LOCUS       NM_001414399            8200 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus lipoxygenase homology domains 1 (Loxhd1), transcript
            variant 2, mRNA.
ACCESSION   NM_001414399 XM_006526434
VERSION     NM_001414399.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8200)
  AUTHORS   Wang,P., Miller,K.K., He,E., Dhawan,S.S., Cunningham,C.L. and
            Grillet,N.
  TITLE     LOXHD1 is indispensable for maintaining TMC1 auditory
            mechanosensitive channels at the site of force transmission
  JOURNAL   Nat Commun 15 (1), 7865 (2024)
   PUBMED   39256406
  REMARK    Erratum:[Nat Commun. 2024 Oct 15;15(1):8878. doi:
            10.1038/s41467-024-52972-5.. PMID: 39406713]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8200)
  AUTHORS   Trouillet,A., Miller,K.K., George,S.S., Wang,P., Ali,N.E., Ricci,A.
            and Grillet,N.
  TITLE     Loxhd1 Mutations Cause Mechanotransduction Defects in Cochlear Hair
            Cells
  JOURNAL   J Neurosci 41 (15), 3331-3343 (2021)
   PUBMED   33707295
  REMARK    GeneRIF: Loxhd1 Mutations Cause Mechanotransduction Defects in
            Cochlear Hair Cells.
REFERENCE   3  (bases 1 to 8200)
  AUTHORS   Nakano,Y., Wiechert,S., Fritzsch,B. and Banfi,B.
  TITLE     Inhibition of a transcriptional repressor rescues hearing in a
            splicing factor-deficient mouse
  JOURNAL   Life Sci Alliance 3 (12), e202000841 (2020)
   PUBMED   33087486
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8200)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8200)
  AUTHORS   Xiong,W., Grillet,N., Elledge,H.M., Wagner,T.F., Zhao,B.,
            Johnson,K.R., Kazmierczak,P. and Muller,U.
  TITLE     TMHS is an integral component of the mechanotransduction machinery
            of cochlear hair cells
  JOURNAL   Cell 151 (6), 1283-1295 (2012)
   PUBMED   23217710
REFERENCE   6  (bases 1 to 8200)
  AUTHORS   Grillet,N., Schwander,M., Hildebrand,M.S., Sczaniecka,A.,
            Kolatkar,A., Velasco,J., Webster,J.A., Kahrizi,K., Najmabadi,H.,
            Kimberling,W.J., Stephan,D., Bahlo,M., Wiltshire,T.,
            Tarantino,L.M., Kuhn,P., Smith,R.J. and Muller,U.
  TITLE     Mutations in LOXHD1, an evolutionarily conserved stereociliary
            protein, disrupt hair cell function in mice and cause progressive
            hearing loss in humans
  JOURNAL   Am J Hum Genet 85 (3), 328-337 (2009)
   PUBMED   19732867
  REMARK    GeneRIF: Hearing loss in the ethylnitrosourea (ENU)-induced samba
            mouse line is caused by a mutation in Loxhd1.
REFERENCE   7  (bases 1 to 8200)
  AUTHORS   Schwander,M., Sczaniecka,A., Grillet,N., Bailey,J.S., Avenarius,M.,
            Najmabadi,H., Steffy,B.M., Federe,G.C., Lagler,E.A., Banan,R.,
            Hice,R., Grabowski-Boase,L., Keithley,E.M., Ryan,A.F.,
            Housley,G.D., Wiltshire,T., Smith,R.J., Tarantino,L.M. and
            Muller,U.
  TITLE     A forward genetics screen in mice identifies recessive deafness
            traits and reveals that pejvakin is essential for outer hair cell
            function
  JOURNAL   J Neurosci 27 (9), 2163-2175 (2007)
   PUBMED   17329413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102124.16 and AC102135.12.
