LOCUS       NM_027133               8692 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus lunapark, ER junction formation factor (Lnpk),
            transcript variant 1, mRNA.
ACCESSION   NM_027133
VERSION     NM_027133.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8692)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8692)
  AUTHORS   de Almeida-Faria,J., Duque-Guimaraes,D.E., Ong,T.P.,
            Pantaleao,L.C., Carpenter,A.A., Loche,E., Kusinski,L.C.,
            Ashmore,T.J., Antrobus,R., Bushell,M., Fernandez-Twinn,D.S. and
            Ozanne,S.E.
  TITLE     Maternal obesity during pregnancy leads to adipose tissue ER stress
            in mice via miR-126-mediated reduction in Lunapark
  JOURNAL   Diabetologia 64 (4), 890-902 (2021)
   PUBMED   33501603
  REMARK    GeneRIF: Maternal obesity during pregnancy leads to adipose tissue
            ER stress in mice via miR-126-mediated reduction in Lunapark.
REFERENCE   3  (bases 1 to 8692)
  AUTHORS   Breuss,M.W., Nguyen,A., Song,Q., Nguyen,T., Stanley,V., James,K.N.,
            Musaev,D., Chai,G., Wirth,S.A., Anzenberg,P., George,R.D.,
            Johansen,A., Ali,S., Zia-Ur-Rehman,M., Sultan,T., Zaki,M.S. and
            Gleeson,J.G.
  TITLE     Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction
            Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome
  JOURNAL   Am J Hum Genet 103 (2), 296-304 (2018)
   PUBMED   30032983
REFERENCE   4  (bases 1 to 8692)
  AUTHORS   Bouilloux,F., Thireau,J., Venteo,S., Farah,C., Karam,S.,
            Dauvilliers,Y., Valmier,J., Copeland,N.G., Jenkins,N.A., Richard,S.
            and Marmigere,F.
  TITLE     Loss of the transcription factor Meis1 prevents sympathetic neurons
            target-field innervation and increases susceptibility to sudden
            cardiac death
  JOURNAL   Elife 5, e11627 (2016)
   PUBMED   26857994
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8692)
  AUTHORS   Delpretti,S., Montavon,T., Leleu,M., Joye,E., Tzika,A.,
            Milinkovitch,M. and Duboule,D.
  TITLE     Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during
            cecum budding
  JOURNAL   Cell Rep 5 (1), 137-150 (2013)
   PUBMED   24075990
REFERENCE   6  (bases 1 to 8692)
  AUTHORS   Herault,Y., Fraudeau,N., Zakany,J. and Duboule,D.
  TITLE     Ulnaless (Ul), a regulatory mutation inducing both loss-of-function
            and gain-of-function of posterior Hoxd genes
  JOURNAL   Development 124 (18), 3493-3500 (1997)
   PUBMED   9342042
REFERENCE   7  (bases 1 to 8692)
  AUTHORS   Peichel,C.L., Prabhakaran,B. and Vogt,T.F.
  TITLE     The mouse Ulnaless mutation deregulates posterior HoxD gene
            expression and alters appendicular patterning
  JOURNAL   Development 124 (18), 3481-3492 (1997)
   PUBMED   9342041
REFERENCE   8  (bases 1 to 8692)
  AUTHORS   Peichel,C.L., Abbott,C.M. and Vogt,T.F.
  TITLE     Genetic and physical mapping of the mouse Ulnaless locus
  JOURNAL   Genetics 144 (4), 1757-1767 (1996)
   PUBMED   8978061
REFERENCE   9  (bases 1 to 8692)
  AUTHORS   Rusiniak,M.E., O'Brien,E.P., Novak,E.K., Barone,S.M., McGarry,M.P.,
            Reddington,M. and Swank,R.T.
  TITLE     Molecular markers near the mouse brachymorphic (bm) gene, which
            affects connective tissues and bleeding time
  JOURNAL   Mamm Genome 7 (2), 98-102 (1996)
   PUBMED   8835524
REFERENCE   10 (bases 1 to 8692)
  AUTHORS   Davisson,M.T. and Cattanach,B.M.
