LOCUS       NM_001286182            4494 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus lysyl oxidase (Lox), transcript variant 3, mRNA.
ACCESSION   NM_001286182
VERSION     NM_001286182.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4494)
  AUTHORS   Coren,L., Zaffryar-Eilot,S., Odeh,A., Kaganovsky,A. and Hasson,P.
  TITLE     Fibroblast diversification is an embryonic process dependent on
            muscle contraction
  JOURNAL   Cell Rep 43 (12), 115034 (2024)
   PUBMED   39636726
REFERENCE   2  (bases 1 to 4494)
  AUTHORS   Stoyell-Conti,F.F., Suresh Kumar,M., Zigmond,Z.M., Rojas,M.G.,
            Santos Falcon,N., Martinez,L. and Vazquez-Padron,R.I.
  TITLE     Gene inactivation of lysyl oxidase in smooth muscle cells reduces
            atherosclerosis burden and plaque calcification in hyperlipidemic
            mice
  JOURNAL   Atherosclerosis 397, 118582 (2024)
   PUBMED   39260002
REFERENCE   3  (bases 1 to 4494)
  AUTHORS   Karagianni,A., Karkempetzaki,A.I., Brooks,D., Matsuura,S.,
            Dambal,V., Trackman,P.C. and Ravid,K.
  TITLE     Deletion of mouse lysyl oxidase in megakaryocytes affects bone
            properties in a sex-dependent manner
  JOURNAL   Blood 143 (25), 2666-2670 (2024)
   PUBMED   38635757
  REMARK    GeneRIF: Deletion of mouse lysyl oxidase in megakaryocytes affects
            bone properties in a sex-dependent manner.
REFERENCE   4  (bases 1 to 4494)
  AUTHORS   Palamakumbura,A.H., Jeay,S., Guo,Y., Pischon,N., Sommer,P.,
            Sonenshein,G.E. and Trackman,P.C.
  TITLE     The propeptide domain of lysyl oxidase induces phenotypic reversion
            of ras-transformed cells
  JOURNAL   J Biol Chem 279 (39), 40593-40600 (2004)
   PUBMED   15277520
  REMARK    GeneRIF: lysyl oxidase functions to inhibit ras-dependent cell
            transformation
REFERENCE   5  (bases 1 to 4494)
  AUTHORS   Contente,S., Csiszar,K., Kenyon,K. and Friedman,R.M.
  TITLE     Structure of the mouse lysyl oxidase gene
  JOURNAL   Genomics 16 (2), 395-400 (1993)
   PUBMED   8100214
REFERENCE   6  (bases 1 to 4494)
  AUTHORS   Chang,Y.S., Svinarich,D.M., Yang,T.P. and Krawetz,S.A.
  TITLE     The mouse lysyl oxidase gene (Lox) resides on chromosome 18
  JOURNAL   Cytogenet Cell Genet 63 (1), 47-49 (1993)
   PUBMED   8095446
REFERENCE   7  (bases 1 to 4494)
  AUTHORS   Mock,B.A., Contente,S., Kenyon,K., Friedman,R.M. and Kozak,C.A.
  TITLE     The gene for lysyl oxidase maps to mouse chromosome 18
  JOURNAL   Genomics 14 (3), 822-823 (1992)
   PUBMED   1358813
REFERENCE   8  (bases 1 to 4494)
  AUTHORS   Kenyon,K., Contente,S., Trackman,P.C., Tang,J., Kagan,H.M. and
            Friedman,R.M.
  TITLE     Lysyl oxidase and rrg messenger RNA
  JOURNAL   Science 253 (5021), 802 (1991)
   PUBMED   1678898
REFERENCE   9  (bases 1 to 4494)
  AUTHORS   Starcher,B.C., Madaras,J.A. and Tepper,A.S.
  TITLE     Lysyl oxidase deficiency in lung and fibroblasts from mice with
            hereditary emphysema
  JOURNAL   Biochem Biophys Res Commun 78 (2), 706-712 (1977)
   PUBMED   20889
REFERENCE   10 (bases 1 to 4494)
  AUTHORS   Rowe,D.W., McGoodwin,E.B., Martin,G.R. and Grahn,D.
  TITLE     Decreased lysyl oxidase activity in the aneurysm-prone, mottled
            mouse
  JOURNAL   J Biol Chem 252 (3), 939-942 (1977)
   PUBMED   14140
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK164634.1, AC109203.9 and
            BQ033730.1.
