LOCUS       NM_172827               5181 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus leucyl/cystinyl aminopeptidase (Lnpep), mRNA.
ACCESSION   NM_172827
VERSION     NM_172827.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5181)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5181)
  AUTHORS   Zuchowski,Y., Carty,J., Terker,A.S., Bock,F., Trapani,J.B.,
            Bhave,G., Watts,J.A., Keller,S., Zhang,M., Zent,R., Harris,R.C. and
            Arroyo,J.P.
  TITLE     Insulin-regulated aminopeptidase is required for water excretion in
            response to acute hypotonic stress
  JOURNAL   Am J Physiol Renal Physiol 324 (6), F521-F531 (2023)
   PUBMED   36995926
  REMARK    GeneRIF: Insulin-regulated aminopeptidase is required for water
            excretion in response to acute hypotonic stress.
REFERENCE   3  (bases 1 to 5181)
  AUTHORS   Weimershaus,M., Carvalho,C., Rignault,R., Waeckel-Enee,E.,
            Dussiot,M., van Endert,P., Maciel,T.T. and Hermine,O.
  TITLE     Mast cell-mediated inflammation relies on insulin-regulated
            aminopeptidase controlling cytokine export from the Golgi
  JOURNAL   J Allergy Clin Immunol 151 (6), 1595-1608 (2023)
   PUBMED   36708814
  REMARK    GeneRIF: Mast cell-mediated inflammation relies on
            insulin-regulated aminopeptidase controlling cytokine export from
            the Golgi.
REFERENCE   4  (bases 1 to 5181)
  AUTHORS   Drajac,C., Laubreton,D., Marquant,Q., Chottin,C., Ferret,C.,
            Bouguyon,E., Schwartz-Cornil,I., Saveanu,L., Riffault,S. and
            Descamps,D.
  TITLE     Control of IFN-I responses by the aminopeptidase IRAP in neonatal
            C57BL/6 alveolar macrophages during RSV infection
  JOURNAL   Mucosal Immunol 14 (4), 949-962 (2021)
   PUBMED   33846534
  REMARK    GeneRIF: Control of IFN-I responses by the aminopeptidase IRAP in
            neonatal C57BL/6 alveolar macrophages during RSV infection.
REFERENCE   5  (bases 1 to 5181)
  AUTHORS   Walton,S.L., Mirabito Colafella,K.M., Ansari,A., Chai,S.Y. and
            Denton,K.M.
  TITLE     Insulin-regulated aminopeptidase deficiency impairs cardiovascular
            adaptations and placental development during pregnancy
  JOURNAL   Clin Sci (Lond) 134 (23), 3213-3228 (2020)
   PUBMED   33252660
  REMARK    GeneRIF: Insulin-regulated aminopeptidase deficiency impairs
            cardiovascular adaptations and placental development during
            pregnancy.
REFERENCE   6  (bases 1 to 5181)
  AUTHORS   Keller,S.R.
  TITLE     The insulin-regulated aminopeptidase: a companion and regulator of
            GLUT4
  JOURNAL   Front Biosci 8, s410-s420 (2003)
   PUBMED   12700100
  REMARK    GeneRIF: Initial characterization of knockout mice in which
            IRAP/P-LAP was deleted revealed that GLUT4 protein levels were
            dramatically decreased in all fat and muscle tissues.
            Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5181)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5181)
  AUTHORS   Bose,A., Guilherme,A., Robida,S.I., Nicoloro,S.M., Zhou,Q.L.,
            Jiang,Z.Y., Pomerleau,D.P. and Czech,M.P.
  TITLE     Glucose transporter recycling in response to insulin is facilitated
            by myosin Myo1c
  JOURNAL   Nature 420 (6917), 821-824 (2002)
   PUBMED   12490950
REFERENCE   9  (bases 1 to 5181)
  AUTHORS   Keller,S.R., Davis,A.C. and Clairmont,K.B.
  TITLE     Mice deficient in the insulin-regulated membrane aminopeptidase
            show substantial decreases in glucose transporter GLUT4 levels but
            maintain normal glucose homeostasis
  JOURNAL   J Biol Chem 277 (20), 17677-17686 (2002)
   PUBMED   11884418
REFERENCE   10 (bases 1 to 5181)
  AUTHORS   Jiang,H., Li,J., Katz,E.B. and Charron,M.J.
  TITLE     GLUT4 ablation in mice results in redistribution of IRAP to the
            plasma membrane
  JOURNAL   Biochem Biophys Res Commun 284 (2), 519-525 (2001)
   PUBMED   11394912
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC147983.3 and
            AC121795.3.
