LOCUS       NM_008508               1777 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus loricrin cornified envelope precursor protein
            (Loricrin), mRNA.
ACCESSION   NM_008508
VERSION     NM_008508.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Wang,Q., Zeng,S., Liang,Y., Zhou,R. and Wang,D.
  TITLE     ASH2L Mediates Epidermal Differentiation and Hair Follicle
            Morphogenesis through H3K4me3 Modification
  JOURNAL   J Invest Dermatol 144 (11), 2406-2416 (2024)
   PUBMED   38582368
REFERENCE   2  (bases 1 to 1777)
  AUTHORS   Olczak,A., Pieczonka,T.D., Lawicki,S., Lukaszyk,K.,
            Pulawska-Czub,A., Cambier,L. and Kobielak,K.
  TITLE     The overexpression of R-spondin 3 affects hair morphogenesis and
            hair development along with the formation and maturation of the
            hair follicle stem cells
  JOURNAL   Front Physiol 15, 1424077 (2024)
   PUBMED   39351282
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1777)
  AUTHORS   Deng,Z., Carpinelli,M.R., Butt,T., Magor,G.W., Zhao,P.,
            Gillinder,K.R., Perkins,A.C. and Jane,S.M.
  TITLE     Single-cell transcriptomics reveals the cellular identity of a
            novel progenitor population crucial for murine neural tube closure
  JOURNAL   Heliyon 10 (17), e37259 (2024)
   PUBMED   39296075
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1777)
  AUTHORS   Liu,H., Su,P., Li,Y., Hoover,A., Hu,S., King,S.A., Zhao,J.,
            Guan,J.L., Chen,S.Y., Zhao,Y., Tan,M. and Wu,X.
  TITLE     VAMP2 controls murine epidermal differentiation and carcinogenesis
            by regulation of nucleophagy
  JOURNAL   Dev Cell 59 (15), 2005-2016 (2024)
   PUBMED   38810653
REFERENCE   5  (bases 1 to 1777)
  AUTHORS   Kumar,N., Prakash,P.G., Wentland,C., Kurian,S.M., Jethva,G.,
            Brinkmann,V., Mollenkopf,H.J., Krammer,T., Toussaint,C.,
            Saliba,A.E., Biebl,M., Jurgensen,C., Wiedenmann,B., Meyer,T.F.,
            Gurumurthy,R.K. and Chumduri,C.
  TITLE     Decoding spatiotemporal transcriptional dynamics and epithelial
            fibroblast crosstalk during gastroesophageal junction development
            through single cell analysis
  JOURNAL   Nat Commun 15 (1), 3064 (2024)
   PUBMED   38594232
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1777)
  AUTHORS   DiSepio,D., Jones,A., Longley,M.A., Bundman,D., Rothnagel,J.A. and
            Roop,D.R.
  TITLE     The proximal promoter of the mouse loricrin gene contains a
            functional AP-1 element and directs keratinocyte-specific but not
            differentiation-specific expression
  JOURNAL   J Biol Chem 270 (18), 10792-10799 (1995)
   PUBMED   7738016
REFERENCE   7  (bases 1 to 1777)
  AUTHORS   Rothnagel,J.A., Longley,M.A., Bundman,D.S., Naylor,S.L.,
            Lalley,P.A., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            Roop,D.R.
  TITLE     Characterization of the mouse loricrin gene: linkage with
            profilaggrin and the flaky tail and soft coat mutant loci on
            chromosome 3
  JOURNAL   Genomics 23 (2), 450-456 (1994)
   PUBMED   7835895
REFERENCE   8  (bases 1 to 1777)
  AUTHORS   Byrne,C., Tainsky,M. and Fuchs,E.
  TITLE     Programming gene expression in developing epidermis
  JOURNAL   Development 120 (9), 2369-2383 (1994)
   PUBMED   7525178
REFERENCE   9  (bases 1 to 1777)
  AUTHORS   Yoneda,K., Hohl,D., McBride,O.W., Wang,M., Cehrs,K.U., Idler,W.W.
            and Steinert,P.M.
  TITLE     The human loricrin gene
  JOURNAL   J Biol Chem 267 (25), 18060-18066 (1992)
   PUBMED   1355480
REFERENCE   10 (bases 1 to 1777)
  AUTHORS   Mehrel,T., Hohl,D., Rothnagel,J.A., Longley,M.A., Bundman,D.,
            Cheng,C., Lichti,U., Bisher,M.E., Steven,A.C., Steinert,P.M. et al.
  TITLE     Identification of a major keratinocyte cell envelope protein,
            loricrin
  JOURNAL   Cell 61 (6), 1103-1112 (1990)
   PUBMED   2190691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163215.4.
