LOCUS       NM_010725               5377 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus LIM homeobox transcription factor 1 beta (Lmx1b),
            mRNA.
ACCESSION   NM_010725
VERSION     NM_010725.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5377)
  AUTHORS   Baltar,J., Miranda,R.M., Cabral,M., Rebelo,S., Grahammer,F.,
            Huber,T.B., Reguenga,C. and Monteiro,F.A.
  TITLE     Neph1 is required for neurite branching and is negatively regulated
            by the PRRXL1 homeodomain factor in the developing spinal cord
            dorsal horn
  JOURNAL   Neural Dev 19 (1), 13 (2024)
   PUBMED   39049046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5377)
  AUTHORS   McCallum-Loudeac,J., Moody,E., Williams,J., Johnstone,G.,
            Sircombe,K.J., Clarkson,A.N. and Wilson,M.J.
  TITLE     Deletion of a conserved genomic region associated with adolescent
            idiopathic scoliosis leads to vertebral rotation in mice
  JOURNAL   Hum Mol Genet 33 (9), 787-801 (2024)
   PUBMED   38280229
REFERENCE   3  (bases 1 to 5377)
  AUTHORS   Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A.,
            Martins,G.G., Novoa,A. and Mallo,M.
  TITLE     Tgfbr1 controls developmental plasticity between the hindlimb and
            external genitalia by remodeling their regulatory landscape
  JOURNAL   Nat Commun 15 (1), 2509 (2024)
   PUBMED   38509075
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5377)
  AUTHORS   Koutsioumpa,C., Santiago,C., Jacobs,K., Lehnert,B.P., Barrera,V.,
            Hutchinson,J.N., Schmelyun,D., Lehoczky,J.A., Paul,D.L. and
            Ginty,D.D.
  TITLE     Skin-type-dependent development of murine mechanosensory neurons
  JOURNAL   Dev Cell 58 (20), 2032-2047 (2023)
   PUBMED   37607547
REFERENCE   5  (bases 1 to 5377)
  AUTHORS   Chen,Y., Zhou,T., Liao,Z., Gao,W., Wu,J., Zhang,S., Li,Y., Liu,H.,
            Zhou,H., Xu,C. and Su,P.
  TITLE     Hnrnpk is essential for embryonic limb bud development as a
            transcription activator and a collaborator of insulator protein
            Ctcf
  JOURNAL   Cell Death Differ 30 (10), 2293-2308 (2023)
   PUBMED   37608075
REFERENCE   6  (bases 1 to 5377)
  AUTHORS   Chen,H., Lun,Y., Ovchinnikov,D., Kokubo,H., Oberg,K.C.,
            Pepicelli,C.V., Gan,L., Lee,B. and Johnson,R.L.
  TITLE     Limb and kidney defects in Lmx1b mutant mice suggest an involvement
            of LMX1B in human nail patella syndrome
  JOURNAL   Nat Genet 19 (1), 51-55 (1998)
   PUBMED   9590288
REFERENCE   7  (bases 1 to 5377)
  AUTHORS   Dreyer,S.D., Zhou,G., Baldini,A., Winterpacht,A., Zabel,B.,
            Cole,W., Johnson,R.L. and Lee,B.
  TITLE     Mutations in LMX1B cause abnormal skeletal patterning and renal
            dysplasia in nail patella syndrome
  JOURNAL   Nat Genet 19 (1), 47-50 (1998)
   PUBMED   9590287
REFERENCE   8  (bases 1 to 5377)
  AUTHORS   Loomis,C.A., Kimmel,R.A., Tong,C.X., Michaud,J. and Joyner,A.L.
  TITLE     Analysis of the genetic pathway leading to formation of ectopic
            apical ectodermal ridges in mouse Engrailed-1 mutant limbs
  JOURNAL   Development 125 (6), 1137-1148 (1998)
   PUBMED   9463360
REFERENCE   9  (bases 1 to 5377)
  AUTHORS   Cygan,J.A., Johnson,R.L. and McMahon,A.P.
