LOCUS       NM_033325               5186 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus lysyl oxidase-like 2 (Loxl2), mRNA.
ACCESSION   NM_033325 XM_913969
VERSION     NM_033325.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5186)
  AUTHORS   Wang,H., Martinez Yus,M., Brady,T., Choi,R., Nandakumar,K.,
            Smith,L., Jang,R., Wodu,B.P., Almodiel,J.D., Stoddart,L., Kim,D.H.,
            Steppan,J. and Santhanam,L.
  TITLE     Sex differences and role of lysyl oxidase-like 2 in angiotensin
            II-induced hypertension in mice
  JOURNAL   Am J Physiol Heart Circ Physiol 327 (3), H642-H659 (2024)
   PUBMED   39028284
REFERENCE   2  (bases 1 to 5186)
  AUTHORS   Zeng,R., Zhang,D., Zhang,J., Pan,Y., Liu,X., Qi,Q., Xu,J., Xu,C.,
            Shi,S., Wang,J., Liu,T. and Dong,L.
  TITLE     Targeting lysyl oxidase like 2 attenuates OVA-induced airway
            remodeling partly via the AKT signaling pathway
  JOURNAL   Respir Res 25 (1), 230 (2024)
   PUBMED   38824593
  REMARK    GeneRIF: Targeting lysyl oxidase like 2 attenuates OVA-induced
            airway remodeling partly via the AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5186)
  AUTHORS   Wang,Y., Chen,Y., Yang,F., Yu,X., Chu,Y., Zhou,J., Yan,Y. and Xi,J.
  TITLE     MiR-4465-modified mesenchymal stem cell-derived small extracellular
            vesicles inhibit liver fibrosis development via targeting LOXL2
            expression
  JOURNAL   J Zhejiang Univ Sci B 25 (7), 594-604 (2024)
   PUBMED   39011679
  REMARK    GeneRIF: MiR-4465-modified mesenchymal stem cell-derived small
            extracellular vesicles inhibit liver fibrosis development via
            targeting LOXL2 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5186)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 5186)
  AUTHORS   Lee,Y.S., Kim,H.S., Kim,H.J., Kang,H.W., Lee,D.E., Kim,M.J.,
            Hong,W.C., Kim,J.H., Kim,M., Cheong,J.H. and Park,J.S.
  TITLE     The role of LOXL2 induced by glucose metabolism-activated NF-kappaB
            in maintaining drug resistance through EMT and cancer stemness in
            gemcitabine-resistant PDAC
  JOURNAL   J Mol Med (Berl) 101 (11), 1449-1464 (2023)
   PUBMED   37737908
  REMARK    GeneRIF: The role of LOXL2 induced by glucose metabolism-activated
            NF-kappaB in maintaining drug resistance through EMT and cancer
            stemness in gemcitabine-resistant PDAC.
REFERENCE   6  (bases 1 to 5186)
  AUTHORS   Pischon,N., Maki,J.M., Weisshaupt,P., Heng,N., Palamakumbura,A.H.,
            N'Guessan,P., Ding,A., Radlanski,R., Renz,H., Bronckers,T.A.,
            Myllyharju,J., Kielbassa,A.M., Kleber,B.M., Bernimoulin,J.P. and
            Trackman,P.C.
  TITLE     Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype
  JOURNAL   Calcif Tissue Int 85 (2), 119-126 (2009)
   PUBMED   19458888
REFERENCE   7  (bases 1 to 5186)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   8  (bases 1 to 5186)
  AUTHORS   Atsawasuwan,P., Mochida,Y., Parisuthiman,D. and Yamauchi,M.
  TITLE     Expression of lysyl oxidase isoforms in MC3T3-E1 osteoblastic cells
  JOURNAL   Biochem Biophys Res Commun 327 (4), 1042-1046 (2005)
   PUBMED   15652501
  REMARK    GeneRIF: LoxL2 is not expressed in MC3T3-E1 cells.
REFERENCE   9  (bases 1 to 5186)
  AUTHORS   Jourdan-Le Saux,C., Le Saux,O., Gleyzal,C., Sommer,P. and
            Csiszar,K.
  TITLE     The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14
            and is highly expressed in skin, lung and thymus
  JOURNAL   Matrix Biol 19 (2), 179-183 (2000)
   PUBMED   10842102
REFERENCE   10 (bases 1 to 5186)
  AUTHORS   Jang,W., Hua,A., Spilson,S.V., Miller,W., Roe,B.A. and Meisler,M.H.