            
            On Jan 10, 2022 this sequence version replaced NM_008508.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026781.2, M34398.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC163215.4         12774-12820
            48-1777             AC163215.4         13914-15643
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.14 cM"
     gene            1..1777
                     /gene="Loricrin"
                     /gene_synonym="Lor"
                     /note="loricrin cornified envelope precursor protein"
                     /db_xref="GeneID:16939"
                     /db_xref="MGI:MGI:96816"
     exon            1..47
                     /gene="Loricrin"
                     /gene_synonym="Lor"
                     /inference="alignment:Splign:2.1.0"
     exon            48..1777
                     /gene="Loricrin"
                     /gene_synonym="Lor"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1531
                     /gene="Loricrin"
                     /gene_synonym="Lor"
                     /codon_start=1
                     /product="loricrin"
                     /protein_id="NP_032534.2"
                     /db_xref="CCDS:CCDS17546.1"
                     /db_xref="GeneID:16939"
                     /db_xref="MGI:MGI:96816"
                     /translation="MSHQKKQPTPCPPVGCGKTSGGGGGGGGGGGGGYYSGGGSGCGG
                     GSSGGGSSCGGGGGGSYGGGSSCGGGGGSGGGVKYSGGGGGSSCGGGYSGGGGGSSCG
                     GGYSGGGGGSSCGGGYSGGGGGSSCGGGSYSGGGSSCGGGGGSGGGVKYSGGGGGGGS
                     SCGGGSSGGGGGGSSCGGGSGGGGSYCGGSSGGGSSGGCGGGSGGGKYSGGGGGSSCG
                     GGYSGGGGSSGGSSCGGGYSGGGGSSCGGGGGYSGGGGSSCGGGSSGGGGGGSSQQYQ
                     CQSYGGGSSGGSSCGGRYSGGGGSSCGGGYSGGGGSSCGGGSSGGGSSCGGSGGGGYS
                     GGGGGSCGGGSSGGGGGYYSSQQTSQTSCAPQQSYGGGSSGGGGSCGGGSSGGGGGGG
                     CYSSGGGGSSGGCGGGYSGGGGGCGGGSSGGSGGGCGGGSSGGSGGGCGGGYSGGGGG
                     GSSCGGGSSGGGSGGGKGVPVCHQTQQKQAPTWPCK"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Loricrin"
                     /gene_synonym="Lor"
                     /note="hexamer: AATAAA"
     polyA_site      1777
                     /gene="Loricrin"
                     /gene_synonym="Lor"
                     /note="major polyA site"
ORIGIN      
        1 acatcagcat cacctccttc cctcactcat cttccctggt gcttcagggt aacccttctc
       61 cttaaacaag atgtctcacc agaaaaagca gcccactccc tgccctcctg tgggttgtgg
      121 aaagacctct ggtggaggag gaggcggcgg cggcggcggc ggcggcggct attatagcgg
      181 tggcggctct ggctgcggag gcggctcatc tggaggaggc tctagctgtg gaggcggagg
      241 cggtggttcc tatggaggtg gttccagctg cggcggtgga ggcggctccg gtgggggcgt
      301 caagtactcc ggaggcggcg gtggctctag ctgcggcggc ggctactccg gaggcggtgg
      361 tggctctagc tgcggcggtg gctactctgg gggcggcggc ggctccagct gcggaggtgg
      421 ctactccgga ggcggcggcg gctccagctg cggcggcggc agctactccg ggggtggctc
      481 cagctgtgga ggcggtggcg gctctggtgg gggcgtcaag tactccggag gtggtggcgg
      541 cggcggctct agctgcggcg gcggctcctc cgggggtggc ggcggcggct ccagctgcgg
      601 aggcggatca ggaggcggcg gctcctactg cggaggctcc tctggaggcg gcagctccgg
      661 tggctgcggc ggcggttccg gaggcggcaa gtactctggt ggcggcggtg gctccagctg
      721 cggaggcggc tattccggcg gcggtggaag cagcggcggc tctagctgtg gcggcggcta
      781 ctcaggtggc ggtggatcca gctgcggcgg cggcggcggc tattccggtg gcggcggcag
      841 cagctgcgga ggtggttcct ccggtggcgg cggcggcgga tcgtcccaac agtatcagtg
      901 ccagagctac ggaggcggtt ctagcggtgg ctccagctgc ggcggccgtt actccggggg
      961 cggaggctcc agctgcggtg gcggctactc cgggggcgga ggctctagct gcggaggcgg
     1021 ctcctctggt ggtggctcca gttgcggcgg cagcggcggc ggcggctatt ccggtggtgg
     1081 cggtggcagc tgcggcggcg gctcctctgg cggcggaggg ggctattact cctctcagca
     1141 gaccagtcag acctcctgcg ccccccagca gagctacgga gggggctctt ccggaggagg
     1201 tggtagctgt ggaggtggct cctctggcgg cggtggcggc ggtggctgct actccagcgg
     1261 tggtggcggc agcagcggtg gctgcggtgg aggctactcc ggaggcggcg gtggctgtgg
     1321 cggcggctct tccgggggca gcggcggtgg ctgcggaggt ggctcttccg gaggcagcgg
     1381 cggtggctgc ggaggaggct actccggagg cggaggcggt ggctccagct gcggaggcgg
     1441 ctcctctggt ggcggctctg gaggtggcaa gggtgtgcca gtctgccacc agacccagca
     1501 gaagcaggcg cctacctggc cgtgcaagta aggtcaccgg gttgcaacgg agacaacaga
     1561 gctggaagag ttctccgtgg gcgccgatgg gcttaacttt ctcatgaatt tgcctgaggt
     1621 ttccaaaccc ttcacatttt aagcgcccct tcccccagaa gaagccattg agtcgctcaa
     1681 ggtgtatcct gttctgcaga tttttcatct tggtttctga atgactacct cccaattcta
     1741 gtgtctcctc agtcaataaa tttgctattc atgagaa
//
