LOCUS       NM_001029878            6884 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus LON peptidase N-terminal domain and ring finger 2
            (Lonrf2), mRNA.
ACCESSION   NM_001029878 XM_006496123 XM_355299
VERSION     NM_001029878.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6884)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6884)
  AUTHORS   Li,D., Johmura,Y., Morimoto,S., Doi,M., Nakanishi,K., Ozawa,M.,
            Tsunekawa,Y., Inoue-Yamauchi,A., Naruse,H., Matsukawa,T.,
            Takeshita,Y., Suzuki,N., Aoki,M., Nishiyama,A., Zeng,X.,
            Konishi,C., Suzuki,N., Nishiyama,A., Harris,A.S., Morita,M.,
            Yamaguchi,K., Furukawa,Y., Nakai,K., Tsuji,S., Yamazaki,S.,
            Yamanashi,Y., Shimada,S., Okada,T., Okano,H., Toda,T. and
            Nakanishi,M.
  TITLE     LONRF2 is a protein quality control ubiquitin ligase whose
            deficiency causes late-onset neurological deficits
  JOURNAL   Nat Aging 3 (8), 1001-1019 (2023)
   PUBMED   37474791
  REMARK    GeneRIF: LONRF2 is a protein quality control ubiquitin ligase whose
            deficiency causes late-onset neurological deficits.
REFERENCE   3  (bases 1 to 6884)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124699.4.
            
            On or before Feb 15, 2019 this sequence version replaced
            XM_006496123.3, NM_001029878.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.28744.1,
                                           SRR7652917.264366.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-917               AC124699.4         136283-137199       c
            918-1036            AC124699.4         121659-121777       c
            1037-1159           AC124699.4         118574-118696       c
            1160-1315           AC124699.4         116477-116632       c
            1316-1523           AC124699.4         113725-113932       c
            1524-1620           AC124699.4         113056-113152       c
            1621-1735           AC124699.4         112224-112338       c
            1736-1857           AC124699.4         108348-108469       c
            1858-2016           AC124699.4         107553-107711       c
            2017-2179           AC124699.4         104751-104913       c
            2180-2329           AC124699.4         101163-101312       c
            2330-6884           AC124699.4         94181-98735         c
FEATURES             Location/Qualifiers
     source          1..6884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 17.17 cM"
     gene            1..6884
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /note="LON peptidase N-terminal domain and ring finger 2"
                     /db_xref="GeneID:381338"
                     /db_xref="MGI:MGI:1920209"
     exon            1..917
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..2524
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /codon_start=1
                     /product="LON peptidase N-terminal domain and RING finger
                     protein 2"
                     /protein_id="NP_001025049.2"
                     /db_xref="CCDS:CCDS14900.2"
                     /db_xref="GeneID:381338"
                     /db_xref="MGI:MGI:1920209"
                     /translation="MSPEPAPPEPQGVRRSLEEPPEEPQGQGSAAFLAGDYEVAAELF
                     RSLLAGLAQPERGLCLQLGEALARAGRLPEAIGAFRGAALLGPLQPGELSELASGLAR
                     ALGLREKRPPVAARPSGCASGAPGPVAPRDLLGCPRCGRLLYKPVTLSSGLTVCKRCV