            
            On May 2, 2007 this sequence version replaced NM_172827.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029094.1, BC120925.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                AC147983.3         116327-116422       c
            97-937              AC121795.3         171146-171986       c
            938-1076            AC121795.3         167863-168001       c
            1077-1208           AC121795.3         166561-166692       c
            1209-1329           AC121795.3         164240-164360       c
            1330-1484           AC121795.3         163488-163642       c
            1485-1598           AC121795.3         160935-161048       c
            1599-1730           AC121795.3         159297-159428       c
            1731-1862           AC121795.3         155367-155498       c
            1863-2023           AC121795.3         145776-145936       c
            2024-2112           AC121795.3         145484-145572       c
            2113-2296           AC121795.3         138998-139181       c
            2297-2453           AC121795.3         137425-137581       c
            2454-2638           AC121795.3         131134-131318       c
            2639-2800           AC121795.3         129528-129689       c
            2801-2941           AC121795.3         123752-123892       c
            2942-3023           AC121795.3         123091-123172       c
            3024-5181           AC121795.3         120337-122494       c
FEATURES             Location/Qualifiers
     source          1..5181
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 9.77 cM"
     gene            1..5181
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /note="leucyl/cystinyl aminopeptidase"
                     /db_xref="GeneID:240028"
                     /db_xref="MGI:MGI:2387123"
     exon            1..96
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..3155
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /EC_number="3.4.11.3"
                     /note="OTase; oxytocinase; cystinyl aminopeptidase"
                     /codon_start=1
                     /product="leucyl-cystinyl aminopeptidase"
                     /protein_id="NP_766415.1"
                     /db_xref="CCDS:CCDS37457.1"
                     /db_xref="GeneID:240028"
                     /db_xref="MGI:MGI:2387123"
                     /translation="MESFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEV
                     EYEPRGSRLLVRGLGEHEMDEDEEDYESSAKLLGMSFMNRSSGLRNSAAGYRQSPDGT
                     CSLPSARTLVICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPVATNGKV
                     FPWAQIRLPTAIIPLCYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISR
                     VTFMSAVSSQEKQVEILEYPYHEQIAVVAPEPLLTGHNYTLKIEYSANISNSYYGFYG
                     ITYTDKSNEKKYFAATQFEPLAARSAFPCFDEPAFKATFIIKITRNEHHTALSNMPKK
                     SSVPAEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIGQVHH
                     ALDTTIKLLEFYQTYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATS
                     SVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSY
                     EDFLDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSED
                     VFRHAVILYLHNHSYAAIQSDDLWDSFNEVTDKTLDVKKMMKTWTLQKGFPLVTVQRK
                     GTELLLQQERFFLRMQPESQPSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVIN
                     LTEQVQWVKVNSNMTGYYIVHYAHDDWTALINQLKRNPYVLSDKDRANLINNIFELAG
                     LGKVPLRMAFDLIDYLKNETHTAPITEALFQTNLIYNLLEKLGHMDLSSRLVARVHKL
                     LQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATNLFDSWMASNGTQSLP
                     TDVMVTVFKVGARTEKGWLFLFSMYSSMGSEAEKNKILEALASSEDVHKLYWLMKSSL
                     DGDIIRTQKLSLIIRTVGRHFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTH
                     LFSTKTHLSEVQAFFENQSEATLKLRCVQEALEVIQLNIQWMVRNLKTLSQWL"
     exon            97..937
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1076
