LOCUS       NM_001290990            5030 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus lemur tyrosine kinase 3 (Lmtk3), transcript variant 1,
            mRNA.
ACCESSION   NM_001290990
VERSION     NM_001290990.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5030)
  AUTHORS   Montrose,K., Kobayashi,S., Manabe,T. and Yamamoto,T.
  TITLE     Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have
            an Impairment in GluA1 Trafficking
  JOURNAL   Neuroscience 414, 154-167 (2019)
   PUBMED   31310731
  REMARK    GeneRIF: Behavioral analysis of Lmtk3-KO mice revealed a number of
            abnormalities that have been linked to psychiatric disease such as
            hyper-sociability, PPI deficits and cognitive dysfunction. Further
            investigation revealed abnormalities in GluA1 trafficking after
            AMPA stimulation in Lmtk3-KO neurons, along with a reduction in
            GluA1 expression in the post-synaptic density.
REFERENCE   2  (bases 1 to 5030)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 5030)
  AUTHORS   Inoue,T., Hoshina,N., Nakazawa,T., Kiyama,Y., Kobayashi,S., Abe,T.,
            Yamamoto,T., Manabe,T. and Yamamoto,T.
  TITLE     LMTK3 deficiency causes pronounced locomotor hyperactivity and
            impairs endocytic trafficking
  JOURNAL   J Neurosci 34 (17), 5927-5937 (2014)
   PUBMED   24760852
  REMARK    GeneRIF: the dopamine metabolite levels and dopamine turnover rate
            are increased in the striata of Lmtk3(-/-) mice compared with
            controls. In addition, we found that LMTK3 is involved in the
            endocytic trafficking of N-methyl-d-aspartate receptors.
REFERENCE   4  (bases 1 to 5030)
  AUTHORS   Tomomura,M., Morita,N., Yoshikawa,F., Konishi,A., Akiyama,H.,
            Furuichi,T. and Kamiguchi,H.
  TITLE     Structural and functional analysis of the apoptosis-associated
            tyrosine kinase (AATYK) family
  JOURNAL   Neuroscience 148 (2), 510-521 (2007)
   PUBMED   17651901
REFERENCE   5  (bases 1 to 5030)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   6  (bases 1 to 5030)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167242.4 and AC149053.3.
            
            On Dec 13, 2019 this sequence version replaced NM_001290990.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AC167242.4         186007-186341
            336-469             AC167242.4         187111-187244
            470-620             AC167242.4         187470-187620
            621-697             AC167242.4         188054-188130
            698-816             AC167242.4         188564-188682
            817-904             AC167242.4         191535-191622
            905-1053            AC167242.4         191955-192103
            1054-1138           AC167242.4         192971-193055
            1139-1260           AC167242.4         193137-193258
            1261-1410           AC167242.4         193351-193500
            1411-3848           AC167242.4         193784-196221
            3849-4243           AC167242.4         198859-199253
            4244-4379           AC167242.4         201096-201231
            4380-4517           AC167242.4         201572-201709
            4518-5030           AC149053.3         157562-158074       c
FEATURES             Location/Qualifiers
     source          1..5030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.5 cM"
