LOCUS       NM_025827               2936 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus lon peptidase 2, peroxisomal (Lonp2), transcript
            variant 1, mRNA.
ACCESSION   NM_025827 XM_001000506 XM_001000516 XM_001000539 XM_001000552
            XM_001000568
VERSION     NM_025827.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2936)
  AUTHORS   McLachlan,S., Lee,S.M., Steele,T.M., Hawthorne,P.L., Zapala,M.A.,
            Eskin,E., Schork,N.J., Anderson,G.J. and Vulpe,C.D.
  TITLE     In silico QTL mapping of basal liver iron levels in inbred mouse
            strains
  JOURNAL   Physiol Genomics 43 (3), 136-147 (2011)
   PUBMED   21062905
REFERENCE   2  (bases 1 to 2936)
  AUTHORS   Sajedi,E., Gaston-Massuet,C., Andoniadou,C.L., Signore,M.,
            Hurd,P.J., Dattani,M. and Martinez-Barbera,J.P.
  TITLE     DNMT1 interacts with the developmental transcriptional repressor
            HESX1
  JOURNAL   Biochim Biophys Acta 1783 (1), 131-143 (2008)
   PUBMED   17931718
REFERENCE   3  (bases 1 to 2936)
  AUTHORS   Kikuchi,M., Hatano,N., Yokota,S., Shimozawa,N., Imanaka,T. and
            Taniguchi,H.
  TITLE     Proteomic analysis of rat liver peroxisome: presence of
            peroxisome-specific isozyme of Lon protease
  JOURNAL   J Biol Chem 279 (1), 421-428 (2004)
   PUBMED   14561759
REFERENCE   4  (bases 1 to 2936)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132147.4 and BC049090.1.
            
            On Dec 12, 2009 this sequence version replaced NM_025827.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049090.1, AK151103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC132147.4         77706-77769         c
            65-2936             BC049090.1         1-2872
FEATURES             Location/Qualifiers
     source          1..2936
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 42.1 cM"
     gene            1..2936
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /note="lon peptidase 2, peroxisomal"
                     /db_xref="GeneID:66887"
                     /db_xref="MGI:MGI:1914137"
     exon            1..373
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2699
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /EC_number="3.4.21.53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal Lon protease homolog 2; lon protease homolog
                     2, peroxisomal; lon protease 2; lon protease-like protein
                     2"
                     /codon_start=1
                     /product="lon protease homolog 2, peroxisomal isoform 1"
                     /protein_id="NP_080103.1"
                     /db_xref="CCDS:CCDS22503.1"
                     /db_xref="GeneID:66887"
                     /db_xref="MGI:MGI:1914137"
                     /translation="MSSVSPIQIPSRLPLLLTHESVLLPGSTMRTSVDTARNLQLVRS
                     RLLKGTSLQSTILGVIPNTPDPASDTQDLPPLHRIGTAALAVQVVGSNWPKPHYTLLI
                     TGLCRFQIVQVLKEKPYPVAEVEQLDRLEEFPNICKSREELGELSEQFYRYAVQLVEM
                     LDMSVPAVAKLRRLLDNLPREALPDILTSIIRTSNKEKLQILDAVSLEDRFKMTIPLL
                     VRQIEGLKLLQKTRKPKQDDDKRVIAIRPIRRIPHIPGTLEDEEEEEDNDDIVMLEKK
                     IRTSSMPEQAHKVCVKEIKRLKKMPQSMPEYALTRNYLELMVELPWNKSTTDRLDIRA
                     ARILLDNDHYAMEKLKRRVLEYLAVRQLKNNLKGPILCFVGPPGVGKTSVGRSVAKTL
                     GREFHRIALGGVCDQSDIRGHRRTYVGSMPGRIINGLKTVGVNNPVFLLDEVDKLGKS
                     LQGDPAAALLEVLDPEQNHNFTDHYLNVAFDLSQVLFIATANTTATIPPALLDRMEII
                     QVPGYTQEEKIEIAHRHLIPKQLEQHGLTPQQIQIPQHTTLAIITRYTREAGVRSLDR
                     KFGAICRAVAVKVAEGQHKEAKLDRSDVADGEGCKEHVLEDAKPESISDTADLALPPE
                     MPILIDSHALKDILGPPLYELEVSERLSQPGVAIGLAWTPLGGKIMFVEASRMDGEGQ
                     LTLTGQLGDVMKESAHLAISWLRSNAKKYHLTNAFGSFDLLDNTDIHLHFPAGAVTKD
                     GPSAGVTIVTCLASLFSGRLVRSDVAMTGEITLRGLVLPVGGIKDKVLAAHRAGLKQI
                     IIPQRNEKDLEEIPSNVRQDLSFVTASCLDEVLNAAFDGGFPVKTRPGLIDSKL"
     exon            374..608
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            609..740
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            741..863
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1027
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1122
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1381
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1523
