LOCUS       NP_034855                401 aa            linear   ROD 04-DEC-2024
DEFINITION  LIM homeobox transcription factor 1-beta [Mus musculus].
ACCESSION   NP_034855
VERSION     NP_034855.3
DBSOURCE    REFSEQ: accession NM_010725.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 401)
  AUTHORS   Baltar,J., Miranda,R.M., Cabral,M., Rebelo,S., Grahammer,F.,
            Huber,T.B., Reguenga,C. and Monteiro,F.A.
  TITLE     Neph1 is required for neurite branching and is negatively regulated
            by the PRRXL1 homeodomain factor in the developing spinal cord
            dorsal horn
  JOURNAL   Neural Dev 19 (1), 13 (2024)
   PUBMED   39049046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 401)
  AUTHORS   McCallum-Loudeac,J., Moody,E., Williams,J., Johnstone,G.,
            Sircombe,K.J., Clarkson,A.N. and Wilson,M.J.
  TITLE     Deletion of a conserved genomic region associated with adolescent
            idiopathic scoliosis leads to vertebral rotation in mice
  JOURNAL   Hum Mol Genet 33 (9), 787-801 (2024)
   PUBMED   38280229
REFERENCE   3  (residues 1 to 401)
  AUTHORS   Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A.,
            Martins,G.G., Novoa,A. and Mallo,M.
  TITLE     Tgfbr1 controls developmental plasticity between the hindlimb and
            external genitalia by remodeling their regulatory landscape
  JOURNAL   Nat Commun 15 (1), 2509 (2024)
   PUBMED   38509075
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 401)
  AUTHORS   Koutsioumpa,C., Santiago,C., Jacobs,K., Lehnert,B.P., Barrera,V.,
            Hutchinson,J.N., Schmelyun,D., Lehoczky,J.A., Paul,D.L. and
            Ginty,D.D.
  TITLE     Skin-type-dependent development of murine mechanosensory neurons
  JOURNAL   Dev Cell 58 (20), 2032-2047 (2023)
   PUBMED   37607547
REFERENCE   5  (residues 1 to 401)
  AUTHORS   Chen,Y., Zhou,T., Liao,Z., Gao,W., Wu,J., Zhang,S., Li,Y., Liu,H.,
            Zhou,H., Xu,C. and Su,P.
  TITLE     Hnrnpk is essential for embryonic limb bud development as a
            transcription activator and a collaborator of insulator protein
            Ctcf
  JOURNAL   Cell Death Differ 30 (10), 2293-2308 (2023)
   PUBMED   37608075
REFERENCE   6  (residues 1 to 401)
  AUTHORS   Chen,H., Lun,Y., Ovchinnikov,D., Kokubo,H., Oberg,K.C.,
            Pepicelli,C.V., Gan,L., Lee,B. and Johnson,R.L.
  TITLE     Limb and kidney defects in Lmx1b mutant mice suggest an involvement
            of LMX1B in human nail patella syndrome
  JOURNAL   Nat Genet 19 (1), 51-55 (1998)
   PUBMED   9590288
REFERENCE   7  (residues 1 to 401)
  AUTHORS   Dreyer,S.D., Zhou,G., Baldini,A., Winterpacht,A., Zabel,B.,
            Cole,W., Johnson,R.L. and Lee,B.
  TITLE     Mutations in LMX1B cause abnormal skeletal patterning and renal
            dysplasia in nail patella syndrome
  JOURNAL   Nat Genet 19 (1), 47-50 (1998)
   PUBMED   9590287
REFERENCE   8  (residues 1 to 401)
  AUTHORS   Loomis,C.A., Kimmel,R.A., Tong,C.X., Michaud,J. and Joyner,A.L.
  TITLE     Analysis of the genetic pathway leading to formation of ectopic
            apical ectodermal ridges in mouse Engrailed-1 mutant limbs
  JOURNAL   Development 125 (6), 1137-1148 (1998)
   PUBMED   9463360
REFERENCE   9  (residues 1 to 401)
  AUTHORS   Cygan,J.A., Johnson,R.L. and McMahon,A.P.
  TITLE     Novel regulatory interactions revealed by studies of murine limb
            pattern in Wnt-7a and En-1 mutants
  JOURNAL   Development 124 (24), 5021-5032 (1997)
   PUBMED   9362463
REFERENCE   10 (residues 1 to 401)
  AUTHORS   Matise,M.P. and Joyner,A.L.
  TITLE     Expression patterns of developmental control genes in normal and
            Engrailed-1 mutant mouse spinal cord reveal early diversity in
            developing interneurons
  JOURNAL   J Neurosci 17 (20), 7805-7816 (1997)
   PUBMED   9315901
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929212.8.
            
            On Feb 14, 2019 this sequence version replaced NP_034855.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC125469.1, AB221651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164141 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..401
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.48 cM"
     Protein         1..401
                     /product="LIM homeobox transcription factor 1-beta"
                     /note="LMX-1.2; LIM/homeobox protein 1.2; LIM/homeobox
                     protein LMX1B; LIM homeo box transcription factor 1B; GENA
                     191"
                     /calculated_mol_wt=44629
     Region          62..114
                     /region_name="LIM1_Lmx1b"
                     /note="The first LIM domain of Lmx1b; cd09371"
                     /db_xref="CDD:188757"
     Site            order(62,65,83,86,89,92,109,112)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188757"
     Region          121..175
                     /region_name="LIM2_Lmx1a_Lmx1b"
                     /note="The second LIM domain of Lmx1a and Lmx1b; cd09378"
                     /db_xref="CDD:188764"
     Site            order(121,124,143,146,149,152,171,174)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188764"
     Region          182..235
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88609.3)"
     Region          226..282
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..401
                     /gene="Lmx1b"
                     /gene_synonym="Icst; LMX1.1; LMX1.2"
                     /coded_by="NM_010725.3:501..1706"
                     /db_xref="CCDS:CCDS15944.1"
                     /db_xref="GeneID:16917"
                     /db_xref="MGI:MGI:1100513"
ORIGIN      
        1 mdiatgpesl ercfprgqtd cakmldgikm ldgikmeeha lrpgpatlgv llgsdcphpa
       61 vcegcqrpis drflmrvnes swheeclqca acqqalttsc yfrdrklyck qdyqqlfaak
      121 csgcmekiap tefvmralec vyhlgcfccc vcerqlrkgd efvlkegqll ckgdyekekd
      181 llssvspdes dsvksededg dmkpakgqgs qskgsgddgk dprrpkrprt ilttqqrraf
      241 kasfevsskp crkvretlaa etglsvrvvq vwfqnqrakm kklarrhqqq qeqqnsqrlg
      301 qevlssrmeg mmasytplap pqqqivameq spygssdpfq qgltppqmpg ndsifhdids
      361 dtsltslsdc flgssdvgsl qarvgnpidr lysmqssyfa s
//
