LOCUS       NM_080795               4543 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus ligand of numb-protein X 2 (Lnx2), mRNA.
ACCESSION   NM_080795
VERSION     NM_080795.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4543)
  AUTHORS   Lee SJ, Kim J, Han G, Hong SP, Kim D and Cho C.
  TITLE     Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos
  JOURNAL   Int J Mol Sci 24 (2), 1385 (2023)
   PUBMED   36674899
  REMARK    GeneRIF: Impaired Blastocyst Formation in Lnx2-Knockdown Mouse
            Embryos.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4543)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4543)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4543)
  AUTHORS   Sapir T, Levy T, Kozer N, Shin I, Zamor V, Haffner-Krausz R,
            McGlade JC and Reiner O.
  TITLE     Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin
            Ligases
  JOURNAL   Cereb Cortex 28 (9), 3115-3128 (2018)
   PUBMED   28981589
REFERENCE   5  (bases 1 to 4543)
  AUTHORS   Lenihan JA, Saha O, Heimer-McGinn V, Cryan JF, Feng G and Young PW.
  TITLE     Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB
            Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice
  JOURNAL   Mol Neurobiol 54 (10), 8090-8109 (2017)
   PUBMED   27889896
REFERENCE   6  (bases 1 to 4543)
  AUTHORS   Yin FT, Futagawa T, Li D, Ma YX, Lu MH, Lu L, Li S, Chen Y, Cao YJ,
            Yang ZZ, Oiso S, Nishida K, Kuchiiwa S, Watanabe K, Yamada K,
            Takeda Y, Xiao ZC and Ma QH.
  TITLE     Caspr4 interaction with LNX2 modulates the proliferation and
            neuronal differentiation of mouse neural progenitor cells
  JOURNAL   Stem Cells Dev 24 (5), 640-652 (2015)
   PUBMED   25279559
  REMARK    GeneRIF: Caspr4 inhibits neuronal differentiation in a
            LNX-dependent manner.
REFERENCE   7  (bases 1 to 4543)
  AUTHORS   Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J,
            Muhr J, Lenhard B, Sandelin A and Ericson J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   8  (bases 1 to 4543)
  AUTHORS   Mirza M, Hreinsson J, Strand ML, Hovatta O, Soder O, Philipson L,
            Pettersson RF and Sollerbrant K.
  TITLE     Coxsackievirus and adenovirus receptor (CAR) is expressed in male
            germ cells and forms a complex with the differentiation factor
            JAM-C in mouse testis
  JOURNAL   Exp Cell Res 312 (6), 817-830 (2006)
   PUBMED   16410001
REFERENCE   9  (bases 1 to 4543)
  AUTHORS   Mirza M, Raschperger E, Philipson L, Pettersson RF and Sollerbrant
            K.
  TITLE     The cell surface protein coxsackie- and adenovirus receptor (CAR)
            directly associates with the Ligand-of-Numb Protein-X2 (LNX2)
  JOURNAL   Exp Cell Res 309 (1), 110-120 (2005)
   PUBMED   15979067
  REMARK    GeneRIF: coxsackievirus and adenovirus receptor is a partner in a
            protein complex organized at specific subcellular sites by LNX2
REFERENCE   10 (bases 1 to 4543)
  AUTHORS   Rice DS, Northcutt GM and Kurschner C.
  TITLE     The Lnx family proteins function as molecular scaffolds for Numb
            family proteins
  JOURNAL   Mol Cell Neurosci 18 (5), 525-540 (2001)
   PUBMED   11922143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036218.1 and AL513345.20.
            
            [WARNING] On Oct 5, 2023 this sequence was replaced by NM_080795.5.