     gene            1..5030
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /note="lemur tyrosine kinase 3"
                     /db_xref="GeneID:381983"
                     /db_xref="MGI:MGI:3039582"
     exon            1..335
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..4534
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase LMTK3;
                     apoptosis-associated tyrosine kinase 3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LMTK3 precursor"
                     /protein_id="NP_001277919.1"
                     /db_xref="CCDS:CCDS39961.1"
                     /db_xref="GeneID:381983"
                     /db_xref="MGI:MGI:3039582"
                     /translation="MPAPGALILLAAVSASGCLASPAHPDGFALSRAPLAPPYAVVLI
                     SCSGLLAFIFLLLTCLCCKRGDVRFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYI
                     LPLAEVSLPMPAPQPPHSDISTPLGLSRQHLSYLQEIGSGWFGKVILGEVFSDYSPAQ
                     VVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGVCVETLPFLLIMEFCQLGDL
                     KRYLRAQRPPEGMSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTS
                     DLTVRIGDYGLAHSNYKEDYYLTPERLWVPLRWAAPELLGELHGSFVLVDQSRESNVW
                     SLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCW
                     RPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPSHSAPRPGTLSSQ
                     FPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPPWQPASAPPAPHT
                     NPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPG
                     PQAPQTPSEVPQLVSETWASPLFPAPRPFPAQSSGSGGFLLSGWDPEGRGAGETLAGD
                     PAEVLGEQGTAPWAEEEEEESSPGEDSSSLGGGPSRRGPLPCPLCSREGPCSCLPLER
                     GDAVAGWGDHPALGCPHPPEDDSSLRAERGSLADLPLVPPTSAPLEFLDPLMGAAAPQ
                     YPGRGPPPAPPPPPPPPRASAEPAASPDPPSALASPGSGLSSPGPKPGDSGYETETPF
                     SPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGSQEKPTFVVQVST
                     EQLLMSLREDVTKNLLGDKGSTPGETGPRKAGRSPANREKGPGPNRDLTSLVSRKKVP
                     SRSLPVNGVTVLENGKPGVPDMKEKVAENGLESPEKEERALVNGEPMSPEAGEKVLAN
                     GVLMSPKSEEKVAENGVLRLPRNTERPPEIGPRRVPGPWEKTPETGGLAPETLLDRAP
                     APCEAALPQNGLEMAPGQLGPAPKSGNPDPGTEWRVHESGGAPRAPGAGKLDLGSGGR
                     ALGGVGTAPAGGPASAVDAKAGWVDNSRPLPPPPQPLGAQQRRPEPVPLKARPEVAQE
                     EEPGVPDNRLGGDMAPSVDEDPLKPERKGPEMPRLFLDLGPPQGNSEQIKAKLSRLSL
                     ALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEDEEAA
                     GSRDPGRTREAPVPVVVSSADGDTVRPLRGLLKSPRAADEPEDSELERKRKMVSFHGD
                     VTVYLFDQETPTNELSVQGTPEGDTEPSTPPAPPTPPHPTTPGDGFPNSDSGFGGSFE
                     WAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN"
     exon            336..469
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            470..620
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            621..697
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..816
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            817..904
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1053
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1138
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1260
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1410
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..3848
