LOCUS       NM_010729               3338 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus lysyl oxidase-like 1 (Loxl1), mRNA.
ACCESSION   NM_010729 XM_134932
VERSION     NM_010729.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3338)
  AUTHORS   Zhang,N., Yang,A., Zhang,W., Li,H., Xu,A., Yan,X., Han,Q., Wang,B.,
            You,H. and Chen,W.
  TITLE     Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their
            half-lives and regulates liver fibrosis through Notch signal
  JOURNAL   Hepatol Commun 8 (4), e0391 (2024)
   PUBMED   38466882
  REMARK    GeneRIF: Crosstalk of lysyl oxidase-like 1 and lysyl oxidase
            prolongs their half-lives and regulates liver fibrosis through
            Notch signal.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3338)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3338)
  AUTHORS   Suarez,M.F., Schmitt,H.M., Kuhn,M.S., Watkins,T., Hake,K.M.,
            Weisz,T., Flynn,E.J. 3rd, Elliott,M.H., Hauser,M.A. and Stamer,W.D.
  TITLE     Genetic background determines severity of Loxl1-mediated systemic
            and ocular elastosis in mice
  JOURNAL   Dis Model Mech 16 (11) (2023)
   PUBMED   37905384
  REMARK    GeneRIF: Genetic background determines severity of Loxl1-mediated
            systemic and ocular elastosis in mice.
REFERENCE   4  (bases 1 to 3338)
  AUTHORS   Yang,A., Yan,X., Xu,H., Fan,X., Zhang,M., Huang,T., Li,W., Chen,W.,
            Jia,J. and You,H.
  TITLE     Selective depletion of hepatic stellate cells-specific LOXL1
            alleviates liver fibrosis
  JOURNAL   FASEB J 35 (10), e21918 (2021)
   PUBMED   34569648
  REMARK    GeneRIF: Selective depletion of hepatic stellate cells-specific
            LOXL1 alleviates liver fibrosis.
REFERENCE   5  (bases 1 to 3338)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3338)
  AUTHORS   Kim,Y., Peyrol,S., So,C.K., Boyd,C.D. and Csiszar,K.
  TITLE     Coexpression of the lysyl oxidase-like gene (LOXL) and the gene
            encoding type III procollagen in induced liver fibrosis
  JOURNAL   J Cell Biochem 72 (2), 181-188 (1999)
   PUBMED   10022501
REFERENCE   7  (bases 1 to 3338)
  AUTHORS   Guttinger,M., Sutti,F., Panigada,M., Porcellini,S., Merati,B.,
            Mariani,M., Teesalu,T., Consalez,G.G. and Grassi,F.
  TITLE     Epithelial V-like antigen (EVA), a novel member of the
            immunoglobulin superfamily, expressed in embryonic epithelia with a
            potential role as homotypic adhesion molecule in thymus
            histogenesis
  JOURNAL   J Cell Biol 141 (4), 1061-1071 (1998)
   PUBMED   9585423
REFERENCE   8  (bases 1 to 3338)
  AUTHORS   Tchernev,V.T., Yang,T.P. and Kingsmore,S.F.
  TITLE     Genetic mapping of lysyl oxidase-2 (Loxl) on mouse chromosome 9
  JOURNAL   Mamm Genome 8 (8), 621-622 (1997)
   PUBMED   9250877
REFERENCE   9  (bases 1 to 3338)
  AUTHORS   Wydner,K.S., Kim,Y., Csiszar,K., Boyd,C.D. and Passmore,H.C.
  TITLE     An intron capture strategy used to identify and map a lysyl
            oxidase-like gene on chromosome 9 in the mouse
  JOURNAL   Genomics 40 (2), 342-345 (1997)
   PUBMED   9119402
REFERENCE   10 (bases 1 to 3338)
  AUTHORS   Zuberi,A.R., Nguyen,H.Q., Auman,H.J., Taylor,B.A. and
            Roopenian,D.C.
  TITLE     A genetic linkage map of mouse chromosome 2 extending from
            thrombospondin to paired box gene 1, including the H3 minor
            histocompatibility complex
  JOURNAL   Genomics 33 (1), 75-84 (1996)
   PUBMED   8617512
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC160976.2.
            
            On Aug 12, 2009 this sequence version replaced NM_010729.2.
            
            Summary: This gene encodes a member of the lysyl oxidase family of
            copper-dependent enzymes that catalyze the formation of
            lysine-derived crosslinks in proteins such as collagen and elastin.