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1208
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1329
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1484
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1598
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1730
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1862
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2023
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2112
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2296
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2453
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2638
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2800
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2941
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2942..3023
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            3024..5181
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3365..3370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /note="hexamer: AATGAA"
     polyA_site      3392
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
     regulatory      4692..4697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /note="hexamer: AATAAA"
     polyA_site      4722
                     /gene="Lnpep"
                     /gene_synonym="2010309L07Rik; 4732490P18Rik; CAP; gp160;
                     IRAP; PLAP; vp165"
                     /note="major polyA site"
ORIGIN      
        1 agtcgtcagg accgcttcgg ctctcggagt aggaagcttg gggcgctggg ctggtaagga
       61 cccgcggcgg ggcgaagatg gagtccttta ccaatgatcg gcttcagctt ccaaggaata
      121 tgatcgaaaa cagcatgttt gaagaagagc cagatgtggt agatttagcc aaagaacctt
      181 gtttacatcc tctggaaccc gatgaagtgg aatatgagcc ccgaggttcg aggcttctgg
      241 tgcgaggtct tggtgagcat gagatggacg aggatgaaga ggattatgag tcctctgcga
      301 agctgctggg catgtccttc atgaacagaa gctcaggcct gcggaacagt gcagcaggct
      361 acaggcagag tccagatggg acttgttcat taccctctgc caggacctta gtgatctgtg
      421 tttttgtcat tgtggttgcg gtctctgtaa tcatggtgat ttatctactg cctagatgta
      481 cctttaccaa agaaggctgc cacaaaacaa accagtcagc agaactcatc cagccagttg
      541 ctacaaacgg gaaagtgttc ccatgggctc aaattaggct tcccactgcc attattcctc
      601 tatgctatga acttagccta catccaaacc taacctcaat gacattcagg ggatctgtga
      661 caatttcact tcaggctctt caagacacac gggatatcat tctccatagc acaggacata
      721 atatttcaag agtgacattt atgtcagcag tttcaagtca agaaaaacaa gttgaaattc
      781 tggaatatcc atatcatgaa caaatcgccg ttgttgcccc ggaacctctt ctaacaggac
      841 acaattatac cctgaagata gagtattcag caaatatatc taactcttat tatgggtttt
      901 atggcatcac ctacacagat aaaagtaatg agaaaaagta ctttgcagca actcagtttg
      961 aacctctggc agcaagatct gcttttcctt gttttgatga accagcattt aaggccacat
     1021 ttatcatcaa gatcacaagg aatgagcacc atactgcgtt atcaaatatg cctaagaagt
     1081 catcggtccc tgcagaagaa ggacttattc aagatgagtt ttctgaaagt gtgaaaatga
     1141 gcacatacct ggttgctttc attgtagggg agatgaggaa cctgagtcag gatgtaaatg
     1201 gaactctggt ttctgtgtat gctgtaccag aaaaaattgg tcaagttcac catgccttgg
     1261 acacaactat aaagcttctt gagttttatc aaacttactt tgaaattcag tacccactta
     1321 agaaattgga tttggtggcc attcctgact ttgaagcagg agcaatggaa aactggggcc
     1381 tgcttacatt ccgagaagag actcttctgt atgacaatgc aacttcttca gtagcagaca
     1441 gaaaactggt cactaaaatc attgctcacg aactggcaca tcagtggttt ggaaatctgg
     1501 ttacaatgca gtggtggaat gacctgtggc taaatgaagg ctttgccact ttcatggagt
     1561 atttctctgt ggaaaaaata ttcaaagagc tcaacagtta tgaagacttc ttagatgctc
     1621 gatttaaaac catgaggaaa gattccttga attcgtctca tccaatatca tcatctgttc
     1681 agtcttcgga acaaatagaa gaaatgtttg attctctctc ctattttaag ggagcttctc
     1741 tcttgttgat gctgaaaagt taccttagtg aagatgtatt tcggcatgct gtcattcttt
     1801 acctgcacaa tcacagctat gcagctatcc aaagtgatga tctctgggac agcttcaatg
     1861 aggtcacaga caaaactcta gatgtaaaga aaatgatgaa aacctggacc ctacagaaag
     1921 gattcccgtt agtgacagtc cagaggaagg ggactgagct tcttctacaa caggaaagat
     1981 tttttctacg catgcaacca gaaagtcagc cttcagatac aagccacctt tggcatattc
