LOCUS       NM_013586               4070 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus lysyl oxidase-like 3 (Loxl3), mRNA.
ACCESSION   NM_013586 XM_358895
VERSION     NM_013586.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4070)
  AUTHORS   Zhan,M., Ding,Y., Huang,S., Liu,Y., Xiao,J., Yu,H., Lu,L. and
            Wang,X.
  TITLE     Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote
            liver cancer chemoresistance by stabilizing dihydroorotate
            dehydrogenase
  JOURNAL   Nat Commun 14 (1), 3123 (2023)
   PUBMED   37253718
  REMARK    GeneRIF: Lysyl oxidase-like 3 restrains mitochondrial ferroptosis
            to promote liver cancer chemoresistance by stabilizing
            dihydroorotate dehydrogenase.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4070)
  AUTHORS   Melamed,S., Zaffryar-Eilot,S., Nadjar-Boger,E., Aviram,R., Zhao,H.,
            Yaseen-Badarne,W., Kalev-Altman,R., Sela-Donenfeld,D., Lewinson,O.,
            Astrof,S., Hasson,P. and Wolfenson,H.
  TITLE     Initiation of fibronectin fibrillogenesis is an enzyme-dependent
            process
  JOURNAL   Cell Rep 42 (5), 112473 (2023)
   PUBMED   37148241
REFERENCE   3  (bases 1 to 4070)
  AUTHORS   Liu,Z., Mo,F., Dong,X., Chen,G., Gao,J. and Zhang,J.
  TITLE     Progressive degeneration of the retina in Loxl3 mutant mouse model
            of Stickler syndrome
  JOURNAL   Dev Biol 495, 54-62 (2023)
   PUBMED   36610533
  REMARK    GeneRIF: Progressive degeneration of the retina in Loxl3 mutant
            mouse model of Stickler syndrome.
REFERENCE   4  (bases 1 to 4070)
  AUTHORS   Santamaria,P.G., Dubus,P., Bustos-Tauler,J., Floristan,A.,
            Vazquez-Naharro,A., Morales,S., Cano,A. and Portillo,F.
  TITLE     Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse
            Development
  JOURNAL   Int J Mol Sci 23 (10), 5730 (2022)
   PUBMED   35628534
  REMARK    GeneRIF: Loxl2 and Loxl3 Paralogues Play Redundant Roles during
            Mouse Development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4070)
  AUTHORS   Vazquez-Naharro,A., Bustos-Tauler,J., Floristan,A., Yuste,L.,
            Oltra,S.S., Vinyals,A., Moreno-Bueno,G., Fabra,A., Portillo,F.,
            Cano,A. and Santamaria,P.G.
  TITLE     Loxl3 Promotes Melanoma Progression and Dissemination Influencing
            Cell Plasticity and Survival
  JOURNAL   Cancers (Basel) 14 (5), 1200 (2022)
   PUBMED   35267510
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4070)
  AUTHORS   Zhang,J., Liu,Z., Zhang,T., Lin,Z., Li,Z., Zhang,A., Sun,X. and
            Gao,J.
  TITLE     Loss of Lysyl Oxidase-like 3 Attenuates Embryonic Lung Development
            in Mice
  JOURNAL   Sci Rep 6, 33856 (2016)
   PUBMED   27645581
  REMARK    GeneRIF: loss of LOXL3 attenuates mouse embryonic lung development.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4070)
  AUTHORS   Kraft-Sheleg,O., Zaffryar-Eilot,S., Genin,O., Yaseen,W.,
            Soueid-Baumgarten,S., Kessler,O., Smolkin,T., Akiri,G., Neufeld,G.,
            Cinnamon,Y. and Hasson,P.
  TITLE     Localized LoxL3-Dependent Fibronectin Oxidation Regulates Myofiber
            Stretch and Integrin-Mediated Adhesion
  JOURNAL   Dev Cell 36 (5), 550-561 (2016)
   PUBMED   26954549
  REMARK    GeneRIF: that lysyl oxidase-like 3 is a key regulator of integrin
            signaling that ensures localized control of the cascade
REFERENCE   8  (bases 1 to 4070)
  AUTHORS   Zhang,J., Yang,R., Liu,Z., Hou,C., Zong,W., Zhang,A., Sun,X. and
            Gao,J.