            
            On Jan 18, 2008 this sequence version replaced NM_080795.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090665.1, AK170146.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2309              AK036218.1         2-2310
            2310-4543           AL513345.20        100890-103123       c
FEATURES             Location/Qualifiers
     source          1..4543
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 86.69 cM"
     gene            1..4543
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /note="ligand of numb-protein X 2"
                     /db_xref="GeneID:140887"
                     /db_xref="MGI:MGI:2155959"
     exon            1..155
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /inference="alignment:Splign:2.1.0"
     exon            156..623
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..2277
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /note="numb-binding protein 2"
                     /codon_start=1
                     /product="ligand of Numb protein X 2"
                     /protein_id="NP_542985.4"
                     /db_xref="CCDS:CCDS19875.1"
                     /db_xref="GeneID:140887"
                     /db_xref="MGI:MGI:2155959"
                     /translation="MGTTSDEMVPVEQASSTSSLDPLCFECGQQHWARENHLYNYQGE
                     VDDDLVCHICLQPLLQPLDTPCGHTFCHKCLRNFLQEKDFCPLDRKRLHFKLCKKSSI
                     LVHKLLDKLLVLCPFSPVCQDVMQRCDLEAHLKNRCPGASHRRVDLERRKTSQTQTQI
                     EGETGSTVIDPPGTLPPETDCSGTVPGERNLTPASLPVWTEEPGLDNPAFEESAAADS
                     VQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRL
                     LAGDQILQVNNYDISNVSHNHARAVLSQPCSTLQLTVLRERRFGSRANSHADGSAPRD
                     EVFQVLLHKRDSTEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLNSNDRVLAINGH
                     DLKHGTPELAAQIIQASGERVNLTIARPGKPQPSNGSREAGAHSSSNHAQPPSHSRPG
                     SHKDLTRCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDG
                     RIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVILKALEVQIAEEAAQATEEQP
                     SAFSENEYDASWSPSWVMWLGLPSALHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQP
                     FFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICW
                     PGSLV"
     exon            624..865
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1065
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1434
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1572
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1750
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1982
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2141
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..4543
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4100
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
     polyA_site      4543
                     /gene="Lnx2"
                     /gene_synonym="9630046H24"
ORIGIN      
        1 gccccctagg ggaaaggcag caggggcggt tgagaagtaa agtcttggcc ggactttgct
       61 tctcgccagg aaatcggcgg cggcgagtcc cagcggagcg gagccgggcg gcgtcctcgt
      121 cagcgctccc gcggggagcc cgccgctttc cctcagcaga cacgcacccc gcaagtgtta
      181 gacccatgag cctccgggaa ctgccgattc acaatgggaa caaccagtga cgagatggtg
      241 cccgtggagc aggcctcctc gacctcctcc ctagatcccc tgtgcttcga gtgcggccag
      301 cagcactggg cgagagaaaa ccacctgtat aactaccagg gggaggtgga cgacgacctc
      361 gtgtgccaca tttgcctcca gcccctgctc cagccgctcg acacgccctg cggacacacg
      421 ttctgccaca agtgcctcag aaacttcctg caggagaagg atttctgccc gctggaccgc
      481 aagcggcttc atttcaagct gtgtaagaag tctagcatcc tggtccacaa gctgctggac
      541 aaactgctgg tcctgtgtcc gttctctccc gtgtgccaag atgtgatgca gcgctgtgac
      601 ctagaggcac atcttaaaaa caggtgtcct ggagcctctc accggagagt cgatctagag
      661 agaaggaaaa cgagtcaaac tcaaacacag attgagggtg aaactggatc tactgtcata
      721 gatcctccag gcaccttgcc cccagaaacg gactgctcgg gcaccgtgcc tggcgagagg
      781 aacttgacac cagcatctct tcctgtgtgg accgaggagc ctggcctgga caaccccgcc
      841 ttcgaggaga gcgctgcagc tgactctgta cagcagccgc ttagtttacc agaaggagag
      901 atcaccacca ttgagatcca ccgctctaac ccgtacatcc agttaggaat cagcatcgtg
      961 ggcggcaacg agacaccact gatcaacatc gtcattcagg aagtctaccg ggacggggtc
     1021 atcgccagag atggaaggct ccttgccgga gaccagattc tccaggtcaa caactatgac
