LOCUS       NM_001159577            2571 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ligand of numb-protein X 1 (Lnx1), transcript variant
            1, mRNA.
ACCESSION   NM_001159577
VERSION     NM_001159577.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2571)
  AUTHORS   Zhang,T., Wang,C., Wei,J., Zhu,Z., Wang,X. and Sun,C.
  TITLE     Ligand-of-Numb protein X1 controls the coxsackievirus B3-induced
            myocarditis via regulating the stability of coxsackievirus and
            adenovirus receptor
  JOURNAL   Genes Immun 23 (1), 42-46 (2022)
   PUBMED   35115665
  REMARK    GeneRIF: Ligand-of-Numb protein X1 controls the coxsackievirus
            B3-induced myocarditis via regulating the stability of
            coxsackievirus and adenovirus receptor.
REFERENCE   2  (bases 1 to 2571)
  AUTHORS   Liu,X.D., Ai,P.H., Zhu,X.N., Pan,Y.B., Halford,M.M., Henkemeyer,M.,
            Feng,D.F., Xu,T.L., Sun,S. and Xu,N.J.
  TITLE     Hippocampal Lnx1-NMDAR multiprotein complex mediates initial social
            memory
  JOURNAL   Mol Psychiatry 26 (8), 3956-3969 (2021)
   PUBMED   31772302
  REMARK    GeneRIF: Hippocampal Lnx1-NMDAR multiprotein complex mediates
            initial social memory.
REFERENCE   3  (bases 1 to 2571)
  AUTHORS   Fu,B., Xue,W., Zhang,H., Zhang,R., Feldman,K., Zhao,Q., Zhang,S.,
            Shi,L., Pavani,K.C., Nian,W., Lin,X. and Wu,H.
  TITLE     MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium
            tuberculosis through Targeting LNX1 via NEK6 Accumulation to
            Promote Anti-Apoptotic STAT3 Signaling
  JOURNAL   mBio 11 (3), e00557-20 (2020)
   PUBMED   32487755
  REMARK    GeneRIF: MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium
            tuberculosis through Targeting LNX1 via NEK6 Accumulation to
            Promote Anti-Apoptotic STAT3 Signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2571)
  AUTHORS   Liu,X.D., Zhu,X.N., Halford,M.M., Xu,T.L., Henkemeyer,M. and
            Xu,N.J.
  TITLE     Retrograde regulation of mossy fiber axon targeting and terminal
            maturation via postsynaptic Lnx1
  JOURNAL   J Cell Biol 217 (11), 4007-4024 (2018)
   PUBMED   30185604
  REMARK    GeneRIF: Retrograde regulation of mossy fiber axon targeting and
            terminal maturation via postsynaptic Lnx1.
REFERENCE   5  (bases 1 to 2571)
  AUTHORS   Lenihan,J.A., Saha,O. and Young,P.W.
  TITLE     Proteomic analysis reveals novel ligands and substrates for LNX1 E3
            ubiquitin ligase
  JOURNAL   PLoS One 12 (11), e0187352 (2017)
   PUBMED   29121065
  REMARK    GeneRIF: These findings provide functional insights into the LNX
            protein family, particularly the neuronal LNX1p70 isoform.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2571)
  AUTHORS   Nie,J., McGill,M.A., Dermer,M., Dho,S.E., Wolting,C.D. and
            McGlade,C.J.
  TITLE     LNX functions as a RING type E3 ubiquitin ligase that targets the
            cell fate determinant Numb for ubiquitin-dependent degradation
  JOURNAL   EMBO J 21 (1-2), 93-102 (2002)
   PUBMED   11782429
REFERENCE   7  (bases 1 to 2571)
  AUTHORS   Rice,D.S., Northcutt,G.M. and Kurschner,C.
  TITLE     The Lnx family proteins function as molecular scaffolds for Numb
            family proteins
  JOURNAL   Mol Cell Neurosci 18 (5), 525-540 (2001)
   PUBMED   11922143
REFERENCE   8  (bases 1 to 2571)
  AUTHORS   Xie,Y., Zhao,W., Wang,W., Zhao,S., Tang,R., Ying,K., Zhou,Z. and
            Mao,Y.
  TITLE     Identification of a human LNX protein containing multiple PDZ
            domains
  JOURNAL   Biochem Genet 39 (3-4), 117-126 (2001)
   PUBMED   11521506
REFERENCE   9  (bases 1 to 2571)
  AUTHORS   Dho,S.E., French,M.B., Woods,S.A. and McGlade,C.J.
  TITLE     Characterization of four mammalian numb protein isoforms.
            Identification of cytoplasmic and membrane-associated variants of
            the phosphotyrosine binding domain
  JOURNAL   J Biol Chem 274 (46), 33097-33104 (1999)
   PUBMED   10551880
REFERENCE   10 (bases 1 to 2571)
  AUTHORS   Dho,S.E., Jacob,S., Wolting,C.D., French,M.B., Rohrschneider,L.R.
            and McGlade,C.J.
