LOCUS       NM_020028               5701 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus lysophosphatidic acid receptor 2 (Lpar2), mRNA.
ACCESSION   NM_020028
VERSION     NM_020028.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5701)
  AUTHORS   Taketomi,Y., Higashi,T., Kano,K., Miki,Y., Mochizuki,C.,
            Toyoshima,S., Okayama,Y., Nishito,Y., Nakae,S., Tanaka,S.,
            Tokuoka,S.M., Oda,Y., Shichino,S., Ueha,S., Matsushima,K.,
            Akahoshi,N., Ishii,S., Chun,J., Aoki,J. and Murakami,M.
  TITLE     Lipid-orchestrated paracrine circuit coordinates mast cell
            maturation and anaphylaxis through functional interaction with
            fibroblasts
  JOURNAL   Immunity 57 (8), 1828-1847 (2024)
   PUBMED   39002541
REFERENCE   2  (bases 1 to 5701)
  AUTHORS   Kim,T.Y., Kim,A., Aryal,Y.P., Sung,S., Pokharel,E., Neupane,S.,
            Choi,S.Y., Ha,J.H., Jung,J.K., Yamamoto,H., An,C.H., Suh,J.Y.,
            Sohn,W.J., Lee,Y., Jang,I.H., Norman,D.D., Tigyi,G.J., An,S.Y. and
            Kim,J.Y.
  TITLE     Functional modulation of lysophosphatidic acid type 2 G-protein
            coupled receptor facilitates alveolar bone formation
  JOURNAL   J Cell Physiol 239 (1), 112-123 (2024)
   PUBMED   38149778
  REMARK    GeneRIF: Functional modulation of lysophosphatidic acid type 2
            G-protein coupled receptor facilitates alveolar bone formation.
REFERENCE   3  (bases 1 to 5701)
  AUTHORS   Uenaka,M., Uyeda,A., Nakahara,T. and Muramatsu,R.
  TITLE     LPA2 promotes neuronal differentiation and neurite formation in
            neocortical development
  JOURNAL   Biochem Biophys Res Commun 598, 89-94 (2022)
   PUBMED   35151977
  REMARK    GeneRIF: LPA2 promotes neuronal differentiation and neurite
            formation in neocortical development.
REFERENCE   4  (bases 1 to 5701)
  AUTHORS   Geng,H., Lan,R., Liu,Y., Chen,W., Wu,M., Saikumar,P., Weinberg,J.M.
            and Venkatachalam,M.A.
  TITLE     Proximal tubule LPA1 and LPA2 receptors use divergent signaling
            pathways to additively increase profibrotic cytokine secretion
  JOURNAL   Am J Physiol Renal Physiol 320 (3), F359-F374 (2021)
   PUBMED   33427061
  REMARK    GeneRIF: Proximal tubule LPA1 and LPA2 receptors use divergent
            signaling pathways to additively increase profibrotic cytokine
            secretion.
REFERENCE   5  (bases 1 to 5701)
  AUTHORS   McDonald,W.S., Miyamoto,K., Rivera,R., Kennedy,G., Almeida,B.S.V.,
            Kingsbury,M.A. and Chun,J.
  TITLE     Altered cleavage plane orientation with increased genomic
            aneuploidy produced by receptor-mediated lysophosphatidic acid
            (LPA) signaling in mouse cerebral cortical neural progenitor cells
  JOURNAL   Mol Brain 13 (1), 169 (2020)
   PUBMED   33317583
  REMARK    GeneRIF: Altered cleavage plane orientation with increased genomic
            aneuploidy produced by receptor-mediated lysophosphatidic acid
            (LPA) signaling in mouse cerebral cortical neural progenitor cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5701)
  AUTHORS   Contos,J.J. and Chun,J.
  TITLE     The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic
            structure, chromosomal localization, and expression pattern
  JOURNAL   Gene 267 (2), 243-253 (2001)
   PUBMED   11313151
  REMARK    Erratum:[Gene 2001 Jul 11;272(1-2):345]
REFERENCE   7  (bases 1 to 5701)
  AUTHORS   Contos,J.J., Ishii,I. and Chun,J.
  TITLE     Lysophosphatidic acid receptors
  JOURNAL   Mol Pharmacol 58 (6), 1188-1196 (2000)
   PUBMED   11093753
  REMARK    Review article
REFERENCE   8  (bases 1 to 5701)
  AUTHORS   Contos,J.J., Fukushima,N., Weiner,J.A., Kaushal,D. and Chun,J.
  TITLE     Requirement for the lpA1 lysophosphatidic acid receptor gene in
            normal suckling behavior
  JOURNAL   Proc Natl Acad Sci U S A 97 (24), 13384-13389 (2000)
   PUBMED   11087877
REFERENCE   9  (bases 1 to 5701)
  AUTHORS   Contos,J.J. and Chun,J.
