LOCUS       NM_010728               4671 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus lysyl oxidase (Lox), transcript variant 1, mRNA.
ACCESSION   NM_010728
VERSION     NM_010728.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4671)
  AUTHORS   Coren,L., Zaffryar-Eilot,S., Odeh,A., Kaganovsky,A. and Hasson,P.
  TITLE     Fibroblast diversification is an embryonic process dependent on
            muscle contraction
  JOURNAL   Cell Rep 43 (12), 115034 (2024)
   PUBMED   39636726
REFERENCE   2  (bases 1 to 4671)
  AUTHORS   Stoyell-Conti,F.F., Suresh Kumar,M., Zigmond,Z.M., Rojas,M.G.,
            Santos Falcon,N., Martinez,L. and Vazquez-Padron,R.I.
  TITLE     Gene inactivation of lysyl oxidase in smooth muscle cells reduces
            atherosclerosis burden and plaque calcification in hyperlipidemic
            mice
  JOURNAL   Atherosclerosis 397, 118582 (2024)
   PUBMED   39260002
REFERENCE   3  (bases 1 to 4671)
  AUTHORS   Karagianni,A., Karkempetzaki,A.I., Brooks,D., Matsuura,S.,
            Dambal,V., Trackman,P.C. and Ravid,K.
  TITLE     Deletion of mouse lysyl oxidase in megakaryocytes affects bone
            properties in a sex-dependent manner
  JOURNAL   Blood 143 (25), 2666-2670 (2024)
   PUBMED   38635757
  REMARK    GeneRIF: Deletion of mouse lysyl oxidase in megakaryocytes affects
            bone properties in a sex-dependent manner.
REFERENCE   4  (bases 1 to 4671)
  AUTHORS   Palamakumbura,A.H., Jeay,S., Guo,Y., Pischon,N., Sommer,P.,
            Sonenshein,G.E. and Trackman,P.C.
  TITLE     The propeptide domain of lysyl oxidase induces phenotypic reversion
            of ras-transformed cells
  JOURNAL   J Biol Chem 279 (39), 40593-40600 (2004)
   PUBMED   15277520
  REMARK    GeneRIF: lysyl oxidase functions to inhibit ras-dependent cell
            transformation
REFERENCE   5  (bases 1 to 4671)
  AUTHORS   Contente,S., Csiszar,K., Kenyon,K. and Friedman,R.M.
  TITLE     Structure of the mouse lysyl oxidase gene
  JOURNAL   Genomics 16 (2), 395-400 (1993)
   PUBMED   8100214
REFERENCE   6  (bases 1 to 4671)
  AUTHORS   Chang,Y.S., Svinarich,D.M., Yang,T.P. and Krawetz,S.A.
  TITLE     The mouse lysyl oxidase gene (Lox) resides on chromosome 18
  JOURNAL   Cytogenet Cell Genet 63 (1), 47-49 (1993)
   PUBMED   8095446
REFERENCE   7  (bases 1 to 4671)
  AUTHORS   Mock,B.A., Contente,S., Kenyon,K., Friedman,R.M. and Kozak,C.A.
  TITLE     The gene for lysyl oxidase maps to mouse chromosome 18
  JOURNAL   Genomics 14 (3), 822-823 (1992)
   PUBMED   1358813
REFERENCE   8  (bases 1 to 4671)
  AUTHORS   Kenyon,K., Contente,S., Trackman,P.C., Tang,J., Kagan,H.M. and
            Friedman,R.M.
  TITLE     Lysyl oxidase and rrg messenger RNA
  JOURNAL   Science 253 (5021), 802 (1991)
   PUBMED   1678898
REFERENCE   9  (bases 1 to 4671)
  AUTHORS   Starcher,B.C., Madaras,J.A. and Tepper,A.S.
