LOCUS       NP_001401328            2278 aa            linear   ROD 01-MAY-2025
DEFINITION  lipoxygenase homology domain-containing protein 1 isoform 2 [Mus
            musculus].
ACCESSION   NP_001401328 XP_006526497
VERSION     NP_001401328.1
DBSOURCE    REFSEQ: accession NM_001414399.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 2278)
  AUTHORS   Wang,P., Miller,K.K., He,E., Dhawan,S.S., Cunningham,C.L. and
            Grillet,N.
  TITLE     LOXHD1 is indispensable for maintaining TMC1 auditory
            mechanosensitive channels at the site of force transmission
  JOURNAL   Nat Commun 15 (1), 7865 (2024)
   PUBMED   39256406
  REMARK    Erratum:[Nat Commun. 2024 Oct 15;15(1):8878. doi:
            10.1038/s41467-024-52972-5. PMID: 39406713]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 2278)
  AUTHORS   Trouillet,A., Miller,K.K., George,S.S., Wang,P., Ali,N.E., Ricci,A.
            and Grillet,N.
  TITLE     Loxhd1 Mutations Cause Mechanotransduction Defects in Cochlear Hair
            Cells
  JOURNAL   J Neurosci 41 (15), 3331-3343 (2021)
   PUBMED   33707295
  REMARK    GeneRIF: Loxhd1 Mutations Cause Mechanotransduction Defects in
            Cochlear Hair Cells.
REFERENCE   3  (residues 1 to 2278)
  AUTHORS   Nakano,Y., Wiechert,S., Fritzsch,B. and Banfi,B.
  TITLE     Inhibition of a transcriptional repressor rescues hearing in a
            splicing factor-deficient mouse
  JOURNAL   Life Sci Alliance 3 (12), e202000841 (2020)
   PUBMED   33087486
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 2278)
  AUTHORS   Potter,P.K., Bowl,M.R., Jeyarajan,P., Wisby,L., Blease,A.,
            Goldsworthy,M.E., Simon,M.M., Greenaway,S., Michel,V., Barnard,A.,
            Aguilar,C., Agnew,T., Banks,G., Blake,A., Chessum,L., Dorning,J.,
            Falcone,S., Goosey,L., Harris,S., Haynes,A., Heise,I., Hillier,R.,
            Hough,T., Hoslin,A., Hutchison,M., King,R., Kumar,S., Lad,H.V.,
            Law,G., MacLaren,R.E., Morse,S., Nicol,T., Parker,A., Pickford,K.,
            Sethi,S., Starbuck,B., Stelma,F., Cheeseman,M., Cross,S.H.,
            Foster,R.G., Jackson,I.J., Peirson,S.N., Thakker,R.V., Vincent,T.,
            Scudamore,C., Wells,S., El-Amraoui,A., Petit,C.,
            Acevedo-Arozena,A., Nolan,P.M., Cox,R., Mallon,A.M. and Brown,S.D.
  TITLE     Novel gene function revealed by mouse mutagenesis screens for
            models of age-related disease
  JOURNAL   Nat Commun 7, 12444 (2016)
   PUBMED   27534441
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 2278)
  AUTHORS   Xiong,W., Grillet,N., Elledge,H.M., Wagner,T.F., Zhao,B.,
            Johnson,K.R., Kazmierczak,P. and Muller,U.
  TITLE     TMHS is an integral component of the mechanotransduction machinery
            of cochlear hair cells
  JOURNAL   Cell 151 (6), 1283-1295 (2012)
   PUBMED   23217710
REFERENCE   6  (residues 1 to 2278)
  AUTHORS   Grillet,N., Schwander,M., Hildebrand,M.S., Sczaniecka,A.,
            Kolatkar,A., Velasco,J., Webster,J.A., Kahrizi,K., Najmabadi,H.,
            Kimberling,W.J., Stephan,D., Bahlo,M., Wiltshire,T.,
            Tarantino,L.M., Kuhn,P., Smith,R.J. and Muller,U.