            
            Summary: This gene encodes a precursor protein that belongs to the
            lysyl oxidase family of proteins. The secreted proprotein is
            proteolytically processed to an active mature peptide and a
            propeptide. This propeptide is thought to function in tumor
            suppression by inhibiting the Ras signaling pathway. The active
            enzyme plays a role in cross-linking of collagen and elastin and is
            essential for development of cardiovascular and respiratory
            systems, and development of skin and connective tissue. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Oct 2013].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1104              AK164634.1         2-1105
            1105-1105           AC109203.9         6428-6428
            1106-4468           AK164634.1         1107-4469
            4469-4494           BQ033730.1         1-26                c
FEATURES             Location/Qualifiers
     source          1..4494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 28.22 cM"
     gene            1..4494
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /note="lysyl oxidase"
                     /db_xref="GeneID:16948"
                     /db_xref="MGI:MGI:96817"
     exon            1..37
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            38..687
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1310
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /EC_number="1.4.3.13"
                     /note="protein-lysine 6-oxidase; ras excision protein"
                     /codon_start=1
                     /product="protein-lysine 6-oxidase preproprotein"
                     /protein_id="NP_001273111.1"
                     /db_xref="CCDS:CCDS50289.1"
                     /db_xref="GeneID:16948"
                     /db_xref="MGI:MGI:96817"
                     /translation="MRFAWAVLLLGPLQLCPLLRCAPQTPREPPAAPGAWRQTIQWEN
                     NGQVFSLLSLGAQYQPQRRRDPSATARRPDGDAASQPRTPILLLRDNRTASTRARTPS
                     PSGVAAGRPRPAARHWFQAGFSPSGARDGASRRAANRTASPQPPQLSNLRPPSHIDRM
                     VGDDPYNPYKYSDDNPYYNYYDTYERPRPGSRNRPGYGTGYFQYGLPDLVPDPYYIQA
                     STYVQKMSMYNLRCAAEENCLASSAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRP
                     RYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFAC
                     TAHTQGLSPGCYDTYAADIDCQWIDITDVQPGNYILKVSVNPSYLVPESDYTNNVVRC
                     DIRYTGHHAYASGCTISPY"
     exon            688..796
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            797..934
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1091
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1187
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1303
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..4477
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4451..4456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /note="hexamer: AATAAA"
     polyA_site      4471
                     /gene="Lox"
                     /gene_synonym="rrg; TSC-160"
                     /note="major polyA site"
ORIGIN      
        1 atgttcggcc cagattaagt cgagtgtgtc tcaggatcca cgtcctcccc gagaagggac
       61 gagccgggag caccatgcgt ttcgcctggg ctgtgctcct tctggggcca ctgcagcttt
      121 gtccccttct ccgctgcgcc ccgcagaccc cgcgcgagcc gcccgccgcc cctggtgcct
      181 ggcgccagac aatccaatgg gagaacaacg ggcaggtgtt cagtctgctg agcctcgggg
      241 cgcagtacca gcctcagcga cgccgcgacc ccagtgccac tgcccggaga cccgacggcg
      301 acgcagcctc gcagccgcgc acgcccattc ttctgctgcg tgacaaccgc accgcctcta
      361 cccgtgcgag gacgccaagc ccgtctgggg tcgccgcggg tcgtccccgg cccgccgccc
      421 gccactggtt ccaagctggt ttctcgccgt cgggggctcg cgatggagcc tcacggcgcg
      481 cggcgaaccg gactgcatcg ccacagcctc cgcagctcag taatctgagg ccacccagcc
      541 acatagatcg catggtgggc gacgacccct acaatcccta caagtactcc gacgacaacc
      601 cctattataa ctactatgac acgtatgaga ggccccggcc cgggagcagg aaccgacctg
      661 gatacggcac cggttacttc cagtacggtc tcccggacct ggtgcccgac ccctactaca
      721 tccaggcttc cacgtacgtc cagaagatgt ctatgtacaa cctgagatgc gctgcggaag
      781 aaaactgcct ggccagttca gcatataggg cggatgtcag agactatgac cacagggtac
      841 tgctacgatt tccgcaaaga gtgaagaacc aagggacatc ggacttctta ccaagccgcc
      901 ctcggtactc ctgggagtgg cacagctgtc accaacatta ccacagcatg gacgaattca
      961 gccactatga cctgcttgat gccaacacac agaggagagt ggctgaaggc cacaaagcaa