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..4243
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4379
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            4380..4517
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            4518..5030
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5030
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /note="major polyA site"
ORIGIN      
        1 ctaccccagc aaccccggct ccccagctcc tctcctccgt ccgcctctcc atcccttcat
       61 ccgtctgtcc tttcgaggag ggggaggggg gtatcagaac cagtaagcaa cccctccctc
      121 cccctgtcct gcatctcccg cccctctcct gggctgaggg aggccagggt tgagcgggtc
      181 cccatggctg ggggctgagg gcccgccccc cctcctcccc agccgccgat tcctccacct
      241 cccttccatc ctggacaaga tgcctgcacc cggcgcactc atcctcctgg cggccgtctc
      301 cgcctccggc tgcctggcgt ccccagcgca cccggatgga ttcgctctga gccgggcccc
      361 tttggctccg ccctacgctg tggtcctcat ttcctgttcg ggtctgctgg ccttcatctt
      421 tctcctcctt acctgtctgt gttgcaaacg gggtgatgtt cgtttcaagg agtttgagaa
      481 cccggaaggg gaggactgct ctggggagta caccccccct gcggaggaga cctcctcctc
      541 acagtcgctg cctgatgtct atattctgcc gctggcagag gtctcactgc caatgcctgc
      601 cccgcagcct ccacactcag acatcagcac ccccctgggc ctgagccgcc agcacctcag
      661 ctacctgcag gagattggca gcggctggtt tgggaaggtg atcctcgggg aggttttctc
      721 agactactcg ccagcccagg tggtggtgaa ggaactccgg gctagtgccg ggcccctgga
      781 acagcgcaag ttcatctccg aggctcagcc ctacaggagc ctgcagcatc ccaacgtcct
      841 ccagtgcctg ggcgtctgtg tggagacctt gcccttcctg ttgatcatgg agttctgcca
      901 gctgggggac ctgaagcgat accttcgggc ccagcggcca cctgaaggca tgtcccctga
      961 acttccccct cgagaccttc ggacactgca gaggatgggt ctagagattg cccgaggact
     1021 ggcacacctg cactctcaca actatgtgca cagcgatctg gcgctgcgca actgcctgct
     1081 aacttcagac ctgactgtgc gtattggaga ctatgggctg gcgcacagca actacaagga
     1141 agactactac ctgacacccg agcgcctatg ggtgccgctg cgctgggcag cgcccgagct
     1201 gctgggcgag ctgcacggca gcttcgtgct ggtagatcaa agccgggaga gtaatgtctg
     1261 gtccctgggg gtgacactct gggagctatt cgagttcggg gcacagccct atcgtcacct
     1321 atcggatgag gaggtcctgg cctttgttgt ccgccagcag cacgtgaagc tggcccggcc
     1381 caggctcaag ctgccctacg ctgactattg gtatgacatt ttgcagtctt gctggcggcc
     1441 gccagcccag cgcccctcag cttctgatct ccagctgcag ctcacttacc tgctgtctga
     1501 gcggcccccc aggccccctc ctccaccacc ccctccccga gatgggccct tcccctggcc
     1561 ctggcccccc tcgcatagtg cgccgcgccc agggaccctg tcctcccagt tcccccttct
     1621 ggatggcttc cccggggctg accctgatga tgtactcaca gtcaccgaga gcagccgtgg
     1681 cctcaacctt gagtgcctgt gggagaaggc ccgccgtggg gcaggccggg gtgggggtgc
     1741 acctccctgg caacccgctt ctgcgcctcc tgcgccccat accaatccat ccaatccctt
     1801 ctatgaggcg ctgtccaccc ctagcgtgct tccggtcatc agcgcacgca gtccctcggt
     1861 gagcagcgag tactatatcc gcctggagga gcacggttct ccaccagagc ccctcttccc
     1921 caacgactgg gacccgctgg acccaggagt acccggtccc caggcccccc agactccctc
     1981 cgaggtccct cagctggtgt ccgagacctg ggcttccccc ctcttccccg cgccccgacc
     2041 cttcccggcc cagtcctcgg gatcaggtgg tttcctgctg agcggctggg accccgaggg
     2101 ccggggcgca ggagagaccc tggcaggaga tcctgccgag gtgcttgggg aacagggtac
     2161 cgcaccctgg gccgaagagg aggaggaaga gagctcccca ggcgaggaca gcagcagcct
     2221 tggaggggga cccagccgca ggggacccct cccctgtccc ttgtgcagcc gcgagggtcc
     2281 ctgctcctgt ctgccattgg agcgggggga cgctgtggcc ggctgggggg accaccctgc
