LOCUS       NM_053083               5444 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus lysyl oxidase-like 4 (Loxl4), transcript variant 2,
            mRNA.
ACCESSION   NM_053083
VERSION     NM_053083.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5444)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5444)
  AUTHORS   Li,H., Guo,J., Jia,Y., Kong,W. and Li,W.
  TITLE     LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced
            Thoracic or Abdominal Aortic Aneurysm in Mice
  JOURNAL   Genes (Basel) 12 (4), 513 (2021)
   PUBMED   33807332
  REMARK    GeneRIF: LOXL4 Abrogation Does Not Exaggerate Angiotensin
            II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5444)
  AUTHORS   Goodwin,A.F., Chen,C.P., Vo,N.T., Bush,J.O. and Klein,O.D.
  TITLE     YAP/TAZ Regulate Elevation and Bone Formation of the Mouse
            Secondary Palate
  JOURNAL   J Dent Res 99 (12), 1387-1396 (2020)
   PUBMED   32623954
REFERENCE   4  (bases 1 to 5444)
  AUTHORS   Choi,S.K., Kim,H.S., Jin,T. and Moon,W.K.
  TITLE     LOXL4 knockdown enhances tumor growth and lung metastasis through
            collagen-dependent extracellular matrix changes in triple-negative
            breast cancer
  JOURNAL   Oncotarget 8 (7), 11977-11989 (2017)
   PUBMED   28060764
  REMARK    GeneRIF: These results demonstrate that weak LOXL4 expression leads
            to remodeling of the extracellular matrix through induction of
            collagen synthesis, deposition, and structural changes.
REFERENCE   5  (bases 1 to 5444)
  AUTHORS   Zhang,J., Liu,Z., Zhang,T., Lin,Z., Li,Z., Zhang,A., Sun,X. and
            Gao,J.
  TITLE     Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development
            in Mice
  JOURNAL   Sci Rep 6, 33856 (2016)
   PUBMED   27645581
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5444)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 5444)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   8  (bases 1 to 5444)
  AUTHORS   Pischon,N., Maki,J.M., Weisshaupt,P., Heng,N., Palamakumbura,A.H.,
            N'Guessan,P., Ding,A., Radlanski,R., Renz,H., Bronckers,T.A.,
            Myllyharju,J., Kielbassa,A.M., Kleber,B.M., Bernimoulin,J.P. and
            Trackman,P.C.
  TITLE     Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype
  JOURNAL   Calcif Tissue Int 85 (2), 119-126 (2009)
   PUBMED   19458888
REFERENCE   9  (bases 1 to 5444)
  AUTHORS   Ito,H., Akiyama,H., Iguchi,H., Iyama,K., Miyamoto,M., Ohsawa,K. and
            Nakamura,T.
  TITLE     Molecular cloning and biological activity of a novel lysyl
            oxidase-related gene expressed in cartilage
  JOURNAL   J Biol Chem 276 (26), 24023-24029 (2001)
   PUBMED   11292829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124552.3, BY145829.1, AK014331.1 and BC053925.1.
            
            On Aug 27, 2009 this sequence version replaced NM_053083.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the middle portion of the coding region, compared to
            variant 1. This results in a shorter protein (isoform 2), compared
            to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068307.1, SRR13948564.4754203.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC124552.3         75682-75715
            35-367              BY145829.1         2-334
            368-1029            AK014331.1         368-1029
            1030-1231           AK014331.1         1033-1234
            1232-1232           AC124552.3         84497-84497
            1233-1398           AK014331.1         1236-1401
            1399-1399           AC124552.3         85164-85164