            The encoded preproprotein undergoes proteolytic processing to
            generate the mature, functional enzyme. Mice lacking the encoded
            protein fail to deposit normal elastic fibers in the uterine tract
            post partum and develop pelvic organ prolapse, enlarged airspaces
            of the lung, loose skin and vascular abnormalities with concomitant
            tropoelastin accumulation. [provided by RefSeq, Sep 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037999.1, AF357006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1527              AC160976.2         20308-21834
            1528-1636           AC160976.2         35791-35899
            1637-1774           AC160976.2         39024-39161
            1775-1931           AC160976.2         39791-39947
            1932-2027           AC160976.2         40856-40951
            2028-2143           AC160976.2         42650-42765
            2144-3338           AC160976.2         44603-45797
FEATURES             Location/Qualifiers
     source          1..3338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.65 cM"
     gene            1..3338
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /note="lysyl oxidase-like 1"
                     /db_xref="GeneID:16949"
                     /db_xref="MGI:MGI:106096"
     exon            1..1527
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..2150
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /EC_number="1.4.3.13"
                     /note="lysyl oxidase homolog 1; lysyl oxidase 2; lysyl
                     oxidase-like protein 1"
                     /codon_start=1
                     /product="lysyl oxidase homolog 1 preproprotein"
                     /protein_id="NP_034859.2"
                     /db_xref="CCDS:CCDS52813.1"
                     /db_xref="GeneID:16949"
                     /db_xref="MGI:MGI:106096"
                     /translation="MALAGAGSQLRTLVWSACLCVLVHGQQAQPGQGSDPGRWRQLIQ
                     WENNGQVYSLLNSGSEYVPAGPQRGETSSRVLLAGAPQTSQRRSQGGPRRRQAPSLPL
                     PGRVGSDTVRGQTRHPFGFGQVPDNWREVAVGDSTGMARARTSVSQQRHGGSASSSVS
                     ASAFATTYRQPSSYPQQFPYPQAPFVNQYENYDPASRTYEQGYVYYRGAGGGMGAGAA
                     AVASAGVIYPFQPRARYEDYGGGGGEEQPEYPAQGFYPAPERPYVPQPQPQPQPQPQP
                     QPQPSDGLDRRYSHSLYNEGTPGFEQAYPDPSTDVSQAPAGAGGTYGGAGDPRLGWYP
                     PYAANVPPEAYVPPRAVEPQPPFRVLEPPYLPVRSSDAPSQGGERNGAQQGRLSVGSV
                     YRPNQNGRGLPDLVPDPNYVQASTYVQRAHLYSLRCAAEEKCLASTAYAPEATDYDLR
                     VLLRFPQRVKNQGTADFLPNRPRHTWEWHSCHQHYHSMDEFSHYDLLDASTGKKVAEG
                     HKASFCLEDSTCDFGNLKRYACTSHTQGLSPGCYDTYNADIDCQWIDITDVQPGNYIL
                     KVHVNPKYIVLESDFTNNVVRCNIHYTGRYVSTTNCKIVQS"
     exon            1528..1636
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1774
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1931
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2027
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2143
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..3338
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2434..2439
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /note="hexamer: AATAAA"
     polyA_site      2460
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /note="major polyA site"
     regulatory      3302..3307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
                     /note="hexamer: AATAAA"
     polyA_site      3333
                     /gene="Loxl1"
                     /gene_synonym="Loxl"
ORIGIN      
        1 gttgcttatt cattcagagt gggaaagcgc cagcctagcg agcagccagc cagtgtgggg
       61 ctggccatgt aagggcccca ggaggtcctg cccgtcccgt gccctacgga aagcctcgtg
      121 cagccctggg caccgcccct gccctgccct gaccccttgg cctcgaaatg ctgtcatcgg
      181 aggagccgtc ccgctcggga caaggccagg atggacaaag ctagagcttg ggcaggcgaa