  TITLE     Comparative sequence of human and mouse BAC clones from the mnd2
            region of chromosome 2p13
  JOURNAL   Genome Res 9 (1), 53-61 (1999)
   PUBMED   9927484
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160639.2, AK045019.1, AK159386.1 and AA437829.1.
            
            On Mar 24, 2009 this sequence version replaced NM_033325.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045019.1, SRR17253012.797844.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC160639.2         107047-107137       c
            92-1091             AK045019.1         92-1091
            1092-2592           AK159386.1         1126-2626
            2593-5138           AC160639.2         20821-23366         c
            5139-5186           AA437829.1         327-374
FEATURES             Location/Qualifiers
     source          1..5186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.06 cM"
     gene            1..5186
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /note="lysyl oxidase-like 2"
                     /db_xref="GeneID:94352"
                     /db_xref="MGI:MGI:2137913"
     exon            1..91
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            92..498
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2465
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /EC_number="1.4.3.13"
                     /note="lysyl oxidase homolog 2; lysyl oxidase-like protein
                     2"
                     /codon_start=1
                     /product="lysyl oxidase homolog 2 precursor"
                     /protein_id="NP_201582.2"
                     /db_xref="CCDS:CCDS27241.1"
                     /db_xref="GeneID:94352"
                     /db_xref="MGI:MGI:2137913"
                     /translation="MELHFGSCLSGCLALLVLLPSLSLAQYEGWPYQLQYPEYFQQPA
                     PEHHQRQVPSDVVKIQVRLAGQKRKHNEGRVEVYYEGQWGTVCDDDFSIHAAHVVCRQ
                     VGYVEAKSWAASSSYGPGEGPIWLDNIYCTGKESTLASCSSNGWGVTDCKHTEDVGVV
                     CSEKRIPGFKFDNSLINQIESLNIQVEDIRIRPILSAFRHRKPVTEGYVEVKEGKAWK
                     QICNKHWTAKNSHVVCGMFGFPAEKTYNPKAYKTFASRRKLRYWKFSMNCTGTEAHIS
                     SCKLGPSVTRDPVKNATCENGQPAVVSCVPSQIFSPDGPSRFRKAYKPEQPLVRLRGG
                     AQVGEGRVEVLKNGEWGTICDDKWDLVSASVVCRELGFGTAKEAITGSRLGQGIGPIH
                     LNEVQCTGTEKSIIDCKFNTESQGCNHEEDAGVRCNIPIMGFQKKVRLNGGRNPYEGR
                     VEVLTERNGSLVWGTVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGNIFANNVV
                     MSGVKCSGTELSLAHCRHDEEVACPEGGVRFGAGVACSETAPDLVLNAEIVQQTAYLE
                     DRPMSLLQCAMEENCLSASAVHTDPTRGHRRLLRFSSQIHNNGQSDFRPKNGRHAWIW
                     HDCHRHYHSMEVFTYYDLLSLNGTKVAEGHKASFCLEDTECEGDIQKSYECANFGEQG
                     ITMGCWDMYRHDIDCQWIDITDVPPGDYLFQVVINPNYEVPESDFSNNIMKCRSRYDG
                     YRIWMYNCHVGGAFSEETEQKFEHFSGLLNNQLSVQ"
     exon            499..674
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            675..886
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1109
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1293
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1445
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1613
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1776
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2020
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2136
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2273
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2385