  TITLE     The mammalian numb phosphotyrosine-binding domain. Characterization
            of binding specificity and identification of a novel PDZ
            domain-containing numb binding protein, LNX
  JOURNAL   J Biol Chem 273 (15), 9179-9187 (1998)
   PUBMED   9535908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120865.7, AF034745.1 and AI850871.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF034745.1, SRR13422598.592417.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC120865.7         19579-19595         c
            18-2169             AF034745.1         18-2169
            2170-2571           AI850871.1         1-402               c
FEATURES             Location/Qualifiers
     source          1..2571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.52 cM"
     gene            1..2571
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /note="ligand of numb-protein X 1"
                     /db_xref="GeneID:16924"
                     /db_xref="MGI:MGI:1278335"
     exon            1..112
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     exon            113..589
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     exon            590..831
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     exon            832..984
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1187
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1559
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1694
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1863
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2089
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2248
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2555
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2532..2537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /note="hexamer: AATAAA"
     polyA_site      2555
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /note="major polyA site"
ORIGIN      
        1 gtacaccgaa gttgagaccg gtcacagctc aggcggccct agacgcttct ggcacaggga
       61 tggaggctgg ctggtcactg ctgctttgaa agtcccaaac atctttgaac agggttgcat
      121 gtgggtgact cttagaatat cttgacctgc tcctgaggaa atactgcttt cctgagtttc
      181 ctgaacccta cacagccatg aaccaaccgg accttgcaga tgacccagat cccagtcccg
      241 agcctctgtg catagtgtgt gggcaaaacc actccccaga ggaaaaccac ttctacacgt
      301 acacagagga tgtagatgac gacctcatat gccacatctg tctgcaagca ttgctggacc
      361 ctctggacac tccatgtgga cacacctact gcaccctgtg tctcaccaac ttcctggtgg
      421 agaaggactt ctgccctgtg gatcgaaagc ctgtggttct gcagcactgc aagaaatcca
      481 gtatcttggt caacaagctt ctcaataagc tgttggtcac ctgcccgttc acggagcact
      541 gcactgaggt gctacagcgc tgtgatctcc agcatcattt ccagacaagc tgcaaagggg
      601 cctcccacta tggcctgacc aaggacagga aaaggcgctc tcaagatggc tgtcctgatg
      661 gttgcgccag cctcatggca acgacgctct ccccagaggt ttctgcagcc gccaccatct
      721 ctttaatgac agatgagcct ggcctagaca accctgccta cgtgtcctcg gtggaggatg
      781 gtgagccagt agccaactcc tcagactctg gccggagcaa ccggactagg gcacggccct
      841 ttgagcgctc cactatgaga agccggtctt tcaagaagat caaccgagct ctaagtgctc
      901 tccggaggac gaagagcggg agtgtcgttg ccaaccatgt tgaccagggc agggacaact
      961 ctgagaacac cactgtcccc gaagtcttcc caaggttgtt tcacctgatt ccagatggtg
     1021 aaattacaag catcaaaatc aacagagcgg atcccagcga aagcctctcc ataaggctgg
     1081 tggggggcag cgagacgccg ctggtccaca tcatcatcca gcatatttat cgcgatggag
     1141 tgattgccag agatggacgg ctgctgccag gagacatcat tctcaaggtc aacggcatgg
     1201 acatcagcaa tgtccctcat aactatgccg tgcggctcct gcggcagccc tgccaggtgc
     1261 tgcggctaac ggtgctgcgg gagcagaagt tccgtagcag aagcaatgcg cacgtgccgg
     1321 actcctatgg acctcgggat gacagcttcc atgtaatcct caacaaaagc agccccgagg
     1381 agcagcttgg cataaagctg gtgcgccggg tggatgagcc cggcgtgttc atcttcaacg
     1441 tgctaaatgg gggtgtcgcc gaccgacacg gccagctgga ggagaatgac cgtgtgctgg
     1501 ccatcaacgg gcatgacctt cgatttggca gtccagagag tgcagctcat ctgattcagg
     1561 ccagtgaaag acgcgtccat ctcgtcgtgt cccgccaggt tcgacagtcc agcccagaca
     1621 tctttcaaga agctggctgg atcagcaatg gccagcaatc cccaggccca ggagagagga
     1681 acacagcttc taagcctgca gccacctgtc atgagaaggt tgtaagtgtc tggaaagacc
     1741 ccagcgagtc tctcggcatg accgtcggag ggggagcatc ccacagggaa tgggacttgc
     1801 ccatctatgt catcagtgtt gaacccggcg gagtcataag cagagacggg agaataaaaa
     1861 caggtgacat tttattgaat gtgaatggga ttgagctcac agaggtcagc cggacagagg
     1921 ccgttgccat actgaagagc gcaccctcct cagtggtact caaagccttg gaagtcaagg
     1981 aacaggaggc ccaggaagac tgcagcccag cagccctgga ctccaaccac aacgtgaccc
     2041 cgcctggtga ctggtcccca tcctgggtca tgtggctgga attaccacag tacttatgta
     2101 actgtaaaga tgtgatactg cgaaggaaca cagctggaag cctgggcttc tgcattgtgg
     2161 gaggttatga agaatacagt gggaacaaac ctttttttat caagtccatt gttgaaggaa
     2221 cacctgcata caatgacgga agaatcagat gtggtgacat tcttctcgct gtcaacggta
     2281 gaagtacatc gggtatgata cacgcttgcc tggccaggat gctcaaggaa cttaaaggga
     2341 gaattactct gaccattgct tcttggcctg gtactttttt ataaaatcaa tgatggatct
     2401 tagaaaaacc acagataggc taggtaaaat tgtatttatc ttgtcaattt ttatatttaa
     2461 agaatatatt gtaaaaaatg ccagaaaagt atgatattat gaaaagttac acctcagaga
     2521 ctgttctcaa aaataaaaac tagtgataat ttttaaaaaa aaaaaaaaaa a
//