     1081 atcagcaacg tgtcccacaa ccacgcccgg gccgtgcttt cccagccctg cagcacgctg
     1141 cagctgacag tgctgcggga gaggcgcttt ggcagccgtg ccaacagcca cgcggacggc
     1201 agcgcgccac gggacgaggt cttccaggtg ctgctccaca agcgagactc gacagagcag
     1261 ctcggcatta aactagtccg aaggacagat gagccgggcg ttttcattct tgacctcctg
     1321 gaaggggggc tggcagcaca ggacggcagg ctcaacagca atgaccgggt gctggccatc
     1381 aacgggcatg acctgaagca tgggacccca gagctcgctg cccagattat tcaggccagt
     1441 ggagagaggg tgaacttaac aattgccaga ccagggaagc cccagcccag caatggcagc
     1501 cgtgaggccg gagcacacag cagcagcaac cacgctcagc caccctcgca cagccgaccg
     1561 ggctcacaca aggacctcac ccggtgcgtc acgtgccagg agaagcacat cactgtaaag
     1621 aaggagccgc atgaatccct cgggatgacg gttgctgggg gcagagggag caagagtggt
     1681 gagctgccca tctttgtgac cagcgtgcca ccccacggct gcctcgctcg agacggcagg
     1741 atcaagagag gtgacgtgtt gctgaacatc aacggcattg acctgaccaa cctaagtcac
     1801 agcgaggctg tggccatgct gaaagccagc gctgcgtctc cggccgtcat cctcaaggcc
     1861 ctggaagtgc agatcgccga ggaagcagcc caggccaccg aggagcagcc gagcgccttc
     1921 agtgagaacg agtacgacgc cagctggtcc ccgtcctggg tcatgtggct cgggctgcca
     1981 agtgcccttc acagttgtca cgacatcgtc ttacgcagaa gctacttggg aagctggggc
     2041 ttcagcatcg tgggtgggta cgaagagaac cacaccaatc agcccttctt cattaagacc
     2101 atcgtcttag gaacccctgc ttactatgac ggaagattaa agtgtggaga catgatcgta
     2161 gcagtaaacg gcctgtcgac tgtgggcatg agtcactctg ctctggtgcc catgttgaaa
     2221 gaacagagga acaaggtcac gctgacggtc atctgctggc caggcagcct cgtatagagt
     2281 cttgacatca gactccagtc tcaattcttc ctgcaggtcc gtgaaggaag cccctccagg
     2341 gtggcatatc tgctgggcag cgacacagga cagcaatact gacatcatcc tgtgtttccc
     2401 cttggctcgg aatcggctcc caccagcccc aggggctcat ttcagatgct ctcggtggct
     2461 gccacgactg tccctggctg gacggaagtg gcctctgtgc ctgcagcagc ctgcagcagc
     2521 tcagtcatga agcgagttcc acccgcaact cctccatccg cagcacctcg ctgctgcagc
     2581 gtccgcagca ccccctgccc cggagacaga gctgcggagg ggcgcatctt aggttttcct
     2641 cattttccat tggtgccaac atttcaagat ttttataccg tttataaagt gacttttggg
     2701 ctcgtttcta ctgcggctga tcttcagtcc tcaactgaag acataaaccg aacaccactg
     2761 atgagactta aataatgtac tgcggttaaa ataggagaga gtcaagaata atgctattga
     2821 agggacagag caacctggga ggcgacttct ggaactggca aagctatgtt gcctggaaca
     2881 gcccagaagc acgaagactc tgttcaaaag gaaagctttg ttgcgtagga aaagtttgga
     2941 gatgtttttc taaaagtcat ttctagagtt tatatttatc agcaatcttg tctggagaag
     3001 tttttgtgat ttatgcaatt gaactaggtg attaaataac attacttctt aaacatgagt
     3061 gcgcatacac acacatacac acacacacat acacacatac acacacacac cacagctaag
     3121 ttgaaaggga gcctttgatt tttgttcctg tgtattttag aaatccttag tttcccccaa
     3181 gagaccaaaa agctctgttt ttgttcttgt ttttttaatc tgaaatagta gattttagat
     3241 gttagtgtct tcagctgttg gtcacttaac tttctttatc tttttttttt tttaatgttt
     3301 agaaagctgt ttgtccttta ttcaacacag atgaccctta gacggcataa tgagaaagta
     3361 aataagagga aacaaccttt gcctggttaa tatttatact tgaaaaattc cacttagaaa
     3421 cctcgttcaa agtcagagct aacttacacg tgagctcaga gacagatggc atcgataatc
     3481 gtacaggctg cggtgccgct gggcgagcca cctcctcagc cagtattgct gggctttgta
     3541 tccctgtcgc tggttcttcc aagttaaatt catagtaaga agccaaacag gtctctctgt
     3601 ggtagataag ggttgcaatg gtggttgcta ctggcttgtt cagccccgag ctccccagtc
     3661 accacgcagc cagcacacac acacagaccc ccagagaggg atgcggcccg agcacccccc
     3721 ccccaatcac ctatgaagca atttgatcct gaagtgcaat tgacgtgaaa cagtgtgtcc
     3781 tgctccccag gtacaatttt gtaaccagcc ttgctacttt ttaaagactt tgtaaaacct
     3841 gtcatttctc tggggagtgg ccatccaaca gataatcata actgccactt tgttatacat
     3901 aaaaatatgt ccaacctggt ggtctggtga atatttgggg ggggggggta ggattctttc
     3961 aatattattt ttcttatgaa aatctcagag gacactggct gttccggggt ctctgtaatg
     4021 gaatttctcc ctgatctgtt agtgttgatg tatttgtact ttgtcagcta agcacttaat
     4081 aactgaatat tttgatttgt tctgtgcctt cagcttacat tcttccagaa tttctcagat
     4141 gtttacatag cggtgcaacg gccgttctgg gtggaggtaa atgccatccg cttcggagca
     4201 gcgcaggcat tcatccgaga gctgtgtccc tattcacaga gccactgccc tcagtcactg
     4261 cctgctgtgc ctgagcccca cacacacaca cccatgatgc ccctgctcct gcagacagaa
     4321 cacaccatag cctatgctgt cttatgtctt ccccatccag agtacctcca gcccttggct
     4381 gtccctgaag cttggccccc acggtgtgct gagctgacag agtcttggat gcactgggtt
     4441 gtattgggtt acatagaata tgttattacc ggtttctctc ttactttttc tcgtgttact
     4501 tactagaacc gctttcaata attgaattgt aatgacatcg gga
//