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..5180
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5156..5161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5180
                     /gene="Loxl2"
                     /gene_synonym="1110004B06Rik; 4930526G11Rik;
                     9430067E15Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtctcacttt gcccgggtcc cgggaggccg tcgacttatc ctaggagctc ggagcttttc
       61 ttctgggcaa ccagggcgct tccagacaga gttcctgctg ccacccacca cccccctctc
      121 agcacaggac aaggatggag ctccattttg gctcctgcct ctccggctgt ttggctctgc
      181 ttgtcttgct gccttccctg agcctagcac agtacgaggg ctggccctac cagctccagt
      241 accctgagta cttccagcag cccgctcctg agcaccatca gcggcaggtg ccctccgatg
      301 tggtcaagat ccaggtccgc ctggcgggcc agaagaggaa gcacaatgag ggccgcgtgg
      361 aggtctacta cgaaggccag tggggcacgg tgtgcgacga tgacttctcg atccatgccg
      421 cccatgtggt ctgccggcaa gtgggctatg tagaggccaa gtcctgggct gccagctcct
      481 cctacggtcc aggcgaaggc cccatctggt tggacaatat ctactgtact ggcaaagagt
      541 cgaccctggc atcttgctcc tccaatggct ggggtgtcac tgactgcaag cacactgaag
      601 acgttggagt ggtgtgtagt gagaaaagaa ttcctggctt caaatttgac aattcgttga
      661 tcaaccaaat agagagccta aatatacagg tggaagacat ccggattcgg cccatccttt
      721 ctgcctttcg ccatcgcaag cctgtgacag agggctacgt ggaggtgaag gagggcaagg
      781 cttggaagca gatctgcaac aaacactgga cagccaagaa ttcccacgtg gtctgtggca
      841 tgttcggctt ccctgcagag aagacctaca accccaaagc ctataaaacc tttgcctcgc
      901 ggaggaagct gcgttactgg aagttttcta tgaactgcac gggcactgaa gcgcatatct
      961 ccagctgcaa gctgggccct tccgtgaccc gggaccctgt gaagaacgcc acctgtgaga
     1021 acgggcagcc agctgtggtc agttgtgtgc ctagccagat cttcagcccc gatggaccct
     1081 caaggttccg gaaagcctac aagccagagc aacccttggt gcgcctgaga ggtggagccc
     1141 aggtcgggga gggccgagtg gaggtgctga agaatggaga atggggaacc atctgcgatg
     1201 acaagtggga cctggtatct gccagtgtgg tctgccgaga gctgggcttt gggaccgcta
     1261 aagaggccat cacaggctcc agactagggc aagggattgg gcccatccat ctcaatgaag
     1321 tccagtgcac agggactgag aagtccatca tagactgcaa attcaacaca gagtctcaag
     1381 gctgcaacca tgaagaagat gccggggtgc gatgcaacat ccccatcatg ggtttccaga
     1441 aaaaggtgcg cctgaatgga ggccgcaatc cttatgaggg ccgagtggag gtgctaacag
     1501 agagaaatgg gtcccttgtt tgggggactg tatgcggcca gaactggggc attgtggaag
     1561 ccatggtggt ctgccggcag ctaggcctgg gctttgccag caatgccttt caggagacct
     1621 ggtactggca tggaaatatc ttcgccaaca acgtggtcat gagtggagtg aagtgctcag
     1681 gaacggagct gtccctagca cactgccgcc atgacgagga ggtggcctgc cccgagggcg
     1741 gggtgcggtt tggtgctgga gtcgcctgct cggaaactgc acctgacctg gtgcttaatg
     1801 ctgagattgt ccagcagact gcctacctgg aggacaggcc catgtccttg ctgcagtgtg
     1861 ccatggagga gaactgcctc tccgcctccg ctgtgcacac cgaccccacc agaggccacc
     1921 ggcgcctttt acgcttctcc tcccagatcc acaacaatgg ccagtctgac ttccgcccca
     1981 agaatggccg ccatgcgtgg atttggcacg actgccacag gcactaccac agcatggaag
     2041 tcttcactta ctatgacctg ctgagcctca acggcaccaa ggtggctgag ggccacaagg
     2101 ccagcttctg cctggaggac actgagtgtg agggagacat tcagaagagt tacgagtgtg
     2161 ccaactttgg agaacaaggc atcaccatgg gctgctggga catgtaccgt catgacattg
     2221 actgccagtg gatagacatc accgatgtgc cccctggaga ctacctgttc caggttgtca
     2281 ttaaccccaa ctatgaagtg ccagaatcag atttctctaa caacatcatg aagtgcagga
     2341 gccgctatga tggctaccgc atctggatgt acaactgtca cgtaggtgga gccttcagtg
     2401 aggagacaga acagaagttc gaacacttca gtggacttct aaataaccag ctctctgtac