     2041 caatatccta tgtcactgat ggaagaaact attcagaata tcgatcagtt tcactactgg
     2101 acaagaaatc agatgtcatc aatcttacag aacaagtgca gtgggtcaaa gtcaattcaa
     2161 acatgactgg ctattacatt gttcactatg ctcatgatga ctggacagct ctaatcaatc
     2221 agttaaaaag aaacccttat gttctgagtg acaaagaccg agccaacctg atcaataaca
     2281 tctttgaact tgcaggtctt ggcaaagtgc ctcttcggat ggcatttgat ttgattgact
     2341 atcttaaaaa tgagacccac actgcaccga tcactgaagc cctgttccag acaaacctta
     2401 tctataatct cctagaaaaa ctggggcaca tggacctgtc ctcaagattg gtggccagag
     2461 tacataaatt gctccagaac caaatccagc agcagacttg gacagatgaa ggcacaccat
     2521 ccatgcgaga gcttcggtca gccttgctgg aatttgcctg tgcccacagc ctagagaact
     2581 gtaccactat ggccacaaat ctgtttgaca gttggatggc atcaaatgga actcagagcc
     2641 tgcctactga tgtcatggtc actgtgttca aggtgggagc gagaaccgag aaaggctggt
     2701 tgttcctctt tagcatgtat tcctccatgg gctctgaagc agaaaagaat aaaattcttg
     2761 aagctcttgc cagctcagag gatgtacata aactttactg gttaatgaaa agtagccttg
     2821 atggtgacat catccgaaca cagaagttgt cacttatcat tagaacagtg ggcagacatt
     2881 ttcctggaca cttgctggct tgggattttg ttaaagaaaa ctggaataag cttgtacata
     2941 agttccatct gggctcctat accatacaaa gtattgttgc tggatctact cacttatttt
     3001 caacaaagac acatttatct gaggtccagg cattctttga aaatcagtca gaggcaacct
     3061 tgaagcttcg gtgtgttcag gaggctttgg aagtgattca gctgaatatc cagtggatgg
     3121 tcaggaatct gaaaacgctc tcccagtggc tgtagcactc acagctgatc tccggcgccc
     3181 atggctctgc tgctttcgca aaggttgagt gaaggccggc ctgctgctga gttgtttgca
     3241 ctgttaggag ttctagttag ctcagggccc aattgtattt ttcatatctt ttctgaaatg
     3301 tctttaggca gtagttattt attacaaaat tatattcacc tgtatgtcat ccatctacaa
     3361 taacaatgaa taacttttct ttgacacaca aatggagaaa aaagtcagat ttgaaatttt
     3421 gttttatttc ttagtgtcca gagtattact gttacagtgc aaccaaggaa ggtctgctgt
     3481 aagaaccact gtgtttgtag gttgctgatt gatcaactgt ttgttgcttt ttgttaaata
     3541 gatacacctg ggtttggtag tgcagtggca aagacattga aggtacagct ctagacagat
     3601 gacctgattg ggggttcttt aaaaaaagtt ttgtccagtt tccagttttt tcctgcaaaa
     3661 tagccaggtt ctaaagactt tttcatattt ctgttaaatt gaacagctga acagtcaggc
     3721 tcaaagtttc agttttccaa atatttaaca ctttctgctt catcttcatg acactatgta
     3781 ggaagtgttc tgaactgagt taacattaat tactttactc atgaattcca gtacccctaa
     3841 ctttgtatcc tggtaaggcc ttccaccagc tttctcctgt agaggagcac tccatgcttg
     3901 ggaggatttc tcctgtagag gagcactcca tgccatgctt gggaggattt ctgtgagcgc
     3961 tggtggcttt gtcattactt tcacccaaga atgtaatttg tttaagttgc tgtttgaacc
     4021 ttacaaatca taccctcttc tctgtgaatc atacccatgt gtgggtttta ctttatgtta
     4081 cagagtatat tagaagcatt tcttaaatag gatcttcaag aaattaaagc tttttatttt
     4141 gaagttcacc ataatacctt aaaggaataa tgagaatgtg gagcaggagg aagttgaaaa
     4201 tatggtgggc tatgaattct ttttttcact gttaaaaaca gtgtttttat ttagttgaaa
     4261 aaattacagg ttttttgttt gtttgtttgt ttgtttatca tggccaaact acgttaaaca
     4321 gagtggccaa gaatcaagca gaggacaagg gagggaggga acccagagca gaatgtgggc
     4381 gctttcactc cttctgaagg agaaggattg tacttgaact ttttgagcta tgcagactta
     4441 ttcctagatt gttgtgtttc tttgaatctt aggagagaag ctttcttctt aataactcat
     4501 gagaagtcta tattttgttt gaaaacagtg tctgtgtaca taaaaaggga atcactcatt
     4561 tctgaacact gaaaacactc cacagagtca gaccatagag aggccacttg tttttattca
     4621 gctgttgtaa agttagaata tgtggagtta tatacaaagt tatagtttat tttatgagaa
     4681 tatttttata taataaaatt ttaatggctg acaagctgaa aatagcctgc tttaatccta
     4741 gagtttgctc ccaatttcat cttttctaaa cagtttttgg gtttttgttt gtttgtttgt
     4801 tttttaattt gtgctttttt tagtagaaac tgttattcct gagaatcata gaatcatctt
     4861 tctattttag tgaaataggt aattatagat ctctattccc cttgtatttt tggtaaatgt
     4921 ctgacagttg tgttgatact gaaggttagt agggttttat atttttagag tgaaggacaa
     4981 atactcttgt gggttttggt tgtccctttt cattttttac catgctgtat tactagatta
     5041 tactttgata acagagttta acttttgcta cttctcaaga tcagttcaac cttgagattt
     5101 acctgcccat ctttttgttg atcttatagt ctttgtaatt ctgcatatgg caaatcttgt
     5161 cctaaataat actttttttc c
//