  TITLE     The mouse mutation ulnaless on chromosome 2
  JOURNAL   J Hered 81 (2), 151-153 (1990)
   PUBMED   2338491
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY770278.1, AY312281.1, AL928644.12, AL929455.8 and CJ260754.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_027133.4.
            
            On Oct 31, 2007 this sequence version replaced NM_027133.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.93291.1,
                                           SRR1660821.41018.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BY770278.1         1-79
            80-2137             AY312281.1         1-2058
            2138-6460           AL928644.12        2001-6323           c
            6461-8227           AL929455.8         82621-84387         c
            8228-8692           CJ260754.1         1-465
FEATURES             Location/Qualifiers
     source          1..8692
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.13 cM"
     gene            1..8692
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /note="lunapark, ER junction formation factor"
                     /db_xref="GeneID:69605"
                     /db_xref="MGI:MGI:1918115"
     exon            1..130
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            131..219
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1470
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /note="isoform a is encoded by transcript variant 1;
                     protein lunapark; protein ulnaless; limb and neural
                     patterns; ER junction formation factor 1; ER junction
                     formation factor lunapark; endoplasmic reticulum junction
                     formation protein lunapark"
                     /codon_start=1
                     /product="endoplasmic reticulum junction formation protein
                     lunapark isoform a"
                     /protein_id="NP_081409.1"
                     /db_xref="CCDS:CCDS16137.1"
                     /db_xref="GeneID:69605"
                     /db_xref="MGI:MGI:1918115"
                     /translation="MGGLFSRWRAKPSTVEVLENIDKEIQALEEFREKNQRLQKLWVG
                     RLIIYSSILYLFTCLIVYLWYLPDEFTARLVMTLPFFAFPLIIWTLRTVLIFFFSKRT
                     ERNNEALDDLKSQKKKILEEVMEKETYKTAKLILERFDPDSKKAKEFEPPSAGAAVTA
                     KPGQEIRQRTAAQRNLSPAPASSSQGPPPQGPVSPGPAKDASAPGGPPERTVAPALPR
                     RLGSPATSVPGMGLHPPGPPLARPILPRERGALDRIVEYLVGDGPQNRYALICQQCFS
                     HNGMALKEEFEYIAFRCAYCFFLNPARKTRPQAPRLPEFSFEKRQAVEGSSSTGPTLL
                     ESVPSAESQLIEDSLEEQDVLDNSTEQRDDKIPVTEQTSQVIEKTSGPEEPAENQEET
                     ENEETSTNEAKSPVLRADSVPNLEPSEESLVTK"
     exon            220..261
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            262..449
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            450..508
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            509..549
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            550..633