                     EQVPVRAQARRVNVMLSGLLERCFPAECRLRRLACQARGLHRQQQPEAALLRCQQALD
                     MAPDDNSLLLLRAELYLTMKNYDQALQDAEAVCQREPLLTKGHHIKAQILSGLGRHRE
                     VLKEFIYCLALNPECNSAKKETQKVICEVFFSTSESEHQTSTSSTETGPEALCEGQTN
                     PQYPLEEAGGHANADNPKTPSEKSDAPADINSSVLYFILGLHCEEDKKALEGIVPAAP
                     SSTLKRQLPSDAQDDEELKANTPEKIPKKDADSPPQRNASSLEEEPEFTIDATDFECA
                     LCMRLLFEPVTTPCGHTFCLKCLERCLDHAPHCPLCKDKLSELLATRNFNVTVLTEEL
                     IFRYLPDELSDRKRVYDEEMSELSNLTRDVPIFVCAMAFPTVPCPLHVFEPRYRLMIR
                     RCMETGTKRFGMCLSAENAGISEYGCMLEIKDVRTFPDGSSVVDAIGISRFRVLSHRH
                     RDGYNTADIEYLEDEKVEGPEFEELTALHESVYQQSVSWFASLQDHMKKQILSHFGSM
                     PDREPEPQSNSSGPAWSWWILAVLPLERKAQLAILGMASLKERLLAIRRILVIITRKL
                     NSRQEMANNTQRDN"
     exon            918..1036
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1159
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1315
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1523
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1620
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1735
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1857
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2016
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2179
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2329
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..6884
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6857..6862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /note="hexamer: AATAAT"
     polyA_site      6884
                     /gene="Lonrf2"
                     /gene_synonym="2900060P06Rik"
                     /note="major polyA site"
ORIGIN      
        1 aatcaggacg ccggcgctgt gaggtggtcg ccacgctccc acggtcactt ggctgacgtg
       61 agccactggg gcgcgcactg ggacgcgcac ggcgcctcgc acgagccggg gctgggccgc
      121 gtgcgctgcg ctgcgcttcc tccgggcccg tctcgcgtgg tccccacggc tggcagcacc
      181 cggtccgccg acgcgcgtgg ctgacggtga agagggcaga agccgcgctc cggctgccaa
      241 gaatccccgt ctctgcacca tgagtcccga gcccgcgcct ccggagccgc agggcgtgcg
      301 ccgcagcctc gaggagcccc cggaggagcc ccagggacag ggctccgcgg ccttcctcgc
      361 tggcgactac gaagtggcgg ccgagctctt ccgctcgctg ctggccggcc tggcgcagcc
      421 ggagcgcggc ctgtgcttgc agctggggga agcgctggcc cgcgcaggcc gcctgcccga
      481 ggccatcggc gcgttccgcg gcgctgcgct gctcggcccg ctgcagccgg gagagctctc
      541 ggagctggcg agcggcctgg cgcgcgccct gggcctgcgc gagaaacggc cgcctgtggc
      601 ggcgaggccc agcggctgcg cgtccggggc cccggggccc gtggcgccgc gcgacctgct
      661 gggctgtccg cgctgcgggc ggctgctcta caagccggtg acgttgtcca gcgggctcac
      721 ggtgtgcaag cgctgcgtgg agcaggtgcc ggtgcgggcg caggcccggc gcgtgaacgt
      781 gatgctgagc gggctgctgg agaggtgctt ccctgccgag tgtcgcctgc gcaggctggc
      841 gtgccaggcg cgggggctgc atcgccagca gcagcccgag gccgcgctgc tcaggtgcca
      901 gcaggccctg gacatggccc cggatgacaa ctcattattg ctgctgagag ctgagttata
      961 tttaaccatg aagaactatg atcaagccct gcaggatgct gaagcagttt gtcagaggga
     1021 acctctcctg accaaggggc accatataaa agcccagatt ctttctggat tgggaagaca
     1081 tagagaagtg ttaaaggaat ttatctactg ccttgcttta aaccctgagt gcaactcggc
     1141 gaagaaagaa acacagaagg taatatgtga ggtgttcttt tcaacttcag aaagtgagca
     1201 ccaaacctca acatcttcca ctgaaactgg accagaggcc ctgtgtgaag gccagacgaa
     1261 tccccagtat cctctggaag aagcaggcgg tcacgctaat gcagacaatc ctaagactcc
     1321 atctgagaag tcagatgcac ccgcggatat caactcttcg gttttatatt ttattctggg