            
            On Nov 23, 2022 this sequence version replaced XM_006526434.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AC102124.16        150639-151068       c
            431-545             AC102124.16        146247-146361       c
            546-626             AC102124.16        139412-139492       c
            627-811             AC102124.16        136809-136993       c
            812-910             AC102124.16        111055-111153       c
            911-1059            AC102124.16        103398-103546       c
            1060-1183           AC102124.16        101661-101784       c
            1184-1434           AC102124.16        99911-100161        c
            1435-1570           AC102124.16        93149-93284         c
            1571-1731           AC102124.16        92560-92720         c
            1732-1818           AC102124.16        91514-91600         c
            1819-1954           AC102124.16        90663-90798         c
            1955-2109           AC102124.16        76537-76691         c
            2110-2270           AC102124.16        75807-75967         c
            2271-2347           AC102124.16        70928-71004         c
            2348-2544           AC102124.16        69056-69252         c
            2545-2737           AC102124.16        66138-66330         c
            2738-2898           AC102124.16        63443-63603         c
            2899-3373           AC102124.16        60295-60769         c
            3374-3528           AC102124.16        59703-59857         c
            3529-3662           AC102124.16        57528-57661         c
            3663-3829           AC102124.16        52170-52336         c
            3830-3934           AC102124.16        51084-51188         c
            3935-4063           AC102124.16        48874-49002         c
            4064-4228           AC102124.16        47640-47804         c
            4229-4410           AC102124.16        44208-44389         c
            4411-4527           AC102124.16        38235-38351         c
            4528-4690           AC102124.16        37242-37404         c
            4691-4845           AC102124.16        33591-33745         c
            4846-5055           AC102124.16        30039-30248         c
            5056-5191           AC102124.16        29760-29895         c
            5192-5400           AC102124.16        27719-27927         c
            5401-5586           AC102124.16        26724-26909         c
            5587-5714           AC102124.16        23897-24024         c
            5715-5832           AC102124.16        22107-22224         c
            5833-6007           AC102124.16        20414-20588         c
            6008-6193           AC102124.16        18477-18662         c
            6194-6364           AC102124.16        6973-7143           c
            6365-6497           AC102124.16        2702-2834           c
            6498-6656           AC102124.16        1501-1659           c
            6657-8200           AC102135.12        21723-23266
FEATURES             Location/Qualifiers
     source          1..8200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.2 cM"
     gene            1..8200
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /note="lipoxygenase homology domains 1"
                     /db_xref="GeneID:240411"
                     /db_xref="MGI:MGI:1914609"
     exon            1..430
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..7137