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            634..685
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            686..883
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            884..989
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1060
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1231
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..8692
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1469..1474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /note="hexamer: AGTAAA"
     polyA_site      1498
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /note="major polyA site"
     regulatory      2174..2179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /note="hexamer: AATAAA"
     polyA_site      2196
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /note="major polyA site"
     regulatory      3175..3180
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
                     /note="hexamer: AATATA"
     polyA_site      3195
                     /gene="Lnpk"
                     /gene_synonym="2310011O18Rik; 4921514L11Rik;
                     9530051D01Rik; Lnp; Lnpk1; Ul; ulnaless"
ORIGIN      
        1 gatgggaagg cattggccgg gcccagcgct ctatctgtag gtgctgctgc ctgctccaga
       61 ggctctacgc ggtggcgacc caggcttccc cgagtggacg cccaggccga gcggcgcccg
      121 cttttctcag ctgtgacttc ttttggacaa ctcatgatat ttattattgt gccaagtttc
      181 tgcaaataaa agatgggtgg attattttct cgatggaggg caaaaccttc aacagtagaa
      241 gttctagaaa atatagataa ggaaattcaa gcattggaag aatttagaga aaaaaatcag
      301 agattgcaaa aattatgggt tggaagatta attatctatt cttcaattct ttacctgttt
      361 acctgtttaa ttgtgtactt gtggtatctt cctgatgagt ttacagcaag acttgtcatg
      421 acactcccat tttttgcttt tcctttgatc atctggacat taagaactgt acttattttc
      481 ttcttttcca agagaacaga gagaaataat gaagcattgg atgatttaaa atcccagaag
      541 aaaaagatac ttgaagaagt catggaaaaa gaaacttata agacagctaa gttaattctt
      601 gaaaggtttg atccagactc aaagaaagca aaggagtttg agccgccatc tgctggagca
      661 gctgtaactg caaagccagg acaagagatt cgtcagcgaa ctgcagctca aagaaacctt
      721 tccccagcac cagcaagctc tagtcagggt cctcctccac aaggtccagt gtctcctggg
      781 ccagcgaagg acgcttcagc tcctggggga ccgccagaaa gaactgttgc tccagccttg
      841 cccaggcgcc ttggatcccc tgctacttca gttcctggaa tgggccttca ccctccaggt
      901 ccacctttag caagacccat tctcccccga gaacgaggtg ctctggatag aattgttgaa
      961 tacttagttg gtgatggtcc acagaacagg tacgccctca tatgtcagca gtgtttttct
     1021 cacaatggca tggctttgaa ggaagaattt gaatatattg cttttcgatg tgcctactgt
     1081 tttttcttga atcctgcaag aaaaacgaga cctcaagctc cacggcttcc agagtttagt
     1141 tttgagaaga ggcaggcagt ggaaggctca agctcaactg gtcccacgct actagaaagt
     1201 gtgccctcag cagaaagcca gctcattgaa gactctttag aagaacaaga tgttcttgat
     1261 aatagtactg agcagagaga tgacaaaata ccagttacag agcagacaag ccaagtgatt
     1321 gaaaaaacat ctggtccaga ggagccagca gagaaccaag aagagactga gaacgaggaa
     1381 acctcaacaa acgaagccaa gtcacctgtt ctcagagctg attctgttcc taatcttgaa
     1441 ccaagtgaag aatctttggt gacaaagtag taaatacttc catgtgcctt caactggata