     1021 gcttctgtct ggaggacacg tcctgtgact atgggtacca caggcgcttt gcgtgcactg
     1081 cacacacaca gggattgagt cctggatgtt atgacaccta tgcggcagac atagactgcc
     1141 agtggattga tattacagat gtacaacctg gaaactacat tctaaaggtc agtgtaaacc
     1201 ccagctacct ggtgcctgaa tcagactaca ctaacaatgt tgtacgctgt gacattcgct
     1261 acacaggaca tcatgcctat gcctcaggct gcacaatttc accgtattag aaagaagccc
     1321 agttcccagt ggataaagcc gtacctggtg tttggacata tggaaactat agattagctt
     1381 aagtaggaag gacttacata ttttaaaaga caaacagtaa acaacaaagg aggttttgtt
     1441 tggactcttt cgcaacaaat gacataactg gattttgagt gtttaaacca acaatatttg
     1501 gcaaatttta aatccttact catgttattt tgtgaattag cagtgtttca attctgtggg
     1561 tgcatagtgg gctctttcaa agaactctga atttcttatg ttcttttgaa attatagtgc
     1621 aaatgagaaa ttgatatttt aatgagtgag ccacaatttg aacggattct tttctaaagt
     1681 gctgaaacca gtgaaacaat gatgatgagc ctatatttgc ctcgacttag attgattttt
     1741 taaaaaggtg tccctattgt gtaaacagaa atggatacac ttggtgctga ggaagggcca
     1801 aacatctaac tattgttgtc atgaagtata atcagaaaga tggcgatata tgtattcaga
     1861 tagttacatc cctatataaa attatgttta cattttagag ttactagaca atttcctttc
     1921 tcttaattgc ttaatttcac tctgacttga gtcaacttgt tttggaatga attggaaaat
     1981 tccaagatcc tgtttgatac ttgttgctat tcgatcccac gctgcttagc ttttctgtgg
     2041 gcagaaatgt ctaatgtgac aatcagcaca tccccattgt gaggtttcac ggcataggga
     2101 aatcattccg atgaccaaca gctgtgatca gtggagagct aacatgccct gcagcatatt
     2161 ttactgttag ccagaattaa gtcactgctg acacagcaat tatacaagga atctctaaca
     2221 tcacaatcat ctttcaaata ctgtcaaaag aaaatactgg aaaacctttt agattttttt
     2281 ttcaactcta ctacacttct gaaatgttca gctattaagg agaatgttga atttatatat
     2341 atataaaacc atccgtaata gatgacctac tgtgtgcaat gcagcaccat catcttagac
     2401 tcttcaggag ttgggtatat acgtttttgt gtatttacaa aatacaaccc aaattagcga
     2461 agcacatagc attgtatact tgagaggttg gcgaacaaga gggaagcaga gccttcctgc
     2521 aaaaaccaag gagcacgcac cacaacgaga ccgctgtgac cttacgtaaa actgtgaaac
     2581 tgtgtgtagc agtgggattt ggagactctt acattcagaa ggtgcagaaa gaaatcaagt
     2641 tagactttta aattcctggt gcttgtgccg aagtcgtact tcatttacca gcgttaaaat
     2701 ctcaagtaag gcatctcctc ctgtggtaga acgtgtcagg tagagctttc taagtgagct
     2761 gggatcctga ctcacgtgtc atagacttgt aagagcagca gtctctaatc atctcgctgt
     2821 agactcattg ctgcagagca agtgggaggg gccagagatg ggcagtcgcc aggggtggat
     2881 agcgcggtac acataattct catctgcctg aaagcacact tacccataag caaatgcagg
     2941 cagaactctg attgagctgg tttctgatcc acaggattgc ttcttcgatg tacctctttg
     3001 ccctagctag catttcagtt ttgatactgt agaacgatcc tttcaaatta taatcattct
     3061 gatagaggta ttttaatata catgctttta aaaacaaaac aaaaaactac tgtcagtatg
     3121 aatactgagc cagactggca tatatagatt taacatcttg tcctactaag attcttaact
     3181 gtataaaaat aatatggctt ttagacatat aggatactaa tttcaatgag acccttatct
     3241 ctttattgaa cattatgtta gggacagtaa aagccatgca cttacctgct acccattgga
     3301 aaataaaacg actgtcccca acctaagtaa gtatgaaaat taggctagcc ttatttcatc
     3361 tttaactact aaaagtaagt ctatagaact taaaatttaa gcactattag ttgtcatggc
     3421 tatattttat tttccaaaaa ttaagttaaa agtcattaat gtcattgatt atatacatgt
     3481 atgtttttct aataattaaa atacctttca aatccatgga atgtctggct tttaaatgta
     3541 atttgacctt tttgcttgat ttttttttca tttaagtagc tatttatttg taaacatttc
     3601 tttcctttcc acgatttaaa aacacttcca attgacttta aatcctgact taccactttg
     3661 tatttttgac ctttgggtat ctgttctctg tttaattggt gtagaataat gattttaaaa
     3721 gaaatcccaa gctagtctaa ccaaactcta aatttttaaa aaagtactaa gtgagaatga
     3781 cacaaagatc atcaaagatt gtctttacac taacaacggc cgtgaagaaa tggaagacag
     3841 catagttaag tctactcttt gccatctgag ttgtatcatg acatggagac tgcagactcc
     3901 atcttcagtg ggaccgtggt ctagctttcc tagttccagg aaattttctt cacattttat
     3961 ataactattt aattacaagt tccattgaat tattcgctag gcactctttg taacagtagt
     4021 gtggtgctct ttaaaatatt gatgttagac acgtgtggac atcattccct gtgttcattc
     4081 tctccccatt gatcattagt cttcagcagg ttttatgaaa atactgagcc cttagtcatg
     4141 aactacttta gaaataattt tgctaacaat atattaagta ataaaattac ccactttatg
     4201 tatgcttcat ttttaaattc acatagacaa ttttaaaaaa aatcaacggt ttaaatttta
     4261 ttcccagcta cccaacgtcc tagccagctt ttgaacacag attttgttag ccttcaagtt
     4321 taaacggtgc tgaattgtct taacttgaat gtaaaaatgg attaaggttt agctcatggg
     4381 atacacacat ttaatatatg actgcttgct gtgtagtagg ggacatgtca tttggtgtta
     4441 aattgtctaa aataaagttc agtttctccc agtttcaaaa aaaaaaaaaa aaaa
//