  TITLE     Novel regulatory interactions revealed by studies of murine limb
            pattern in Wnt-7a and En-1 mutants
  JOURNAL   Development 124 (24), 5021-5032 (1997)
   PUBMED   9362463
REFERENCE   10 (bases 1 to 5377)
  AUTHORS   Matise,M.P. and Joyner,A.L.
  TITLE     Expression patterns of developmental control genes in normal and
            Engrailed-1 mutant mouse spinal cord reveal early diversity in
            developing interneurons
  JOURNAL   J Neurosci 17 (20), 7805-7816 (1997)
   PUBMED   9315901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929212.8.
            
            On Feb 14, 2019 this sequence version replaced NM_010725.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125469.1, AB221651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-657               AL929212.8         196509-197165       c
            658-844             AL929212.8         195556-195742       c
            845-1077            AL929212.8         125117-125349       c
            1078-1259           AL929212.8         123215-123396       c
            1260-1337           AL929212.8         122952-123029       c
            1338-1404           AL929212.8         122738-122804       c
            1405-1548           AL929212.8         121149-121292       c
            1549-5377           AL929212.8         117032-120860       c
FEATURES             Location/Qualifiers
     source          1..5377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.48 cM"
     gene            1..5377
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /note="LIM homeobox transcription factor 1 beta"
                     /db_xref="GeneID:16917"
                     /db_xref="MGI:MGI:1100513"
     exon            1..657
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..844
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1077
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1259
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1337
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1404
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1548
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..5377
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5357..5362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /note="hexamer: AATAAA"
     polyA_site      5377
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /note="major polyA site"
ORIGIN      
        1 aaaccgagcg gctcctcggg cgcaccatgg cactggagta gtgcggggag cgcgcctgga
       61 gccccgcggc ctgctgcgcc ccgcccggga ccctgctgcg acgcccgcgc ccccccagcc
      121 cgcggggccg cccctgcacc cccgccccct cccccgcccg ccgccgccgc cgccgcctcc
      181 tcctactcct ccgggcggct ccgcgtgccg cccgctgctg cagccgggac ccggggctga
      241 caagcaggtg acaggcgagc agcgagtgcg cgtggctgcg agtagccggt agagagcggc
      301 gcgcggggct gccagccgcc cgggccctcc cgcacgacgc cggggcccgg ggccagcgcg
      361 ccgccgctcc acgctcgccc cggggcagcg ggcggccccg accccgcggg cgccgcgcct
      421 ccccggctgc agcggagcgg gcggacgggc cggagggtga gcggcccagc cggcggggtc
      481 cgcagcgcgc cgggcgtccc atggatatag caacaggtcc cgagtcgctg gagaggtgct