     1501 tttgtagtct tgttgatgtt agttactgct tttttttttt tttttgtggt actcaagaaa
     1561 aatttgcctt ctagatatac gcttaatatt attcatattc agattgccca gcaagttcag
     1621 tgtatccaag tactaccact aggtattgac agtaaaagca cgtggtatca gttaatatgc
     1681 agaggcatag ctgtgcattc taaagttaaa aaaatgtttt ttacatgtat aacttgtaaa
     1741 taatacccac tttgacatag gaacaaattt ggctaggaat aatttcttcc atagtattta
     1801 agggttgaaa cataattaag attttgaata cttcatcatt aaattttaac tttggagata
     1861 tttgccagtg ggaaggaaat atctgtttag gtgtttacac caagtaatgc tgaaagctgt
     1921 aaccttaatt acatacgcat tggtacgaat tctcagtaag aatgcaacta aacagtcaag
     1981 tgcagtattt ctcttgatgt cttttatttt acaactgggc caaaggcaca taatgtatat
     2041 agttaatgtt tacatagtaa taggaaatac atctgcactt gactgtactt gaattcttgg
     2101 tattatttat atttgtaata taatgatgat atataaatgg tttttgtgtg tgtgtgtgtg
     2161 ttttgttaag gaaaataaag atgacctggc agcgtttttc tttgttaaat atctagactt
     2221 cctcacatag tatgttgatg gatgacttgg ctatctgaaa aataccttgg tagggaaaac
     2281 tcactgtatg aaaactatat agcaaattat gatgtttttc ttttcattta gactttcaaa
     2341 atcagtgaca taagaggttt agtgtttcta atcagaagtt aaattttttc tgattttgaa
     2401 acatattatg gcataggtag tttttaactt tgagagacaa ataaatgcat ttttaaagat
     2461 aagacagtta aatttaatga aactcactag actgagtatg tataccaagt atcaggtggg
     2521 aagatttttg atgtagacta gttattctta aacacaatat gattatttgt tctagtttcc
     2581 ttttatgtgt cttatgttga aacaactgaa gtgaatttac atcatagggg agacatgtta
     2641 cgatagtgtt tctggctaat cctttagcta tcaaatgttt aaatatactt attatcattt
     2701 aaaagtttat atttatgagt aatacctcat ctgacatata taaaagaacc cagtttgtta
     2761 atattctgag gcattttagt gtagtgcctg taattgaagc atgtggaact ggacttgaat
     2821 gtcagctttg caatcgtggg catttcacct aacctctctg catttattta agctgtaaaa
     2881 tgaaaagaat aatatgtttt ccataggtac tgggaagtta aaaataagtt atatgatgtg
     2941 cctagctttc ttgctagata attaattaat aggtattagg ttacatggta gaatttattg
     3001 gtattattga aacccttgtg aaatatggaa ggaccgtaga tcctttcttt ggtagataat
     3061 gaaattaaag aaaactatga gcattcaatt tatttgttct gaacagaaat tttctgcatt
     3121 aatgtcatat gcacgtgtca atgatagatt aaagaaatgg agaactgaaa ctagaatata
     3181 atctttttat aaaaagatgt gtttattttt attttatgag tataaatgtt tgacttgcat
     3241 aaatgtctgt gtccaacatg tcttgacagg tatctgtaga ggtcagatac ctgggtcatt
     3301 tgaaatgata gttacagatg gctgtgagct gccacgtggg tgctagggat caaacttggc
     3361 ttagtcacta cgccattttt ccagcttcat ataacctttt tttgtttgta aattttacaa
     3421 ggggtgtgtg tgtgtgtgtt tgtgtgtgtg ttagtagcac catattaagt cttgttaaaa
     3481 catctgatat gcactgctca aaaatgagta cctcagagaa atgggattta atgaagaaac
     3541 caagaagata ttataaaaac atcccccaaa aggaatataa agggggagct agagaggtgt
     3601 ctcagtgtta agaatgggaa ctgctcttac agaatgccag agtgtgcttt tcagctccca
     3661 gcttgggtgg cttgctccct cctgtagctc tagatccagc agaattgatg gcttctccct
     3721 ggcctcctag gacactagcc taatgtgtac tctcttcccc acagatacac atagttaaaa
     3781 ataaaaatcc aaatcttaaa aggagcttag taaaattaac acaacaggtg ggtaattgtt
     3841 ggtgtatttt aaaacaaaat attattctga tatagtagac aatgtctgaa gtgaatgaga