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /note="isoform 2 is encoded by transcript variant 2;
                     lipoxygenase homology domain-containing protein 1"
                     /codon_start=1
                     /product="lipoxygenase homology domain-containing protein
                     1 isoform 2"
                     /protein_id="NP_001401328.1"
                     /db_xref="GeneID:240411"
                     /db_xref="MGI:MGI:1914609"
                     /translation="MMAQKKKRRKKDIDFLGLYEEELLNYDSEDGEDELEHEYYKAKV
                     YEVVTATGDVRGAGTDANVFITLFGENGLSPKLHLTSKSESAFEKANVDVFRVRTNNV
                     GLIYKIRIEHDNTGLNASWYLDRVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDLL
                     ASFDPMDMPRGNKYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKG
                     AEDKFTLDAPDLGQLMKINVGHNNKGGSAGWFLSKIIIEDIGNKRKYDFPLNRWLALD
                     EDDGKIQRDILVGGAETTAITYIVTVFTGDIRGAGTKSKIYLVMYGARGNKNSGKIFL
                     EGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYCEKVVILCPFTGIQQTF
                     PCSNWLDEKKADGLIERQLYEMVSLRKKRLKKYPWSLWVWTTDLKKAGTNSPIFIQIY
                     GKKGRTDEILLNPNNKWFKPGIIEKFRMELPDLGRFYKIRAWHDRQNPGSGWHLEKMT
                     LMNTINKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYRVTVCTGELEG
                     AGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRKVRRVRVRH
                     DGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLPSDSNATLK
                     NFRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNNLKDYFERGRVDEFT
                     LETLNIGTINRLVIGHDSTGMHAGWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRL
                     EVELYPSEVVEIQKLVHYEIEIWTGDVGGAGTTSRVFVQIYGEEGKTEVLFLSSRSKV
                     FDRGSKDIFQLEAVDVGEIYKIRLGHTGEGFGPSWFVDTVWLRHLVVQEENLTPEEEA
                     RKKKEKDKLRQLLKKERLKAKLQRKKKKKKKGSDDEEEGGEEEESSSEESSSEEEEEE
                     ESEEEEEEEEYGPGMQEVIVQYKFDVNRWLARGKEDNELVVELVPAGQSGPEPNTYEV
                     QVITGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLG
                     ALTKIRIRHDNTGNRPGWFLDRVDITDVNNETTYYFPCQRWLAVEEDDGQLSRELLPV
                     DESYVLPSEDEEGGGQGDNNPLDNLALEQKDKSTTFSVTIKTGDKKNAGTDANVFITL
                     FGTQDNNGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRIGHDNTGKAPGWFV
                     DWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHAELQTRLYTPFVPYEITLYTS
                     DVFAAGTDANIFIVIYGCDAVCTRQKFLCTNKREQKLFFERKSASRFIVELEDVGEII
                     EKIRIGHDNTGINPGWHCSHVDIRRLLPEKDGTETLTFPCDRWLATSEDDKKTIRELV
                     PYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNVPGAGTDAKVYITIYGDLG
                     DTGERYLGKSENRTNKFEKGTADTFIIEAADLGVIYKIKLRHDNTKWCADWYVEKVEI
                     WNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKM
                     ADVDIDTVTGPMVDYVQDGPVIPYYVSVTTGKHKEAATDSRAFVLLIGEDDECTNRIW
                     LDYPQGKRGFSCGSVEEFYVGGLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGT
                     KYTLRCNCWLAKDRGDGVTSRVFDLLDAMVVNIGKKVLYEMTVWTGDVVGGGTDSNIF
                     MTLYGINGSTEEVQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGMGSRPEWFL
                     ERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICAVIDGEEMMEWTSYTVSVKTSD
                     ILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFSDMLSLGHLCKLR
                     VWHDNKGIFPGWHLSYVDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACANNEIRD
                     ELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLVENSSRQRAFRKGTTDTFEF
                     DSIFLGDIASLCVGHLAREDRFIPKRELVWHVKTITITEMEYGNVYFFNCDCLIPLKR
                     KRKYFKVFEVTKTTESFASKIQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDT
                     GKRELKQKMRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYYSGWLVEKVEVTNTS
                     TGVATIFSCGRWLDKSRGDGLTWRELFPSV"
     exon            431..545
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            546..626
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            627..811
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            812..910
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1059
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1183
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1434
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1570
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1731
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1818
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1954
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2109
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2270
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2347
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2544
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            2545..2737
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2898
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3373
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3528
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            3529..3662
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            3663..3829
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3934
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            3935..4063
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4228
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4410
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            4411..4527
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            4528..4690
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4845
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            4846..5055
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            5056..5191
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5400
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            5401..5586
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            5587..5714
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            5715..5832
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            5833..6007
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            6008..6193
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            6194..6364
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            6365..6497
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            6498..6656
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     exon            6657..8200
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7539..7544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /note="hexamer: ATTAAA"
     polyA_site      7559
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
     polyA_site      7597
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /note="major polyA site"
     regulatory      8176..8181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /note="hexamer: ATTAAA"
     polyA_site      8200
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /note="major polyA site"
ORIGIN      
        1 agaagctctg gggctggtgc agagtgagag acggtggcag agaagggctg gggacagaaa
       61 gaagaaaaca ggacggggtg cggggccggc agagcgctgc gttaggctga ggcaccagag
      121 aagaggaaag cgggacagaa ctttgggatt ggggacccag gagacccagg gagagcctga
      181 cctgaaaccc tagtgggggg cggggggctc ttcagcttgg tgagtgagag acagaggtcc
      241 aaggaagcca ggaaggtgaa ccggtgagcc tatagggtcc cagaagaggc aggtagcaaa
      301 atgatggccc agaagaagaa gcggaggaag aaagacattg acttcctggg cttgtacgag
      361 gaggagctgc tgaactacga ctcggaggat ggcgaggatg agttggaaca tgagtactac
      421 aaagccaagg tgtatgaggt ggtcacagcc acaggggatg ttcgtggtgc agggacagat
      481 gccaatgtgt tcatcacact ctttggagag aatgggctct ctcccaagct ccatctcacc
      541 agcaagagtg agtctgcttt cgagaaagcc aacgttgacg tattccgggt gcgaaccaat
      601 aacgtgggcc tcatctataa aatcaggatc gagcatgata acacaggctt gaatgccagc
      661 tggtacctgg accgagttat agtgactgac atgaagaggc cacatctccg ctactacttc
      721 aactgcaaca actggctgag caaggtggag ggtgaccgtc agtggtgccg ggacctgctg
      781 gccagcttcg accccatgga catgccaaga ggaaacaaat acgagatcaa ggtgtacact
      841 ggtgacgtga ttggtgcagg gacagatgct gatgtcttta tcaacatctt tggagagtat
      901 ggagacacag gcgagcgtag gctggaaaac gaaaaggaca actttgaaaa gggagctgaa
      961 gacaagttca cactggacgc tccggatttg gggcagctga tgaagatcaa tgtgggccac
     1021 aacaacaagg gggggtccgc aggctggttc ctgtccaaga tcatcattga agatattgga
     1081 aacaaaagga aatacgactt cccccttaac cgctggctgg cgctggatga agatgatggc
     1141 aaaatccaga gagacatctt agtgggcgga gctgagacca cagccataac ctacattgtc
     1201 actgtcttca cgggggatat ccgtggagct gggaccaaat ctaaaatcta tttggtcatg
     1261 tatggagcca gagggaacaa gaacagtggg aaaatcttcc tggagggtgg cgtgtttgac
     1321 agaggccgca cagatatctt ccacatcgac ctggccgtcc tccttagccc tctgagccgg
     1381 gtctccatcg ggcatggcaa cataggcgtc aaccgcggct ggtactgtga gaaggtggtg
     1441 atcctgtgcc cctttactgg cattcagcag actttcccct gcagcaactg gctggatgag
     1501 aagaaggcag acgggctgat tgagaggcag ctctatgaga tggtgtctct gaggaagaag
     1561 cggctgaaaa aatatccttg gtccctttgg gtctggacaa ctgatctgaa gaaagccggc
     1621 accaactcgc ccatcttcat ccagatttac gggaagaagg ggaggacgga tgagattctt
     1681 ctgaacccca acaacaagtg gttcaagcca ggcatcattg agaagttcag gatggagctc
     1741 ccagatctcg gcaggttcta taagattcgg gcgtggcatg ataggcagaa ccctggctct
     1801 gggtggcatt tagaaaagat gactctgatg aataccatca ataaggataa atataacttc
     1861 aattgcaatc gctggctgga tgccaatgaa gatgacaatg agatcgtgag ggagatgacc
     1921 gcagaaggcc caactgtgcg gaggatcatg ggaatggccc ggtatcgtgt gactgtatgc
     1981 acaggggaac ttgaaggtgc aggaactgat gccaatgtct atctctgcct ttttggtgat
     2041 gtgggggaca caggggagcg gctgctttac aactgcagga acaacaccga cctgtttgag
     2101 aaaggcaatg ccgacgagtt taccattgag tctgtcacca tgaggaaagt gaggagggtg
     2161 agggtcagac atgacggcaa aggctctggc agtggctggt acctggacag ggtgctggtg
     2221 agagaagagg gacaacccga gagtgacaac gtggagttcc cctgcctcag gtggctggac
     2281 aaagacaagg atgatggaca gctggttcga gagttgctgc ccagtgacag caatgccacg
     2341 ctcaagaatt tccgttatca catcagcgtg aagactgggg atgtctctgg ggccagcaca
     2401 gattctcggg tgtacatcaa gctctatgga gagaagtctg ataccatcaa gcaggttctt
     2461 cttgtctccg acaacaacct caaagactac tttgaacgtg gccgggtaga tgagtttact
     2521 ctggagacgc tgaacattgg aaccatcaac aggctggtga ttgggcacga cagcacgggc
     2581 atgcatgcag gctggttcct gggcagcgtc cagatccgtg tgccccgcca aggcaagcag
