LOCUS       NM_028782               2970 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus lon peptidase 1, mitochondrial (Lonp1), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_028782 XM_128721
VERSION     NM_028782.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2970)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Alexander,L.E.C., Borok,Z., Shen,Y.,
            Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   2  (bases 1 to 2970)
  AUTHORS   Zhu,W., Tan,C. and Zhang,J.
  TITLE     Aging of alveolar type 2 cells induced by Lonp1 deficiency
            exacerbates pulmonary fibrosis
  JOURNAL   Biomol Biomed 24 (5), 1258-1272 (2024)
   PUBMED   38625722
  REMARK    GeneRIF: Aging of alveolar type 2 cells induced by Lonp1 deficiency
            exacerbates pulmonary fibrosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2970)
  AUTHORS   Zhang,C., Shen,S., Xu,L., Li,M., Tian,B., Yao,L. and Zhu,X.
  TITLE     LONP1 alleviates ageing-related renal fibrosis by maintaining
            mitochondrial homeostasis
  JOURNAL   J Cell Mol Med 28 (17), e70090 (2024)
   PUBMED   39261902
  REMARK    GeneRIF: LONP1 alleviates ageing-related renal fibrosis by
            maintaining mitochondrial homeostasis.
REFERENCE   4  (bases 1 to 2970)
  AUTHORS   Shen,T., Wang,S., Huang,C., Zhu,S., Zhu,X., Li,N., Wang,H.,
            Huang,L., Ren,M., Han,Z., Ge,J., Chen,Z. and Ouyang,K.
  TITLE     Cardiac-specific deletion of heat shock protein 60 induces
            mitochondrial stress and disrupts heart development in mice
  JOURNAL   Biochem Biophys Res Commun 710, 149883 (2024)
   PUBMED   38588611
REFERENCE   5  (bases 1 to 2970)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2970)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 2970)
  AUTHORS   Lu,B., Liu,T., Crosby,J.A., Thomas-Wohlever,J., Lee,I. and
            Suzuki,C.K.
  TITLE     The ATP-dependent Lon protease of Mus musculus is a DNA-binding
            protein that is functionally conserved between yeast and mammals
  JOURNAL   Gene 306, 45-55 (2003)
   PUBMED   12657466
REFERENCE   8  (bases 1 to 2970)
  AUTHORS   Bota,D.A., Van Remmen,H. and Davies,K.J.
  TITLE     Modulation of Lon protease activity and aconitase turnover during
            aging and oxidative stress
  JOURNAL   FEBS Lett 532 (1-2), 103-106 (2002)
   PUBMED   12459471
  REMARK    GeneRIF: Modulation of Lon protease activity during aging and
            oxidative stress.
REFERENCE   9  (bases 1 to 2970)
  AUTHORS   Zhu,Y., Wang,M., Lin,H., Huang,C., Shi,X. and Luo,J.
  TITLE     Epidermal growth factor up-regulates the transcription of mouse lon
            homology ATP-dependent protease through extracellular
            signal-regulated protein kinase- and
            phosphatidylinositol-3-kinase-dependent pathways
  JOURNAL   Exp Cell Res 280 (1), 97-106 (2002)
   PUBMED   12372343
  REMARK    GeneRIF: Epidermal growth factor up-regulates the transcription of
            ATP-dependent protease through extracellular signal-regulated
            protein kinase- and 1-phosphatidylinositol 3-kinase-dependent
            pathways.
REFERENCE   10 (bases 1 to 2970)
  AUTHORS   Burks,D.J., Wang,J., Towery,H., Ishibashi,O., Lowe,D., Riedel,H.
            and White,M.F.
  TITLE     IRS pleckstrin homology domains bind to acidic motifs in proteins
  JOURNAL   J Biol Chem 273 (47), 31061-31067 (1998)
   PUBMED   9813005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY247676.1, AK160071.1 and CK428749.1.