     1381 cctccactgt gaagaggata aaaaggctct ggaaggcatc gtcccagcgg cacccagcag
     1441 caccttgaag aggcagcttc ccagtgatgc ccaggacgat gaggagctca aagcgaatac
     1501 ccctgagaag attcccaaga aagatgcaga ctccccacct cagaggaatg cgagctcgtt
     1561 agaggaagag ccagagttca caatcgatgc gactgacttt gagtgtgcgc tgtgcatgag
     1621 gctgctcttt gaacctgtca ctacaccctg tggacatacg ttttgcctca aatgccttga
     1681 gcgttgcctg gaccacgccc ctcactgtcc actgtgcaag gacaagcttt ctgagctgtt
     1741 ggcaaccaga aattttaatg taactgttct gactgaagag ctgatattcc gatacttacc
     1801 agatgagtta tctgacagga agagggtcta tgatgaagag atgtcagagc tgtccaatct
     1861 gaccagagat gtgcccatct ttgtgtgtgc catggccttc cctacggttc cttgccctct
     1921 ccatgtgttc gagccccgct accggctcat gataaggaga tgcatggaaa ctggcaccaa
     1981 gcggtttggc atgtgtttat ccgcggagaa cgcagggatt tcagagtatg ggtgcatgtt
     2041 ggagataaag gatgtcagga ctttccctga tggaagctct gttgtggatg caattgggat
     2101 cagccgcttc agagtcctga gccaccgcca ccgagatggc tacaacacgg cggacatcga
     2161 gtacctggag gacgagaagg tggaaggtcc agagtttgaa gaacttaccg ccctccatga
     2221 gtctgtttac cagcagtctg tgtcctggtt tgcttcactc caggatcaca tgaagaaaca
     2281 aattcttagc cattttgggt cgatgccaga cagggagcca gagccacaga gcaattctag
     2341 tggccctgcc tggtcctggt ggattctggc cgtgttgccc ttggaacgca aggctcaact
     2401 ggccattctc ggcatggcct ccctgaaaga gcgtcttctg gccattcgac gaatattagt
     2461 catcattaca cgtaagctga atagtcgcca agaaatggct aacaacacac agagagataa
     2521 ttgattttcc tctagattaa ggttgccgga agccccagtg tttttgagtt ccagaaactg
     2581 acaaataccc gtcctcttcg gcgcactttg taaaatcttg tcaatgtggt ggtaagtggg
     2641 acatttgcca aatactgaat ttctcatgca gtagaagtct atctgctaga cttggacact
     2701 gtgcaagatt cgactgaagt tcaagtagac ggtacaggtg agaaatcctt gagaatctct
     2761 tccgagcaga tgcttcagga ctacagcttg ctacagtatg ggacgttcac atgggtgaca
     2821 tgtgacttcg gtatcaaagg tgatacaatc ctagctagta tctcgatgtg ataggtggac
     2881 aatgcgagtg ccagtgttta gacagtgagt gggaacagac atattaagat ataagcaagc
     2941 caaaactgga cttgggttct gtgtgtcgcc gtgaacttgt ttgcaaaatt aatgaactga
     3001 atcactatcc agcccttacc gaagaattaa gttattaccg ggcagagccg tgtttgtgtt
     3061 tcgtgtcctg ctgtaacccc gggtgttgta aattgcatgt tgtaattaaa tgaatgtaaa
     3121 actacaagaa gatgtatctt acatatagaa aagtctgagg attgccagta ttttgagaat
     3181 atatattcat aaacactcca gaagggtagt caaaaatgag ttaagagatg tgtgtccatt
     3241 gggatgtcaa acttacagcc aaacgcattg taaacaaagt tttatcttta ttcaactggg
     3301 gaatttccat cagataatga taagtgcaac tcccaacctc cagtgcatgt tgggaatgtc
     3361 atttggaata acccagacat tcttgccgcc gcctgagcag ctggtgcgga cagcctgcta
     3421 cttagtctgt aagatgtgca tctgactgac aataccctgc tgagctgatc tcagcggcac
     3481 cttctgcttt cttcattcaa ggtgtgtggg tttaatttaa atgtatattt tatgatacaa
     3541 aatgttgatg gcttatcaac ccatcaggca ttttattaga aagccgtaag atcagagcaa
     3601 tgttgatttt attgttcttt tcagtaactg aaactcagct tcaccatggg actttgaata
     3661 aaaacacgca tctcatttac tatgaacctt tgacttcacc cttgagaggg gataaaagcc
     3721 cttttgagca agacattcca cgcattaaga gttcaactct atttagcatt tatgacatca
     3781 tctgaccact taaaactgta actcttgtga cagaaatcct tgactagagt ttgctcatgg
     3841 cagttaatgg gttttgaatt attctttttc tttttggggg ggaaaaagta ggaattggta
     3901 ttgttactgt ttctgtacgg aagtgtctat ccagtgtgaa catagcttct ccacgactct
     3961 actggaagtt ttgtctgtgc tgagttagtg ttggggaggt tttctcctac ctgctgacgt
     4021 gttagctttt ataacttacc gagttcagaa ccattatgct gctcttcctg gttctgtcca
     4081 cctctttttt cccctcagtg ttcttacgta aaagccccca tggcagtgat gctaaggaga