  TITLE     Genomic characterization of the lysophosphatidic acid receptor
            gene, lp(A2)/Edg4, and identification of a frameshift mutation in a
            previously characterized cDNA
  JOURNAL   Genomics 64 (2), 155-169 (2000)
   PUBMED   10729222
REFERENCE   10 (bases 1 to 5701)
  AUTHORS   Morris,M.D., Bhuvaneswaran,C., Shio,H. and Fowler,S.
  TITLE     Lysosome lipid storage disorder in NCTR-BALB/c mice. I. Description
            of the disease and genetics
  JOURNAL   Am J Pathol 108 (2), 140-149 (1982)
   PUBMED   6765731
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064676.1 and AC158564.7.
            
            On May 27, 2006 this sequence version replaced NM_020028.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064676.1, BC060131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2479              BC064676.1         137-2615
            2480-5701           AC158564.7         21907-25128
FEATURES             Location/Qualifiers
     source          1..5701
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.91 cM"
     gene            1..5701
                     /gene="Lpar2"
                     /gene_synonym="Edg4; IPA2; LPA2"
                     /note="lysophosphatidic acid receptor 2"
                     /db_xref="GeneID:53978"
                     /db_xref="MGI:MGI:1858422"
     exon            1..147
                     /gene="Lpar2"
                     /gene_synonym="Edg4; IPA2; LPA2"
                     /inference="alignment:Splign:2.1.0"
     exon            148..889
                     /gene="Lpar2"
                     /gene_synonym="Edg4; IPA2; LPA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1203
                     /gene="Lpar2"
                     /gene_synonym="Edg4; IPA2; LPA2"
                     /note="LPA-2; LPA receptor 2; lysophosphatidic acid
                     receptor Edg-4; endothelial differentiation,
                     lysophosphatidic acid G-protein-coupled receptor 4"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 2"
                     /protein_id="NP_064412.2"
                     /db_xref="CCDS:CCDS40362.1"
                     /db_xref="GeneID:53978"
                     /db_xref="MGI:MGI:1858422"
                     /translation="MGQCYYNETIGFFYNNSGKELSLHWRPKDVVVVALGLTVSVLVL
                     LTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGMAYLFLMFHTGPRTARLSIKGWF
                     LRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVTLIVGVWAAALGLGL
                     LPAHFWHCLCDLDSCSRMVPLFSRSYLAAWALSSLLVFLLMVAVYTRIFFYVRRRVER
                     MAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLDCKSCNVLAVEKY
                     FLLLAEANSLVNAVVYSCRDAEMRRTFRRLLCCMCLRWSSHKSARYSASAQTGASTRI
                     MLPENGRPLMDSTL"
     exon            890..5701
                     /gene="Lpar2"
                     /gene_synonym="Edg4; IPA2; LPA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2703..2708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar2"
                     /gene_synonym="Edg4; IPA2; LPA2"
                     /note="hexamer: ATTAAA"
     polyA_site      2723
                     /gene="Lpar2"
                     /gene_synonym="Edg4; IPA2; LPA2"
                     /note="major polyA site"
     regulatory      5674..5679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar2"
                     /gene_synonym="Edg4; IPA2; LPA2"
                     /note="hexamer: AATAAA"
     polyA_site      5696
                     /gene="Lpar2"
                     /gene_synonym="Edg4; IPA2; LPA2"
ORIGIN      
