LOCUS       NP_001153049             728 aa            linear   ROD 01-JUN-2024
DEFINITION  E3 ubiquitin-protein ligase LNX isoform 1 [Mus musculus].
ACCESSION   NP_001153049
VERSION     NP_001153049.1
DBSOURCE    REFSEQ: accession NM_001159577.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 728)
  AUTHORS   Zhang,T., Wang,C., Wei,J., Zhu,Z., Wang,X. and Sun,C.
  TITLE     Ligand-of-Numb protein X1 controls the coxsackievirus B3-induced
            myocarditis via regulating the stability of coxsackievirus and
            adenovirus receptor
  JOURNAL   Genes Immun 23 (1), 42-46 (2022)
   PUBMED   35115665
  REMARK    GeneRIF: Ligand-of-Numb protein X1 controls the coxsackievirus
            B3-induced myocarditis via regulating the stability of
            coxsackievirus and adenovirus receptor.
REFERENCE   2  (residues 1 to 728)
  AUTHORS   Liu,X.D., Ai,P.H., Zhu,X.N., Pan,Y.B., Halford,M.M., Henkemeyer,M.,
            Feng,D.F., Xu,T.L., Sun,S. and Xu,N.J.
  TITLE     Hippocampal Lnx1-NMDAR multiprotein complex mediates initial social
            memory
  JOURNAL   Mol Psychiatry 26 (8), 3956-3969 (2021)
   PUBMED   31772302
  REMARK    GeneRIF: Hippocampal Lnx1-NMDAR multiprotein complex mediates
            initial social memory.
REFERENCE   3  (residues 1 to 728)
  AUTHORS   Fu,B., Xue,W., Zhang,H., Zhang,R., Feldman,K., Zhao,Q., Zhang,S.,
            Shi,L., Pavani,K.C., Nian,W., Lin,X. and Wu,H.
  TITLE     MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium
            tuberculosis through Targeting LNX1 via NEK6 Accumulation to
            Promote Anti-Apoptotic STAT3 Signaling
  JOURNAL   mBio 11 (3), e00557-20 (2020)
   PUBMED   32487755
  REMARK    GeneRIF: MicroRNA-325-3p Facilitates Immune Escape of Mycobacterium
            tuberculosis through Targeting LNX1 via NEK6 Accumulation to
            Promote Anti-Apoptotic STAT3 Signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 728)
  AUTHORS   Liu,X.D., Zhu,X.N., Halford,M.M., Xu,T.L., Henkemeyer,M. and
            Xu,N.J.
  TITLE     Retrograde regulation of mossy fiber axon targeting and terminal
            maturation via postsynaptic Lnx1
  JOURNAL   J Cell Biol 217 (11), 4007-4024 (2018)
   PUBMED   30185604
  REMARK    GeneRIF: Retrograde regulation of mossy fiber axon targeting and
            terminal maturation via postsynaptic Lnx1.
REFERENCE   5  (residues 1 to 728)
  AUTHORS   Lenihan,J.A., Saha,O. and Young,P.W.
  TITLE     Proteomic analysis reveals novel ligands and substrates for LNX1 E3
            ubiquitin ligase
  JOURNAL   PLoS One 12 (11), e0187352 (2017)
   PUBMED   29121065
  REMARK    GeneRIF: These findings provide functional insights into the LNX
            protein family, particularly the neuronal LNX1p70 isoform.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 728)
  AUTHORS   Nie,J., McGill,M.A., Dermer,M., Dho,S.E., Wolting,C.D. and
            McGlade,C.J.
  TITLE     LNX functions as a RING type E3 ubiquitin ligase that targets the
            cell fate determinant Numb for ubiquitin-dependent degradation
  JOURNAL   EMBO J 21 (1-2), 93-102 (2002)
   PUBMED   11782429
REFERENCE   7  (residues 1 to 728)
  AUTHORS   Rice,D.S., Northcutt,G.M. and Kurschner,C.
  TITLE     The Lnx family proteins function as molecular scaffolds for Numb
            family proteins
  JOURNAL   Mol Cell Neurosci 18 (5), 525-540 (2001)
   PUBMED   11922143
REFERENCE   8  (residues 1 to 728)
  AUTHORS   Xie,Y., Zhao,W., Wang,W., Zhao,S., Tang,R., Ying,K., Zhou,Z. and
            Mao,Y.
  TITLE     Identification of a human LNX protein containing multiple PDZ
            domains
  JOURNAL   Biochem Genet 39 (3-4), 117-126 (2001)
   PUBMED   11521506
REFERENCE   9  (residues 1 to 728)
  AUTHORS   Dho,S.E., French,M.B., Woods,S.A. and McGlade,C.J.