  TITLE     Loss of lysyl oxidase-like 3 causes cleft palate and spinal
            deformity in mice
  JOURNAL   Hum Mol Genet 24 (21), 6174-6185 (2015)
   PUBMED   26307084
  REMARK    GeneRIF: evidence that LOXL3 is indispensable for mouse
            palatogenesis and vertebral column development
REFERENCE   9  (bases 1 to 4070)
  AUTHORS   Pischon,N., Maki,J.M., Weisshaupt,P., Heng,N., Palamakumbura,A.H.,
            N'Guessan,P., Ding,A., Radlanski,R., Renz,H., Bronckers,T.A.,
            Myllyharju,J., Kielbassa,A.M., Kleber,B.M., Bernimoulin,J.P. and
            Trackman,P.C.
  TITLE     Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype
  JOURNAL   Calcif Tissue Int 85 (2), 119-126 (2009)
   PUBMED   19458888
REFERENCE   10 (bases 1 to 4070)
  AUTHORS   Jang,W., Hua,A., Spilson,S.V., Miller,W., Roe,B.A. and Meisler,M.H.
  TITLE     Comparative sequence of human and mouse BAC clones from the mnd2
            region of chromosome 2p13
  JOURNAL   Genome Res 9 (1), 53-61 (1999)
   PUBMED   9927484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104324.21.
            
            On May 29, 2018 this sequence version replaced NM_013586.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF053368.1, AK030548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC104324.21        70746-70830
            86-428              AC104324.21        71996-72338
            429-592             AC104324.21        73970-74133
            593-807             AC104324.21        74936-75150
            808-1027            AC104324.21        84529-84748
            1028-1208           AC104324.21        85119-85299
            1209-1363           AC104324.21        85410-85564
            1364-1531           AC104324.21        85725-85892
            1532-1694           AC104324.21        86025-86187
            1695-1938           AC104324.21        86315-86558
            1939-2054           AC104324.21        86657-86772
            2055-2191           AC104324.21        86849-86985
            2192-2303           AC104324.21        87099-87210
            2304-4070           AC104324.21        87341-89107
FEATURES             Location/Qualifiers
     source          1..4070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..4070
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /note="lysyl oxidase-like 3"
                     /db_xref="GeneID:16950"
                     /db_xref="MGI:MGI:1337004"
     exon            1..85
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            86..428
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2377
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /EC_number="1.4.3.13"
                     /note="lysyl oxidase-like 2; lysyl oxidase homolog 3;
                     lysyl oxidase-like protein 3; lysyl oxidase-related
                     protein 2"
                     /codon_start=1
                     /product="lysyl oxidase homolog 3 precursor"
                     /protein_id="NP_038614.2"
                     /db_xref="CCDS:CCDS20266.1"
                     /db_xref="GeneID:16950"
                     /db_xref="MGI:MGI:1337004"
                     /translation="MRAVSVWYCCPWGLLLLHCLCSFSVGSPSPSISPEKKVGSQGLR
                     FRLAGFPRKPYEGRVEIQRAGEWGTICDDDFTLQAAHVLCRELGFTEATGWTHSAKYG
                     PGTGRIWLDNLSCRGTEGSVTECASRGWGNSDCTHDEDAGVICKDQRLPGFSDSNVIE
                     VEHQLQVEEVRLRPAVEWGRRPLPVTEGLVEVRLPEGWSQVCDKGWSAHNSHVVCGML
                     GFPGEKRVNMAFYRMLAQKKQHSFGLHSVACVGTEAHLSLCSLEFYRANDTTRCSGGN
                     PAVVSCVLGPLYATFTGQKKQQHSKPQGEARVRLKGGAHQGEGRVEVLKAGTWGTVCD