            
            On Oct 13, 2006 this sequence version replaced NM_028782.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004820.1, AK131910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               BY247676.1         2-192
            192-2963            AK160071.1         177-2948
            2964-2970           CK428749.1         97-103
FEATURES             Location/Qualifiers
     source          1..2970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.42 cM"
     gene            1..2970
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /note="lon peptidase 1, mitochondrial"
                     /db_xref="GeneID:74142"
                     /db_xref="MGI:MGI:1921392"
     exon            1..423
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            424..512
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            513..632
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            633..867
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            868..929
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1059
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1143
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1364
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1503
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1682
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1770
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1893
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2010
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2151
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2317
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2535
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2700
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2967
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2950..2955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /note="hexamer: AAGAAA"
     polyA_site      2967
                     /gene="Lonp1"
                     /gene_synonym="1200017E13Rik; LON; Prss15"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggtgc gccgtcagta tggctgttcc atggcggcga gcacaggcta cgtgcggctc
       61 tgggccgctg cgcggtgctg ggttctgcgg cggccgctgc tggctgtcac cggaggccgg
      121 gtcccgagcg cgtccgggtc gtggctgcgc cgaggatgtc gggcctgcga catgtcagct
      181 ccctggggcg gccgcgttct tcccggcggg gtccagtggc gggggctgtg ggactcgggc
      241 aaccgcggtg gcagcgacga gacctccgag ggcggtgcgg aggacggggc cacggcgagc
      301 accggggaag gcccggtcgt cacagcgctc gcgcccatga ccgtcccgga tgtgtttcct
      361 cacctgccgc tcatcgccat cacccgcaac cctgtgttcc cgcgctttat caagatcgtg
      421 gaggttaaaa ataagaagtt ggttgagctc ctgagaagga aagtccgact tgcacagccc
      481 tatgttggcg tcttcctaaa gagagatgac aacaatgagt cggacgtggt ggagagcctg
      541 gatgaaatct accatacggg aacattcgct cagattcatg agatgcagga cctcggagac
      601 aagttgcgaa tgattgtcac tggccacaga aggattcaca tcagccggca gctggaggtg
      661 gaaccagagg ggcttgagcc agaggcagag aaacaaaagt ccaggaggaa gctgaagcga
      721 ggcaagaaag aggtggagga tgagctgggc cccaagcccc agctggagat ggtgaccgag
      781 gctgccactg acacatccaa ggaggtgctc atggtggagg ttgagaatgt agcccatgaa
      841 gacttccagg tcacagagga agtgaaggcc ctgactgcag agattgtgaa gaccattcgg
      901 gatatcatcg ccttgaaccc tctgtacaga gagtccgtgc tgcagatgat gcaggcaggc
      961 cagcgtgtgg tggacaaccc catctacttg agcgacatgg gtgcggcact cactggggcg
     1021 gagtcccatg agctgcaaga tgttctggaa gagaccaaca tccttaagcg gctctataag
     1081 gccctgtctc tcttgaagaa ggagtttgag ttgagcaagc ttcagcaacg cctaggccgt
     1141 gaggtagagg agaagatcaa gcagacacac aggaagtacc tgctgcagga gcagttgaag
     1201 atcatcaaga aggaattggg gctggagaaa gatgataaag atgccattga ggagaagttc
     1261 cgggaacgcc tcagggagct tgtggttccc aagcatgtga tggacgtggt ggatgaggag
     1321 ctgagcaagc ttgctctact ggacaaccac tcctctgagt tcaatgtcac tcgaaactac
     1381 ctggactggc tgacatccat cccatggggc cggcagagtg atgagaactt ggacttggct
     1441 cgggcccagg ctgtgctgga ggaggaccac tacggcatgg aggatgtgaa gaagcgtgtc
     1501 ctggagttca ttgcagtcag ccagctcaga ggctccacac aaggcaagat cctctgcttc
     1561 cacggcccac cgggggtggg caagaccagc attgcacgct ccattgcccg tgcccttggc
     1621 cgagaatact tccgtttcag tgttggtggc atgacagatg tggcagaaat caaggggcac
     1681 aggcgtacct acgtgggggc catgcctggg aagatcatcc agtgtctgaa gaagaccaag
     1741 acagagaacc cgctagtgct cattgatgag gtggacaaga ttggccgagg ctaccaaggg
     1801 gacccgtcat cagcactgct ggagttgctg gaccctgagc agaatgccaa cttcctggac
     1861 cactacctgg atgtgccagt ggatctgtcc aaggtgctat tcatctgcac ggccaatgtc
     1921 attgacacca tcccagaacc actgagggac cgcatggaga tgatcaatgt gtctggctat
     1981 gtagcacagg agaagctggc catcgcagag cggtacctgg tgccacaggc ccgcaccctg
     2041 tgtggcctag atgagagcaa ggcccagctg tcagcagcag tgctcacact gctcatcaag
     2101 caatactgca gggagagtgg tgtgcgcaac ctacagaagc aggtggagaa ggtgctgcgc
     2161 aaggctgcat acaagatcgt aagtggggag gcccagacag tacaggtgac acctgagaac
     2221 ctacaagact ttgttgggaa gcctgtgttc acagtggagc gcatgtacga agtcacacct
     2281 cctggcgtgg tcatgggttt ggcctggact gccatggggg gctctacatt gtttgtggag
     2341 acatctttga ggcggcccca gcctagtggc agcaaggagg acaaggatgg cagcctagag
     2401 gtgacaggtc agctgggaga tgtgatgaaa gagagtgccc gcatagccta cacctatgct
     2461 cgtgccttcc tgatggagca ggaccctgaa aatgacttcc tagtcacctc acacatccac
     2521 ctgcatgtgc ctgagggtgc tacccccaag gatggtccca gcgcaggctg tactattgtc
     2581 actgcactgc tgtccctggc tctgggccag ccagtgttgc agaacctggc tatgactggg
     2641 gaggtctccc tcactggcaa ggtgttgcct gtgggtggca tcaaggagaa gaccattgcg
     2701 gctaagcgtg caggtgtgac ctgcatcatt ctgcctgctg agaacagaaa ggactactcg
     2761 gatttagctc cttttatcac agagggcctt gaagttcact tcgtggaaca ctatcgggac
     2821 atattcccca ttgccttccc ccggcgagag cacagggagg cactggccgt ggagagatga
     2881 cacaggggcc tgggactaaa taaatcatgg tgtggcggag ccacgagcac agctgtagaa
     2941 tcatgaataa agaaaacctt tccaaaaaaa
//