  TITLE     Characterization of four mammalian numb protein isoforms.
            Identification of cytoplasmic and membrane-associated variants of
            the phosphotyrosine binding domain
  JOURNAL   J Biol Chem 274 (46), 33097-33104 (1999)
   PUBMED   10551880
REFERENCE   10 (residues 1 to 728)
  AUTHORS   Dho,S.E., Jacob,S., Wolting,C.D., French,M.B., Rohrschneider,L.R.
            and McGlade,C.J.
  TITLE     The mammalian numb phosphotyrosine-binding domain. Characterization
            of binding specificity and identification of a novel PDZ
            domain-containing numb binding protein, LNX
  JOURNAL   J Biol Chem 273 (15), 9179-9187 (1998)
   PUBMED   9535908
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120865.7, AF034745.1 and AI850871.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF034745.1, SRR13422598.592417.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..728
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.52 cM"
     Protein         1..728
                     /product="E3 ubiquitin-protein ligase LNX isoform 1"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase LNX; numb-binding
                     protein 1; ligand of Numb protein X 1; ligand of
                     Numb-binding protein 1; RING-type E3 ubiquitin transferase
                     LNX"
                     /calculated_mol_wt=80026
     Region          42..83
                     /region_name="mRING-HC-C3HC3D_LNX1"
                     /note="Modified RING finger, HC subclass (C3HC3D-type),
                     found in ligand of numb protein X 1 (LNX1); cd16779"
                     /db_xref="CDD:438435"
     Region          185..220
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70263.1)"
     Region          185..188
                     /region_name="NPXY motif"
                     /note="propagated from UniProtKB/Swiss-Prot (O70263.1)"
     Region          186..244
                     /region_name="Interaction with MAGEB18.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (O70263.1)"
     Region          274..362
                     /region_name="PDZ1_LNX1_2-like"
                     /note="PDZ domain 1 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06677"
                     /db_xref="CDD:467165"
     Site            order(289..295,308,311,341,345,348..349)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467165"
     Region          384..466
                     /region_name="PDZ2_LNX1_2-like"
                     /note="PDZ domain 2 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06678"
                     /db_xref="CDD:467166"
     Site            order(396..402,413,416,446,450,453..454)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467166"
     Site            445
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TBB1; propagated from
                     UniProtKB/Swiss-Prot (O70263.1)"
     Region          481..500
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70263.1)"
     Region          507..592
                     /region_name="PDZ3_LNX1_2-like"
                     /note="PDZ domain 3 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06679"
                     /db_xref="CDD:467167"
     Site            order(518..524,539,542,572,576,579..580)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467167"
     Region          637..725
                     /region_name="PDZ4_LNX1_2-like"
                     /note="PDZ domain 4 of human Ligand of Numb protein X 1
                     (LNX1) and LNX2, and related domains; cd06680"
                     /db_xref="CDD:467168"
     Site            order(648..654,669,672,702,706,709..710)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:467168"
     CDS             1..728
                     /gene="Lnx1"
                     /gene_synonym="Lnx"
                     /coded_by="NM_001159577.1:198..2384"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS51524.1"
                     /db_xref="GeneID:16924"
                     /db_xref="MGI:MGI:1278335"
ORIGIN      
        1 mnqpdladdp dpspeplciv cgqnhspeen hfytytedvd ddlichiclq alldpldtpc
       61 ghtyctlclt nflvekdfcp vdrkpvvlqh ckkssilvnk llnkllvtcp ftehctevlq
      121 rcdlqhhfqt sckgashygl tkdrkrrsqd gcpdgcaslm attlspevsa aatislmtde
      181 pgldnpayvs svedgepvan ssdsgrsnrt rarpferstm rsrsfkkinr alsalrrtks
      241 gsvvanhvdq grdnsenttv pevfprlfhl ipdgeitsik inradpsesl sirlvggset
      301 plvhiiiqhi yrdgviardg rllpgdiilk vngmdisnvp hnyavrllrq pcqvlrltvl
      361 reqkfrsrsn ahvpdsygpr ddsfhvilnk sspeeqlgik lvrrvdepgv fifnvlnggv
      421 adrhgqleen drvlainghd lrfgspesaa hliqaserrv hlvvsrqvrq sspdifqeag
      481 wisngqqspg pgerntaskp aatchekvvs vwkdpseslg mtvgggashr ewdlpiyvis
      541 vepggvisrd griktgdill nvngieltev srteavailk sapssvvlka levkeqeaqe
      601 dcspaaldsn hnvtppgdws pswvmwlelp qylcnckdvi lrrntagslg fcivggyeey
      661 sgnkpffiks ivegtpaynd grircgdill avngrstsgm ihaclarmlk elkgritlti
      721 aswpgtfl
//