     3901 ctccacattt ctgattatta agattagtgt aaatgaggga gaacttccct gttcacaaat
     3961 gctcagcatg tcattgttta atgtccctct cactgtgtcc tcagtgtggc ctgaagacag
     4021 ggcttagctt ctctctctgt ctttcctacc cacacctttc tactgtagct ataggactct
     4081 cgctcagttc tgtggctatg ctttgccttt tctgcctcaa tgtcagcttc atttttctct
     4141 gacagagaga gcctcctctt ctctctgtct gaagctaacc cttttagtcc tgtatcaggt
     4201 cactttgtct ttgctctgaa ttcttactgc agggtatctt gttttccctc aactgtcttc
     4261 acaatttgct tttcttctgt ctgtatgtgg agtgcctgct catttttcat gtggataacg
     4321 taccagatcc agggactgct cagtgcttaa ctcatgcgct tgcttggcag attgacttgg
     4381 ctgagtgttc tttttctgag acacctttat cctttaggtt ctgcatgtgc actgctgtta
     4441 ccttccctgg cttcttgttt tcagcatcct ttgaagactt cctctgccat ctttaaatgt
     4501 tgatgctctc tggcttccag ctattgtcag ttcttattct gtgcattcat tctcaagccc
     4561 agggacttaa tagttactgt ctgtctatga atgtcagagc ttagtgtggt ctgtttcttt
     4621 gccttcgtag ctatgtattt acgcacctac tgccatggca tagtgaagtc agtatttctt
     4681 taaaaaacaa aacaaaacaa aaaacaaaaa cccctactta ttcaaacttg tgtgtcattt
     4741 caccaaatac catcagtatt aaaaccagaa tttaaaatat attccctctt tccctctgac
     4801 tttaaagtat tcattcccag tttcttcccc cacatcccca gtagaatatt gcaatatagc
     4861 ccagcctggc ttggctttgt gacttgaggc ctcagattcc taggtgctgg aatcattcta
     4921 tgagttgctg tgccttgctc tcctctaaac attttacact tatattattt ttctatttct
     4981 tttgaattat attaatgata aatctgcatt gttccaccaa acaaatgcta cctgctgtat
     5041 gtatgtgtgc ttacacacaa ttttgttttt ggggggaaca gtcctgtgga gattttgtat
     5101 cttgagtatg ggaaagaaac aggatgtaga aagactaagc agccttccta gaggtctcta
     5161 ttggtgtgtg gaaacgtctg agatctgact gtaagcagat cacttgtgat gccgttggca
     5221 ttgaagccac agcctcatac atgctaagcc ctgctctgag ctgaactgtt tcttccactc
     5281 ccaaggcctt actgttaatc atcattgtat taccttctaa ttcctgcctc tgtcacctca
     5341 cgggatgaaa gctacctttt aaactctgtc tgcgatcatg ctgctttcct atccattctg
     5401 tgcagtgggt cctcagacct ttgtggctgt cttcagtctt tctgtgtttg agagaggaca
     5461 tctgaattac tgtattgact gataaagtcc ggagcagttg tctttccagt tggctctcac
     5521 agcaactttt ttgcattaca actactgtcg ctgctccctc ccctccactg cttacgtcct
     5581 ttcagtatac ataggttatt gttttcagtg ctgcatatat gcaaagtttc tcctagttgc
     5641 ctacatttct caagctcttc ctcctgaaat acctcgttta tgtaataaat agcttatgta
     5701 atcaataaat atatagctgc tgaattggag tagcaccgct tggaacccaa ggttggaaat
     5761 gttattattt attataaact atgagttttt caccatgtac tcattgtaca tatacatctt
     5821 cacagtagaa tcaagtctgt aactgaatgt gttacgtgtg tgtgtgtgtg tgtgtgtgtg
     5881 tgtgtgtgtg tagggagaga gaggtagatg ggtgggggga ggagagattg cttttaatta
     5941 tgtaatgatt gtcattaaga taatatatgc tgagttccag aatgttaaat gattgtcagt
     6001 tttaggtcag ggatacttgg catctgagcc aagtcagatt taatgaagga ctatttatat
     6061 tgtaccatga attttcactg tttcaatatt aatacgttca tgatttcgtt aacaggttaa
     6121 tttctaactg acagtaccta ccttaattac ctaccatata ccatgttagc tttttgtatg
     6181 tgtcacttaa gggtagactg aggagaacag ctgttttgag tggttgtggg caatggaact
     6241 tctctaggaa gttagcagaa aaaatgtttc tatgtggtat aaaaattgta gatgacatta
