcttcccc tggggaaaga gctgttaagc
     1321 gtcctcacct gtctcacaaa gcacgtggac agggttgttt gagggctcca tgcatcactt
     1381 ctggggcttt taagttttca tggtcaagga aaatagattt acggcgttta gtaaaagcgc
     1441 acaggaaagg gagagatgag cagtgggttc cggcttgtct gtgatccgct cccaacatcc
     1501 tccagctctt gcgagagcca tgctgggctc tgtcaccatc ttgccaccat tgtctgtgtg
     1561 ttttcaatga tggtgttgaa agtcctaggt caaaagaaag tagtaaataa tggtacctga
     1621 gccccccatt gtgtggctac tagattctgt agttgtttcc gcatgggttt aaaatgttca
     1681 gaaaaatatt ttagcagtga actttgattt cctcagagaa gccatggcca ggagctaggt
     1741 gggcaactgt atagtagagt aagtgatgat attgaccggt aggttgaact tcttccaaat
     1801 agcgtcaaat atgagcacga ttagatcttc agtcttggtt atcaggatac cgctgagggg
     1861 cttgctggat cccaagtgca aagtaattgc acatcgagta ttttaaccaa agctgccagc
     1921 gtattctatc ttgtggactg cattttgatc ttgtattttt ctccttcaaa gacctctgaa
     1981 aggtagatca gttaaaaaca aaaatagtgt tcatacacat aggctactga ccagtgtttt
     2041 cggtgtaaga cgtttagagt gtattctgac aaagtaagaa taacttcaag gcaggcacta
     2101 tggtatttat gtagcttgca aacgtttaca tgttctctct ctctctctct ctctctctct
     2161 ctctctctct ctctcccctc tgctgttgtg atgtaacatt tatgtgcaca aactacttgt
     2221 aataaaatat tttaagaagc tatgctttga gatataatgg cctaaaatat agagcgttat
     2281 gatttgaagt cttagatttt tacatgcttg atgcagtagg taggtgtacg caaagcttat
     2341 gtgaaagcta cctataaaat aataatttgc gaggacctgt tatcccttga tgagggccat
     2401 tattgctctg tatattatct aagcaaaaat acagcatgtg gtaactgtga ctcacacttg
     2461 tattgtagaa gaaaaaaaaa tcaaatttgc catg
//