        1 gaggtcccgc ctctcccgcc tcctcagccg ggggctccag gaacaccgga cgctgctgcg
       61 caaccgctcg gttgcccggc catgggtctc agtcctgctt caacccaccg cgagccagcc
      121 ccatctgccg cttgactgga tgtgcaggca gccatcatgg gccagtgcta ctacaacgag
      181 accatcggct ttttctataa taacagcggc aaggagctca gccttcactg gcgccccaaa
      241 gatgtggtgg tggtggccct ggggctgaca gtcagtgtgc tggtattgct gaccaatctg
      301 ctggttattg cagccatcgc ctccaaccga cgcttccacc agcccatata ctacctgctt
      361 ggcaacttgg ctgcggctga cctcttcgct ggcatggcct acctcttcct catgttccat
      421 actggcccac gcactgccag gctctccatc aaaggctggt tcctgcgaca gggcctgctg
      481 gacaccagcc tcacggcgtc agtggccaca ctgctggcca tcgctgtgga acggcaccgc
      541 agtgtgatgg cggtacagct acacagccgc ctgccccggg gccgtgtggt cacactcatc
      601 gtgggtgtgt gggcggctgc actgggtctg gggttgctac ctgcacactt ctggcactgc
      661 ctctgtgact tggacagttg ctcacgcatg gtgcccctgt tcagccgctc ctacttggct
      721 gcgtgggccc tatccagcct gcttgtcttc ctactcatgg tagctgtcta cacacgaatt
      781 ttcttctatg tgcgtagacg ggtggaacgc atggcggagc acgtcagctg ccatccccgc
      841 taccgagaga ccacactcag cctagtcaag acggttgtca tcattctggg ggcatttgtg
      901 gtgtgctgga caccgggcca ggtggtgctg ctcctggatg gcctggactg taagtcctgc
      961 aacgttctgg ctgtggagaa gtacttcctg ctcctggctg aggccaactc actggtcaat
     1021 gcagtggtat attcctgccg agatgctgag atgcgccgca ccttccgccg ccttctctgc
     1081 tgcatgtgtc tccgctggtc cagccacaag tctgcccgtt actcagcttc tgcccagacg
     1141 ggtgccagca cgcggatcat gcttcctgag aatggccgcc cactgatgga ctccaccctt
     1201 taaaccttgg actgaggcag gagactggag cttcatctgc agcctatggt cacttgcaga
     1261 gcctctgact caagccagcc cagcagatgc atggctcttc aacactccct gccccaggga
     1321 cagagagagt ctgcctgccc ctggacagag ggacttgggg acatctccgt ccatgcacct
     1381 ggggagagca tcctaatggg acttggccgt ctggttctca atcatctcag gttttagggt
     1441 ttttaacaga cattttcata tttttactgt gttatctctg gatgtctgtg gactgctgct
     1501 tcctacatgg tgctgtagct attgggacag aagaggtgag agctgtccca ggctatacca
     1561 cctactgtta cagggtagac tgtaggagta ctgtcttcct gaggcggctt ttggttgttt
     1621 tgttttgctt ttgagatagg ctctcatgta gcctaggcgg ccttgaattc actgtgtagg
     1681 tgaggatggc cttgaactct tgatggtcct gactcccaag tgctagtact gaagctgatt
     1741 ccttagatgt gctgagcagc ctgagggctc acctgcctcc cttagtacga gggaccccat
     1801 gacacagagc aagcctttcc actctgaggt tgcagagttg gggtttggtt tggtttagtt
     1861 aggatttttt tctgttggtt ggcaggtgtt ttgccattac ttcagtcagt ctgtcccagt
     1921 gtcctggaat catgactcag ggctgccaag aatccttcaa catgaaatcc catggcccca
     1981 gccagccttg aacttgctgc atagactagg ctgttcttga atccattgtc ttgcctccga
     2041 attgtagatg ttgggattag agctatatgc tgccataccc agtttttgtc tcttcctgga
     2101 gtcttacaaa tgtttctttc cttttgcctc tgtcctaccc agctctctct ttaaagaacc
     2161 taggatgatt tctagtttgt gcaaaccttc tccttctgcc tgcctcaccc cctttttttt
     2221 tagacccaaa gtctcacagt gcagcccagt ccaccctaga gctcactgtg ccactcaggc
     2281 taatatcaaa ctctcaggtc tcttcctgcc tgggctccct gagtgctagg aatgacaagc
     2341 catattgagc ctgtgtctga ctgcacagct tggaaaagca cagctatgca gggggcacca
     2401 gaaaactcca tgaggaaggg cttcagtgtc ccttggactt tctacttctg agtcccccaa
     2461 gacctcagat atgccaggcc tgaggttaac tccctccctc cctccctccc tccctccctc
     2521 cctccctccc tccctccctc cctcgccaga gaagcctcct agcaggcagt gtgagccatg
     2581 aacttggctc cctgctctgc ctcaccagag aggagtcggg gttatgttct cacctcagat
     2641 tcacagccga ggaacagcag gaacttgaac ctctgtctta tctgaggcca aattcttaag
     2701 gcattaaagc atctgtttct taagaacgga aaacgtctct ttctttctac agtcagtgcc
     2761 cggcttttcc cacagctagg accttgcaca ctctaggcaa gttccccagc acagatcttc
     2821 tatcacgtga gccatgtcca aaaggaaaac agtgcagacc gaactgaagg gctggattgc