            1400-2054           AK014331.1         1403-2057
            2055-2055           AC124552.3         89783-89783
            2056-2607           AK014331.1         2058-2609
            2608-5444           BC053925.1         951-3787
FEATURES             Location/Qualifiers
     source          1..5444
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 36.56 cM"
     gene            1..5444
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /note="lysyl oxidase-like 4"
                     /db_xref="GeneID:67573"
                     /db_xref="MGI:MGI:1914823"
     exon            1..89
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            90..385
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2379
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /EC_number="1.4.3.13"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; lysyl oxidase homolog 4; lysyl oxidase-related
                     protein C; lysyl oxidase-like protein 4"
                     /codon_start=1
                     /product="lysyl oxidase homolog 4 isoform 2 precursor"
                     /protein_id="NP_444313.3"
                     /db_xref="CCDS:CCDS29830.1"
                     /db_xref="GeneID:67573"
                     /db_xref="MGI:MGI:1914823"
                     /translation="MMWPQPPTFSLFLLLLLSQAPSSRPQSSGTKKLRLVGPTDRPEE
                     GRLEVLHQGQWGTVCDDDFALQEATVACRQLGFESALTWAHSAKYGQGEGPIWLDNVR
                     CLGTEKTLDQCGSNGWGVSDCRHSEDVGVVCHPRRQHGYHSEKVSNALGPQGRRLEEV
                     RLKPILASAKRHSPVTEGAVEVRYDGHWRQVCDQGWTMNNSRVVCGMLGFPSQTSVNS
                     HYYRKVWNLKMKDPKSRLNSLTKKNSFWIHRVDCLGTEPHLAKCQVQVAPGRGKLRPA
                     CPGGMHAVVSCVAGPHFRRQKPKPTRKESHAEELKVRLRSGAQVGEGRVEVLMNRQWG
                     TVCDHRWNLISASVVCRQLGFGSAREALFGAQLGQGLGPIHLSEVRCRGYERTLGDCL
                     ALEGSQNGCQHANDAAVRCNIPDMGFQNKVRLAGGRNSEEGVVEVQVEVNGVPRWGTV
                     CSDHWGLTEAMVTCRQLGLGFANFALKDTWYWQGTPEAKEVVMSGVRCSGTEMALQQC
                     QRHGPVHCSHGPGRFSAGVACMNSAPDLVMNAQLVQETAYLEDRPLSMLYCAHEENCL
                     SKSADHMDWPYGYRRLLRFSSQIYNLGRADFRPKAGRHSWIWHQCHRHYHSIEVFTHY
                     DLLTLNGSKVAEGHKASFCLEDTNCPSGVQRRYACANFGEQGVAVGCWDTYRHDIDCQ
                     WVDITDVGPGDYIFQVVVNPTNDVAESDFSNNMIRCRCKYDGQRVWLHNCHTGDSYRA
                     NAELSLEQEQRLRNNLI"
     exon            386..564
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            565..770
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            771..809
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1029
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1213
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1368
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1536
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1699
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1943
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2059
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2196
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2308
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..5434
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3730..3735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /note="hexamer: AATAAA"
     regulatory      3738..3743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /note="hexamer: AATAGA"
     polyA_site      3755
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /note="major polyA site"
     polyA_site      3758
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
     regulatory      4797..4802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /note="hexamer: AGTAAA"