  TITLE     Lysyl oxidase deficiency in lung and fibroblasts from mice with
            hereditary emphysema
  JOURNAL   Biochem Biophys Res Commun 78 (2), 706-712 (1977)
   PUBMED   20889
REFERENCE   10 (bases 1 to 4671)
  AUTHORS   Rowe,D.W., McGoodwin,E.B., Martin,G.R. and Grahn,D.
  TITLE     Decreased lysyl oxidase activity in the aneurysm-prone, mottled
            mouse
  JOURNAL   J Biol Chem 252 (3), 939-942 (1977)
   PUBMED   14140
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC161119.3 and AC109203.9.
            
            On Nov 14, 2022 this sequence version replaced NM_010728.3.
            
            Summary: This gene encodes a precursor protein that belongs to the
            lysyl oxidase family of proteins. The secreted proprotein is
            proteolytically processed to an active mature peptide and a
            propeptide. This propeptide is thought to function in tumor
            suppression by inhibiting the Ras signaling pathway. The active
            enzyme plays a role in cross-linking of collagen and elastin and is
            essential for development of cardiovascular and respiratory
            systems, and development of skin and connective tissue. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Oct 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M65142.1, BC018439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-887               AC161119.3         119237-120123
            888-996             AC161119.3         120453-120561
            997-1134            AC109203.9         715-852
            1135-1291           AC109203.9         2514-2670
            1292-1387           AC109203.9         6415-6510
            1388-1503           AC109203.9         6844-6959
            1504-4671           AC109203.9         8520-11687
FEATURES             Location/Qualifiers
     source          1..4671
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 28.22 cM"
     gene            1..4671
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /note="lysyl oxidase"
                     /db_xref="GeneID:16948"
                     /db_xref="MGI:MGI:96817"
     exon            1..887
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1510
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /EC_number="1.4.3.13"
                     /note="protein-lysine 6-oxidase; ras excision protein"
                     /codon_start=1
                     /product="protein-lysine 6-oxidase preproprotein"
                     /protein_id="NP_034858.2"
                     /db_xref="CCDS:CCDS50289.1"
                     /db_xref="GeneID:16948"
                     /db_xref="MGI:MGI:96817"
                     /translation="MRFAWAVLLLGPLQLCPLLRCAPQTPREPPAAPGAWRQTIQWEN
                     NGQVFSLLSLGAQYQPQRRRDPSATARRPDGDAASQPRTPILLLRDNRTASTRARTPS
                     PSGVAAGRPRPAARHWFQAGFSPSGARDGASRRAANRTASPQPPQLSNLRPPSHIDRM
                     VGDDPYNPYKYSDDNPYYNYYDTYERPRPGSRNRPGYGTGYFQYGLPDLVPDPYYIQA
                     STYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRP
                     RYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFAC
                     TAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYTNNVVRC
                     DIRYTGHHAYASGCTISPY"
     exon            888..996
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1134
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1291
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1387
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1503
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..4671
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4651..4656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /note="hexamer: AATAAA"
     polyA_site      4671
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /note="major polyA site"
ORIGIN      
        1 agactctgtg cgctttccca gaccttcgtg cgcagctccc cgtcgccttc cagggctggg
       61 aaaggggaga ggaggaccgt gccacgtccg acggcagcct gggctggggg cagggtctgc
      121 tgttcgccct ggcacgactc cctgcgaccc atccccgcgc ctcgcccttc tcctccctgc
      181 tcggagaggt ctccctcctt cgtgggatct gagtcccggt cttccttttt ctcctagcca
      241 cgtcctcccc gagaagggac gagccgggag caccatgcgt ttcgcctggg ctgtgctcct
      301 tctggggcca ctgcagcttt gtccccttct ccgctgcgcc ccgcagaccc cgcgcgagcc
      361 gcccgccgcc cctggtgcct ggcgccagac aatccaatgg gagaacaacg ggcaggtgtt
      421 cagtctgctg agcctcgggg cgcagtacca gcctcagcga cgccgcgacc ccagtgccac
      481 tgcccggaga cccgacggcg acgcagcctc gcagccgcgc acgcccattc ttctgctgcg
      541 tgacaaccgc accgcctcta cccgtgcgag gacgccaagc ccgtctgggg tcgccgcggg
      601 tcgtccccgg cccgccgccc gccactggtt ccaagctggt ttctcgccgt cgggggctcg
      661 cgatggagcc tcacggcgcg cggcgaaccg gactgcatcg ccacagcctc cgcagctcag
      721 taatctgagg ccacccagcc acatagatcg catggtgggc gacgacccct acaatcccta
      781 caagtactcc gacgacaacc cctattataa ctactatgac acgtatgaga ggccccggcc
      841 cgggagcagg aaccgacctg gatacggcac cggttacttc cagtacggtc tcccggacct
      901 ggtgcccgac ccctactaca tccaggcttc cacgtacgtc cagaagatgt ctatgtacaa
      961 cctgagatgc gctgcggaag aaaactgcct ggccagttca gcatataggg cggatgtcag
     1021 agactatgac cacagggtac tgctacgatt tccgcaaaga gtgaagaacc aagggacatc
     1081 ggacttctta ccaagccgcc ctcggtactc ctgggagtgg cacagctgtc accaacatta
     1141 ccacagcatg gacgaattca gccactatga cctgcttgat gccaacacac agaggagagt
     1201 ggctgaaggc cacaaagcaa gcttctgtct ggaggacacg tcctgtgact atgggtacca
     1261 caggcgcttt gcgtgcactg cacacacaca gggattgagt cctggatgtt atgacaccta
     1321 tgcggcagac atagactgcc agtggattga tattacagat gtacaacctg gaaactacat
     1381 tctaaaggtc agtgtaaacc ccagctacct ggtgcctgaa tcagactaca ctaacaatgt
     1441 tgtacgctgt gacattcgct acacaggaca tcatgcctat gcctcaggct gcacaatttc
     1501 accgtattag aaagaagccc agttcccagt ggataaagcc gtacctggtg tttggacata
     1561 tggaaactat agattagctt aagtaggaag gacttacata ttttaaaaga caaacagtaa
     1621 acaacaaagg aggttttgtt tggactcttt cgcaacaaat gacataactg gattttgagt
     1681 gtttaaacca acaatatttg gcaaatttta aatccttact catgttattt tgtgaattag
     1741 cagtgtttca attctgtggg tgcatagtgg gctctttcaa agaactctga atttcttatg
     1801 ttcttttgaa attatagtgc aaatgagaaa ttgatatttt aatgagtgag ccacaatttg
     1861 aacggattct tttctaaagt gctgaaacca gtgaaacaat gatgatgagc ctatatttgc
     1921 ctcgacttag attgattttt taaaaaggtg tccctattgt gtaaacagaa atggatacac
     1981 ttggtgctga ggaagggcca aacatctaac tattgttgtc atgaagtata atcagaaaga
     2041 tggcgatata tgtattcaga tagttacatc cctatataaa attatgttta cattttagag
