LOCUS       NM_172989               3451 bp    mRNA    linear   ROD 07-MAR-2023
DEFINITION  Mus musculus lysophosphatidic acid receptor 1 (Lpar1), transcript
            variant 2, mRNA.
ACCESSION   NM_172989
VERSION     NM_172989.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3451)
  AUTHORS   Neyama H, Nishiyori M, Cui Y, Watanabe Y and Ueda H.
  TITLE     Lysophosphatidic acid receptor type-1 mediates brain activation in
            micro-positron emission tomography analysis in a fibromyalgia-like
            mouse model
  JOURNAL   Eur J Neurosci 56 (3), 4224-4233 (2022)
   PUBMED   35666711
  REMARK    GeneRIF: Lysophosphatidic acid receptor type-1 mediates brain
            activation in micro-positron emission tomography analysis in a
            fibromyalgia-like mouse model.
REFERENCE   2  (bases 1 to 3451)
  AUTHORS   Axelsson Raja A, Wakimoto H, DeLaughter DM, Reichart D, Gorham J,
            Conner DA, Lun M, Probst CK, Sakai N, Knipe RS, Montesi SB, Shea B,
            Adam LP, Leinwand LA, Wan W, Choi ES, Lindberg EL, Patone G, Noseda
            M, Hubner N, Seidman CE, Tager AM, Seidman JG and Ho CY.
  TITLE     Ablation of lysophosphatidic acid receptor 1 attenuates
            hypertrophic cardiomyopathy in a mouse model
  JOURNAL   Proc Natl Acad Sci U S A 119 (28), e2204174119 (2022)
   PUBMED   35787042
  REMARK    GeneRIF: Ablation of lysophosphatidic acid receptor 1 attenuates
            hypertrophic cardiomyopathy in a mouse model.
REFERENCE   3  (bases 1 to 3451)
  AUTHORS   Kim H, Gao EB, Draper A, Berens NC, Vihma H, Zhang X,
            Higashi-Howard A, Ritola KD, Simon JM, Kennedy AJ and Philpot BD.
  TITLE     Rescue of behavioral and electrophysiological phenotypes in a
            Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4
            expression
  JOURNAL   Elife 11, e72290 (2022)
   PUBMED   35535852
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3451)
  AUTHORS   Cordova-Casanova A, Cruz-Soca M, Chun J, Casar JC and Brandan E.
  TITLE     Activation of the ATX/LPA/LPARs axis induces a fibrotic response in
            skeletal muscle
  JOURNAL   Matrix Biol 109, 121-139 (2022)
   PUBMED   35385768
REFERENCE   5  (bases 1 to 3451)
  AUTHORS   Ahmadzai MM, McClain JL, Dharshika C, Seguella L, Giancola F, De
            Giorgio R and Gulbransen BD.
  TITLE     LPAR1 regulates enteric nervous system function through glial
            signaling and contributes to chronic intestinal pseudo-obstruction
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   35166239
  REMARK    GeneRIF: LPAR1 regulates enteric nervous system function through
            glial signaling and contributes to chronic intestinal
            pseudo-obstruction.
REFERENCE   6  (bases 1 to 3451)
  AUTHORS   Fukushima N, Kimura Y and Chun J.
  TITLE     A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins
            and mediates multiple cellular responses to lysophosphatidic acid
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6151-6156 (1998)
   PUBMED   9600933
REFERENCE   7  (bases 1 to 3451)
  AUTHORS   An S, Dickens MA, Bleu T, Hallmark OG and Goetzl EJ.
  TITLE     Molecular cloning of the human Edg2 protein and its identification
            as a functional cellular receptor for lysophosphatidic acid
  JOURNAL   Biochem Biophys Res Commun 231 (3), 619-622 (1997)
   PUBMED   9070858
REFERENCE   8  (bases 1 to 3451)
  AUTHORS   Macrae AD, Premont RT, Jaber M, Peterson AS and Lefkowitz RJ.
  TITLE     Cloning, characterization, and chromosomal localization of rec1.3,
            a member of the G-protein-coupled receptor family highly expressed
            in brain
  JOURNAL   Brain Res Mol Brain Res 42 (2), 245-254 (1996)
   PUBMED   9013780
REFERENCE   9  (bases 1 to 3451)
  AUTHORS   Hecht JH, Weiner JA, Post SR and Chun J.
  TITLE     Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid
            receptor expressed in neurogenic regions of the developing cerebral
            cortex
  JOURNAL   J Cell Biol 135 (4), 1071-1083 (1996)
   PUBMED   8922387
REFERENCE   10 (bases 1 to 3451)
  AUTHORS   Thompson HA, Burson JM, Lang JA, Gross KW and Sigmund CD.