      541 tccctcgcgg gcagacggac tgcgccaaga tgttggacgg catcaagatg ttggacggca
      601 tcaagatgga ggagcacgcc cttcgccccg ggcccgccac cctgggggtg ctgctgggct
      661 ccgactgccc gcatcccgcc gtctgcgagg gctgccagcg gcccatctcc gaccgcttcc
      721 tgatgcgagt caacgagtcg tcctggcacg aggagtgttt gcagtgcgcg gcatgtcagc
      781 aagccctcac caccagctgc tacttccggg atcggaaact gtactgcaaa caagactacc
      841 aacagctctt cgcggcaaag tgcagcggct gcatggagaa gatcgcccct accgagttcg
      901 tcatgcgggc gctggagtgt gtgtaccact tgggctgttt ctgctgctgt gtgtgcgaga
      961 ggcaactgcg caagggggac gagttcgtgc tcaaggaggg ccagctgctg tgcaagggtg
     1021 actatgagaa ggagaaagac ctgctcagct ccgtgagccc ggacgagtct gactctgtga
     1081 agagtgagga tgaagatgga gacatgaagc cggccaaggg gcagggcagc cagagtaaag
     1141 gcagtggaga tgacgggaaa gacccgagaa ggcccaaacg gccccgaacc atcctcacca
     1201 cacagcagcg aagagctttc aaggcatcct ttgaggtctc ctccaagccc tgtcggaagg
     1261 tccgagagac attggcagca gagacaggcc tcagcgtgcg tgtggtccag gtctggtttc
     1321 agaaccaaag agcaaagatg aagaagctgg cccggagaca ccagcaacag caggagcagc
     1381 agaactccca gcggctgggc caagaggttc tgtcaagccg catggagggc atgatggcct
     1441 cctacacgcc gctggcccct ccgcagcagc agatcgtggc catggagcag agcccctacg
     1501 gaagtagcga ccccttccaa cagggcctca cgccgcccca aatgccaggg aacgactcca
     1561 tcttccacga tatcgatagt gatacctccc tcaccagcct cagcgactgc ttcctcggct
     1621 cttccgacgt gggctccctg caggcccgcg tggggaaccc cattgaccgg ctctactcca
     1681 tgcagagctc ctactttgcc tcctgagagc cagccgggcc gcatggacgc ttgggcctgg
     1741 gcctagggtg gagccacagg cctctgcagc cagccggccc cccagcccac cacccgctca
     1801 gactcttcag acagccatac ggtgccctcc cctcggccag ccagacctgg ctcaagtgcc
     1861 caccgggcac agccaggcaa ggcagatggg tgcagcctgg gcagggactg tgtcctgccc
     1921 acagagacct tgtgacccct ggggacccag agctcttgga cagtcacttg cctcccagtc
     1981 ctttgacttc atcactacct tccccgtccc cgcctctttt tgggggaagc ttaaatttgt
     2041 tcgttctttc ttttctttct ttctttcttt ctttctttct ttctttcttt ctttctttct
     2101 ttcttttttt ttataaacat tctgtttcca gccaacctcc attgtccctg caaggccagc
     2161 cctgggacag tgcctggtac ccgagaaaca gttatacggg tgtcctgcgc tggagaccac
     2221 ttccccttct ggttagctcg ggggatggtt tctgggtcct gggaggccca gggtcactgt
     2281 tcccagccct aggctggagc acaggagagg agggcccatg caggtgtgac aggctctttg
     2341 gccctgcctg aactgggagt ctcagcaaga ggagggatgt ggacaaagcc cagagagacc
     2401 caaagggaca gagatgcgcg cacgtaaagc cactcacatc tgtaggcaca cctgtgcaag
     2461 catgcatata tacacctggt gcacacgcac acaaagatgg aagagctgcc tttcctttcc
     2521 agaagcagcg gtgaggtcag cgagcagggc ctacctctaa gagcaattgg agagggagga
     2581 aggacgtagg cctgaggtgt gagcagacag acctgggtgg accccaggct ctgtacaggt
     2641 catgactgcc agggcaggag ggtagtcaca aacctacagg tcccagggca aagctggagt
     2701 ccagagaacc cagtatacac agacctcagc agacactcca gatggagagg acctcaagag
     2761 tctgaccctt ggtaccatcc gatacttaac tccctcggtc cttcttctta cccagggcca
     2821 gcgatggcca gctgccctcc ttgtgggctc ccctgaccct caatctcctc ttgcctgtca
     2881 gctgaggctg tccgctggca gggctcctga ccttagccag ctcgcactca acaaggccag