     2341 ccttggttgt ccccaccccc cagaggacga ctcttccttg cgtgcagagc ggggctcctt
     2401 ggccgacctg cctctggtcc cccctacctc agcccctctc gagtttctgg acccccttat
     2461 gggggccgca gcgccccagt accccgggcg ggggccacct cccgctcccc cccctccacc
     2521 gccccctccc cgggcctccg cggaaccggc cgcgtccccc gaccccccgt cggccctggc
     2581 cagtccaggc tccggcctat cgtctccggg ccccaagccg ggggacagcg gctacgagac
     2641 cgagacccct ttttcccccg agggagcctt cccaggtggg ggggcggccg aggaggaagg
     2701 ggtccctcgg ccacgggctc cccccgagcc acccgaccca ggagcgcccc ggccaccccc
     2761 agacccgggt cccctcccac tcccagggtc ccaggagaag ccaacctttg tagttcaggt
     2821 gagcaccgag cagctgctga tgtccctacg ggaggatgtg acaaagaacc tcctagggga
     2881 caaggggtcg acacccgggg agacaggacc caggaaggcg gggagaagcc ccgcgaacag
     2941 agagaagggc ccaggcccga acagggacct gacatccctg gtcagcagga agaaagtccc
     3001 cagcaggagc cttccagtga acggggtgac agtgttggag aacgggaagc caggagtccc
     3061 ggacatgaag gagaaggtgg cggagaatgg cctggaatct ccggagaaag aagagagagc
     3121 cctggtgaat ggggagccga tgtccccaga ggccggggag aaggtgctgg cgaatggggt
     3181 tctgatgtcc ccaaagagcg aggagaaggt ggcagagaat ggggtcctga ggctgcccag
     3241 gaacacggag aggccaccag agattggacc tcggagagtc ccagggccct gggagaagac
     3301 gcccgagact gggggtctag ctcccgagac cctgctggat cgagcccctg cgccctgcga
     3361 ggcagccttg ccccagaacg gcttggagat ggcccctggc cagcttggcc cagcccccaa
     3421 gagcgggaac ccagaccccg ggaccgagtg gagagtccac gagagtgggg gggcaccgag
     3481 agcccccggg gctgggaagc tggacctcgg gagtgggggc cgagccctgg ggggcgtggg
     3541 gacggccccc gccggcggcc ccgcaagcgc cgtggacgca aaggccggat gggtagacaa
     3601 ctcgagacca ctgccacctc cgccacagcc actgggggcc caacagagga ggccggagcc
     3661 agtgcccctg aaagccaggc cggaggtggc ccaagaggaa gagccagggg tcccagacaa
     3721 caggctcggc ggagacatgg cccccagcgt agacgaggac cccctcaagc cggagaggaa
     3781 gggccccgag atgccacgct tgttcctgga cttgggacca cctcagggga acagcgagca
     3841 gatcaaagcc aaactctccc ggctctcgct ggcgctccca ccgctcacgc tcacgccgtt
     3901 cccgggcccg ggcccgcggc ggccaccttg ggagggcgcg gacgcagggg cagctggcgg
     3961 ggaggccggc ggggcggggg cgccggggcc agcggaggag gacggggagg acgaggacga
     4021 ggacgaggag gacgaggagg cagcgggctc tcgggatccc gggaggacgc gggaagcccc
     4081 agtgcccgtc gtggtgagca gcgccgacgg ggacacggtc cgcccgctgc gggggctgct
     4141 caagtctcca cgcgcggccg acgagccaga ggacagcgag ctggagagga agcgcaagat
     4201 ggtctccttc cacggggacg tgaccgtcta cctcttcgac caggagactc caaccaacga
     4261 gttgagcgtc cagggcaccc ccgaggggga cacggagcca tcaactcccc cagcgccccc
     4321 gacgcctccc caccccacca ccccaggaga tgggtttccc aacagcgaca gcggctttgg
     4381 cggcagtttc gagtgggcgg aggatttccc cctcctcccc ccgccaggcc cccccctgtg
     4441 cttctcccgc ttctccgtct cacctgcact ggagaccccg gggcctcccg cccgggctcc
     4501 cgacgcccgg cccgcaggcc ccgtggagaa ctgactcccc aaagacccag cccctttgca
     4561 tcccaagaag agggcttgcg agcagaatct tgtgtggacg atggagccat tgcccctgac
     4621 actgacacag cctctgggga ggtgcctgag gctgggccct ccctctcctc caccatgtgc
     4681 caaacaggag gcccaggccc tccacccagc cccccagatg agtcccctga tccccctgac
     4741 ccccccgacc cccttggagc cacatgaggc aggaagcccc atcgctggac agccacacgt
     4801 cttggaactg aactgaaccg aactcttttg ggcccagagc cccctggcac agcagaggtc
     4861 tctcctggcc ccatgagggc cactggcttc aggaacctgg cccccccccc ccatcttgcg
     4921 tctccccttc ccccaagcct ggcccctgga gggggcctct gattcaaacc ttcgcgtgac
     4981 attttcacat tatttaaaaa aaaaagacaa aaacaacttt tggaggaaaa
//