  TITLE     Mutations in LOXHD1, an evolutionarily conserved stereociliary
            protein, disrupt hair cell function in mice and cause progressive
            hearing loss in humans
  JOURNAL   Am J Hum Genet 85 (3), 328-337 (2009)
   PUBMED   19732867
  REMARK    GeneRIF: Hearing loss in the ethylnitrosourea (ENU)-induced samba
            mouse line is caused by a mutation in Loxhd1.
REFERENCE   7  (residues 1 to 2278)
  AUTHORS   Schwander,M., Sczaniecka,A., Grillet,N., Bailey,J.S., Avenarius,M.,
            Najmabadi,H., Steffy,B.M., Federe,G.C., Lagler,E.A., Banan,R.,
            Hice,R., Grabowski-Boase,L., Keithley,E.M., Ryan,A.F.,
            Housley,G.D., Wiltshire,T., Smith,R.J., Tarantino,L.M. and
            Muller,U.
  TITLE     A forward genetics screen in mice identifies recessive deafness
            traits and reveals that pejvakin is essential for outer hair cell
            function
  JOURNAL   J Neurosci 27 (9), 2163-2175 (2007)
   PUBMED   17329413
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102124.16 and AC102135.12.
            
            On Nov 23, 2022 this sequence version replaced XP_006526497.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2278
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 52.2 cM"
     Protein         1..2278
                     /product="lipoxygenase homology domain-containing protein
                     1 isoform 2"
                     /note="lipoxygenase homology domain-containing protein 1"
                     /calculated_mol_wt=259650
     Region          43..162
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          172..289
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          296..414
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          426..542
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          554..675
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          684..805
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          816..>896
                     /region_name="PLAT"
                     /note="PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin)
                     domain or LH2 (Lipoxygenase homology 2) domain. It
                     consists of an eight stranded beta-barrel. The domain can
                     be found in various domain architectures, in case of
                     lipoxygenases, alpha toxin, lipases and...; cl00011"
                     /db_xref="CDD:412108"
     Region          1026..1146
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          1180..1300
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          1311..1437
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          1465..1585
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          1634..1749
                     /region_name="PLAT"
                     /note="PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin)
                     domain or LH2 (Lipoxygenase homology 2) domain. It
                     consists of an eight stranded beta-barrel. The domain can
                     be found in various domain architectures, in case of
                     lipoxygenases, alpha toxin, lipases and...; cl00011"
                     /db_xref="CDD:412108"
     Region          1763..1880
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          1890..2010
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     Region          2023..2124
                     /region_name="PLAT"
                     /note="PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin)
                     domain or LH2 (Lipoxygenase homology 2) domain. It
                     consists of an eight stranded beta-barrel. The domain can
                     be found in various domain architectures, in case of