  TITLE     Tissue-specific expression of novel messenger ribonucleic acids
            cloned from a renin-expressing kidney tumor cell line (As4.1)
  JOURNAL   Endocrinology 136 (7), 3037-3045 (1995)
   PUBMED   7789330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ175997.1, BY716867.1, AK030330.1 and AL807748.10.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_172989.2.
            
            Transcript Variant: This variant (2) represents the longest
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.175130.1, AK030330.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               CJ175997.1         4-133
            131-666             BY716867.1         90-625
            667-1830            AK030330.1         631-1794
            1831-3451           AL807748.10        104703-106323       c
FEATURES             Location/Qualifiers
     source          1..3451
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 32.2 cM"
     gene            1..3451
                     /gene="Lpar1"
                     /gene_synonym="Edg2; Gpcr26; Kdt2; lpA1; vzg-1"
                     /note="lysophosphatidic acid receptor 1"
                     /db_xref="GeneID:14745"
                     /db_xref="MGI:MGI:108429"
     exon            1..160
                     /gene="Lpar1"
                     /gene_synonym="Edg2; Gpcr26; Kdt2; lpA1; vzg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            161..320
                     /gene="Lpar1"
                     /gene_synonym="Edg2; Gpcr26; Kdt2; lpA1; vzg-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1370
                     /gene="Lpar1"
                     /gene_synonym="Edg2; Gpcr26; Kdt2; lpA1; vzg-1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     endothelial differentiation lysophosphatidic acid
                     G-protein-coupled receptor 2; rec1.3; LPA receptor 1;
                     lysophosphatidic acid receptor Edg-2; G-protein coupled
                     receptor 26"
                     /codon_start=1
                     /product="lysophosphatidic acid receptor 1 isoform 1"
                     /protein_id="NP_766577.1"
                     /db_xref="CCDS:CCDS18212.1"
                     /db_xref="GeneID:14745"
                     /db_xref="MGI:MGI:108429"
                     /translation="MAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATE
                     WNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAY
                     FYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMS
                     NRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTF
                     VVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLV
                     LLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENP
                     NGPTEGSDRSASSLNHTILAGVHSNDHSVV"
     exon            321..1068
                     /gene="Lpar1"
                     /gene_synonym="Edg2; Gpcr26; Kdt2; lpA1; vzg-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..3451
                     /gene="Lpar1"
                     /gene_synonym="Edg2; Gpcr26; Kdt2; lpA1; vzg-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3422..3427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lpar1"
                     /gene_synonym="Edg2; Gpcr26; Kdt2; lpA1; vzg-1"
     polyA_site      3441
                     /gene="Lpar1"
                     /gene_synonym="Edg2; Gpcr26; Kdt2; lpA1; vzg-1"
     polyA_site      3448
                     /gene="Lpar1"
                     /gene_synonym="Edg2; Gpcr26; Kdt2; lpA1; vzg-1"
ORIGIN      
        1 gtgcgcgcgc ccgcgggccc ggagtgggtg ggtgtgcgcg cgtgtgtgag gccgcctgca
       61 ggaggcgagg ctgccctggc ctcccgcacc agccggtgga actcagcccg ggagggaagt
      121 cgccgcagcc gcccgggcgg ccctcccgac ctttggccag gcttacagtt cctcctagca
      181 tgaccgagat ctgatcagcc aacccgcgca ttgctttttg tgcctggcac tgcagtgcag
      241 ggggcctctt catcgcccca aactacagca ctgtcatggc agctgcctct acttccagcc