     2461 agtaaagaag atcctgggcc aggcatgatg gctcatgcct gtaatccctg cactcatgct
     2521 gaggcaggag gattgccaca agatttccac tctggacatt aaaccaagct tcagtttcaa
     2581 aagaaatgaa tgaaagaaag gaaggaagga aggaaggaag gaaggaagga aggaaggaag
     2641 gaaggaagaa aggggaaagg gaaagggaag aaaaatgact taatggtcac ttactgactc
     2701 ctgggggaat actgattacc acctcttttc tagccagatc cagctgagaa gaaaggtgct
     2761 cattcactcc ccagacactg ccgtgtgtcc ctgtcctgag gccttagggg cagggctcgg
     2821 gcacatggcc atggaaactt gatgacaagc ttagagcagc ttatcccatc cgagctttgg
     2881 catgtcccaa gtgtgacatc atctgtgctc tgcacagagg ggccgttttc ttctgggaac
     2941 acagcaggca tgaactcagc aactgcagag gtgatcgggc tgaactccgt ttttcccctt
     3001 cttaggtcat ttctggaaaa cttgaatatc aagacctctg tattaagttt gtttggtttt
     3061 ttgttttgtt ttgttttgtt ttttcttctc attgtacaaa ctgcttggca aaatcaactt
     3121 gaagaaggaa ggctttatgt gagctcgtgg tttgaggaac caatctgtag tggcaaagaa
     3181 agtatgacag caggagcgtg aggtgtctgg ttccaaaact cagttatgga gctgaggatg
     3241 accttggacc tctgagcctc cctcccgctt tcaactccag agtgctggga tcaaacccag
     3301 gactgcacac ttgtaaggca acatgctctc tatcggttgt agctgctttc tgagcactta
     3361 cccttctctg ctgctctaaa cctgtacgtg atctttgcct taccgatccg cacatttttc
     3421 tgtctctgtg ctccacttgc tcattgtcac tgtgggtctg agtaagagca gtgaccagaa
     3481 atgcatagca cagcctgaat gctaccctgt cttaaaatgt tctctgccaa gcaaatgtgt
     3541 ccattactct tgagttaaga ctcactcgag tgctcagaac acaggcagga tgcagctgga
     3601 ttcttgccag ggtgtaacct gattggcttc tagctcagtt tcagatagat agtccttggt
     3661 taccactaaa acctcaggta ccaggcctcc actctccacg ttccacttgg cgctctggtc
     3721 ttccaaactc ccaccacaat aacccattca gttctgttct ctaaaagcgc tctagggctt
     3781 ctggacccaa agttctaagt tcttccagat tctcccccca agccaacccc caaagctcaa
     3841 gaactccacg accatgcttc tgacctcagt gatcagtgac agctctagtc ttctgtatta
     3901 tacttgacaa aaacaactta agggaaggct acttttggct tacagttcga gagttcagtc
     3961 cctcacagcg ggtaaagcat ggcggcagga gcagctggtc atgtggcatc cacagtcagg
     4021 aagcagaatg acgaatgcag gtgctcaact tgctctcacc tttatattca gcctacaacc
     4081 ccagctcatg gaatggtgct actggtgtct agggtgggcc ttccctcttg tgttaaacct
     4141 cttctggaga cacccctata gacccaccca ggggtgtttc catagtggtt ctaaatccca
     4201 gctagctgat aatcaaggtt atctataaca acctcttgca gttaaaccca cgtctgtatt
     4261 ccatgcaatt atagccacga cttaaagtac aatagcaagg catacatccc aaggctccaa
     4321 gggatggctg aagacttgga tggttctggg acaggatagg aagagaaagt catgggggaa
     4381 caacatgcaa ggggctcttc acctcagagc ctggcttatg ccagctgaga ctcccaacac
     4441 agatagcatt gtgaatggtg ctaatatagg gtcagtattc attttgcata tttatataca
     4501 attatagata tacaagtata gatatttcaa gtaagaatat taaaatagca aggaatgatg
     4561 attaaggctg aagtgtaaat ggcctttttc ctttcctggc tgtagacata caattcccta
     4621 caactttgcc agaaacccca cttactaaaa ggcatatctc aagaccccta tgctggccca
     4681 atgttttcat cttatcaggg cgcagtccta tccaaggtac ctctggagcc accttataat
     4741 cttactatca aaagggggaa gggggggtgg gacttagaaa ccaatcgagc aacaccaaag
     4801 gcttcgggac tcctgtgtgt agctagttat taagacactt aagaactctc gtcctggggc
     4861 tggtgagatg gctcagtggg taagagcacc cgactgctct tccgaaggtc tagagttcaa
     4921 atcccagcaa ccacatggtg gctcacaacc atctgtaatg agatctgact ccctcttctg
     4981 gtgtgtctga agacagctac agtgtactta catataataa ataaataaat ctttaaaaaa
     5041 aaaaaaagaa ctctcgtcct tggagaagcc cacagcccag ctctctggtg tgtcttactc
     5101 tttccctgag cacctcttaa cccctgtaac ttaaatttat atttaaaata ttttaaataa
     5161 acgtttaact ctctgcttta aaaaaa
//