     2941 caccttctct gctcttggca ccttagctct gctgatgcgg cttaggtctc atgactttgg
     3001 agccccatcc ttgttccata atgacccccc tccccggggc ctcacacagg cacagtgaca
     3061 agctacaaac tccttcaata tgtgtggatg ggatgttgat tgcttagagc ccatggaaga
     3121 ccaccgcttg tacctggttg cctttccttt tgttggctca gtcagcttgg ggcgttactc
     3181 tgaagccact gtatctgttc cctctgtctc agctgcatca ggtcagccct gtggggcgcc
     3241 ccacagaatc cttgcacagt tataggccac cagcatttca gcctcctgag tcacccccag
     3301 cccccagtct cctggactct tcctgcctga agctgaagca gccgtggttc tttccttgtc
     3361 accccccccc cgcacaccac cccccaacct ctggcaagca ctgtgttcca ggccagaagc
     3421 ccaggagaag gctgccattc atttaacgca gactcctagc cacccctcac ccaccaaccc
     3481 acccgtcctg atgtctgccg agctctagct gtgagcacgg caggatgagt atctctctgt
     3541 cgcccgccat tttgggctcc tgtgcctggt tagttaagct gcgtgggtta atttcctgtc
     3601 tctggggaga cctcagaccc ccttagcccc acccagatgt cacaatatgg agtcagcagg
     3661 gaagagcagc tagcacagcc ctcccgtgtc ccccattcta tcactatcct ccatgctgaa
     3721 ggtgtggtcc tgagctagct gcttgtgtgg ctcgcccttg cctcctctgg cacaggcccc
     3781 tggctgaatg gtacagtgca tactccgggc agacccaggg taaataggag ctccaggaac
     3841 ccgggcctac tctcatccac tttttaagtt gggagatgca atccagtaga ctgtgtcgct
     3901 gctgagaaac ctgagacagg agaagagctg ggatgtgctc aaggcttcac agcaacgtag
     3961 tgacagagcc acagatgagg agaggacatt aggtctgtcc ccatctctgt ctcacatatg
     4021 caccccacca ccaccaccag ggaccaatgc gttctcacca cacctgctga ccccaagggt
     4081 cctccaaacc gagtccagcc ctggcctctg ctgttgccat gctggtgtcc ccaagccaga
     4141 agatgttatc acttctaagt tgccagagga gggtcccccc agccaccaca ccagagatgc
     4201 cctggcagcc actctcagca ttctttcacc acggctgtgg cctgctgccc tgctgagaca
     4261 acatggctgc tgcagggaca agggcttctg tcccgtggga agagacagcc tttgatcttg
     4321 cccagacctt gttagatagc acactcaggc ttctggaact gaggctggaa ggaggcagtg
     4381 gtggagggtt gaaggtgggg ggtggggcta gcctgcagcc tgaaagggca gagggatatg
     4441 ggagaatgag gtagaaattg agagagaaaa tccaagttcc acctcctggc tgggggtgtg
     4501 gcatgttgag gctcaggcag agaggaagga gcctgtccag gtgtcacaca ggagtgacaa
     4561 gaacctgagc tttgtcccag ccagggccct atctgtagat tcattccatg aggcttccct
     4621 tctctctgct gtcctcagag actcagaaga ggccccacac acagacacca caccaggggt
     4681 gagagtcaga ccaaggggtg gcacagacag cctgctgtta tggaggcttc cttagtggca
     4741 ggtgggcatt gagaaactgc ccttacataa gagatccagc tcaagggcag cctctcctcc
     4801 tttagggaca tccctttgaa gtgagaccac ctccctgtct gtctgattgt accccccccc
     4861 cccccgctca gcaggggaag atggactcag agctctgggc acccctagga ccagggggac
     4921 gctgcagccc agggctgacc gatgcgtgga aggggcagca cactcacaca cgtgcgcaca
     4981 cactcacacc cgaaacaagg aggctcacac atggcctggg agcagggaga caggaaggac
     5041 ccttcaacat gtggcccttg acaggggcaa ttgccaatgg tctctgggct gctgccctgc
     5101 cctggggtcc cgcttggagg gcgtttgttg cagctggact ggggccaggc cacccatcgt
     5161 attctttccg tttaccttgt acagactgcc cgcctgccat ccccacacac attttattta
     5221 ataacttgtc attgttaaat tatttattag cgtttccaca tcaccacccc cgccttccac
     5281 tcaccttctg cctcttccca caaaagcaga aaatggaaac agcaagaaaa aaagacaaga
     5341 tgttggtata tttgtaaata aacaacctgt acactcc
//