     4141 acaacacaag tttttgggat tcagtgccga agagaacgtg gcatgattgt cacgttctct
     4201 gttacacatt gcactgttgg gagcagacca gtagtcactg ggtactttta ggggattctt
     4261 ggttattgga caatttcagt agcacaacag ttaaaagtac cacgttctct ctgaactgta
     4321 ctgggtgtcg atttataaat ggcagctaac aatgaatacc attgagagag aagtttactg
     4381 ttccagacaa agagaggctc atggcctaga ttctgtgaga agcagttatg tcaggcggct
     4441 aggagtgcag gtgattctca ggctccattg tatgggtttc agttttaaca gtgatggatt
     4501 gtaacagcag caggcagcag aagagaccct gactacccac caagcccttt cttgatggca
     4561 tcatactaga tgtgcaaaac cctgttttcc agaattacag acaactccag agcgcctgtg
     4621 ctagctgtgt ggctgtgtaa aatgcctccc aatccattgt tattcctaga acaaactgga
     4681 gcaagctctt tggtctgagc caactaagaa tttagagttt ctttcttcat ggctctaact
     4741 gggttgcagc agctcgttct gagcaagtat gcactctagg aagaaagaaa ctctgtaagt
     4801 cagcagacca ggtcagcgga gcccatgctg ggcttaagca gtaactcccc caccttcccc
     4861 aaccacggtt aggagtagca gggtttagta catttccgta gtttgtatgg agattagaag
     4921 gagacaaagg atttccaaag atgctatgtt tgactggaac gcagcaggca gggtttccac
     4981 agactgcaaa gcatagaaga aaaacccatt ccctaaagct gaggtagaag aggcccctcc
     5041 ctatcagttg acagtaaccc cagtggctgc tcctgcttct aatgaggaca tcccttaagg
     5101 ccaagtgcac agtacacagt ggtcctctgc tctccactcc catactgcct aacagcttct
     5161 gtttcctgat ggttatgcct agtgtaattt ggaagttgaa tagctggggt tgattacata
     5221 gtcagcttca tctggcccaa agctcctcac ccttactttc aaggccaagg ttcatagtga
     5281 gttcctacaa gagtggggct gttaacagac ttgaacctgt cgtatcccgc agaatccaaa
     5341 aggatgctta ccttttgtta caggccagag aaaactcaaa tagtttctga ttctcttggg
     5401 tgagacagga attccatcag ccttcacaca gcccctcatt ggtgtgtttt tttttttttc
     5461 tttttcccct tggtacctat tggcattctg taaatcacac tatgtggtgg tctgagtcat
     5521 tttcagactc ctcttcacgg ggagagcata gcaacagacc agctgcacac tggaatcaca
     5581 gagcagccag gccccatcgc agtgcctgaa aagacaagat ggagctgtag tagacctctg
     5641 tgccatggtc caggtgtgct ggtggctttt ccaagaaaag actttctctg tgtggatgtt
     5701 taaatgagaa atgcacacac atgcagactc tagtatctga acacttgatc tgcacttcgt
     5761 gccactattt ggctgacatt atggaggctt tagcaggtgc agccttgctg gagtatgcat
     5821 gtccctgggg gtggactttt gagagtttat cgatttgccc cacttggagt tgctctctgt
     5881 gcttcacgtt ggctgttgaa gatgtgacct ctcggcttcc tgctctggct ccttgttgcc
     5941 atgactcccg taccatatgg gctggcgcat gcactctctc ttctctctct ctctgtctct
     6001 ctctcctctc tctctcttct ctctctctct ctctctctct ctctctctct ctctctctct
     6061 ctctctctct ctctctctct ctctctctct ctcagccatg gtgtttatca gagccaacag
     6121 gagagtacgc agtgcacctt cacaactgga atatgacgga aagctggaca aagcttgagt
     6181 actgtgaacc atgttgaaac ccttggtaag tctttgcttt gtctgcttcc gctggggtcc
     6241 ccactgcaga cagcactgtt ttcgaagtag actttccacc ctgtaaagct atttccttga
     6301 ccagcattcc ttccatacag cttataccgc aacacacttt tgtccactga gctttggaaa
     6361 aagtggctaa tcggtaggtt gcaaagctgc ctagtcctgc ctcgttcact tgtgatactt
     6421 accacctgac ttaccttaca gctgatttac taagtcctgc ctcgttcact tgtgatattt
     6481 accacctgac ttaccttaca gctgacttag tacccgtgaa atgattggta ccacttgagc
     6541 attgtgaata atttttcttt atttagaaca ggtttgaaca agttaagtct ctatcaatta
     6601 acattatgtg tcttgcctct ttagaggtca gtagtgatgt ggaatattca cccagcttcg
     6661 cgctctcatt gggacaaaga tgcgagtagc aacatttggc atttgttgtt tcttacacaa
     6721 gactggtttt taaatgttgc aaatgtttac ttcattgtat tcttttccct gtccatttca
     6781 actcattgaa attgtgtatc taatatgtga tatttggact agataaaacg taaagtgttg
     6841 taaatgtttt caaataaata atcactccca gataacaagg tgaa
//