     polyA_site      4820
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
     regulatory      5406..5411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
                     /note="hexamer: AATAAA"
     polyA_site      5434
                     /gene="Loxl4"
                     /gene_synonym="4833426I20Rik; Loxc"
ORIGIN      
        1 ggataaaaag cccccagggc gccccgggag gcccgttagc gctgctctgc cgtggcgccc
       61 agcccagccc cgacctccag atcctgccgg cgctctgaaa tcaccatgat gtggccccaa
      121 ccacccacct tctccctgtt cctgctactg ctgctaagcc aagccccttc cagcaggcca
      181 cagtcatcag gcaccaagaa gctcaggctt gtggggccaa cggacagacc agaggagggc
      241 cgcttggagg tgctgcacca gggccagtgg ggcacggtgt gtgatgatga cttcgctctc
      301 caggaggcta ctgtggcctg ccgacagctg ggctttgagt cagccttgac ctgggcacac
      361 agtgccaagt atggtcaagg agagggtccc atctggctgg acaatgttcg ttgtttgggc
      421 accgagaaga ccctagatca gtgtggctct aacggctggg gtgtcagtga ctgcagacac
      481 tcagaagatg ttggggtggt atgtcaccca cggcgccagc acggatatca ctctgagaag
      541 gtctccaatg ccctcgggcc tcagggccgg cggctagaag aggtacggct gaaacccatc
      601 ctcgccagtg ccaaaaggca cagcccagtg actgaggggg ctgtggaagt acggtacgac
      661 ggccactgga ggcaggtgtg tgaccagggc tggaccatga acaacagcag ggttgtatgc
      721 gggatgctgg gctttcccag tcagacatct gtcaacagcc actactacag aaaagtctgg
      781 aatctgaaga tgaaggatcc caagtctagg ctcaacagcc tgacaaaaaa gaattccttc
      841 tggattcacc gggttgactg tctggggaca gagccccact tggccaagtg ccaggtacag
      901 gtggctccag gaaggggcaa gcttcggcca gcctgtccag gcggcatgca cgctgtggtc
      961 agctgtgtgg cagggcccca cttccgccga cagaagccaa agccgacgcg caaggagtcc
     1021 catgcagagg agctgaaagt gcgcctgcgc tctggggctc aggtgggtga gggccgtgtg
     1081 gaagtgctca tgaaccgcca gtggggcaca gtctgtgacc acaggtggaa cctcatctca
     1141 gccagcgtcg tgtgtcgcca gcttggcttt ggctctgccc gggaggccct ttttggggcc
     1201 cagttgggtc aagggctagg acccatccac ctgagtgagg tgcgctgccg ggggtatgag
     1261 cggaccctgg gtgactgcct tgccctggaa gggtcccaga atggttgtca acatgcaaac
     1321 gacgctgctg tcaggtgcaa catcccagac atgggcttcc agaacaaggt gcgcttggct
     1381 ggtgggcgca actccgaaga gggagtggtg gaggtgcagg tggaggtgaa tggggtccca
     1441 cgatggggga ctgtatgcag tgaccactgg gggctcaccg aagccatggt gacctgtcgg
     1501 caacttggtc tgggatttgc caactttgct ctcaaggaca cctggtactg gcaggggaca
     1561 ccagaggcca aagaagtggt gatgagtgga gttcgctgct caggcacaga aatggccctg
     1621 cagcagtgtc agagacatgg gcccgtgcac tgttcccacg gcccagggcg cttctcggct
     1681 ggcgttgcct gtatgaacag tgctccagac ctcgtgatga acgcccagct ggtacaagag
     1741 acggcgtact tggaggatcg tccactcagc atgctgtact gtgctcacga ggaaaactgc
     1801 ctttccaagt ccgctgatca catggactgg ccctacgggt accggcgctt gctgcgcttc
     1861 tcctcacaga tctacaacct tggccgggcc gacttccgtc ccaaggctgg acgccacagc
     1921 tggatttggc accagtgcca caggcactac cacagcatcg aagtcttcac tcattatgac
     1981 ctgctcacgc tcaatggctc caaggtggcc gagggacaca aggccagctt ctgtctagaa
     2041 gatacaaact gcccctcagg agtgcagcgg cgctatgcat gtgccaactt tggggaacag
     2101 ggagtggctg taggctgctg ggacacctac cggcatgaca tcgattgcca gtgggtggat
     2161 atcacagatg tgggtccagg ggactatatc ttccaggtgg ttgtgaaccc cacaaacgat
     2221 gttgcagagt ccgatttctc caataacatg atacggtgcc gctgcaagta tgatggacag
     2281 cgagtctggt tgcacaactg ccacacagga gattcctacc gagccaatgc agagctctcc
     2341 ctggagcagg aacagcgact caggaacaac ttgatctgaa gccattactg cactcccagc
     2401 tctgctcaca caccagatac ctcagctgac tggagccatg cccttcacaa agccctgact
     2461 cacaggacaa ggggctagtg acaaggagca ccaagaagct gctcaggagg cctttcggtg
     2521 gccagatcat cacccgggat ggcagttctc tcaggatggc tctgggccag ctcaaccttc