                     RKWDLQAASVVCRELGFGTAREALSGARMGQGMGAIHLSEVRCSGQEPSLWRCPSKNI
                     TAEDCSHSQDAGVRCNLPYTGVETKIRLSGGRSRYEGRVEVQIGIPGHLRWGLICGDD
                     WGTLEAMVACRQLGLGYANHGLQETWYWDSGNVTEVVMSGVRCTGSELSLNQCAHHSS
                     HITCKKTGTRFTAGVICSETASDLLLHSALVQETAYIEDRPLHMLYCAAEENCLASSA
                     RSANWPYGHRRLLRFSSQIHNLGRADFRPKAGRHSWVWHECHGHYHSMDIFTHYDILT
                     PNGTKVAEGHKASFCLEDTECQEDVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDI
                     TDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKYDGHRIWVHNCHIGDAFSEEANR
                     RFERYPGQTSNQIV"
     exon            429..592
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            593..807
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1027
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1208
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1363
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1531
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1694
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1938
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2054
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2191
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2303
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..4070
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2809..2814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /note="hexamer: TATAAA"
     polyA_site      2828
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /note="major polyA site"
     regulatory      3065..3070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /note="hexamer: CATAAA"
     polyA_site      3092
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
     regulatory      3437..3442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
                     /note="hexamer: CATAAA"
     polyA_site      3464
                     /gene="Loxl3"
                     /gene_synonym="Lor2; Loxl2"
ORIGIN      
        1 gaacactttt tttctgagaa gtcctgaaag taatctccag gaccaggact ctgcttccag
       61 cctctggagt tgtgcctagt cgaagtgccc ccctccttgg gccccacccg ccatgagagc
      121 tgtcagtgtg tggtattgct gcccatgggg actactgctg ctacactgtc tgtgcagctt
      181 cagtgtgggg tctccgtctc cttctatcag cccagagaag aaggtaggaa gccaggggct
      241 gaggttccgg ctggctggct ttcctagaaa gccctatgaa ggtcgagtgg agatacagcg
      301 agctggtgaa tggggcacca tctgtgatga tgacttcacg ctgcaggctg cccatgtcct
      361 ctgccgggag ctgggcttca cagaagccac agggtggacc catagtgcca aatatggccc
      421 tggaacaggc cgaatctggt tggacaatct gagctgcagg gggactgaag gaagtgtgac
      481 agaatgcgcc tctcggggct ggggaaacag tgactgtacc catgatgagg atgccggggt
      541 catctgcaag gaccagcgcc ttcccggttt ctcagactcc aacgtcattg aggtggagca
      601 tcagttgcaa gtggaggagg tgcgactccg acctgcggtg gagtggggaa ggagacccct
      661 gcctgtgact gagggcctgg ttgaagtcag gcttcctgaa ggctggtcgc aagtgtgtga
      721 caaaggctgg agtgcccaca acagccacgt agtctgcggt atgctgggct tccccggaga
      781 aaagagagtc aacatggcct tctacaggat gctggcccag aagaagcaac actcctttgg
      841 tctgcacagt gtggcatgtg tgggcacaga agcccacctc tccctttgct ctctagagtt
      901 ctatcgtgcc aatgacacca ccaggtgctc tgggggaaac cctgcagtgg tgagctgtgt
      961 gctgggccct ctttatgcca cctttactgg tcagaagaag cagcaacact ctaagcctca
     1021 aggggaggct cgtgtgcgtc taaagggtgg tgcccaccag ggagaaggca gagtggaagt
     1081 cctgaaggct ggcacatggg gaacagtctg tgaccgaaag tgggacctgc aggcagccag
     1141 tgtggtgtgt cgagaactgg gctttggcac tgcccgagag gccctgagtg gtgcccgcat
     1201 ggggcagggc atgggtgcca tccacttgag tgaagttcgg tgctctggcc aggagccctc