     2641 tacaccttcc cggctaaccg gtggctggat aagaaccaag ctgatgggcg tctggaggtg
     2701 gagctgtatc ccagcgaggt ggtggagatc cagaaattgg tccactacga gattgagatt
     2761 tggacggggg atgtgggtgg cgccggcacc acttcccgag tcttcgtgca gatctacggg
     2821 gaagaaggca agaccgaagt cctcttcctc tccagccgtt ccaaagtgtt tgatcggggg
     2881 tccaaggaca ttttccagct ggaagccgtg gacgtgggtg agatctacaa gatccgactg
     2941 ggacacacag gcgagggctt cgggcccagc tggtttgtgg acacagtgtg gctgcggcac
     3001 ctggtggtgc aggaggagaa cctgaccccg gaggaggagg cccggaagaa gaaggagaag
     3061 gacaagctgc ggcagctgct gaagaaggag aggctgaagg ctaagctgca gagaaagaag
     3121 aagaaaaaga agaaaggcag cgatgatgag gaggaggggg gtgaggaaga agagtcctcc
     3181 tcagaggagt cctcatccga ggaggaggaa gaggaggagt cagaggagga ggaggaggaa
     3241 gaggagtatg ggccagggat gcaggaggtg attgtgcagt acaagttcga cgttaaccgc
     3301 tggctggccc ggggcaagga agacaatgaa cttgttgtgg aattggttcc ggctggccag
     3361 tctggtcctg agcccaacac ctacgaggtc caagtgatca cagggaacgt gcccaaggcc
     3421 ggcaccgatg ccaacgtcta cctgaccatc tacggtgaag agtatgggga cacgggggag
     3481 cggcccctga agaaatcaga caagtccaac aagtttgagc agggccagac agataccttc
     3541 accatctatg ccattgacct gggggctctt accaagattc ggattcgcca tgataacacg
     3601 ggcaacaggc caggctggtt cctggacaga gtagacatca ccgacgtgaa taacgagacc
     3661 acgtactact tcccatgcca gcgatggtta gcagttgaag aggatgatgg ccagctgtcc
     3721 agggagctgc tgccagtgga cgagtcctac gtgctaccca gtgaagacga ggagggcggg
     3781 gggcagggtg acaataaccc ccttgacaac ctggctctgg aacaaaaaga taaatctacc
     3841 acattttccg tgaccataaa gactggggac aagaagaatg caggcacaga tgccaacgtc
     3901 ttcatcacgc tctttggcac ccaagataac aacggaatga ccctcctgaa gtcctccaaa
     3961 accaacagtg acaaatttga aagggacagc attgaaatct tcactgtgga gacgctggat
     4021 ctgggagacc tttggaaagt taggatcggc catgacaaca caggcaaggc cccaggctgg
     4081 tttgtagact gggtagaggt ggatgcccca tctcttggga agtgcatgac ttttccctgt
     4141 ggccgctggc tggcaaagaa tgaggacgac ggcagcatcg tcagggacct cttccacgca
     4201 gagcttcaga cgaggcttta cacaccattt gtcccctatg agatcaccct ctacaccagt
     4261 gacgtcttcg cggccggcac ggacgccaac atcttcatag tcatctacgg ctgtgacgcc
     4321 gtgtgcaccc ggcagaagtt cctgtgcacc aacaagaggg aacagaaact gttcttcgag
     4381 aggaagtcgg cttcccgctt cattgtggag ttagaagacg taggtgagat catagaaaaa
     4441 attcggattg gccatgacaa cacaggcata aaccctgggt ggcactgctc ccacgtggac
     4501 atccgcaggc tcctccctga gaaagatggc acagaaacct tgactttccc ctgtgatcga
     4561 tggcttgcca cctctgagga tgacaagaag accatccgag aactggtccc ttatgacatc
     4621 ttcactgaga agtatatgaa agatggatcc ttaagacaag tctacaagga agtggaggag
     4681 cctctggaca ttgtgctgta ctcggtgcag atcttcacag ggaatgttcc tggggcaggg
     4741 acagatgcca aggtctacat caccatctac ggagacctcg gggacacagg ggaacgatac
     4801 cttggcaagt cagagaaccg caccaacaag tttgagaaag gaacggctga caccttcatc
     4861 attgaggccg ctgacctggg tgtcatctac aagatcaagc tccgccatga caacaccaag
     4921 tggtgcgctg actggtatgt ggagaaggtg gaaatctgga atgacactaa tgaggatgag
     4981 tttctcttcc tgtgtgggcg ctggctgtcc ctgaagaagg aagacgggcg gctggagagg
     5041 ctcttctatg agaaggagta cactggagac cgcagtagca actgcagcag ccctgctgac
     5101 ttctgggaga tcgccctgag ttccaagatg gcagacgtgg acatcgacac ggtgacagga
     5161 cctatggttg actatgttca ggatggccct gtgattcctt actacgtgtc agtgaccacc
     5221 gggaaacaca aggaggcagc cactgatagc cgtgcctttg tcttgctcat tggggaagat
     5281 gatgaatgca ccaaccgcat ctggctggac tatccccagg ggaagcgagg cttcagctgt
     5341 ggctctgtgg aggagttcta cgttgggggc ttagatgtgg gcatcatcaa gaaaatagag
     5401 ctgggccacg atggagcctc ccctgagagc tgctggctgg tggaggagct gtgcttggcg