      241 gagccatcct gtcctcgagg ccgtgggaag agaagcacgc accgaggccc actctctgcc
      301 cacccggcct ctgcagaagg gccactatgg ctctggccgg agccggcagc cagctgagga
      361 ccctggtgtg gagtgcctgc ctgtgcgtcc tggtgcacgg gcagcaagcg cagccaggac
      421 agggctcgga cccaggacgc tggcggcagc tgatccagtg ggagaacaac gggcaggtgt
      481 acagcttgct caactcgggc tctgagtacg tgcccgcggg gccccaacga ggggagacta
      541 gctccagggt tctactggca ggcgcgcccc aaacgtcgca gcggcgcagt caggggggac
      601 cccggcgtcg gcaggcgccg tccctgcccc tgcccggacg cgtgggttcg gacactgtgc
      661 gcggccaaac gcggcacccg ttcggcttcg gccaggtgcc cgacaactgg agagaggtgg
      721 ccgtcgggga cagtaccggc atggctcggg cccgcacctc cgtctcccag caacggcacg
      781 ggggctccgc ctcctcctcg gtttcggcct cggccttcgc caccacctat cgccagccat
      841 cctcctaccc gcagcagttc ccctatccgc aggcgccctt cgtaaaccag tatgagaact
      901 acgatcccgc gtcacggacc tacgaacagg gctacgtgta ctaccgtggt gcgggcggcg
      961 gcatgggcgc gggggcagcg gctgtagcct cggctggggt catctatccc ttccagcccc
     1021 gggcgcgtta cgaggactac ggaggtggag gaggcgagga gcagcccgag tacccggccc
     1081 agggctttta cccagcccca gagaggccct atgtgcccca gccccaaccc cagccccagc
     1141 cccagccgca gcctcagccc caaccttccg acggccttga ccgtcgttac tcgcacagcc
     1201 tgtacaatga aggcaccccg ggattcgagc aggcctaccc tgatcccagc accgacgtgt
     1261 cgcaggcccc cgcgggggcc ggtggcacct acggtggcgc tggcgatcct cgcctcggct
     1321 ggtacccgcc ctatgcagcc aatgtgccac cggaggccta cgtccctccg cgtgcggtgg
     1381 agccacagcc cccattccgc gtgctggagc caccttactt gcccgtgcga agctctgatg
     1441 cgccctccca gggtggggag cggaacggcg cccagcaggg ccgtctcagc gtgggtagtg
     1501 tgtaccgacc caaccagaat ggtcgcggcc tccctgactt agtcccggac cctaactacg
     1561 tgcaggcatc cacatacgtg cagagagccc atctgtactc cttgcgatgc gcagcagagg
     1621 agaagtgcct ggccagcaca gcctatgccc ctgaggctac cgactatgac ctccgagtgc
     1681 tattgcgctt cccccagcga gtgaaaaacc aaggcacagc ggactttctc cccaaccggc
     1741 cacgccacac ctgggagtgg catagctgtc accaacatta ccacagcatg gacgagttca
     1801 gccactacga cctgcttgat gcatccacgg gcaagaaggt agccgaggga cacaaggcca
     1861 gcttctgcct ggaggacagc acctgtgact tcggcaacct caagcgctat gcctgcacct
     1921 ctcacacgca gggcctgagt ccaggctgct atgacacata caatgcggac attgactgcc
     1981 agtggatcga cataactgat gtgcagcctg ggaactacat cctcaaggtg cacgtgaacc
     2041 ccaagtacat tgttctggag tctgacttca ccaacaacgt ggtgagatgc aacatccact
     2101 acacaggtcg ctacgtttct acaacaaact gcaaaatcgt ccagtcctga tctgagtgga
     2161 cagagccccc cttgtctctc cttgaaaagc aggacctgct tccaggcagc ctcccccatg
     2221 aggctcagcc gcctagccca aggcaaaggc agctggccgc tggggcatcc ctccctgccg
     2281 gcctcaggga gtgaacatgg acccaaacca cagggattct ggatgccaga ccctgtcttg
     2341 tacctacttc tcctctacaa caccatggtg tctgttgttg gttctaattt ttatattttg
     2401 gccatcccac acagcaagat tgcccgggtg ctgaataaaa caagggtttt ctagtctgga
     2461 gctctgctgt gccctgtggt ttggcggacc acagctgggt caagcccaag agatattctg
     2521 gggtttcagc ctttgtgtag gaaaatgttg aagggtagct gctggacggc caggactcca
     2581 gcaacttcca ggccaccagc cttagccatc atggaaatgc tagagagttt agtccaaagc
     2641 catgtcgtct tcctggacag aggaccccat ctcatagaat gaggacagag gtggtaggtg
     2701 gcttcatctc ctagcctctt ccccctaccc tcagtcttcc accttttatt gttcctttcc
     2761 ttctcagact gtagctcacc accagcacct ccccgcacca tcatcatcat cactgtcatc
     2821 accaccatca tcaccaccac caatggcagc agccctgggc ccttaccaca gctttcacag
     2881 tgctgggcat ccttgggaca actggacaga ggcagaggac ccttagagtg ggaaaggtct
     2941 accttcccaa agagagaaga cacatgaatt cttggcagag gggatagcat gggttagagt
     3001 taggtagagt agtgggtctg gaggctctag ggagtgcagg agggaagagc tccactatcc
     3061 ttccctggat atggtatcct agaactcctg gacaccagtc tggaccagga agacgtgaaa
     3121 agaaaatgtc cacttctttg ctcctctccc accagctctc gagctttctt tccgcccacc
     3181 tgccactgcc accctggaga atcactgtag gaacgggaga gagacttggc tcaaggctct
     3241 agttctagcg tttgatgccg agccaggcat gctatgcctc tgtgcctcag gtttcatcat
     3301 caataaaatg gaactgccct cctgcctggc aaagctac
//