     2581 tcttccttca ggagactcga tcttctttac aacttgatgc acagttccca gtttcaggag
     2641 ctctaagttc ctcagggatg aactgtgacc aaggccccct ctaagtggtg ctttgcaaat
     2701 gtcttggagg accaaaggac agacgacccg agaacacaag ctgtggatgg agtcgttttc
     2761 tctgctatac gctccacgca aaaggaccat gtcaaagtca cacctggcag agacgctggt
     2821 gaacacagtc cctcagctta ccctcactta gaactcgcat ctcaggctct gaagcctctc
     2881 cttgcatctt taccttcatt cggtcacaca tggtgtttcc aatatccctg aaccctcagg
     2941 cctcctccat ttcctgatgg gtcaacacct cgattattgg ggctggggag caagtttcac
     3001 agaatgacga gacagggcct ttcctgcaga gtagtcagaa agcaagacga aggctgaggt
     3061 cacatgaatt cagcctcgga ggacctctgc ccagggaggt gccatatctg gcaggcaggc
     3121 cagtctctta gaatcaccca cattgtaggg ttagcctaaa tttcagattt aaccaaagcc
     3181 acttcacctt aaacttttgc aattgagaag aaattggtca gccaagctcc tctgcaggaa
     3241 caccaagaca ggtctagtag agttaggaac agaagacgga gttaacaaga agtgagaagg
     3301 aaacctggga gaggccacca tccagtgagg cggctgtgct ctgttcttgc tcaggtggta
     3361 taagacctgg agtcttccag ggcatgcctg gaccttttct ccactgacat acacacagat
     3421 gatccttcta ggtcttataa tgccaacaaa ggttgctcac tatgggctgc cacaaaggcc
     3481 agaccagctg agcttctgca gcttccactg cactacactc tgccctcttc cctccagagc
     3541 tggatgacgc tcggaacaca atccttggca cagcccaccc tagtacattt cttgggtctc
     3601 acactaacct gcttcaccgt tacgctgccc aaggtcaaca gtgaatcttg ggtcaggaag
     3661 gctgagaggt gaaggggagg aatgagaagg tgtgacccag actttagact tttataacag
     3721 aggctacaaa ataaaaaaat agatgctcgc agacagaact gattttacag cattctcctc
     3781 cccacagtac aagagctacc ctgatagtca aaagacatgt tttgggatac cttctgtgaa
     3841 caaaaagtac ctttttctgt ctcctccatt ccgtcatctc cttcatctgg cacaggaagc
     3901 ctgttttggt gtaacagttt aggtaaacaa gggaaggact gatttcctgt tggatccagc
     3961 aaacagtgat atgatcctca cacatgaagc taatgttctg cacaagaatg tgcgcagcta
     4021 gctagggtgg ggtggcaagt gatgactgga cttgggcagg gaggttaccc tcaccttctt
     4081 gttggatcta gtttccaaga gaccagcaaa agcaggccag gcagacaacc aacagcacgc
     4141 tctcagcttt ccggcccaca tcacacgagt ggtaggtgca gccagttcta attcctggaa
     4201 aaagctatac aagggctgtg ctgttaaact tctgagttga aagggaaaga cacgggcagc
     4261 ttggtggctg gcatgactta taactagatg aggaatgtta acagaatact aaccgccaaa
     4321 ttccagacag aaccaaaaac ctcagaagac tttcaccctg gcacaccttg acttcacgtg
     4381 tgctccagag aagggctagg aagctctcct cagaagttac gctaatagac ttttagacta
     4441 tgaagagaaa actagaatcc acagggactg tagctttcta ctagaaattc tacataaccc
     4501 tgagatttag acgtttacca tatacaaaac atatatgtag agtgtacatg agaggtcatc
     4561 ccccacagct aacttttctt tcagagcagc cacagcactc aaacagctct ccttatcttg
     4621 gagagttctg ttctctgaga gcagcagccg cactgtgttc tcccattagc tcctcttata
     4681 aaccaaggat ttatcctgca tggacaagct tgagccgtgg ctgggacttc ttactactaa
     4741 tacacagcat ccccgactac tggaataatg taagcaaaaa gcatattttc aatggaagta
     4801 aaaacagccc tgtcccaaaa ctttcaaatg ctgactttaa aaaactgttc tccgagactg
     4861 atgggagtta tcctgagagt taaacgtagc tgattatcag acataagatg ggttgcttct
     4921 ttaaaaactg ggtaataaac attagcaatg cctatagaga aggactctaa gcagctaaca
     4981 agaagtcctt tcacagacat gtttgtcctt tctcaaggtc atccagcctg agggtgtagc
     5041 tcagtggtga gtgctgtctg gtacatgtat ggccatggtc tggtatctaa cttggggtag
     5101 ggtgtgaaaa catggcaagt gtgtgccttc aaagtgtctc tcggtataaa gccatgctgg
     5161 ggggctggat cagttaactg ctcagcagtt aggagcctgg ttcttccaga ggacccaggt
     5221 acaattccca acatccatgt ggtggctcag aaccaactgt aattctagtc ccgggagatc
     5281 tacacacact tatggcctcc acagttacca ggaattcaga catacataaa attaataaca
     5341 gaaaaattaa taaggtaaca tgtaatatat aaaaataaat attatattta tattattata
     5401 ttaataataa ataacataaa aataataaaa ggcaaaaaaa aaaa
//