     5461 gtgcctaccc agggtaccaa gtacacatta cgctgcaact gttggcttgc caaggaccga
     5521 ggcgatggtg tcacctcccg tgtctttgac ctcctggacg ccatggttgt gaatattggg
     5581 aagaaggtgc tttatgaaat gacagtatgg actggtgatg tggtcggtgg aggtactgac
     5641 tccaatatct tcatgaccct ctatggcatc aacgggagca cagaagaggt gcagttggac
     5701 aagaagaagg ccaggtttga gcgggaacaa aatgacacct tcatcatgga gatcctggac
     5761 atcgccccct tcaccaagat gcgcatccgc attgatggga tgggtagccg gccagagtgg
     5821 ttcctggaga ggatcctgtt gaagaacatg aacacaggag acctaaccat gttctactat
     5881 ggagactggc tgtcccaaaa gaagggaaag aagacgctgg tgtgtgagat atgtgcagtc
     5941 attgatggag aggagatgat ggagtggaca tcttacacag tctcggtgaa gaccagtgac
     6001 atcttggggg caggcacgga tgccaatgtg ttcatcatca tcttcgggga aaatggagac
     6061 agtgggaccc tggccctgaa gcagtcagcc aactggaaca agtttgagcg gaacaacaca
     6121 gacaccttca acttttctga catgctgagc ctgggacacc tctgcaaact gagggtctgg
     6181 cacgacaaca aagggatatt tcctggatgg cacctgagct acgttgatgt gaaggacaac
     6241 tcccgtgacg agaccttccg attccagtgt gactgctggc tgtccaagag cgaaggtgac
     6301 agacaaacac tccgagactt cgcatgtgcc aacaacgaga tccgtgatga gctggaagag
     6361 accacctacg agattgtcat agaaacaggc aacgggggcg aaaccagaga gaacgtctgg
     6421 ctcatactgg agggcaggaa gaacagatcc aaggagttcc ttgtggaaaa ttcttccaga
     6481 cagagagcct ttcggaaggg gaccacagac acctttgagt ttgacagcat cttcttggga
     6541 gacatcgcct ccctctgtgt gggccacctg gccagggagg accggttcat tcccaagaga
     6601 gagcttgtct ggcacgtcaa gacgatcacc atcaccgaga tggaatatgg caatgtgtac
     6661 ttctttaact gtgattgcct catccccctc aagcggaaga ggaagtactt caaggtattt
     6721 gaggttacga aaacgacaga gagcttcgcc agtaagatcc agagcctggt gccagtcaag
     6781 tacgaggtca tcgtgacgac aggctacgaa ccaggagcgg gtactgatgc caacgtcttt
     6841 gtgaccatct ttggcgcaaa tggggacacg ggcaagcgcg aactgaaaca gaaaatgcgc
     6901 aacctcttcg agaggggcag tacagaccgc ttctttctgg agacgttaga gttgggagag
     6961 ctgcgcaagg ttcggctgga acacgacagc agcggctact actcaggctg gctggtggag
     7021 aaggtggagg tcaccaacac tagtactgga gtggccacaa tcttctcctg cggcaggtgg
     7081 ctagacaagt ctcggggcga tggactcacc tggcgagagc tcttcccgtc tgtctgagat
     7141 gccctggcca caccttatac cctccatctt gtgttcaaca cccatctccc tagctctccg
     7201 ggagtgggac tagggtagtg gacatggggt ctcatatccg ccagaggctg ctccttgcaa
     7261 gtgacagttt gtggaatcct ggcctctacc ttctccatct cttggatata caagaattat
     7321 attcagcaca tctcataatc catgactgta caagctattt ttttaacttt ctttccttgt
     7381 aataataaca gtggtaccca ggttgggact tgctgcaggg tgtggatgga aaattggggc
     7441 ttcactcagg ggaaacaagt ggagaaggag aggttatcaa gatggtatat tttaagcaaa
     7501 aactaattaa cacttttttt ccgaaaaaag ctgggctaat taaattatta cgaaccacac
     7561 ccctcagaga actcatccga gcacctatgt gctaaaacat gtatggtttg ggttgttttt
     7621 ttttcccccc agttccaaaa aaatccaggg tcaagtgcag aaaaacatca ggaagaagta
     7681 ttggaggacc ttgaccctgt ggaaagtaga taattctttc caccacttta cagacaccaa
     7741 gagactagga gctctcagat cctcacacct tggttccccc accccagtct gtctgtctgt
     7801 ctgtctgtct gtctgtctgt ctgtctgtct gtctgtctat ctgtctgcct gtcctgctgc
     7861 tcttttctct cggcccctcc taccccatca caacgtggag aggatcctca gctcagagtc
     7921 cacaccacat ccctctctgc cacctccctc tgacaagtgc tctactatct ctatggcagt
     7981 agggggtctc gtgcttccac gctggtattg gtgtatttca taagtgttgg tgtgctgctc
     8041 ttgggatagg gcaagcccgg ctccaccatg taccacacat agccgaattt cttgccatct
     8101 tcagtctgcc ctgcttgctt tgcattgctt agaggacctg tcaagaccta atgaaaccat
     8161 taccaaactc tctcaattaa actgttgata cttctgttga
//