     1261 cctttggaga tgcccgtcca agaacatcac agctgaggac tgttcccaca gccaggatgc
     1321 gggtgtccgg tgcaacctcc cctacactgg ggtggagacc aagatccgac tcagtggggg
     1381 ccgcagccgg tatgaagggc gagtcgaggt gcaaataggg atacctgggc atctacgctg
     1441 gggcctcatc tgtggggatg actggggaac cctggaggcc atggtggcct gtaggcaact
     1501 tggtcttggc tacgccaacc acggcctgca ggagacctgg tactgggact cagggaatgt
     1561 aactgaggtg gtgatgagcg gagtgcgttg cacggggtct gagctgtccc tgaaccagtg
     1621 tgcccatcac agcagccaca tcacctgcaa gaagacggga acccgcttca ctgcgggggt
     1681 catctgttct gaaactgctt cagatctgct gctgcactcg gcactggtac aggaaactgc
     1741 ttatattgaa gaccggccct tgcacatgtt gtactgtgct gctgaagaga actgcctggc
     1801 tagctctgcc cgctcggcca actggcctta tggccaccgg cgtctgctcc gattctcttc
     1861 ccagatccac aacctaggaa gagctgactt taggcccaag gctgggcgcc attcctgggt
     1921 gtggcatgag tgtcatgggc attaccacag tatggacatc ttcactcatt atgatatcct
     1981 gacccccaat ggcaccaagg tggctgaggg ccacaaagct agtttctgtc tagaagacac
     2041 tgagtgtcaa gaggatgtct ccaagaggta tgagtgcgcc aactttggag agcagggcat
     2101 caccgtggga tgttgggatc tctacaggca tgacattgac tgtcagtgga tcgacatcac
     2161 agatgtgaag ccaggaaact acattcttca ggtcgttatc aacccaaatt ttgaggtagc
     2221 agaaagtgac ttcaccaaca atgcaatgaa gtgtaactgc aaatacgacg ggcatcgcat
     2281 ctgggtgcac aactgccaca tcggtgatgc cttcagcgaa gaagccaaca ggaggtttga
     2341 gcgctaccct ggccagacta gtaaccagat cgtctaaaat gctaccaccc tctctgtaaa
     2401 ccaccactgg cccccaatgg caggggtctg aggctgccat tacctcagga gcttaccaca
     2461 agaacccctg atgtcagcag gcgccctaca ctcaaccacc tgtgcactac aggcaacaaa
     2521 ctgtcaaaca gaagttggtg cctcctttac ggggtcagct gtcattacct ttggccaaca
     2581 agcatggaga atcagccaac agccccagca acagacagaa cacaccacaa agaactgccc
     2641 cacacaggat ggcagcagct cattctcttg aataggggag gtcaagaggg tcagctccca
     2701 tcgctctccg ttctcctaag gaccgcgtta cctctagcca tttggtgggg gagaagatcc
     2761 aacccccact tttgactgta acatgttgct aggtataatt ttattttata taaaatgtgt
     2821 tcttcggagc ccaggactga tgcagcggtt agagggactt gccctccgca ggttcactga
     2881 ctcctcctct acccacatgc actcagaacc taggctagga aagcaaggag gagatcaggg
     2941 caagagcttc acactcttgc cggtccagtc attcattctg tgacctcggg ggtcacatat
     3001 aaggtcagtg tctctgatcc gcgccggatc cgcactgcca gctgtgattg ggttcgaaca
     3061 gcttcataaa catcttcagc attttgtgcc aatttctccc caatggccaa gatcacatca
     3121 ccaggccgca gaccagccct gtggaggatg gacggggcaa ggagagaata gacagagaag
     3181 ttcaaggata catccaccca tcccatccca cccaaccccc ccccccagag cacgctcccc
     3241 atcacctgtg tgcgggggag cccaggataa ctttatgaat gaggacacca tgctgaacat
     3301 cagggaagct tggctcacgg agctgtagtt caataaggat gctgaaaggg cacagacact
     3361 attagctcca cacaggccct ctcccatctt aatagttcac cttctgcctt ctagagctta
     3421 ggaagtggga tatacacata aaagatagct aatttcgaaa gatacatggt gttgatcaac
     3481 ttcacttctg tcatcctgaa gggttagaac ttaagctgag cctagaaggg tgggtcctac
     3541 caccttacga aataaggtat tgagacatag aagtggaaaa tgaaagtagt tccgaagaaa
     3601 cggcaagctg tctggaagga taacgagatg ggtgggaatg ggcgggaatg ggcctccagt
     3661 gctaggtcaa tgttggcttt acatcacagc aatagcagga tgtactcaat ctactgaaag
     3721 atccagatgc agtgggatga gaaagttatg agagggaaca gtgcttgtga cagaagacaa
     3781 cagcttatct taggaaaaaa cagacatgag agaaaaccca agaaaaggat agggtgtgtg
     3841 tatggtgtgt gtgtaggggt gtgtgtgtgt atgtatgtat aggtgtatat atatatacat
     3901 atatatagat atatgtatat atcaccacac taacatacat atatatgtat atgtatatat
     3961 caccacacta acatacctgg gagtcagggt cagcatcatc actccaatgt agcggcgctg
     4021 ggacccactg gttccaaacc aggaatctgt aataaaagag gacaaatgaa
//