     2881 agtgggcctt tgcttctttg tgggttcttt tttctcactc tttatgcctc tggtttcacc
     2941 ccatcagtca caagatagaa aaagaaaaag ggagaaagat actgagatct gtgaatctaa
     3001 tttctttctt cctgtttctt ctttgagcac aactactaac aaactatgat caaccaacca
     3061 cactacctat ggggccctag cattcataca cccttgaaaa agtttccaga attctaaaca
     3121 tcacacaacc acagaaactc tctgcagttg gcaaaactgt gcctcatgtt ccaaggtgat
     3181 agcccaggaa cctctgcagc caggtgttca ttaaggacag tgtccctgaa gccaggtgtc
     3241 catgaaggac agtgtccctg cagccaggtg tccatgaagg acagtgtccc tgcagccagg
     3301 tgtccatgaa ggacagtgtc cctttcctac ctcctaggag ctccaggcat actggacatg
     3361 ggtcacttta gggatgggtg gaggcagcca attgaatcct gatttgggga cctctgatgg
     3421 cctgcagaag tcagctctgt cacctgtcct tagtggctgt cctccatcag caccatccag
     3481 atgctatcca gggatttatc ttgtcaacct ttacatttta ttttcccttt tccacttaga
     3541 ggcattatgc ttttttgttc tttgagacag ggactcactg tgtagcactg gctggcctct
     3601 aactcacaaa gatcagcctg cctctgcctc ctgagagctg ggattaaagg aaagtgcctt
     3661 gtgatttaca gatttctgca cttgcgtgga tgcacctctg catgtggagg ctggagatgt
     3721 gtcaagtcag ccctgaaggc agggccacct tagtcaacat agcagggtct ctgtcacatc
     3781 cagagctcac caatacagct agtctcactg ggcatcttgt tctgagcaat cccctgtctc
     3841 tgccctccaa ggcaggagat atactcagga cactgctcct gtccccactt ttatgtggat
     3901 ttctgaggtt ctgaattctg gtcttcaaac ttgagtagca agcgctttaa aaagtactga
     3961 gccattgccc tagcctggct tttccttgac ttctctgctg tgtgacatca agcttttgtc
     4021 tcttttagac cattggaact tacagtcttc tccctccccc agatcaggcc tgtgcagtgc
     4081 tgggccactg tctgaccttt tgtacactct gggcccacct taaaggcttc tattacttcc
     4141 tgtggctggg gccaagccta gggttttcct tgtgcttaca catttgaatt tcttgccagg
     4201 cacccccgga agtctccatc ttccccatgc cccgtcgccc ccatacacac atgctgcttg
     4261 agtttcctct tcagtaagaa caaaaggcag atgacttgac ttcgcagtca cactgaccct
     4321 tcaccaagcc ttcacctgaa ttctgtctct gagcaaacat tcagggaggc tctgtatctc
     4381 tagagaggga tttgtgtgtg tgtgtgtgtg tgtgtgtccc tttttaggac tcacaaacaa
     4441 gagagacaaa aggcctgtga gagttctctg tcttggggta cacctgagca ttgatattcg
     4501 gcaaagtctt cattctttag ccatgtgcta gcatttgcta gacctggaat gctggggttg
     4561 gaaggaagga ctggatctaa ggaactcagc agggagaagc gcttcctgcc aagcctggca
     4621 acaagagttc aatccctgga ctcatggtag tagagaccca agtcctgaaa gttgttctct
     4681 gacctccaca cttgggctat gatgtacaaa cacatcacac ttgtgctgtg gtgtgtaaac
     4741 acattgtgtg tgtgcatgca cgcacacaca tacacacaat gacaaaattt taaaagaaca
     4801 aacaggttga ggtcactccc acgttggatc ttgataaaac aatagagtta acttctccag
     4861 tggagaaagg tactggattc tagcttcctt cctgccatct acacaaatct acacttttca
     4921 tctgtccccc cacccccccc aagcctggta aaagggaaac agaaaggttt agggaaaggc
     4981 acggtggagg gataaccttt ttgtgcactg tataaagcat gtcttcctat tacccagatg
     5041 ctggttttgt taacacccct ctctcccctt ctgactggtt ttaataaaaa gctgttggcc
     5101 tatagtgaag ccggagactg ccagctccgg acttgcaggg agagattgaa ctctgaagga
     5161 gtcaggctct agaagcccaa catggaggaa gaagcaggct ccagtactag agaccgagag
     5221 gtcacaagcc atgaggcaga catggaataa tataaatgtg ttagtagaag ttgtacgagc
     5281 tagttgggaa caagcctagc tataaggcct aggcatttat aaataaacat gtctctgtat
     5341 ctttattcag agttggggta agcatggaag gtccatacgg ttataacagg attctggtga
     5401 ccagccaaag gagactatgc tcgaggggcc caggacttat gggaaacagt catacccctc
     5461 caggctggat atggtcattg ccatgttgaa tcaagaactg cgttcattca tgcatgacct
     5521 cacaagtttg gaccactaat atgtttttgt acaaatacag gacatatgca taggaccact
     5581 ctcctcaata aagattatag acccataatg aaggtggggg agggaagatg atacatttct
     5641 gctggagctg cccatgcatt ggggaggaac ctcaataaag tccctggttc acaaaactgg
     5701 a
//