     6301 gatacagttc caagtaatga tgaatcagtg tagaaatggt tatgaattaa aaccatttat
     6361 aatttgactt atttcaagtt tattaaattt ctaagtgttt tagtactatt ggccatcaga
     6421 taaaaatatt ctgaagttag acaaacaatt ataaatatgg aaaaattgtg tctttgaaac
     6481 aatgaaaact aaaatgagtg cagaattaaa accttattga attgcatcag tctttaggca
     6541 attaatttgt ctcagcttat ttaaactaat tgtcattttc tacttttttt caaactacta
     6601 cctttaacct tctttagggc ccaagagacg gcccagcagg taaaggtacc tgctgccagg
     6661 tctaatgagc taagtttgat tgctgagagc cacacagtgg aagatgagaa ccaactccct
     6721 cacgttgtct tctgaccttt gtgtgcctgc tgtggcacat ttgtgctccc cccacccccc
     6781 ccacacacac aaatgaaatc aatgtaaaaa taaaatgctg tttaatattg gtgaagtgga
     6841 gctgagaaaa ttgtgtaagc aggagggcct gagtttgtgt ctgcagcacc tgcgtaaacg
     6901 catggcatgg ttggttgcct gctgctgtca ccccattact aaggggtggt gacaggtgga
     6961 ttctagagca tgctggccat ccctgccttt ttcccttggc atcaaaactg ataaatgttg
     7021 gaagtattct gagaagatta aaaagtgttc ttaaaaactt ccctcagtcc agaattctgt
     7081 gaaaagaggc caagttttta gctacttgag gcttttacca gatccctgcc atttgcttta
     7141 ggaaaactga gaaattttat tttcatggaa ataaatttct tagtctgctt tgcccggtgt
     7201 tgcaggcagg attggtgcac acaatgccgc ttgttggtca ggcttgtact ctaggtacaa
     7261 tcacactatt agagttcttc cagtgacttc agggagacaa gtgccacatg tagatggaat
     7321 tcatttccta aagctggttt atagagctgc aaataggatt taaacatggt gactatgatt
     7381 gctttcttta ctatctgtgt gctctccttt gctagcttat ggagttaggc taaagccctt
     7441 cagtttctca tggttggatg gtatctcaca tgtcatttgt atgggagaac cctggttgct
     7501 tattaggtct gcttctcagt tctcatggaa tattgaacac agactatgtt tcttagttat
     7561 atccttcttg atctcaaacc aaagtaaacc agtacttggc acagacatat tacataaata
     7621 atcagaaagc tggattccag ttacttagtg gtggacttgc ctttgctaac taacacacga
     7681 ggttggtgtg ctgtttctgt gtgaagctcc tatgaatgat ggatttggga ctagagaggg
     7741 aacagtaatt gagggctaga atatattgtt tttgttctct tggtgcctga aacaggggag
     7801 cctcaataat atgagtgaac taagctggag atgacctaaa cacacgtgat gaggtgggag
     7861 agtcggcagt gctcagaaga gcctgatact tgggttgggt ttaagaattt tgtgtaagat
     7921 catttgagtt caacaatcct tttcctgctt cttatgagat atgtaaagat atcagtctaa
     7981 gagtatacat agtacactac acacacacac acacacacac acacacacac agagtttcac
     8041 tatgtattcc ttgctgacct tggattgctg tgtagaccac gctggcctta aactcacaga
     8101 gatcagcctg cctcagagta ctggctctgt actgattttc acttacctgc ctctaaccca
     8161 tctgatgcta tgactgatgc ttagagctta cttacatttc tactttttga catctgcgtc
     8221 tagtggggcc tagatacaca cacacacttt tatgcaagat aatctaagac tatttccttt
     8281 ttcaatatat aggttagcat atagacttta aagttgggtt cttgcctcaa cgcaaaacag
     8341 agcaaatgga aatgggtccc gtgcttttat taagacattt ggtgtgtatt ttatgaacta
     8401 taagctgttt ccaaaactga aactggctat tcatgtttta ctgtctatta gcaagaattc
     8461 caaaggcttt gctcacctaa taaaggagag cgtcttttaa aaagttgcaa tggtttgctt
     8521 tatagaaaca atctttcaaa agaaatcaaa tatacttgga ataaaattat tctcaactat
     8581 gtgttcacat agctacagtg tatgcagtgt atggattttc agaatagaat actttgagtc
     8641 ctgtaattga aattgaatat aaactggaat aaaatcaata ttcttgagac ct
//