                     lipoxygenases, alpha toxin, lipases and...; cl00011"
                     /db_xref="CDD:412108"
     Region          2159..2277
                     /region_name="PLAT_repeat"
                     /note="PLAT/LH2 domain repeats of family of proteins with
                     unknown function. In general, PLAT/LH2 consists of an
                     eight stranded beta-barrel and it's proposed function is
                     to mediate interaction with lipids or membrane bound
                     proteins; cd01756"
                     /db_xref="CDD:238854"
     CDS             1..2278
                     /gene="Loxhd1"
                     /gene_synonym="1700096C21Rik; 4932417K07; sba"
                     /coded_by="NM_001414399.1:301..7137"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:240411"
                     /db_xref="MGI:MGI:1914609"
ORIGIN      
        1 mmaqkkkrrk kdidflglye eellnydsed gedeleheyy kakvyevvta tgdvrgagtd
       61 anvfitlfge nglspklhlt sksesafeka nvdvfrvrtn nvgliykiri ehdntglnas
      121 wyldrvivtd mkrphlryyf ncnnwlskve gdrqwcrdll asfdpmdmpr gnkyeikvyt
      181 gdvigagtda dvfinifgey gdtgerrlen ekdnfekgae dkftldapdl gqlmkinvgh
      241 nnkggsagwf lskiiiedig nkrkydfpln rwlaldeddg kiqrdilvgg aettaityiv
      301 tvftgdirga gtkskiylvm ygargnknsg kifleggvfd rgrtdifhid lavllsplsr
      361 vsighgnigv nrgwycekvv ilcpftgiqq tfpcsnwlde kkadglierq lyemvslrkk
      421 rlkkypwslw vwttdlkkag tnspifiqiy gkkgrtdeil lnpnnkwfkp giiekfrmel
      481 pdlgrfykir awhdrqnpgs gwhlekmtlm ntinkdkynf ncnrwldane ddneivremt
      541 aegptvrrim gmaryrvtvc tgelegagtd anvylclfgd vgdtgerlly ncrnntdlfe
      601 kgnadeftie svtmrkvrrv rvrhdgkgsg sgwyldrvlv reegqpesdn vefpclrwld
      661 kdkddgqlvr ellpsdsnat lknfryhisv ktgdvsgast dsrvyiklyg eksdtikqvl
      721 lvsdnnlkdy fergrvdeft letlnigtin rlvighdstg mhagwflgsv qirvprqgkq
      781 ytfpanrwld knqadgrlev elypsevvei qklvhyeiei wtgdvggagt tsrvfvqiyg
      841 eegktevlfl ssrskvfdrg skdifqleav dvgeiykirl ghtgegfgps wfvdtvwlrh
      901 lvvqeenltp eeearkkkek dklrqllkke rlkaklqrkk kkkkkgsdde eeggeeeess
      961 seessseeee eeeseeeeee eeygpgmqev ivqykfdvnr wlargkedne lvvelvpagq
     1021 sgpepntyev qvitgnvpka gtdanvylti ygeeygdtge rplkksdksn kfeqgqtdtf
     1081 tiyaidlgal tkirirhdnt gnrpgwfldr vditdvnnet tyyfpcqrwl aveeddgqls
     1141 rellpvdesy vlpsedeegg gqgdnnpldn laleqkdkst tfsvtiktgd kknagtdanv
     1201 fitlfgtqdn ngmtllkssk tnsdkferds ieiftvetld lgdlwkvrig hdntgkapgw
     1261 fvdwvevdap slgkcmtfpc grwlaknedd gsivrdlfha elqtrlytpf vpyeitlyts
     1321 dvfaagtdan ifiviygcda vctrqkflct nkreqklffe rksasrfive ledvgeiiek
     1381 irighdntgi npgwhcshvd irrllpekdg tetltfpcdr wlatseddkk tirelvpydi
     1441 ftekymkdgs lrqvykevee pldivlysvq iftgnvpgag tdakvyitiy gdlgdtgery
     1501 lgksenrtnk fekgtadtfi ieaadlgviy kiklrhdntk wcadwyvekv eiwndtnede
     1561 flflcgrwls lkkedgrler lfyekeytgd rssncsspad fweialsskm advdidtvtg
     1621 pmvdyvqdgp vipyyvsvtt gkhkeaatds rafvlliged dectnriwld ypqgkrgfsc
     1681 gsveefyvgg ldvgiikkie lghdgaspes cwlveelcla vptqgtkytl rcncwlakdr
     1741 gdgvtsrvfd lldamvvnig kkvlyemtvw tgdvvgggtd snifmtlygi ngsteevqld
     1801 kkkarfereq ndtfimeild iapftkmrir idgmgsrpew flerillknm ntgdltmfyy
     1861 gdwlsqkkgk ktlvceicav idgeemmewt sytvsvktsd ilgagtdanv fiiifgengd
     1921 sgtlalkqsa nwnkfernnt dtfnfsdmls lghlcklrvw hdnkgifpgw hlsyvdvkdn
     1981 srdetfrfqc dcwlsksegd rqtlrdfaca nneirdelee ttyeivietg nggetrenvw
     2041 lilegrknrs keflvenssr qrafrkgttd tfefdsiflg diaslcvghl aredrfipkr
     2101 elvwhvktit itemeygnvy ffncdclipl krkrkyfkvf evtkttesfa skiqslvpvk
     2161 yevivttgye pgagtdanvf vtifgangdt gkrelkqkmr nlfergstdr ffletlelge
     2221 lrkvrlehds sgyysgwlve kvevtntstg vatifscgrw ldksrgdglt wrelfpsv
//