     2101 ttactagaca atttcctttc tcttaattgc ttaatttcac tctgacttga gtcaacttgt
     2161 tttggaatga attggaaaat tccaagatcc tgtttgatac ttgttgctat tcgatcccac
     2221 gctgcttagc ttttctgtgg gcagaaatgt ctaatgtgac aatcagcaca tccccattgt
     2281 gaggtttcac ggcataggga aatcattccg atgaccaaca gctgtgatca gtggagagct
     2341 aacatgccct gcagcatatt ttactgttag ccagaattaa gtcactgctg acacagcaat
     2401 tatacaagga atctctaaca tcacaatcat ctttcaaata ctgtcaaaag aaaatactgg
     2461 aaaacctttt agattttttt ttcaactcta ctacacttct gaaatgttca gctattaagg
     2521 agaatgttga atttatatat atataaaacc atccgtaata gatgacctac tgtgtgcaat
     2581 gcagcaccat catcttagac tcttcaggag ttgggtatat acgtttttgt gtatttacaa
     2641 aatacaaccc aaattagcga agcacatagc attgtatact tgagaggttg gcgaacaaga
     2701 gggaagcaga gccttcctgc aaaaaccaag gagcacgcac cacaacgaga ccgctgtgac
     2761 cttacgtaaa actgtgaaac tgtgtgtagc agtgggattt ggagactctt acattcagaa
     2821 ggtgcagaaa gaaatcaagt tagactttta aattcctggt gcttgtgccg aagtcgtact
     2881 tcatttacca gcgttaaaat ctcaagtaag gcatctcctc ctgtggtaga acgtgtcagg
     2941 tagagctttc taagtgagct gggatcctga ctcacgtgtc atagacttgt aagagcagca
     3001 gtctctaatc atctcgctgt agactcattg ctgcagagca agtgggaggg gccagagatg
     3061 ggcagtcgcc aggggtggat agcgcggtac acataattct catctgcctg aaagcacact
     3121 tacccataag caaatgcagg cagaactctg attgagctgg tttctgatcc acaggattgc
     3181 ttcttcgatg tacctctttg ccctagctag catttcagtt ttgatactgt agaacgatcc
     3241 tttcaaatta taatcattct gatagaggta ttttaatata catgctttta aaaacaaaac
     3301 aaaaaactac tgtcagtatg aatactgagc cagactggca tatatagatt taacatcttg
     3361 tcctactaag attcttaact gtataaaaat aatatggctt ttagacatat aggatactaa
     3421 tttcaatgag acccttatct ctttattgaa cattatgtta gggacagtaa aagccatgca
     3481 cttacctgct acccattgga aaataaaacg actgtcccca acctaagtaa gtatgaaaat
     3541 taggctagcc ttatttcatc tttaactact aaaagtaagt ctatagaact taaaatttaa
     3601 gcactattag ttgtcatggc tatattttat tttccaaaaa ttaagttaaa agtcattaat
     3661 gtcattgatt atatacatgt atgtttttct aataattaaa atacctttca aatccatgga
     3721 atgtctggct tttaaatgta atttgacctt tttgcttgat ttttttttca tttaagtagc
     3781 tatttatttg taaacatttc tttcctttcc acgatttaaa aacacttcca attgacttta
     3841 aatcctgact taccactttg tatttttgac ctttgggtat ctgttctctg tttaattggt
     3901 gtagaataat gattttaaaa gaaatcccaa gctagtctaa ccaaactcta aatttttaaa
     3961 aaagtactaa gtgagaatga cacaaagatc atcaaagatt gtctttacac taacaacggc
     4021 cgtgaagaaa tggaagacag catagttaag tctactcttt gccatctgag ttgtatcatg
     4081 acatggagac tgcagactcc atcttcagtg ggaccgtggt ctagctttcc tagttccagg
     4141 aaattttctt cacattttat ataactattt aattacaagt tccattgaat tattcgctag
     4201 gcactctttg taacagtagt gtggtgctct ttaaaatatt gatgttagac acgtgtggac
     4261 atcattccct gtgttcattc tctccccatt gatcattagt cttcagcagg ttttatgaaa
     4321 atactgagcc cttagtcatg aactacttta gaaataattt tgctaacaat atattaagta
     4381 ataaaattac ccactttatg tatgcttcat ttttaaattc acatagacaa ttttaaaaaa
     4441 aatcaacggt ttaaatttta ttcccagcta cccaacgtcc tagccagctt ttgaacacag
     4501 attttgttag ccttcaagtt taaacggtgc tgaattgtct taacttgaat gtaaaaatgg
     4561 attaaggttt agctcatggg atacacacat ttaatatatg actgcttgct gtgtagtagg
     4621 ggacatgtca tttggtgtta aattgtctaa aataaagttc agtttctccc a
//