      301 ctgtaatttc acagccccag ttcacagcca tgaacgaaca acagtgcttc tacaatgagt
      361 ctatcgcctt cttttataac cggagtggga aatatctagc cacagaatgg aacacagtga
      421 gcaagctggt gatgggactg ggcatcactg tttgcgtgtt catcatgttg gccaatctcc
      481 tggtcatggt ggcaatctac gtcaaccgcc gcttccattt ccctatttat tacttgatgg
      541 ccaacctggc tgctgcagac ttcttcgctg gattggccta cttctacctg atgttcaata
      601 caggacctaa tacccggaga ctgactgtta gcacgtggct cctccggcag ggcctcattg
      661 acaccagcct gacagcttct gtggccaacc tgctggctat tgctatcgag aggcacatca
      721 cggttttccg catgcagctc catacacgaa tgagcaaccg gcgcgtggtg gtggtgattg
      781 tagtcatctg gactatggcc attgtgatgg gtgctatacc cagtgtgggc tggaactgca
      841 tctgtgatat cgatcactgt tccaacatgg cacccctcta cagtgactcc tacttagtct
      901 tctgggccat tttcaacctg gtgacctttg tggtcatggt ggttctctac gctcacatct
      961 ttggctatgt tcgccagagg actatgagga tgtctcggca tagttctgga cccaggagga
     1021 atcgggacac catgatgagc cttctgaaga ctgtggtcat tgtgcttggt gcctttattg
     1081 tctgctggac tccgggattg gtcttgttat tgctggatgt gtgctgcccg cagtgcgatg
     1141 tcctggccta tgagaagttc ttcctcctcc tggccgagtt caactctgct atgaacccca
     1201 tcatctactc ctaccgcgac aaagagatga gcgccacctt caggcagatc ctgtgttgcc
     1261 agcgcaacga gaaccctaat ggccccacgg aaggctctga ccgctctgcc tcctccctca
     1321 accacaccat tctggctgga gttcacagca acgaccactc tgtggtttag aaggaagcca
     1381 gccggcctct gtggatctgt gaaccccacc ctacccccca ttgccagggc aaggtgggga
     1441 gccagaggag atgaggacac tcctgtactt aacactaacc aatggcagta tttgtcccta
     1501 gacccaagag acttgaggat gaatttattt ggcaggcccc atcttctcct ttggaaaaca
     1561 gaaggggacc gtcttgtggt ggaattgaga aatggactct ggggtgaccg tgtagcattc
     1621 actaactaga cttaaaagat tttatgtggt ttggcttaag ccaggaaaaa aaaatctgct
     1681 gaattgagta tacaatcgag tatacacagg cttccccttt aaagaacaaa caatacattg
     1741 catttattaa tgagtatgtt tatgcctgac agcatgtttg tgatcgaaaa gactgctaaa
     1801 ctgacataga tgagttgttt tttttttttt gttttttgtt tttttttaca tgatggagga
     1861 aaagtataaa ttagaatgat ttttgtgttt gtttagaaag caagcatgtg gtgtgtgtat
     1921 tcagtatgcc tttctttaaa gataaaaggc cactatttta aatcttctag ggaatagaag
     1981 aatctagtaa aaaccagtat tcatttaggc tacaggaaaa accatatcct aatcaattac
     2041 cttttaatta aagtaatgaa atatacatga aaggcaaagt aatgtgagct tgtcacccaa
     2101 agagtgtgtg ctctccaaac gctggaggag atgaagctgt agcgttgtcc ctgcatagtg
     2161 aagataccca cgtgcgttct cagtgccaga ccctcagtgg gacttgtttt aaagcctgtg
     2221 gttttccaag ttagaaaata atacctactt actatagaaa acttgaaaat tgcagaactg
     2281 tgtgaaaaaa gaaaaaagaa agaaagattg ctgatatacg acctggaagt agccatcttt
     2341 ccctgctcac ccacgtatgc ctatagacat atattatata cctttttttt tttttacata
     2401 atcgggttga tattgtaaaa tgttttgtaa ctttttcttt cagaattgcc aggtttttct
     2461 atggcatttt ttttcaaaaa cagtgttagc ggctatataa tattccattt aatggatgca
     2521 gctcagttta tttaaccatt cctgtattgt tgactatgtt tttaattttt ttcattatta
     2581 taatattgga agaatcttgt gtatataaaa ctttgccagt atcattgatg atttacttgg
     2641 gctccattcc catgaaggac ctacttttaa aatgtgaaat gtcctcatgt gttgtcactt
     2701 tataaaaagg gatattctac cctcaaactg caggggtgac catgctgaca aaaagctcag
     2761 aaattacctt tttacaaaag aaacacagtg gctactttag ttgcgaatgg gttcttgaca
     2821 agatgtttcc caataaccca gacccttaac ataactagca aatttacttt agtaggaact
     2881 ggtgatccct ttctggacac aagaaaacac aaagacatca agcatcagag tgaatccagc
     2941 aatgcagtac caagcagcct gggtggggtg tgctagcaac tggctgctgt gtggtctcca
     3001 gcaatcaccc aatggacacc ctgtgttcag agatgcccag tacagtgtcc tggagactaa
     3061 ggtctctaat gtcatgctat gaggaacaag gaggaagaag aatagtcctg aagcaggtgt
     3121 ggagaggtca ggaggacgtc tgagagaagg cagtcctgcc aagagtggca ttctagggag
     3181 gaggaaggca gggtgtggct tgtgtctgga cagtcagtgg taggcatgtg acatttgcct
     3241 ggtggaaaaa aaataagtag gcggagatcc agttagcagg acaaagattt tgctcgagga
     3301 ttcacaaaat gcaaagaaat ttatactgga aatgagtgaa acgaacttgg acttttattg
     3361 atgccctttt tatgggggag gtaaggacta tttgaattga aaagcatact aattgaacct
     3421 taataaatca ttctcaatca gtgtttggcg a
//