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1674
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1801
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1935
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2078
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2286
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2477
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2864
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /note="hexamer: AATAAA"
     polyA_site      2864
                     /gene="Lonp2"
                     /gene_synonym="1300002A08Rik; Lonp"
                     /note="major polyA site"
ORIGIN      
        1 ggaaggggcg gtgccggaag cggcggcact caggcctggg ggcgggccgt cgagtgacgg
       61 ctgcggtgcg ttcggcgaag gaagtgtaga gttcgtactt gggagtcctc ctgacacctc
      121 tggtgttgac gaccgtggcc atgtcctccg tgagccccat ccagatcccc agccgccttc
      181 cgctgctgtt gacccacgag agtgtgttgc tgcctggctc cactatgcgc acaagtgtgg
      241 acacggcccg caacttgcag ctggtgcgga gccgcttgct caagggcacg tcgttgcaga
      301 gcaccattct aggagtcatc cccaacacac ccgacccggc cagcgacacg caggacctgc
      361 caccattgca cagaattgga acggctgccc tggcagttca ggttgtgggc agtaattggc
      421 ccaaaccaca ctacacttta ctgatcacag gcctgtgccg gttccagatt gtgcaggtct
      481 taaaagagaa gccatatccc gtggctgaag tggagcagct ggaccgactt gaggaatttc
      541 ccaatatctg caaaagcagg gaggagctgg gagagctgtc agagcaattc tacagatacg
      601 cagtgcagtt ggttgaaatg ttggatatgt ccgtccctgc agttgctaaa ttgagacgtc
      661 ttttagataa tcttccaagg gaagctctac cagacattct aacttcaatt attcgaacaa
      721 gcaacaaaga gaagctccag atcttagatg ccgtgagcct ggaggatcgg ttcaagatga
      781 ccatacctct gcttgttaga cagattgaag gtctgaaatt acttcagaag actcgcaaac
      841 ctaaacaaga tgacgacaag agggttatag caatacgccc catcaggagg attccacaca
      901 tcccaggaac tttagaagat gaggaggagg aagaagataa tgatgacatt gtcatgctgg
      961 agaaaaaaat aagaacatct agtatgccag aacaggctca taaagtctgt gtcaaggaga
     1021 taaaaagact caaaaaaatg cctcagtcaa tgcctgaata tgctctgact agaaattatt
     1081 tggaacttat ggtggagctt ccttggaaca aaagtacaac tgatcgcctg gacattcggg
     1141 cagcccggat tcttctggac aatgaccatt atgccatgga aaaactgaag aggagggttt
     1201 tggaatactt ggctgtgaga caactgaaaa ataacttgaa gggcccaatc ctctgttttg
     1261 ttggcccgcc tggagtaggc aaaacaagtg tggggagatc cgtggccaag actctgggtc
     1321 gggagttcca caggattgca cttgggggtg tgtgtgacca gtctgacatt cgagggcaca
     1381 ggcggaccta tgtgggcagt atgcctggtc gtatcatcaa tggcttgaag accgttgggg
     1441 ttaacaatcc agtgttccta ttggatgagg ttgacaagct ggggaaaagc ctgcaggggg
     1501 atcctgcagc tgcgctgctt gaggtgttgg atcctgaaca aaaccataac ttcacagatc
     1561 actatctaaa tgtggccttt gacctttccc aagttctttt catagcaact gccaacacca
     1621 ctgctactat tccacctgct ttgctggaca ggatggagat cattcaggtt ccagggtaca
     1681 cacaggagga gaagatagag attgcccaca ggcacctgat ccctaagcag ctggagcagc
     1741 acggtctgac tcctcagcag attcagatcc cccagcacac cactctggcc atcattacca
     1801 gatacaccag agaagcagga gtccgttctc tggacagaaa gtttggggct atttgccgtg
     1861 ctgtggcagt gaaagttgca gaaggccagc ataaggaagc caagctggac cgttcggatg
     1921 tggctgatgg agaaggttgc aaagaacatg tgctggaaga tgcaaaacct gaatccatca
     1981 gtgacactgc agacttggcc ctgccacctg aaatgccaat tctgatcgac tcccatgccc
     2041 tgaaagacat cctggggcca ccactgtatg agctggaggt atctgagcgt ttgagtcaac
     2101 ctggagtggc aatagggtta gcatggactc ccttgggtgg caaaatcatg tttgtggaag
     2161 caagtagaat ggacggtgaa ggccaactaa cactgaccgg ccagcttggg gacgtcatga
     2221 aggagtctgc ccatctcgcc attagctggc ttcgaagcaa tgcaaagaaa taccacctga
     2281 ctaatgcttt tggaagtttt gatcttcttg acaacacaga catccatctg cacttcccag
     2341 ctggagctgt cacaaaagat ggaccatctg ctggtgttac catagtaact tgtctcgcct
     2401 cacttttcag tgggcggctt gtgcgctcag atgtagccat gactggggaa attacgctga
     2461 gagggcttgt tcttccagtg ggtggaatta aagacaaagt cctagcagca caccgagcag
     2521 gactgaagca gatcataatt ccgcagagga acgaaaagga ccttgaagag atcccaagca
     2581 acgtcagaca ggatctaagt tttgttacag caagctgcct ggatgaagtt ctaaatgcag
     2641 cttttgatgg tggctttcct gtcaagacca gacctggtct cattgacagc aaactatagg
     2701 cccgaacata agctgaattt aattatgagg caaagcttgt ttgaggcacc aaatgatcaa
     2761 gcaaaatatc cctaatctgt ggatataatc aagatagcaa tgagtctgtt taagtagttg
     2821 tttattacag aaatgttggc ttaataaagt cattaaacct agaaaaaaaa aaaaaaaaaa
     2881 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
